Ngaba wakha wanengxaki yokulawula i-cholesterol yakho, nangona uzame amayeza ahlukeneyo, ukutya okunempilo, kunye nokuzilolonga? Ngamanye amaxesha kuyenzeka. Oku kunzima ngakumbi xa unembali yosapho ene-cholesterol ephezulu. Namhlanje, sithetha ngodidi olutsha lwamayeza anokunceda. La abizwa ngokuba yi-PCSK9 inhibitors.
Zithini ezi PCSK9 Inhibitors?
Ngamafutshane, la ngamayeza anamandla okwehlisa i-cholesterol anikwa njengeenaliti. Ngokuyintloko ajolise kwi -LDL cholesterol (Low-Density Lipoprotein Cholesterol) , "i-cholesterol embi" esiyaziyo sonke njengengalunganga emizimbeni yethu. Oogqirha badla ngokunika la mayeza abantu abangakhange bafumane iziphumo ezinqwenelekayo kwamanye amayeza e-cholesterol, njengee-statins, okanye kubantu abanembali yosapho lwabo ye-cholesterol ephezulu.
Eli yeza lisebenza njani emzimbeni?
Ukuze siqonde oku, masithathe umzekelo omncinci. Khawucinge ukuba i-cholesterol embi (LDL) egazini lakho luhlobo oluthile lwenkunkuma. Ukuze sisuse le nkunkuma size sicoce igazi, isibindi sethu sine "ingqayi yenkunkuma" ekhethekileyo kumphezulu waso. Oku sikubiza ngokwezonyango ngokuba zii-LDL receptors . Oko kwenziwa zezi receptors kukubamba i-LDL cholesterol egazini size siyifake esibindini ukuze itshatyalaliswe.
Nantsi enye. Leyo yiproteni ebizwa ngokuba yi -PCSK9 . Le nayo iveliswa sisibindi sethu. Kodwa umsebenzi wale proteni ye-PCSK9 kukutshabalalisa ii-receptor ze-LDL (iibhokisi zethu zenkunkuma) ezisusa i-cholesterol. Xa inqanaba le-PCSK9 lisanda emzimbeni, uninzi lwee-receptor ze-LDL luyatshatyalaliswa. Emva koko ukususwa kwe-cholesterol egazini kuyehla, kwaye inqanaba le-cholesterol egazini liyenyuka.
Ngoko ke, into eyenziwa yi-PCSK9 inhibitor vaccine kukuthintela loo protein ye-PCSK9 etshabalalisayo kwaye iyithintele ekusebenzeni kwayo. Emva koko ii-receptors zethu ze-LDL azitshatyalaliswa, kwaye zinokusebenza ngokukhululekileyo. Isiphumo kukuba i-cholesterol engaphezulu ye-LDL isusiwe egazini, kwaye amanqanaba e-cholesterol ancitshiswa kakhulu. Kulula kakhulu, akunjalo?
Ngubani ocebisa eli yeza?
Eli asiloyeza elifanela wonke umntu. Ugqirha wakho uya kugqiba ukuba eli yeza likulungele na ngokusekelwe kwizinto ezahlukeneyo.
| Imeko | Inkcazo |
|---|---|
| I-cholesterol ephezulu engalawulwa ngamanye amayeza | Ukuba amanqanaba akho e-LDL asephezulu nangona uthatha idosi ephezulu ye-statin kunye namanye amayeza e-cholesterol. |
| Iimeko ze-cholesterol ephezulu ezizuzwe njengelifa | Abantu ababenamanqanaba aphezulu kakhulu e-cholesterol ukususela ebuntwaneni ngenxa yeemeko zemfuza ezifana ne-Familial Hypercholesterolemia. |
| Kwabo basengozini enkulu yesifo sentliziyo | Ukuba sele une-myocardial infarction okanye i-stroke, kwaye umngcipheko wokuba imeko enjalo yenzeke kwixesha elizayo uphezulu kakhulu. |
Ndingayifumana njani le yeza?
Ezi zinikwa njengenaliti, hayi ipilisi. Ngokuxhomekeke kwingcebiso kagqirha wakho, uya kufumana le naliti esibhedlele okanye ekliniki rhoqo emva kweeveki okanye iinyanga ezimbalwa. Iintlobo ezimbini eziphambili ezisetyenziswayo ngoku eSri Lanka yi -Alirocumab (Praluent®) kunye ne -Evolocumab (Repatha®) .
