Xa sisiva igama elithi 'cholesterol', uninzi lwethu luyathuthumela kancinci, akunjalo? Ingakumbi xa ugqirha esithi, "I-cholesterol yakho embi, oko kukuthi, inqanaba le-LDL, iphezulu kancinci," siyoyika kancinci. Oko sikutyayo nesikuselayo, nokuba siyawuzilolonga okanye asiwulolongi, kwaye ngamanye amaxesha izinto zemfuza nazo ziyayichaphazela le nto. Ngoko ke, phantse sonke sikhe seva ngeepilisi zohlobo lwe-'statin' ezinikwa ukulawula i-cholesterol. Kodwa kwabanye abantu, la mayeza odwa awanele, okanye awakwazi ukusetyenziswa. Namhlanje sithetha ngohlobo olutsha lweyeza oluphucukileyo olusetyenziswa kwiimeko ezinjalo. NguRepatha lowo.
Yintoni iRepatha? Inciphisa njani i-cholesterol?
Ngamafutshane, iRepatha sisitofu esinceda sinciphise amanqanaba e-cholesterol "embi", okanye i-LDL (Low-Density Lipoprotein) emizimbeni yethu. Le asiyopilisi esihlala siyithatha, kodwa sisitofu esifakwa phantsi kolusu.
Ngoku jonga indlela esebenza ngayo le nto. Khawuthelekelele ukuba isibindi sethu sisihluzo esisusa i-cholesterol embi egazini. Kodwa umzimba wethu uneproteni ebizwa ngokuba yi-PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) . Oku kufana nomntu onciphisa ukusebenza kweso sihluzo, asiphazamise. Xa iproteni ye-PCSK9 isanda, amandla esibindi okususa i-LDL egazini ayancipha.
Into eyenziwa yiRepatha kukuthintela umsebenzi weproteni ye-PCSK9 'ephazamisayo' . Xa imisiwe, isihluzo sesibindi sinokusebenza ngokusebenza okuphezulu kwakhona ngaphandle kokuphazamiseka, sibambe kwaye sisuse i-cholesterol embi (LDL) egazini. Uyaqonda? Oku kuthetha ukuba eli yeza linceda inkqubo yendalo yomzimba wethu elawula i-cholesterol.
Ngubani ocebisa eli yeza leRepatha?
Eli yeza alifanele wonke umntu. Ugqirha uza kulicebisa kuphela kwiimeko ezithile ezimbalwa.
- Kwabantu abadala abanesifo sentliziyo: Eli yeza lisetyenziselwa ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo, isifo sohlangothi, okanye esinye isifo sentliziyo. Lidla ngokusetyenziswa kunye namanye amayeza e-cholesterol, anjengee-statins.
- Kubantu abane-cholesterol ephezulu ezuzwe njengelifa: Abanye abantu bane-cholesterol ephezulu kakhulu ngenxa yeemeko ze-genetic ezidluliselwa kwizizukulwana ngezizukulwana. Ezi meko zibizwa ngokuba yi -Heterozygous Familyal Hypercholesterolemia (HeFH) kunye ne-Homozygous Familyal Hypercholesterolemia (HoFH) . I-Repatha icetyiswa kubantu abadala kunye nabantwana abangaphezu kweminyaka eli-10 ubudala abanezi meko zokulawula amanqanaba e-LDL.
Okubaluleke kakhulu, kubalulekile ukulandela ukutya okunempilo kunye nokuzilolonga ngelixa usebenzisa eli yeza.I-Repatha ayilomlingo, yinxalenye nje yesicwangciso sonyango.
Zithini iingenelo kunye nemiphumo yale yeza?
Izifundo zonyango zeRepatha zibonise iziphumo ezithembisayo. Ezi zifundo zithelekise iRepatha ne-placebo (unyango olungelulo udidi) kunye nezinye iziyobisi ze-cholesterol, ezifana nee-statins.
