Ngaba unikwe iPazopanib? Makhe sithethe ngale chiza ngokweenkcukacha!

Ngaba ugqirha wakho umisele iyeza elibizwa ngokuba yiPazopanib? Okanye ngaba kukho umntu omaziyo othatha eli yeza? Kuqhelekile ukuba noloyiko kwaye unomdla malunga neyeza elitsha, ingakumbi kwimeko enzima efana nomhlaza. Imibuzo ifika engqondweni, akunjalo? "Ngaba oku kuya kuyinyanga le sifo?", "Zithini iziphumo ebezingalindelekanga?" Izinto ezinjalo. Ke namhlanje, masithethe ngohlobo lweyeza iPazopanib, indlela yokulisebenzisa, kunye nezinto ekufuneka uzilumkele, ngendlela elula kakhulu onokuyiqonda.

Lithini eli yeza?

Ngamafutshane, iPazopanib liyeza elinceda ekulawuleni ukukhula kweeseli zomhlaza . Likwiqela lamayeza abizwa ngokuba ngamayeza e-biologic . Oku kuthetha ukuba enziwe ngezinto ezifunyenwe kwiiseli eziphilayo. Azifani namayeza aqhelekileyo eekhemikhali, kodwa zintsonkothile kancinci.

I-Pazopanib isetyenziswa kakhulu uku:

• Umhlaza wezintso
• Uhlobo lomhlaza oluvela kwizicubu ezithambileyo ezibizwa ngokuba yi-sarcoma

Nangona kunjalo, ngamanye amaxesha ugqirha wakho unokukunika eli yeza kwezinye iimeko, ngoko ke ukuba unemibuzo, kungcono ubuze ugqirha wakho okanye ingcali yezemithi.

Eli yeza lifumaneka kakhulu kwimarike phantsi kwegama lebrendi elithi Votrient .

Zeziphi izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba usebenzise amayeza?

Ngaphambi kokuba uqale ukusebenzisa iPazopanib, kubaluleke kakhulu ukuxelela ugqirha wakho ngazo zonke iimeko zakho zempilo. Oku kungenxa yokuba abantu abaneemeko ezithile zempilo bafuna unyango olukhethekileyo xa bethatha eli yeza. Qiniseka ukuba uxelela ugqirha wakho ukuba unenye kwezi meko zilandelayo:

• Iingxaki zokopha: Ngaba unengxaki apho ungakwazi ukuyeka ukopha ngokulula? Okanye ngaba uhlala uphuma igazi empumlweni? Ukuba kunjalo, kufuneka usixelele, kuba eli yeza ngamanye amaxesha linokunyusa umngcipheko wokopha.
• Ukuba usandul’ utyando (kwiintsuku ezisi-7) okanye ucwangciselwe utyando kwixesha elizayo: Olu lwazi lubalulekile kuba eli yeza lisenokuchaphazela ukuphiliswa kwenxeba.
• Isifo sentliziyo: Ukuba unesifo sentliziyo, ugqirha wakho kufuneka azi ngaso.
• Uxinzelelo lwegazi oluphezulu: Eli yeza lisenokuchaphazela uxinzelelo lwegazi.
• Imbali yokubetha kwentliziyo ngendlela engacwangciswanga: Sixelele ukuba wakha waba neentliziyo ezingaqhelekanga.
• Ukuba ukhe waba nestroke: Abantu abakhe baba nestroke ngaphambili kufuneka baxelele ugqirha wabo ngale nto.
• Isifo sesibindi: Ukuba unengxaki yesibindi, umthamo wamayeza akho unokufuneka utshintshwe okanye kwenziwe uvavanyo olukhethekileyo.
• Izifo zemiphunga okanye zokuphefumla, umzekelo, i-asthma:Yazisa abo baneengxaki zokuphefumla.
• Ukuba uneproteni kumchamo wakho: Oku kungaba luphawu lwengxaki yezintso.
• Iingxaki ze-thyroid: Amanqanaba e-thyroid hormone anokuchaphazeleka.
• Ukuba ukhe waba nempendulo engaqhelekanga okanye ye-allergy kwiPazopanib okanye nakweyiphi na eminye imithi, ukutya, iidayi, okanye izithinteli: Ukuba une-allergy kuyo nayiphi na into, kubaluleke kakhulu ukuxelela ugqirha wakho.
• Ukuba ukhulelwe okanye uzama ukukhulelwa: Oku kubaluleke kakhulu . Eli yeza alifanelekanga kubafazi abakhulelweyo.
• Ukuba uncancisa: Eli yeza alifanelekanga nakumama oncancisa.

