Ngaba nawe uyafuna ukwazi ngePelger-Huet Anomaly? Masithethe ngayo!

Ngaba wakha waxelelwa ngugqirha ngotshintsho oluncinci kwiiseli zakho ezimhlophe zegazi xa uvavanywa igazi? Isenokuba yiPelger-Huet Anomaly. Igama lisenokuvakala ngathi yinto enkulu, kodwa ungakhathazeki , ngokuqhelekileyo alibi nzulu kangako. Makhe sithethe ngale nto ngokweenkcukacha ezithe vetshe, ngendlela elula.

Yintoni iPelger-Huet Anomaly?

Ngamafutshane, iPelger-Huet Anomaly (PHA) yimeko yemfuza echaphazela ii-neutrophils, uhlobo lweeseli ezimhlophe zegazi emzimbeni wethu. Ii-neutrophils zifana namajoni amancinci emzimbeni wethu anceda umzimba wethu ukulwa neentsholongwane.

Le meko ibangelwa kukwahluka kwi-DNA yethu, ngakumbi kwi-gene ebizwa ngokuba yi-Lamin B Receptor (i-LBR gene). Le gene ye-LBR yiyo enceda iiseli ze-neutrophil ukuba zikhule kwaye zikhule ngokufanelekileyo.

Ngoku khangela, iseli nganye ye-neutrophil ineziko lolawulo, esilibiza ngokuba yi-nucleus . Le nucleus iqulethe lonke ulwazi lwe-DNA olufunekayo kwiseli ukuze isebenze kwaye ikhule. Ngokwesiqhelo, i-nucleus ye-neutrophil esempilweni yahlulwe yangamacandelo amathathu okanye ngaphezulu. Nangona kunjalo, i-nucleus ye-neutrophil kumntu one-Pelger-Huette inamacandelo amabini. Ifana ne-dumbbell, enamafutha kumacala omabini kunye nombindi obhityileyo. Kunqabile kakhulu, kwabanye abantu, le nucleus ye-neutrophil inokwakheka njengeqanda, oko kukuthi, imile njengeqanda.

Kodwa into ebalulekileyo apha kukuba nokuba uzelwe une-Pelger-Huette anomaly, uninzi lwexesha iiseli zakho ze-neutrophil zisebenza ngokuqhelekileyo. Oku kuthetha ukuba aziphazamiseki kangako ekukukhuseleni kwizifo. Ke ngoko, zihlala zibangela iingxaki ezimbalwa zempilo.

Kukho enye imeko ebizwa ngokuba yiPseudo Pelger-Huet Anomaly (PPHA) . Oku kunokwenzeka kwabanye abantu kamva ebomini. I-PPHA ingenzeka njengemiphumo emibi yamayeza athile okanye njengophawu lwenye imeko, njengosulelo.

Zithini iimpawu zePelger-Huette anomaly?

Apha kufuneka sigxile kwiintlobo ezimbini esithethe ngazo ngaphambili.

I-Hereditary Pelger-Huet Anomaly (HPA)

Ukuba une-Pelger-Huette anomaly (HPA), ezuzwe njengelifa, uhlala ungenazo iimpawu. Usenokungazi nokuba unayo le meko. Idla ngokufunyanwa ngengozi xa uvavanyo lwegazi lwenziwa ngesinye isizathu.

I-Pseudo Pelger-Huet Anomaly (PPHA)

Nangona kunjalo, ukuba une-pseudo-Pelger-Huette anomaly (PPHA), oko kuthetha ukuba yavela kamva, unokufumana iimpawu ezinxulumene nemeko engundoqo eyabangela oko.Umzekelo, ukuba i-PPHA ibangelwa lusulelo, kunokubakho iimpawu ezifana nomkhuhlane kunye neentlungu zomzimba ezinxulumene nosulelo olo.

Yintoni ebangela i-Pelger-Huette anomaly?

Isizathu soku siyahluka ngokuxhomekeke kwiintlobo ezimbini esizixubushe ngaphambili.

