Ngaba uneeproteni ezininzi kakhulu zomzimba wakho? Masifunde ngePolyclonal Gammopathy ngokulula!

Ngaba wakha waxelelwa ngugqirha ukuba unezinga eliphezulu kakhulu leeproteni ezithile zokuzikhusela emzimbeni (ii-immunoglobulins) egazini lakho? Kuqhelekile ukuba uzive usoyika kancinci xa usiva into enjalo. Kodwa ungakhathazeki. Namhlanje siza kuthetha ngemeko ebizwa ngokuba yi-"Polyclonal Gammopathy." Siza kuchaza ukuba yintoni, kutheni isenzeka, kunye nento onokuyenza ngayo ngendlela elula neqondakala lula.

Yintoni le Polyclonal Gammopathy?

Ngamafutshane, i-polyclonal gammopathy yimeko apho iiseli ezithile zomzimba ezisegazini lakho zivelisa ii-antibodies ezininzi kakhulu, okanye ii-immunoglobulins, uhlobo lweproteni enceda imizimba yethu ukulwa nesifo. Cinga ngala ma-antibodies njengamajoni okuzikhusela omzimba. Ngawo alwa nesifo kunye neentsholongwane xa zingena.

Ngoko ke, igama elithi "polyclonal" lithetha ukuba iintlobo ezahlukeneyo zeeseli zomzimba ziyadibana kwaye zenze iintlobo ezahlukeneyo zee-antibodies. Kufana namaqela ahlukeneyo asebenza kunye, kungekuphela nje uhlobo olufanayo lwamajoni.

Kutheni oku kusenzeka? Kundichaphazela njani oku?

Ukuba une-polyclonal gammopathy, oko kuthetha ukuba inkqubo yakho yomzimba yokuzikhusela isebenza kakhulu . Kufana nokuba ihlala iphaphile. Isizathu esiphambili soku kukuba inkqubo yakho yomzimba yokuzikhusela ihlala ifumana iimpawu ezivela kusulelo okanye isifo sokuzikhusela komzimba, ixelela ukuba "yenze ii-antibodies, yenze ii-antibodies."

Oko kukuthi, i-polyclonal gammopathy inokuba luphawu lwesinye isifo esingaphantsi . Umzekelo, ukuba unomhlaza, okanye ukuba unesifo sesibindi, okanye ukuba unesifo sokuzikhusela komzimba esifana ne-rheumatoid arthritis, usenokuba nale polyclonal gammopathy. Ngoko ke, xa oogqirha bebona oku, bakhangela, "Kutheni inkqubo yomzimba yokuzikhusela ivuseleleka kangaka?"

Yintoni umahluko phakathi kwe-polyclonal kunye ne-monoclonal gammopathy?

Oku kungabonakala kunzulu kancinci, kodwa masikwenze kube lula. Kukho iintlobo ezimbini zeeseli ezimhlophe egazini lethu ezibizwa ngokuba zii-'B cells' kunye nee-'plasma cells'. Ezi zezona zenza ii-antibodies ('Immunoglobulins') esithethe ngazo ngaphambili.

• I-Polyclonal Gammopathy: Apha, zombini ii-'B cells' kunye 'nee-plasma cells' ziyadibana ukuze zivelise iintlobo ezininzi ezahlukeneyo zee-antibodies. Njengokuba iifektri ezahlukeneyo zivelisa iintlobo ezininzi ezahlukeneyo zeemveliso.
• I-Monoclonal Gammopathy:Okwenzekayo apha kukuba kuphela 'iiseli zeplasma' eziqokelelanayo zenze uhlobo olunye lwe-antibody, olubizwa ngokuba yi-'M protein'. Le yimeko eyahlukileyo kancinci. Oku kunokunxulunyaniswa neemeko zomhlaza ezifana ne-'Multiple Myeloma'. Nangona kunjalo, abanye abantu banokuba nesifo esibizwa ngokuba yi-'Monoclonal Gammopathy of Undetermined Significance' (MGUS). Ukuba oko kuyenzeka, ugqirha wakho uza kukujonga rhoqo ukuze abone ukuba umhlaza uyakhula na. Ngoko ke kulungile ukwazi loo nto.

Kubalulekile: I-Polyclonal gammopathy ayisoloko ingumhlaza. Yimpendulo yenkqubo yomzimba yokuzikhusela.