Hayi nje kuphela ezi zinto, kodwa xelela ugqirha wakho ngazo naziphi na ezinye iingxaki zempilo onazo. Nokuba yinto encinci inokuba yinto ebalulekileyo.

Ndingayisebenzisa njani le yeza?

Kubaluleke kakhulu ukusebenzisa eli yeza ngokuchanekileyo. Ufanele ulithathe kanye njengoko ugqirha wakho ekuxelele, ngedosi efanelekileyo, ngexesha elifanelekileyo.

• Le pilisi kufuneka ithathwe ngomlomo neglasi yamanzi.
• Landela imiyalelo ekwileyibhile kagqirha oyinikwe ngugqirha wakho ngokuchanekileyo.
• Musa ukuphula, ukutyumza, okanye ukuhlafuna ipilisi. Yiginye yonke.
• Eli yeza lifanele lithathwe ungenanto esiswini . Oko kukuthi, ubuncinane iyure enye ngaphambi okanye iiyure ezimbini emva kokutya . Musa ukulisebenzisa eli yeza kunye nokutya.
• Musa ukulisebenzisa eli yeza kunye nejusi yegrapefruit. Ijusi yegrapefruit ingatshintsha indlela umzimba olifunxa ngayo eli yeza.
• Sela amayeza ngexesha elifanelekileyo, kanye njengoko ugqirha wakho ekuxelele. Musa ukuthatha ngaphezu komlinganiselo omiselweyo.
• Musa ukuyeka ukuthatha amayeza ngaphandle kwengcebiso kagqirha wakho. Nokuba uzive ungcono, qhubeka uwathatha ade ugqirha wakho akuxelele ukuba wenjenjalo.

Xa ufumana eli yeza kwikhemesti, uza kunikwa incwadana ekhethekileyo (iMedGuide) . Iqulethe ulwazi olubaluleke kakhulu malunga neli yeza. Ungalibali ukuyifunda ngononophelo loo ncwadana ngalo lonke ixesha ufumana ukugcwalisa okanye ukugcwalisa kwakhona amayeza akho .

Ukuba unika abantwana eli yeza: Thetha nogqirha wakho wabantwana malunga nokunika abantwana eli yeza. Kunokufuneka ukhathalelo olukhethekileyo.

I-Overdose: Ukuba ucinga ukuba usele eli yeza kakhulu, fowunela iziko lolawulo lwetyhefu okanye igumbi longxamiseko ngokukhawuleza.

Kubalulekile: Eli yeza lelakho kuphela. Musa ukwabelana ngalo nabanye. Ngenxa yokuba lisebenza kuwe, lisenokungasebenzi nakwabanye.

Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?

Ngamanye amaxesha uyalibala ukusela amayeza akho, akunjalo? Ukuba oko kuyenzeka, ungakhathazeki.

• Sela amayeza akho ngokukhawuleza xa ukhumbula.
• Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 ngaphambi kokuba uthathe idosi elandelayo, ungayithathi idosi oyiphosileyo. Thatha nje idosi elandelayo ngexesha elicwangcisiweyo.
• Ungaze uthathe idosi ephindwe kabini okanye idosi eyongezelelweyo. Ukwenza njalo kunokubangela iziphumo ebezingalindelekanga.

Ziziphi ezinye izinto ezinokusebenzisana nale mithi?

I-Pazopanib inokusebenzisana namanye amayeza. Oku kuthetha ukuba xa isetyenziswa kunye, ukusebenza kakuhle kweyeza elinye kunokutshintsha okanye iziphumo ebezingalindelekanga zinokwanda.

Musa ukuthatha iPazopanib kunye namayeza alandelayo:

• I-Cisapride
• I-Dronedarone
• I-Fluconazole
• I-Pimozide
• I-Posaconazole
• I-Saquinavir
• I-Thioridazine

Eli yeza linokunxibelelana namayeza alandelayo:

• Amanye amayeza okubulala iintsholongwane, umzekelo i-clarithromycin.
• Amanye amayeza ezifo ezibangelwa yintsholongwane ezifana ne-HIV okanye i-hepatitis.
• Amanye amayeza osulelo lwefungus, umzekelo i-ketoconazole okanye i-itraconazole.
• Amanye amayeza anikwa ukulawula ukuxhuzula, umzekelo i-carbamazepine, i-phenobarbital, kunye ne-phenytoin.
• Amanye amayeza abangela ukubetha kwentliziyo okungahambelaniyo (andisa ixesha le-QT).
• Izinto ezithintela i-asidi yesisu, ezifana ne-lansoprazole, i-omeprazole, okanye i-pantoprazole.