I-Hereditary Pelger-Huette anomaly (HPA)

Oku kubangelwa kukuguquka kwejini yeLamin B Receptor (LBR), njengoko besitshilo ngaphambili. Le jini yeLBR iyalela umzimba wethu ukuba wenze iiproteni ezifunekayo ukukhusela iiseli ze-neutrophil kwaye uzinike imo efanelekileyo. Kwi-Pelger-Huytt anomaly, olu tshintsho lwejini luyayiphazamisa loo nkqubo, nto leyo ebangela ukuba iinuclei ze-neutrophils zithathe loo mo ye-dumbbell. Le yimeko enokuzuzwa ngabazali ukuya ebantwaneni.

I-Pseudo Pelger-Huette anomaly (PPHA)

Esi asisosifo semfuza. Kukho izinto ezininzi ezinokubangela esi sifo:

• Izifo zomongo wethambo: Imizekelo ibandakanya iimeko ze-leukemia ezifana ne-myelodysplastic syndrome kunye ne-acute myeloid leukemia (AML).
• Ezinye izifo: ingakumbi izifo ezithwalwa ziincukuthu.
• Ii-immunosuppressants: La mayeza, anikwa izifo ezithile, nawo asenokuba ngunobangela.
• Ukuvezwa yimitha: Umzekelo, ngexesha lonyango lomhlaza.

Ukuba ugqirha ukuxelela ukuba une-'PHA' okanye 'PPHA', kubaluleke kakhulu ukwazisa ugqirha ngazo zonke amayeza owasebenzisayo, kuquka neevithamini.

Ziziphi izinto ezibangela umngcipheko wale meko?

Eyona nto iphambili ebangela uPelger-Huette anomaly (PHA) kukuba nomzali ozelweyo onesi sifo. Oku kuthetha ukuba ukuba umama okanye utata wakho une-PHA, unethuba elimalunga nama-50% lokuyifumana njengelifa. Kufana nokuphosa ingqekembe, awunakutsho ngokuqinisekileyo, kodwa kusenokwenzeka.

Kwimeko ye-'PPHA`, ukuchatshazelwa ziimeko zonyango okanye unyango olukhankanyiweyo ngaphambili zizinto eziyingozi.

Ngaba kukho naziphi na iingxaki ezibangelwa yile meko?

Ngokwesiqhelo, i-Pelger-Huette anomaly (PHA) yelifa ayibangeli iingxaki ezinkulu. Kuba, nangona itshintsha inkangeleko yeeseli zakho ze-neutrophil, ayitshintshi kakhulu indlela ezisebenza ngayo. Ziyaqhubeka nokulwa neentsholongwane.

Nangona kunjalo, ukuba une-pseudopelgar-huwat anomalous (PPHA), imeko yezonyango ebangele oku (njenge-leukemia) inokubangela iingxaki. Ngoko ke, kubalulekile ukuthetha nogqirha wakho ngale nto kwaye wazi ukuba ulindele ntoni.

Oogqirha bayifumanisa njani into engaqhelekanga kaPelger-Huette?

Oogqirha basebenzisa kakhulu uvavanyo lwegazi ukufumanisa le meko. Ngokukodwa,Kwenziwa uvavanyo olubizwa ngokuba yi-peripheral blood smear. Olu vavanyo lubandakanya ukuthatha ithontsi lesampulu yakho yegazi, ulisasaze kancinci kwislayidi yeglasi, uze ulijonge phantsi kwe-microscope.

Oku kuhlolwa yingcali yezifo okanye yingcali yegazi.

Ukuba une-Pelger-Huette anomaly, olu vavanyo luza kubonisa ngokucacileyo imo engaqhelekanga yeenuclei zeeseli zakho ze-neutrophil (njenge-dumbbell).

Ngaba kukho unyango lwePelger-Huette anomaly?

Nazi iindaba ezimnandi! I-Hereditary Pelger-Huette anomaly (PHA) ayidli ngokubangela zimpawu, ngoko ke ayifuni naluphi na unyango olukhethekileyo. Nokuba unale meko, ungaphila ubomi obuqhelekileyo.

Nangona kunjalo, kwimeko ye-'PPHA', kubalulekile ukunyanga isifo esibangele eso sifo. Nje ukuba eso sifo sinyangwe, imeko ye-'PPHA' nayo inokuphela.

