Ngaba ugqirha wakho ukuxelele ukuba amanqanaba akho e-cholesterol aphezulu? Ukuba kunjalo, kusenokwenzeka ukuba uqalwe nge-statin. Elo lidla ngokuba lolona hlobo lokuqala lonyango. Kodwa ngamanye amaxesha loo mayeza odwa awanelanga. Okanye abanye abantu abakwazi ukunyamezela iziphumo ebezingalindelekanga zamayeza. Yiyo loo nto oogqirha ngoku bethetha ngodidi olutsha lwamayeza 'atshintsha umdlalo'. La abizwa ngokuba yi-PCSK9 Inhibitors. Masithethe ngawo ngokulula namhlanje.
Ngamafutshane, ziintoni ezi PCSK9 Inhibitors?
La luhlobo olutsha lwamayeza anokunciphisa ngempumelelo i-cholesterol 'embi', okanye i-LDL cholesterol , egazini lethu. Okwangoku kukho iintlobo ezimbini eziphambili zamayeza avunyiweyo ehlabathini. Ziyi-'alirocumab (Praluent)' kunye ne-'evolocumab (Repatha)'.
Uphando lubonise ukuba la mayeza, abizwa ngokuba yi-PCSK9 inhibitors, asebenza ngendlela emangalisayo. Kwezinye iimeko, anokuthintela nokuhlaselwa sisifo sentliziyo kunye nokubetha kwentliziyo . La mayeza anokuselwa ewodwa, okanye xa edibene neyeza le-statin osele ulithatha. Kodwa into enye ekufuneka uyikhumbule kukuba abiza kakhulu kunezinye iziyobisi ze-cholesterol.
Kulungile, ngoku makhe sibone ukuba eli yeza lisebenza njani emzimbeni.
Ukuze siqonde oku, makhe sicinge ngebali elincinci. Isitho esiphambili esilawula i-cholesterol emizimbeni yethu sisibindi.
Khawucinge ukuba iiseli zethu zesibindi zine "zi-scavengers" ezincinci (ii-receptors) ezibamba kwaye zisuse i-cholesterol engafunekiyo egazini. Ezi zezona zigcina imithambo yegazi yethu icocekile.
Kodwa, kukho enye iproteni ebizwa ngokuba yi-PCSK9 eveliswa yimizimba yethu. Umsebenzi wayo kukufumana nokutshabalalisa ezo "zicoci zilungileyo." Emva koko, kuba kungekho mntu wokususa i-cholesterol, iqokelelana egazini ize ibekwe eludongeni lwemithambo yegazi.
Kulapho isithethi sethu, iyeza lokuthintela i-PCSK9, lisiza khona. Okwenziwa leli yeza kukuba libamba loo protein ye-PCSK9 imbi lize liyimise ukusebenza. Kufana nokubamba umntwana ongcolileyo limbeke esihlalweni. Emva koko "abacoci" bethu banokwenza umsebenzi wabo ngaphandle kokuthintelwa. Isiphumo? Inqanaba le-cholesterol ye-LDL egazini liyehla ngokukhawuleza.
Zahluke njani ezi 'statins'?
IiStatins kunye nee-PCSK9 inhibitors ziintlobo ezimbini zamayeza anciphisa i-cholesterol, kodwa asebenza ngeendlela ezimbini ezahlukeneyo. Le theyibhile iza kukunceda ukuqonde oku.
| Umahluko | I-Statin | Izithinteli ze-PCSK9 |
|---|---|---|
| Ukusebenza kakuhle | Ithintela ukuveliswa kwe-cholesterol esibindini. | Ithintela ukutshatyalaliswa kwee-receptors ezisusa i-cholesterol kwisibindi. |
| Indlela yokuthatha | Ipilisi ethathwa yonke imihla. | Inaliti inikwa rhoqo kwiiveki ezi-2 okanye ezi-4. |
| Ukusetyenziswa | Ihlala isetyenziswa yodwa, lukhetho lokuqala lokulawula i-cholesterol. | Ingasetyenziswa yodwa okanye xa idibene ne-statins. Iziphumo ziqina nangakumbi. |
Ngubani ke ofuna ukusela eli yeza?
Lo ngumbuzo obalulekileyo kuba ayinguye wonke umntu one-cholesterol ephezulu odinga eli yeza. Ugqirha wakho uza kuqala azame ukulawula i-cholesterol yakho ngee-statins. Kodwa ugqirha wakho angacinga nge-PCSK9 inhibitor kwezi meko zilandelayo:
- Iimeko ze-cholesterol ephezulu kwi-genetic: Abanye abantu banesifo se-genetic esibizwa ngokuba yi-"Familial Hypercholesterolemia." Aba bantu banesiphako kwindlela imizimba yabo elawula ngayo i-cholesterol. Nokuba kukho idosi ephezulu ye-statins, kunzima kakhulu kwaba bantu ukwehlisa i-cholesterol ye-LDL iye kwinqanaba elisempilweni.
