Sonke siziva sinesizungu okanye sinentloko ebuhlungu xa sivuka esitulweni okanye ebhedini. Uninzi lwexesha, kuyaphela emva kwemizuzwana embalwa. Kodwa ukuba oku kuyenzeka rhoqo kuwe, okanye ukuba uziva ngathi uza kuwa uze uwe, kusenokungabi yinto eqhelekileyo. Namhlanje siza kuthetha ngemeko engaqhelekanga ebangela ezi mpawu. Yiyo leyo iPure Autonomic Failure, okanye iPAF ngamafutshane.
Ngamafutshane, yintoni iPure Autonomic Failure (PAF)?
Cinga ngako, kukho iinkqubo ezininzi emzimbeni wethu ezenzeka ngokuzenzekelayo ngaphandle kolawulo lwethu. Umzekelo, ukuphefumla, ukubetha kwentliziyo, ukugaya ukutya, ukulawula ubushushu bomzimba, kunye nokulawula uxinzelelo lwegazi. Konke oku kulawulwa yiNkqubo yethu yeNervous ye-Autonomic. Kufana nenkqubo 'ye-auto-pilot' emzimbeni wethu.
Ukusilela kwe-Autonomic ecocekileyo (i-PAF) yimeko engaqhelekanga ye-neurological ebangela ukuba ukusebenza kwenkqubo ye-autonomic nervous kubuthathaka kancinci kancinci ngokuhamba kwexesha. Eyona nto iphambili eyenzekayo kule meko kukuba xa usukuma ngequbuliso uhleli okanye ulele, uxinzelelo lwakho lwegazi luyehla kakhulu . Ngokwezonyango, silubiza ngokuba yi- orthostatic hypotension . Kodwa le ayisiyongxaki yodwa, i-PAF inokubangela ezinye iingxaki ezininzi.
Le meko idla ngokubonakala kakhulu kubantu abadala abaneminyaka ephakathi kwama-40 nama-60. Ngaphambili, esi sifo sasibizwa ngokuba yiBradbury-Eggleston syndrome.
Zithini iimpawu zesifo se-PAF?
Njengoko besitshilo ngaphambili, uphawu oluqhelekileyo noluphambili sisiyezi kunye nokuquleka xa umile (i-orthostatic hypotension). Nangona kunjalo, ekubeni le nkqubo ye-autonomic nervous system ilawula amalungu amaninzi emzimbeni wethu, iimpawu azipheleli nje kwelinye.
Into ebalulekileyo kukuba ezi mpawu azenzeki ngendlela efanayo okanye ngokulandelelana okufanayo kubo bonke abantu. Abanye abantu banokufumana ezinye iimpawu ngaphambi kokuba bazive benesiyezi xa bema ngeenyawo.
Makhe sibone ukuba zeziphi ezinye iimpawu ezinokubangelwa yi-PAF.
| Inkqubo/inkqubo echaphazelekayo | Iimpawu ezinokwenzeka |
|---|---|
| Ukubila komzimba | Ngokwesiqhelo kukho ukwehla kokubila (anhidrosis) okanye maxa wambi ukubila okugqithisileyo (hyperhidrosis). |
| Amehlo | Umbono ofipheleyo ngenxa yokuba abafundi babengenabukhulu obaneleyo. |
| Inkqubo yomchamo | Ubunzima bokukhupha yonke into kwisinyi (ukugcinwa komchamo) okanye ukungakwazi ukulawula ukuchama (ukungakwazi ukuzibamba komchamo). |
| Inkqubo yokugaya ukutya | Ukuqhinwa okanye ukungakwazi ukuzibamba lindle. |
| Isenzo sokwabelana ngesondo | Iingxaki ezinje ngokungasebenzi kakuhle kwe-erectile okanye i-anorgasmia. |
Ukongeza, malunga nesiqingatha sabantu abane-PAF banokufumana i-anemia encinci.
Yintoni isizathu sokusekwa kwe-PAF?
Eyona nto ibangela oku kuchongwe njengokuqokelelwa okungaqhelekanga kweproteni ebizwa ngokuba yi -alpha-synuclein kwiiseli zethu zemithambo-luvo ezizimeleyo. Njengokungcola okuvalela umbhobho, xa le proteni iqokelelwa kwiiseli zemithambo-luvo, ukusebenza kwazo kuyaphazamiseka.