Olu luhlu alubandakanyi zonke iindlela osebenzisana ngazo. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owasebenzisayo (amayeza amiselweyo, athengiswa ngaphandle kwemvume kagqirha, awemifuno, iivithamini, okanye izongezo zokutya). Kwakhona, xelela ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi. Ezi zinto zinokusebenzisana namayeza akho.

Zeziphi izinto ekufuneka uzilumkele xa usebenzisa amayeza?

Ufanele ukhathalele impilo yakho ngokukodwa xa usebenzisa eli yeza.

• Bona ugqirha wakho rhoqo: Yiya kuhlolo njengoko ugqirha wakho ekuxelela. Kusenokufuneka wenze umsebenzi wegazi ngelixa usebenzisa eli yeza.
• Lumka kwiimpawu zosulelo: Ukuba ubonakalisa iimpawu ezifana nomkhuhlane, ukubanda, umphimbo obuhlungu, okanye impumlo egobhozayo, xelela ugqirha wakho ngoko nangoko. Musa ukuzinyanga. Eli yeza linokunciphisa amandla omzimba wakho okulwa nosulelo. Ngoko zama ukuhlala kude nabantu abagulayo.
• Ingozi yokopha okanye ukukrweleka:Eli yeza linokubangela ukuba abanye abantu bagruzuke okanye bophe igazi lula. Xelela ugqirha wakho ukuba ubona ukopha okungaqhelekanga (umz., empumlweni yakho, kwiintsini, okanye kwindle).
• Lumka malunga nokukhulelwa nokuzala:
• Musa ukukhulelwa ngelixa usela eli yeza kwaye ubuncinane iiveki ezimbini emva kokuyeka ukusebenzisa eli yeza. Abafazi kufuneka bazise ugqirha wabo ukuba baceba ukukhulelwa okanye bakrokrela ukuba bakhulelwe.
• Amadoda afanele akuphephe ukuba nguyise womntwana ngelixa esela eli yeza kwaye ubuncinane iiveki ezimbini emva kokuba eyeke ukusebenzisa eli yeza.
• Kukho amathuba okuba nemiphumo emibi kakhulu kumntwana ongekazalwa. Buza ugqirha wakho okanye ikhemisti ukuze ufumane ulwazi oluthe kratya malunga noku.
• Musa ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza kwaye kangangeeveki ezimbini emva kokuba uyekile ukusebenzisa eli yeza.
• Iziphumo ekuzaleni: Eli yeza lisenokuchaphazela amandla akho okufumana abantwana. Ukuba uneengxaki malunga noku, thetha nogqirha wakho.
• Ngaphambi kotyando: Ukuba uza kutyandwa, thetha nogqirha wakho ngaphambi kokuba wenze njalo uze ufumane imvume. Eli yeza linokulibazisa ukuphiliswa kwamanxeba otyando. Kufuneka uyeke ukuthatha eli yeza iveki enye ngaphambi kotyando. Emva kotyando, linda ubuncinane iiveki ezimbini uze ulinde de inxeba liphole ngokupheleleyo ngaphambi kokuba uqale eli yeza kwakhona. Ukuba unemibuzo malunga noku, thetha nogqirha wakho.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengalo naliphi na iyeza, iPazopanib inokubangela iziphumo ebezingalindelekanga kwabanye abantu. Asinguye wonke umntu ozifumanayo. Nangona kunjalo, kubalulekile ukuqaphela iziphumo ebezingalindelekanga ezinokubakho.

