Ngaba nawe unengxaki ye -cholesterol ? Mhlawumbi usela amayeza owanikwe ngugqirha wakho, ulawula ukutya kwakho , kwaye uzilolonga. Kodwa kusenzima ukunciphisa amanqanaba e-cholesterol yakho, akunjalo? Ngamanye amaxesha, nokuba uzama kangakanani na, amanqanaba e-cholesterol embi emzimbeni wakho anokuhlala ephezulu. Kweli nqaku, siza kuthetha ngodidi olutsha lwamayeza olunokunceda abantu abanjalo.
Ngamafutshane, ziintoni ezi PCSK9 Inhibitors?
Oku kunokuvakala ngathi ligama elintsonkothileyo, kodwa kusebenza ngokulula kakhulu. Ii-PCSK9 inhibitors ziluhlobo lwamayeza anciphisa i-cholesterol. Ngokukodwa, zijolise kwi -LDL (Low-Density Lipoprotein) cholesterol , eyi-"cholesterol embi" eyingozi emizimbeni yethu. Abanye abantu banezinga eliphezulu le-cholesterol ebomini babo bonke. Kwabo bantu, olu hlobo lweyeza lunokuba luncedo kakhulu.
Kulungile, ngoku masibone ukuba igama elithi `PCSK9` lithetha ukuthini. `I-PCSK9` luhlobo olukhethekileyo lweproteni eveliswa sisibindi sethu. Igama lale proteni yi-`proprotein convertase subtilisin/kexin type 9`. Into eyenzayo kukulawula izinto ezibizwa ngokuba yi-`LDL receptors` emzimbeni wethu. Izifundo zonyango zifumanise ukuba ukuba umzimba womntu uvelisa iproteni engaphezulu ye-`PCSK9` ngokwendalo, loo mntu unokuba ne -cholesterol ephezulu .
Ngubani ofuna eli yeza?
Lo ngumbuzo obaluleke kakhulu. Kuba eli yeza alinikwa wonke umntu one-cholesterol ephezulu. Ngokuqhelekileyo kukho iimeko ezimbini eziphambili apho ugqirha wakho anokunika eli yeza elithi `PCSK9 inhibitor`:
1. Xa i-cholesterol ingalawulwa ngamanye amayeza: Ukuba sele usebenzisa amanye amayeza okunciphisa i-cholesterol, afana ne-`(statins)` kodwa amanqanaba akho e-cholesterol asephezulu, ungalijonga eli yeza njengenyathelo elilandelayo.
2. Kwiimeko ezithile zemfuza: Abanye abantu banemeko yokuzalwa ene-cholesterol ephezulu. Oku kubizwa ngokuba yi-"familial hypercholesterolemia" kwisayensi yezonyango.Eli yeza liluncedo kakhulu nakubantu abanale meko.
Khumbula, injongo ephambili yale mithi kukunciphisa amanqanaba akho e-cholesterol, ngaloo ndlela kunciphisa umngcipheko weengxaki ezinkulu zentliziyo kunye nemithambo yegazi ezifana nokuhlaselwa yintliziyo kunye nestroke .
Eli yeza lisebenza njani emzimbeni?
Ukuze sikuqonde oku, makhe sithathe umzekelo omncinci.
Khawuthelekelele ukuba umzimba wakho “unezandla ezibamba i-cholesterol.” Sizibiza ngokuba “zii-LDL receptors.” Ezi “receptors” zifumaneka kakhulu kumphezulu weeseli zethu zesibindi. Ezi “zandla” zibamba i-cholesterol embi edada egazini (i-LDL cholesterol) zize ziyifake esibindini. Isibindi emva koko siyayiqhekeza loo cholesterol size siyisuse emzimbeni. Le yinkqubo eqhelekileyo.
Kodwa kukho inkohlakalo encinci apha. Le yiproteni ethi `(PCSK9)` ebesithethe ngayo ngaphambili. Le protein ethi `PCSK9` isebenza njengesikere`. Into eyenzayo kukutshabalalisa ezo zandla zibamba i-cholesterol, oko kukuthi, ii-`LDL receptors`, kwaye inciphise umsebenzi wazo. Xa iproteni ethi `PCSK9` isanda emzimbeni, inani `lezandla` ezibamba i-cholesterol liyancipha. Emva koko i-cholesterol embi egazini ayinakususwa sisibindi kwaye iqokelelane egazini.
Ngoku mhlawumbi uyaqonda ukuba yintoni eyenziwa liyeza elithi `PCSK9 inhibitor`. Ukuchaneka, eli yeza lithintela iproteni ethi `PCSK9` esebenza njengesikere. Oko kuthetha ukuba, xa eli yeza lisetyenziswa, iproteni ethi `PCSK9` ayinakutshabalalisa ezo zandla zibamba i-cholesterol (ii-LDL receptors).
Kuza kwenzeka ntoni ke ngoko?
- Kukho ii-receptors ze-LDL ezisebenzayo ngakumbi.
- Ezi 'zandla' zisebenzayo zibamba i-cholesterol embi egazini kwaye ziyithumele esibindini.
- Isibindi sisusa loo cholesterol emzimbeni.
