Kutheni isifo sesibindi esibizwa ngokuba yi-PBC sixhaphake kakhulu kubasetyhini? (I-Primary Biliary Cholangitis - PBC)

Ngaba wakha weva nge-PBC, isifo sesibindi? Usenokuba awuqhelananga neli gama. Kodwa ubusazi na ukuba abantu abalithoba kwabalishumi abaphethwe yile meko ngabafazi? Oko kuyamangalisa ngokwenene, akunjalo? Kutheni ke esi sifo sibonakala sijolise kubafazi? Siyintoni isizathu soku? Namhlanje, siza kuthetha ngale nto ngokulula, ngendlela onokuyiqonda.

Masiqale sibone, yintoni iPBC?

Kulungile, eli ligama lesayensi kancinci, kodwa okwenzekayo kulula kakhulu. I-PBC, emele i-Primary Biliary Cholangitis, sisifo apho inkqubo yomzimba wethu yokuzikhusela ingena nzulu kwaye ihlasela isibindi sethu. Sibiza ezi zifo ngokuba zizifo zokuzikhusela komzimba. Cinga ngayo, inkqubo yomzimba wethu yokuzikhusela ifana nomkhosi okhusela ilizwe. Umsebenzi walo mkhosi kukulwa neentsholongwane kunye neentsholongwane ezivela ngaphandle kwaye zisisindise kwizifo. Kodwa ngamanye amaxesha lo mkhosi wenza impazamo kwaye uqale ukuhlasela abantu abamsulwa kwilizwe lawo. Kwenzeka into efanayo kwi-PBC. Inkqubo yethu yokuzikhusela ihlasela imibhobho ye-bile encinci kwisibindi sethu. Le mibhobho ye-bile yinkqubo ebaluleke kakhulu yeetyhubhu ezithwala i-bile eveliswa sisibindi ukuya emathunjini. Xa le mibhobho yonakele, i-bile ayihambi kakuhle kwaye iqokelelana ngaphakathi kwesibindi, iyonakalisa isibindi kancinci kancinci.

Kutheni ke oku kubachaphazela ngakumbi abafazi?

Ngoku makhe sijonge impendulo yombuzo omkhulu wonke umntu anawo. Abaphandi abakafumani sizathu sicacileyo sale nto. Nangona kunjalo, bakholelwa ukuba zithathu izinto eziphambili ezinegalelo kuyo.

1. Impembelelo yeehomoni

Uyazi, imizimba yabasetyhini yahlukile kakhulu kwimizimba yamadoda. Isizathu esiphambili saloo nto zii-hormones. Ngokukodwa, i-hormone i-estrogen idlala indima ebaluleke kakhulu kuzo zonke izigaba zobomi bomfazi. Cinga ngayo, ngomjikelo wenyanga wokuya exesheni, ngakumbi xa umntu eyeka ukuya exesheni, okwenzeka phakathi kweminyaka engama-40-60, kukho utshintsho olukhulu kumanqanaba ale hormone ye-estrogen. Olu tshintsho lwee-hormone luchaphazela ngokuthe ngqo indlela iiseli zenkqubo yethu yokuzikhusela komzimba ezisebenza ngayo. I-hormone ye-estrogen inokuvuselela inkqubo yokuzikhusela komzimba kakhulu. Oko kukuthi, yenza kusebenze "umkhosi" esathetha ngawo ngaphambili kakhulu. Xa oku kusenzeka, umngcipheko wokuhlasela iiseli zayo uyanda. Singawucingela olu nxibelelwano kuba i-PBC ixhaphake kakhulu phakathi kwabasetyhini abakweli qela leminyaka.

2. Iintsholongwane emathunjini

Oku kusenokuba yinto entsha kuwe. Iibhiliyoni zeebhaktheriya ezilungileyo nezimbi zihlala emathunjini ethu. Olu luntu lweebhaktheriya lubaluleke kakhulu kwimpilo yethu. Uphando lufumanise ukuba abantu abane-genetic predisposition yokuphuhlisa i-PBC baneentlobo ezahlukeneyo zeebhaktheriya emathunjini abo kunezinye. Bakwanamanqanaba aphezulu ohlobo lweebhaktheriya oluqhele ukunxulunyaniswa nosulelo lwendlela yomchamo (UTIs). Ngoko ke oku kubonisa ukuba usulelo oluthile lweebhaktheriya kunye nokungalingani kwiibhaktheriya zamathumbu kunokuba negalelo ekuphuhlisweni kwe-PBC ngokuphazamisa inkqubo yomzimba yokuzikhusela.

3. Impembelelo yezakhi zofuzo kunye nemfuza

"Ngaba esi sisifo esizuzwa njengelifa?" usenokuba uzibuza. Ewe, ngandlela ithile, ii-genes zidlala indima.

• Phakathi kwe-1% kunye ne-9% yabantu abane -PBC banelinye ilungu losapho elinesifo.
• Ukuba elinye lamawele amabini afanayo liba ne-PBC, kukho amathuba angama-63% okuba elinye nalo liba ne-PBC.

Okubaluleke ngaphezu kwako konke oku kukubandakanyeka kwe -chromosome X. Ngamafutshane, abafazi bane-chromosome ezimbini ze-X (XX), ngelixa amadoda ene-chromosome enye ye-X kunye ne-chromosome enye ye-Y (XY). Uphando lubonise ukuba abafazi abane-PBC bane-chromosome enye ye-X engekhoyo okanye banotshintsho oluthile kwi-chromosome ye-X kwezinye iiseli zemizimba yabo. Olu tshintsho lunokuchaphazela ukusebenza kwezakhi zofuzo ezibandakanyekayo kwinkqubo yomzimba yokuzikhusela, nto leyo eyonyusa umngcipheko wokufumana esi sifo sokuzikhusela komzimba.

Ngaba kunokwenzeka ukuba uphile kakuhle ne-PBC?

Ewe ngokwenene! I-PBC sisifo esinokulawulwa kakuhle ngonyango olufanelekileyo lwezonyango kunye notshintsho lwendlela yokuphila. Okukhona isifo sifunyanwa kwangoko, kokukhona kulula ukulawula umonakalo wesibindi. Eyona nto ibalulekileyo xa uphila nesi sifo kukugcina ubudlelwane obuhlala buhleli nogqirha wakho . Kubalulekile ukuthatha amayeza awanike wona ngexesha, ukuya kwiikliniki ngexesha. Ukongeza, ngokutya ukutya okunesondlo, ukuphepha ngokupheleleyo utywala, kunye nokwenza umthambo ofanelekileyo njengoko ugqirha wakho ecebisa, ungaphila ubomi obusempilweni. Ngoku kukho unyango oluhle kakhulu lokulawula iimpawu zesifo, njengokudinwa kakhulu kunye nolusu olurhawuzelelayo. Ngoko ke thetha ngokukhululekileyo nogqirha wakho ngaso. I-PBC, i-Primary Biliary Cholangitis, Izifo zesibindi, Impilo yabasetyhini, Izifo ze-Autoimmune, i-estrogen, iiHormones, iiGene, Isifo sesibindi kubafazi IsiSinhala, i-akmawe leda