Iziphumo ebezingalindelekanga ekufuneka uxelele ugqirha wakho ngazo ngoko nangoko:

Ukuba ufumana naziphi na kwezi mpawu, xelela ugqirha wakho okanye umboneleli wezempilo ngokukhawuleza:

• Iimpendulo ze-allergy: Ukurhawuzelela kwesikhumba, ukurhawuzelela okanye ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi.
• Iingxaki zokuphefumla.
• Utshintsho kwimbono.
• Iintlungu zesifuba.
• Ububomvu, ukudumba, ukuxobuka, ukopha, okanye ukudumba kolusu ezintendeni nasezinyaweni.
• Ukuxhuzula.
• Iimpawu zokopha: Igazi elikwisitulo, okanye isitulo esimnyama esirhabaxa; Umchamo obomvu okanye omdaka; Ukuhlanza izinto ezinombala omdaka njengekofu okanye igazi ematheni; Amabala abomvu eluswini; Ukopha okungaqhelekanga okanye ukukrweleka emehlweni, kwiintsini, okanye empumlweni.
• Iimpawu zokuqhekeka kwegazi: Iintlungu zesifuba; Ubunzima bokuphefumla; Intlungu yomlenze, ukudumba, okanye ukufudumala.
• Iimpawu zokusilela kwentliziyo:Ubunzima bokuphefumla; ukubetha kwentliziyo okukhawulezayo nokungaqhelekanga; ukunyuka kobunzima ngequbuliso; ukudumba kwamaqatha, iinyawo, okanye izandla; ukuziva ubuthathaka okanye udiniwe ngendlela engaqhelekanga.
• Iimpawu zosulelo: umkhuhlane; ukubanda; ukukhohlela; umphimbo obuhlungu; intlungu okanye ubunzima bokuchama.
• Iimpawu zokulimala kwesibindi: Umchamo otyheli okanye omdaka omnyama; ukuziva ungaphilanga okanye unomkhuhlane; indle ekhanyayo; ukungabi namdla wokutya; isicaphucaphu; iintlungu esiswini esingaphezulu ngasekunene; ubuthathaka okanye ukudinwa okungaqhelekanga; ukutyheli kolusu okanye amehlo.
• Iimpawu zestroke: Ukutshintsha kombono; ukudideka; ubunzima bokuthetha okanye ukuqonda; intloko ebuhlungu kakhulu; ukudinwa okanye ubuthathaka ngequbuliso ebusweni, engalweni, okanye emlenzeni; ubunzima bokuhamba; isiyezi; ukulahleka kokulinganisela.
• Iimpawu zeTumor Lysis Syndrome: Ukucaphuka, ukuhlanza, urhudo, ukubetha kwentliziyo okungahambelaniyo, ukudinwa, ukuxhuzula, ukudideka, ukuxhuzula kwemisipha okanye iintlungu, ukuncipha kokuphuma komchamo.

Iziphumo ebezingalindelekanga oqhele ukuxelela ugqirha wakho ngazo , kodwa ekufuneka zixelwe ukuba ziyaqhubeka okanye ziyakukhathaza:

Nokuba ezi zinto azibalulekanga kangako, ukuba ziyaqhubeka okanye ziyakukhathaza, xelela ugqirha wakho .

• Ukutshintsha kombala weenwele.
• Utshintsho kwincasa.
• Urhudo.
• Ukutya akunancasa.
• Ukutshintsha kombala wolusu.
• Ukuhla ukusinda.

Olu luhlu lusenokungabandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona nantoni na engaqhelekanga, thetha nogqirha wakho. Ungaxela iziphumo ebezingalindelekanga kwi-FDA ku-1-800-FDA-1088.

Ufanele uwagcine njani amayeza akho?

• Yigcine kude nabantwana.
• Gcina kubushushu begumbi (phakathi kwe-15 kunye ne-30 degrees Celsius / 59 kunye ne-86 degrees Fahrenheit).
• Lahla amayeza aphelelwe lixesha.

Oko sikufundileyo koku (Umyalezo Wokuya Ekhaya)

I-Pazopanib liyeza elibalulekileyo elinceda ekulweni nomhlaza. Kubalulekile ukuba uqaphele eli yeza kwaye ulandele imiyalelo kagqirha wakho ngokuchanekileyo.

Khumbula, ukuba unemibuzo okanye izinto ezikuxhalabisayo, ungoyiki ukubuza ugqirha wakho okanye ingcali yezemithi. Wena nogqirha wakho ningabantu abenza izigqibo ngempilo yenu kunye. Ngoko ke thethani ngokukhululekileyo ngayo yonke into.

Siyathemba ukuba eli nqaku likunike ukuqonda okungcono ngesiyobisi iPazopanib. Sikunqwenelela ukuchacha ngokukhawuleza!

I- Pazopanib, i-Pazopanib, iyeza lomhlaza, umhlaza wezintso, i-sarcoma, iziphumo ebezingalindelekanga zamachiza, unyango lomhlaza