Le protein ifakwa kwi-nerve bundles (i-autonomic ganglia) kumacala omabini omqolo okanye kufutshane nezitho zomzimba. Ekuhambeni kwexesha, inani lala maseli emithambo-luvo liyancipha, kwaye umsebenzi we-autonomic system uyaphazamiseka. Kodwa eyona nto ibalulekileyo kukuba kwi-PAF, ingqondo kunye nomqolo azinakonakala . Ke ngoko, ayichaphazeli izinto ezifana nenkumbulo kunye nobuchule bokucinga.
Abaphandi abakaqondi kakuhle ukuba kutheni le protein igcinwa ngolu hlobo.
Ubudlelwane nezinye izifo
Nantsi into ebalulekileyo ekufuneka uyazi. Le protein inye, i-alpha-synuclein, yiyo eqokelelana engqondweni kwizifo ezifana nesifo sikaParkinson, iMultiple System Atrophy, kunye neLewy Body Dementia. Ngoko ke, abanye abantu abane-PAF (hayi bonke) banethuba lokufumana esinye sezi zifo ekuhambeni kwexesha. Ugqirha wakho uza kukwazisa ngale nto.
Indlela yokuxilonga esi sifo?
Ukuchonga i-PAF yinkqubo enzima, njengoko oogqirha beza kuqala bagwebe ezinye iimeko ezinokubangela iimpawu zakho, ingakumbi ukwehla koxinzelelo lwegazi xa usukuma.
Inkqubo yokuxilonga ingabandakanya:
- Ukubuza imibuzo ngononophelo malunga neempawu zakho kunye nembali yezonyango.
- Uvavanyo olupheleleyo lomzimba kunye novavanyo lwemithambo-luvo.
Emva koko, kunokucetyiswa iimvavanyo ezikhethekileyo ezininzi ukuqinisekisa isifo.
| Uvavanyo | Yenza oku nje... |
|---|---|
| Uvavanyo lweTheyibhile eThambekileyo | Uza kubekwa ebhedini ekhethekileyo uze ngequbuliso ufuduselwe kwindawo yokuma. Uxinzelelo lwegazi kunye nesantya sentliziyo yakho ziya kuhlolwa. |
| Uvavanyo lokubila (QSART) | Oku kujonga indlela esebenza ngayo imithambo-luvo elawula ukubila. Oku kunceda ekuchongeni iingxaki kwinkqubo yemithambo-luvo ezimeleyo. |
| Uvavanyo lokucinga (njenge-MRI) | Izinto ezifana ne-brain MRI scans zenziwa ukuqinisekisa ukuba akukho ezinye izifo ezinokubangela ezi mpawu. |
| Uvavanyo lweLebhu (Igazi kunye nomchamo) | Amanqanaba ekhemikhali ebizwa ngokuba yi-norepinephrine egazini nasemchameni alinganiswa xa elele phantsi nasemva kokuma. Kwi-PAF, kukho utshintsho oluphawulekayo kula manqanaba. |
Kunokuba nzima ukwenza uvavanyo oluninzi kangaka, kodwa kuphela xa sixilonga isifo ngokuchanekileyo apho sinokuthi senze isicwangciso sonyango esifanelekileyo kuwe.
Ziziphi iindlela zonyango ze-PAF?
Akukho nyango loku okwangoku. Kodwa ungakhathazeki. Zininzi izinto onokuzenza ukunceda ukulawula iimpawu zakho nokuphila ubomi obuqhelekileyo. Ugqirha wakho kunye neqela lezonyango baya kusebenzisana nawe ukwenza isicwangciso sonyango esilungele wena.
Ulawulo lwe-Orthostatic Hypotension (uxinzelelo lwegazi oluphantsi xa umile)
Le yeyona ngxaki iphambili. Kukho unyango olungelulo olusebenzisa amayeza kunye namayeza oku.
- Lumka xa utshintsha indlela ohlala ngayo: Xa uvuka ulele okanye uhleli, yenza oko kancinci kakhulu . Musa ukuvuka ngequbuliso.