- Kubantu abasengozini enkulu yokuhlaselwa yintliziyo okanye isifo sohlangothi: Ukuba sele unesifo sentliziyo, kwaye amanqanaba akho e-cholesterol akalawulwa ngokwaneleyo ngamayeza anjenge-statins, ugqirha wakho unokuqwalasela eli yeza.
- Kwabo bangakwaziyo ukunyamezela 'ii-statins': Malunga ne-10%-20% yabantu abasebenzisa ii-statins bafumana iziphumo ebezingalindelekanga ezifana neentlungu zemisipha ezinganyamezelekiyo, ubuthathaka, kunye neentlungu zomzimba . Kwabo bantu, olu lukhetho olufanelekileyo.
Ugqirha ulinika nini eli yeza?
Ugqirha akanakuze ayinike eli yeza lonke ngaxeshanye. Kukho indlela yokwenza oku.
1. Okokuqala, tshintsha indlela ophila ngayo: Ugqirha uthi kuqala qhelisa umzimba kakuhle kwaye utye ukutya okunempilo okuneoyile encinci, iswekile kunye nomgubo .
2. Okulandelayo, 'iStatin': Ukuba utshintsho kwindlela yokuphila alwanelanga, kuqaliswa i-statin. Ukuba i-cholesterol ayinciphi, idosi inyuswa kancinci kancinci.
3. Njengendlela yokugqibela: Ukuba i-cholesterol yakho ayilawulwa nokuba usebenzisa idosi ephezulu yee-statins, okanye ukuba iziphumo ebezingalindelekanga zinzima, ugqirha wakho unokuqwalasela i-PCSK9 inhibitor. Esi sigqibo sinokwenziwa ngokwenza uvavanyo, olufana ne-coronary calcium score, ukuvavanya umngcipheko wakho wesifo sentliziyo.
Lisetyenziswa njani eli yeza kwaye zithini iziphumo ebezingalindelekanga?
Iza njengenaliti engaphantsi kwesikhumba oyinika phantsi kwesikhumba rhoqo emva kweeveki ezimbini okanye ezine . Ungayifumana eluswini lwesisu sakho, ethangeni elingasentla, okanye engalweni engasentla. Ugqirha wakho okanye umongikazi oqeqeshiweyo uza kukubonisa indlela yokuyinika ngokufanelekileyo. Ihlala ingenabuhlungu kwaye ilula.
Xa kufikwa kwimiphumo emibi, eyona ixhaphakileyo ayibalulekanga kangako.
- Intlungu yomqolo
- Iimpawu ezifana nokubanda (umphimbo orhawuzelelayo, ukuveliswa kwe-mucus)
- Ubomvu, ukukrweleka, okanye intlungu encinci kwindawo yokuhlatywa inaliti
Kubaluleke kakhulu: Amaxesha amaninzi, iimpembelelo ezinkulu ze-allergy zinokwenzeka. Ukuba ngequbuliso uvela ii-hives ezinzima, ukudumba kobuso okanye imilebe, okanye ubunzima bokuphefumla , le yimeko engxamisekileyo. Ukuba oku kuyenzeka, kufuneka uye kwisebe lezonyango ezingxamisekileyo lesibhedlele esikufutshane (ETU) ngoko nangoko .
Okokugqibela, xa kufikwa kwixabiso lala mayeza, awafani namayeza aqhelekileyo, kwaye abiza kakhulu . Ke ngoko, olu nyango lusenokungabi naxabiso lifikelelekayo kuye wonke umntu. Kungcono ukuthetha ngokukhululekileyo nogqirha wakho ngale nto kwaye uxoxe ngokuba uyayidinga na, nokuba ikulungele na, kunye neendleko zakho.
Umyalezo Wokuya Ekhaya
- Izithinteli ze-PCSK9 ziludidi olutsha lwamayeza anamandla kakhulu anciphisa amanqanaba aphezulu e-LDL ('amabi') e-cholesterol.
- Ezi azizi njengeepilisi ekufuneka zithathwe yonke imihla, kodwa ziziinaliti ezinikwa rhoqo kwiiveki ezi-2 okanye ezi-4.
- Ezi zihlala zicetyiswa kubantu abaneengxaki ze-cholesterol ezibangelwa lufuzo, abo basengozini enkulu yesifo sentliziyo, okanye abo bangakwaziyo ukunyamezela amayeza e-statin.
- Eli yeza libiza kakhulu, ngoko ke kufuneka ugqibe ukuba lifanelekile na kuwe emva kokuxoxa ngononophelo nogqirha wakho.
- Ungaze wenze izigqibo malunga namayeza ngokusekelwe kumava okanye oko ukubonayo kwi-intanethi. Hlala ulandela icebiso likagqirha wakho.
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