Isiphumo sokugqibela kukwehla okukhulu kwinqanaba le-cholesterol embi egazini lakho.
Lisebenza kangakanani eli yeza? Kwaye zeziphi iintlobo zalo?
Ii-PCSK9 inhibitors ziindidi zamayeza eziye zabonakala zisebenza kakhulu kwabanye abantu. Ezinye izifundo zifumanise ukuba la mayeza anokunciphisa amanqanaba e-cholesterol embi (i-LDL cholesterol) ukuya kuthi ga kwi-70% kwaye anokunciphisa nomngcipheko wokuhlaselwa sisifo sentliziyo malunga nesinye kwisithathu.
Kukho iintlobo ezimbini ze-`PCSK9 inhibitors` ezisetyenziswa kakhulu ngoku eSri Lanka nakwihlabathi liphela:
- `Alirocumab` (igama lophawu: Praluent®)
- `Evolocumab` (igama lophawu: Repatha®)
Ulithatha njani iyeza?
Le ayisiyopilisi yokusela yonke imihla. `Ii-PCSK9 inhibitors` zinikwa njengenaliti.Ngokwesiqhelo kuya kufuneka ufumane olu gonyo rhoqo emva kweeveki ezimbalwa okanye emva kweenyanga ezimbalwa, njengoko ugqirha wakho egqibe.
Ngelixa usebenzisa olu nyango, ugqirha wakho uya kwenza uvavanyo lwegazi rhoqo ukujonga ukuba iyeza lisebenza kakuhle kangakanani na. Ngamanye amaxesha eli yeza lisenokunikwa lodwa, kwaye ngamanye amaxesha linokunikelwa kunye neyeza osele ulisebenzisa, njenge-statin.
Zithini iingenelo kunye nemiphumo enokubakho?
Njengalo naliphi na iyeza, eli yeza linokuba neenzuzo kunye nemiphumo emibi emincinci. Nangona kunjalo, uninzi lwabantu alufumani miphumo emibi kakhulu.
| Inkcazo | Imizekelo |
|---|---|
| Iingenelo eziphambili |
|
| Iziphumo ebezingalindelekanga eziqhelekileyo | |
| Iziphumo ebezingalindelekanga ezingaqhelekanga |
Ingaba iyeza lodwa lanele? Hayi, le yinxalenye yesicwangciso esikhulu.
Oku kubaluleke kakhulu. Nokuba uthatha i-PCSK9 inhibitor okanye elinye iyeza lokunciphisa i-cholesterol, yinxalenye enye yesicwangciso sakho sonyango siphela. Zininzi ezinye izinto onokuzenza ukukhusela impilo yentliziyo yakho, ngaphandle kokuxhomekeka kuphela kumayeza.
- Ukutya okulungileyo: Yitya ioyile encinci, iswekile, netyuwa, kodwa yitya imifuno emininzi, iziqhamo, imifuno eluhlaza, nokutya okunefayibha eninzi.
- Ukuzilolonga: Ziqhelise ukwenza umthambo onempilo yentliziyo, njengokuhamba ngokukhawuleza, ukubaleka, okanye ukukhwela ibhayisekile, ubuncinane iintsuku ezimbalwa ngeveki.
- Ukulawula uxinzelelo: Phumla ingqondo yakho ngezinto ezifana nokucamngca kunye neyoga.
- Lala kakuhle: Lala ubuncinane iiyure ezisi-7-8 ubusuku ngabunye.
- Kuphephe ukutshaya: Ukuba uyatshaya, yeka ngokupheleleyo.
Uza kufumana iziphumo ezilungileyo xa udibanisa ezi nguqu zendlela yokuphila namayeza.
Ngugqirha wakho kuphela onokwenza isigqibo sokugqibela malunga nokuba ufanele uthathe eli yeza ixesha elingakanani, kunye nokuba uyeke okanye uqhubeke nalo. Ngoko ke, kubalulekile ukulandela imiyalelo kagqirha wakho ngokuchanekileyo.
Umyalezo Wokuya Ekhaya
- `Ii-PCSK9 inhibitors` luhlobo olusebenzayo kakhulu lwamayeza, olunikwa njengenaliti, kwiimeko ze-cholesterol ephezulu ezinzima ukuzilawula ngamayeza aqhelekileyo.
- Ezi zinceda isibindi ukuba sisuse "i-cholesterol embi" (LDL) egazini.
- Olu hlobo lonyango alusoloko lunikwa njengonyango lokuqala. Ugqirha wakho uza kulujonga kuphela xa ezinye iindlela zonyango zingaphumelelanga.
- Ngelixa usela la mayeza, kubaluleke kakhulu ukugcina indlela yokuphila elungileyo equka ukutya okunempilo kunye nokuzilolonga.
- Thetha ngokukhululekileyo nogqirha wakho malunga nokuba eli yeza likulungele na okanye alikulungele kunye nalo lonke ulwazi oluhambelana nalo.
Izithinteli ze-PCSK9, i-cholesterol, i-cholesterol, i-LDL cholesterol, uhlaselo lwentliziyo, istroke, i-familial hypercholesterolemia, i-statin, i-Alirocumab, i-Evolocumab
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