Ngaba kukho amanye amagama alo mba?

Ewe, oogqirha basebenzisa amanye amagama amaninzi kwisifo i-polyclonal gammopathy. Awona aphambili ngala:

• I-Hypergammaglobulinemia: Oku kubhekiselele ekwandeni komthamo we-gamma globulin (uhlobo lwe-antibody) egazini.
• Isifo sePolyclonal: Eli ligama elinye.

Zithini izizathu zePolyclonal Gammopathy?

Iingcali zisaphanda unobangela ochanekileyo wale meko. Nangona kunjalo, ixhaphake kakhulu kubantu abanezifo ezithile, izifo zokuzikhusela komzimba, okanye umhlaza wegazi. Ngamanye amaxesha, amayeza athile athathwa kwezinye iimeko anokunyusa umngcipheko.

Zithini iimpawu zale meko?

Uninzi lwexesha, i-polyclonal gammopathy ayibangeli zimpawu zithile. Usenokuba neempawu ngenxa yesifo esibangela i-gammopathy.

Khawuthelekelele ukuba une-pneumonia enomkhuhlane ophezulu kunye nokukhwehlela. Emva koko uza kubonisa iimpawu ezinxulumene naloo pneumonia. Xa ugqirha eyinyanga, angenza uvavanyo lwegazi aze afumane le meko ye-polyclonal gammopathy ngengozi. Oko kukuthi, idla ngokufumaneka xa ufuna enye into.

Ingaba le yinto edluliselwa yintsholongwane okanye yibhaktheriya?

Hayi. I-polyclonal gammopathy ayibangelwa ngqo yintsholongwane okanye yibhaktheriya. Yimpendulo yenkqubo yomzimba yokuzikhusela . Nangona kunjalo, i-polyclonal gammopathy inokubangelwa lusulelo olungaphantsi lwentsholongwane okanye lwebhaktheriya. Oko kukuthi, intsholongwane okanye iibhaktheriya zivuselela inkqubo yomzimba yokuzikhusela.

Oogqirha bayixilonga njani le nto? (Ukuxilongwa)

Oogqirha basebenzisa ikakhulu uvavanyo lwegazi olukhethekileyo ukuxilonga i-polyclonal gammopathy. Oku kubizwa ngokuba yiSerum Protein Electrophoresis (SPEP) .

Ukuba ugqirha wakho sele ekufumanise ukuba unesifo sokuzikhusela komzimba, usulelo, isifo sesibindi, okanye umhlaza, okanye ukrokrela ukuba unesifo esinjalo, angenza olu vavanyo lwe-'SPEP' ukuze afumane indlela echanekileyo amajoni akho omzimba asabela ngayo.

Uvavanyo lwe-`SPEP` lunokunceda njani ekufumaneni oku?

Kulula kakhulu. Ugqirha uthatha isampuli yegazi kuwe. Emva koko, kwilebhu, basebenzisa le ndlela ebizwa ngokuba yi-'SPEP' ukwahlula iintlobo ezahlukeneyo zeeproteni egazini lakho nokujonga amanqanaba azo.

La manqanaba eeproteni anokuxelela ugqirha wakho okuninzi malunga nempilo yenkqubo yakho yomzimba yokuzikhusela . Umzekelo, anokukunika ulwazi malunga nokuba unesifo sesibindi (esinokubangela i-polyclonal gammopathy), okanye ukuba unosulelo okanye umhlaza.

Ngaba kukho ezinye iimvavanyo zokufumanisa oku?

Ewe. Ngamanye amaxesha, ukuba ugqirha wakho ukrokrela ukuba unosulelo lwenkqubo yakho yemithambo-luvo, olufana ne-meningitis, unokuvavanya ulwelo lwakho lwe-cerebrospinal (CSF) , kuba olo sulelo lunokubangela i-polyclonal gammopathy.

Zithini iindlela zonyango zoku?

Into ebalulekileyo ekufuneka uyiqonde apha kukuba i-polyclonal gammopathy yindlela esabela ngayo kwinkqubo yomzimba yokuzikhusela, ayisosifo ngokwaso. Ke ngoko, akukho nyango ngqo lwale meko.

Ugqirha wakho uza kunyanga imeko ebangela ukuba inkqubo yomzimba yokuzikhusela isebenze kakhulu. Umzekelo, ukuba ibangelwa lusulelo, usulelo luya kunyangwa. Ukuba ibangelwa sisifo sokuzikhusela komzimba, unyango olufanelekileyo luya kunikwa.