- Amanzi netyuwa: Ugqirha wakho angacebisa ukuba usele malunga neelitha ezi-3 zamanzi ngosuku. Angakuxelela nokuba wongeze ityuwa encinci ekutyeni kwakho.
- Ukulungiselela ibhedi: Lala intloko yebhedi iphakanyisiwe malunga ne-intshi ezi-4-6. Ngale ndlela, awuyi kuva mahluko mkhulu kuxinzelelo lwegazi xa uvuka.
- Iimpahla Zokuxinzelela: Ukunxiba iikawusi ezikhethekileyo eziqinileyo (iimpahla zokuxinzelela) ezifika esinqeni okanye emathangeni kunceda ekunciphiseni ukuhlangana kwegazi emilenzeni nokugcina uxinzelelo lwegazi luzinzile.
- Ukongeza koku, ugqirha ukwacebisa amayeza athile anyusa uxinzelelo lwegazi.
Iingxaki zokukhupha indle kunye nokuchama
- Ukuqunjelwa: Ungenza izinto ezifana nokutya ukutya okunefayibha eninzi (imifuno, iziqhamo, irayisi yebran) kwaye usebenzise izithambisi-ndlela zokulungisa isitulo.
- Kwiingxaki zomchamo: Ukuba unengxaki yokuchama, kunokufuneka usebenzise i-catheter. Ukuba awukwazi ukulawula umchamo wakho, kukho amayeza akhethekileyo (afana ne-Oxybutynin, iMirabegron).
Ukuziphatha okubi ngokwesondo
Nangona kukho amayeza afana ne-sildenafil okanye i-tadalafil oku, la mayeza anokunyusa umngcipheko we-orthostatic hypotension. Ke ngoko, kufuneka uxoxe ngale nto ngokukhululekileyo nogqirha wakho kwaye uwasebenzise kuphela phantsi kwengcebiso yakhe.
Kuza kwenzeka ntoni kwixesha elizayo kumntu onesi sifo?
Kunzima ukunika impendulo enye malunga nekamva lomntu ophila nesi sifo, kuba siyahluka kumntu nomntu.
I-PAF sisifo esiqhubekekayo. Kodwa kubantu abaninzi, yenzeka kancinci kakhulu, kwiminyaka, kwanamashumi eminyaka. Ezinye izifundo zibonise ukuba umyinge wobomi emva kokufunyaniswa kwe-PAF umalunga neminyaka eli-12.5. Kodwa oku kungumndilili nje, kwaye kunokwahluka kakhulu kuxhomekeke kwiimpawu zakho kunye nempilo yakho. Ngoko ke musa ukulibala kakhulu ngaloo manani.
Ukuba une-PAF, kubalulekile ukubona ugqirha wakho rhoqo ukuqinisekisa ukuba unyango lwakho luyasebenza kwaye imeko yakho iqhubeka njani. Ukuba ubonakalisa iimpawu zesifo sikaParkinson (ezifana nokungcangcazela, ubunzima bokuhamba), kufuneka uxelele ugqirha wakho ngoko nangoko.
Umyalezo Wokuya Ekhaya
- Ukusilela kwe-Autonomic ecocekileyo (i-PAF) sisifo esingaqhelekanga esichaphazela inkqubo yemithambo-luvo elawula iinkqubo ezizenzekelayo emzimbeni wethu.
- Uphawu oluphambili sisiyezi kunye nokuquleka xa uvuka kwindawo ohleli kuyo okanye olele kuyo ngenxa yokwehla koxinzelelo lwegazi.
- Nangona esi sifo singenakunyangwa ngokupheleleyo, iimpawu zinokulawulwa kakuhle kwaye umgangatho wobomi obuphezulu unokugcinwa.
- Akukho ndlela yokuthintela oku, kwaye akulona ityala lakho ukuba kwenzeke.
- Kubaluleke kakhulu ukuhlala unxibelelana rhoqo nogqirha wakho kwaye ulandele isicwangciso sakho sonyango ngokuchanekileyo. Musa ukoyika ukuthetha ngokukhululekileyo ngemibuzo yakho nezinto ezikuxhalabisayo.
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