Emva kokuqalisa olu nyango, ugqirha wakho uza kwenza uvavanyo lwegazi rhoqo aze ajonge amanqanaba akho e-cholesterol ukuze abone ukuba lusebenza kangakanani na.
Zithini iingenelo kunye neziphumo ebezingalindelekanga?
Inzuzo ephambili yale chiza kukuba iyasebenza kakhulu ekunciphiseni amanqanaba e-cholesterol ye-LDL. Ngokwezinye izifundo, zinokunciphisa amanqanaba e-LDL phakathi kwama-50% nama-70% . Oku kunciphisa kakhulu umngcipheko wokuhlaselwa sisifo sentliziyo, isifo sohlangothi, kunye nezinye izifo zentliziyo.
Nangona uninzi lwabantu lungenazo iziphumo ebezingalindelekanga ezinzulu, abanye banokufumana ezingephi.
- Ukudumba, ukuba bomvu, okanye intlungu kwindawo yokujova
- Ukuziva udiniwe (Ukudinwa)
- Intlungu yemisipha
- Iimpawu ezifana nokubanda
Kunqabile kakhulu, abanye abantu banokufumana iziphumo ezithile ekusebenzeni kwesibindi okanye kwezintso zabo. Yiyo loo nto kubaluleke kakhulu ukubona ugqirha wakho rhoqo ukuze ahlolwe . Ukuba ufumana naziphi na iimpawu ezingaqhelekanga, yazisa ugqirha wakho ngoko nangoko.
Akwanelanga na ukusebenzisa eli yeza lodwa?
Lo ngumbuzo obaluleke kakhulu. Impendulo ithi, "Hayi, akwanelanga." Izithinteli ze-PCSK9 azingomlingo. Ziyinxalenye nje yesicwangciso sonyango ngokubanzi.
Khumbula, ukulawula i-cholesterol akupheleli nje ekuseleni ipilisi, kodwa kukutshintsha yonke indlela ophila ngayo.
Ngelixa ufumana olu gonyo, ngokuqinisekileyo kufuneka ukhathalele oku kulandelayo:
- Ukutya okunempilo: Yitya ioyile encinci, iswekile, netyuwa, kodwa yitya iziqhamo nemifuno emininzi kunye nokutya okunefayibha eninzi.
- Ukuzilolonga rhoqo: Zilolonge rhoqo njengokuhamba okanye ukubaleka ubuncinane imizuzu engama-30 ngosuku, ubuncinane iintsuku ezi-5 ngeveki.
- Ukulawula uxinzelelo: Ukuphumla ingqondo ngezinto ezifana neyoga nokucamngca.
- Ubuthongo obaneleyo: Fumana ubuthongo obuhle iiyure ezisi-7-8 yonke imihla.
- Ukuyeka ukutshaya: Ukuyeka ngokupheleleyo ukutshaya kunye neemveliso zecuba.
Uza kufumana iziphumo ezilungileyo kakhulu kwi-PCSK9 inhibitor therapy xa udibanisa ezi nguqu zendlela yokuphila. Ungaze uyeke ukuthatha amayeza okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
Umyalezo Wokuya Ekhaya
- Izithinteli ze-PCSK9 luhlobo olunamandla lwenaliti esetyenziselwa ukunciphisa amanqanaba aphezulu e-cholesterol ye-LDL angalawulwa zezinye iindlela zonyango.
- Oku kukhusela ii-receptor ze-LDL zesibindi kwaye kwenza inkqubo yokususa i-cholesterol egazini isebenze ngakumbi.
- Olu lunyango olucetyiswa ngugqirha kuphela kwiimeko ezithile (umz., i-cholesterol ephezulu yelifa, umngcipheko ophezulu wesifo sentliziyo).
- Kubaluleke kakhulu ukugcina indlela yokuphila esempilweni ngelixa ufumana olu nyango.
- Qhubeka nolu nyango kuphela ngokwengcebiso kagqirha wakho, ugcine unxibelelwano oluqhubekayo naye.
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