Ngelixa enyanga imeko engundoqo, ugqirha wakho uza kuphinda ajonge amanqanaba akho e-immunoglobulin ukuze abone ukuba i-polyclonal gammopathy inciphile okanye ayisekho.

Ngaba uphuhliso lwePolyclonal Gammopathy lungathintelwa?

Ngelishwa, abaphandi abakafumani ndlela yokuthintela le meko. Ngenxa yokuba idla ngokuvela njengesiphumo sesinye isifo, eyona nto ingcono onokuyenza kukuthintela isifo esisisiseko.

Ndingayazi njani ukuba ndisemngciphekweni wokufumana le meko?

Ukuba uneengxaki ezithile zempilo, usemngciphekweni omkhulu wokufumana i-polyclonal gammopathy. Ezinye zezi meko ziquka:

• Iimeko zokuzikhusela komzimba: Imizekelo ibandakanya i-lupus, i-rheumatoid arthritis, kunye ne-Sjogren's syndrome.
• Iingxaki zegazi: Umzekelo, iSickle Cell Anemia.
• Umhlaza wegazi: njenge-leukemia kunye ne-lymphoma.
• Eminye imidla: Umhlaza wezintso, umhlaza wesibindi, umhlaza wemiphunga, umhlaza wesibeleko.
• Usulelo: Usulelo lwe-HIV, iMalariya, iMononucleosis, iPneumonia, iSifo sePhepha.
• Isifo sesibindi: I-Autoimmune Hepatitis, i-Cirrhosis, i-Viral Hepatitis.
• Ukuba ukhe wadibana ne -asbestos .

Ukuba unayo nayiphi na kwezi meko, okanye ukuba uziva ngathi iimpawu zakho ziya zisiba mandundu, qiniseka ukuba uthetha nogqirha wakho. Angakuvavanya i-polyclonal gammopathy ukuba kuyimfuneko.

Yintoni endinokuyilindela ukuba ndinePolyclonal Gammopathy?

Ukuba une-polyclonal gammopathy, usenokuba sengozini enkulu yokosulelwa kunye ne-anemia. Kodwa iindaba ezimnandi zezokuba ngonyango olufanelekileyo lwesifo esibangele i-gammopathy, i-gammopathy kunye neengozi ezinxulumene nayo zinokuphela.

Ingaba le meko ingenzeka ngaphezu kwesihlandlo esinye?

Ewe, i-polyclonal gammopathy inokwenzeka ngaphezu kwesinye, kuba ukuba imbangela eyintloko iphinda ivele, le mpendulo yomzimba inokuphinda ivele.

Ukuba ndinayo le meko, ndingazinyamekela njani?

Eyona nto ibalulekileyo kukulandela imiyalelo kagqirha wakho ngokuchanekileyo. Ingakumbi leyo imalunga nokuzikhusela kwiintsholongwane. Umzekelo, izinto ezilula ezifana nokunxiba imaski xa usiya kwiindawo ezinabantu abaninzi kunye nokuhlamba izandla zakho rhoqo kunokwenza umahluko omkhulu.

Umyalezo Wokuya Ekhaya

Kulungile, ngoko ke ngokwezinto esizithethileyo, ndiyathemba ukuba unoluvo oluhle malunga nePolyclonal Gammopathy okanye iHypergammaglobulinemia.

• Ngamafutshane, oku kuthetha ukuba inkqubo yakho yomzimba ivelisa ii-immunoglobulins (ii-antibodies) ezininzi kakhulu .
• Oku kubonisa ukuba inkqubo yakho yomzimba yokuzikhusela isebenza nzima kakhulu . Kufuneka ukuba kukho isizathu soko.
• Ugqirha wakho uza kunyanga imeko ebangela oku, kwaye le gammopathy idla ngokuba ngcono.

Ngoko ke, musa ukoyika kuba nje into efana nale ikwingxelo. Thetha nogqirha wakho uze uqonde kakuhle ukuba kwenzeka ntoni kwaye yintoni ekufuneka yenziwe. Ndikunqwenelela impilo entle!

"i-polyclonal gammopathy, i-hypergammaglobulinemia, i-immunoglobulin, i-antibody, inkqubo yomzimba yokuzikhusela, i-SPEP, i-B cell, i-plasma cell