Ndifanele ndimbone nini ugqirha?

Ukuba ufumanisa ukuba unesifo esinganyangekiyo sikaPelger-Huette, qiniseka ukuba uxelela ugqirha wakho ukuba kukho naziphi na iimpawu ezintsha (ezifana nomkhuhlane, ukudinwa kakhulu, usulelo oluqhelekileyo). Ugqirha wakho unokufumanisa ukuba iimpawu zinxulumene ne-'PHA`, `PPHA`, okanye enye into.

Xa usiya kugqirha, kukwangcono ukubuza le mibuzo:

• Ingaba ndine-Pelger-Huette anomaly ye-'(HPA)` okanye i-pseudo `(PPHA)`?
• Ngaba kunokwenzeka ukuba abantwana bam bafumane esi sifo njengelifa? (Ukuba yi-HPA)
• Ndifanele ndimbone ugqirha kangaphi?
• Zeziphi iimpawu ekufuneka ndiziqaphele ngokukodwa?

Yintoni endimele ndiyilindele kule meko?

I-Pelger-Huette anomaly (PHA) ngokwayo ayikubangeli ntlungu okanye yenze umahluko omkhulu ebomini bakho. Ngokwesiqhelo ayichaphazeli imisebenzi yakho yemihla ngemihla.

Nangona kunjalo, ukuba unale meko (ingakumbi uhlobo lwe-'PPHA'), inokuba luphawu lwenye imeko yempilo engaphantsi. Yiyo loo nto oogqirha bexhalabile ngayo. Ukuba ugqirha wakho ukrokrela ukuba une-'PHA' okanye 'PPHA', uza kwenza uvavanyo olufunekayo ukuqinisekisa oko, aze athathe amanyathelo okuthintela ezinye iimeko zonyango.

Usenokuba unePelger-Huette anomaly (PHA) kodwa ungayazi kuba awunazo iimpawu. Usenokucinga, "Ukuba ayindikhathazi, kutheni ndicinga ngayo?" Liyinyaniso elokuba usenokungaziva ugula ngenxa yolu tshintsho lweseli. Kodwa kubalulekile ukwazisa ugqirha wakho ngayo. Ugqirha wakho ukhona ukukunceda uhlale uphilile. Kwaye kuyanceda ukwazi ngezi zinto zincinci emzimbeni wakho. Ukuba nje unePelger-Huette anomaly yenye into ekwenza "ube nguwe." Akukho nto ibalulekileyo yokuzikhathaza ngayo.

Isishwankathelo (Umyalezo Wokuya Ekhaya)

Kulungile, masiphinde sichaze ezinye zezinto esithethe ngazo:

• I-Pelger-Huet Anomaly (PHA) yimeko yemfuza ebangela imo engaqhelekanga yenucleus yee-neutrophils, uhlobo lweseli emhlophe yegazi.
• Oku akusoloko kuyingozi kwaye akubonisi zimpawu. Iiseli ze-neutrophil zisebenza ngokuqhelekileyo.
• Kukho iintlobo ezimbini zale nto: `HPA`, eyimfuza, kunye `PPHA`, ebangelwa kamva zezinye izifo okanye amayeza.
• I-HPA ayisoloko ifuna unyango. Kwimeko ye-PPHA, unobangela oyintloko uyanyangwa.
• Le meko ifunyaniswa ngovavanyo lwegazi (i-peripheral blood smear).
• Ukuba ufumanisa ukuba unale meko, ungakhathazeki. Nangona kunjalo, thetha nogqirha wakho ngayo kwaye ufumane icebiso elifunekayo. Yazisa ugqirha wakho ukuba kuvela iimpawu ezintsha.

Ndiyathemba ukuba eli nqaku liphendule uninzi lwemibuzo yakho malunga nePelger-Huette anomaly. Khumbula, kuyo nayiphi na ingxaki yempilo, kungcono ukuthetha ngokukhululekileyo nogqirha wakho.

I- Pelger-Huet Anomaly, iiNeutrophils, iiSeli zeGazi ezimhlophe, izifo zemfuza, uvavanyo lwegazi, i-PPHA, i-HPA