Masicacise oku ngakumbi ngetheyibhile engezantsi.
| Ngubani ocebisa eli yeza? | Iingenelo eziphambili ezibonakaliswe luvavanyo |
|---|---|
| Abantu abadala abasele benesifo sentliziyo (kunye namanye amayeza afana ne-statins) | Kunciphisa kakhulu umngcipheko wokuhlaselwa sisifo sentliziyo, isifo sohlangothi, kunye nokufa ngenxa yesifo sentliziyo. |
| Abantu abadala kunye nabantwana abangaphezu kweminyaka eli-10 ubudala abane-cholesterol ephezulu ngenxa yezizathu zemfuza | Inciphisa ngokukhawuleza nangokusebenzayo inqanaba le-cholesterol "embi" (LDL) egazini. |
Uyazi njani ukuba iyeza liyasebenza?
Ugqirha wakho uza ku-odola uvavanyo lwegazi (uvavanyo lweprofayili yamafutha) ngamaxesha athile. Emva kokuqala iRepatha, ungabona ukwehla okukhulu kwamanqanaba e-cholesterol yakho ye-LDL kwiiveki nje ezili-12 .
Masifunde nangokusetyenziswa kweRepatha kunye nemiphumo emibi.
Ungayisebenzisa njani le nto?
I-Repatha iza njengesirinji ezaliswe kwangaphambili okanye ipeni yokujova. Ifakwa phantsi kwesikhumba rhoqo emva kweeveki ezimbini okanye kube kanye ngenyanga, kuxhomekeke kwidosi oyibekelweyo.
Okubaluleke kakhulu: Kubaluleke kakhulu ukufunda ngqo indlela yokusebenzisa oku kugqirha wakho kuqala. Ngaphambi kokuba uyisebenzise okokuqala, cela umboniso ocacileyo wendlela yokukwenza.
Zithini iziphumo ebezingalindelekanga?
Njengalo naliphi na iyeza, iRepatha inokubangela iziphumo ebezingalindelekanga ezincinci, nangona ingenguye wonke umntu ozifumanayo.
| Iziphumo ebezingalindelekanga eziqhelekileyo | Iingcebiso zokuthintela okanye zokulawula |
|---|---|
| Ububomvu, iintlungu, kunye nokudumba kwindawo yokuhlatywa kwenaliti. | - Soloko ujikeleza indawo ohlatywe kuyo inaliti (umz., kwelinye icala lesisu, kwelinye icala kwixesha elizayo). - Khupha isitofu efrijini, usivumele sihlale imizuzu engama-30-45 , uze usifake emva kokuba sifikelele kubushushu begumbi. |
| Iimpawu ezifana nomkhuhlane (umkhuhlane, iintlungu zomzimba). | Ezi zihlala zizinto zexeshana. Ukuba unengxaki yokungakhululeki, thetha nogqirha wakho. |
| Intlungu yomqolo, amanqanaba aphezulu eswekile egazini. | Xelela ugqirha wakho ukuba kukho naziphi na iziphumo ebezingalindelekanga ezikukhathazayo okanye eziqhubekayo. |
Amanqaku ekufuneka aqwalaselwe ngokukodwa:
- I-Latex Allergy: Ezinye iinaliti zenaliti zinokuba ne-latex kwiingxowa zazo. Ukuba une-latex allergy, qiniseka ukuba uxelele ugqirha wakho ngale nto.
- Ukukhulelwa nokuncancisa: Ukuba ukhulelwe, uzama ukukhulelwa, okanye ukuncancisa, kubalulekile ukuxelela ugqirha wakho ngaphambi kokusebenzisa eli yeza, kuba akukho lwazi lwaneleyo malunga nokhuseleko lwalo kwezi meko.
Ndingayifumana njani le yeza?
Eli asiloyeza onokulithenga kwivenkile yezonyango. Kufuneka ubhale amayeza kagqirha.
Ngokwesiqhelo, umboneleli wakho oyintloko okanye ingcali yentliziyo uya kugqiba ukuba uyalidinga na eli yeza aze alicebise. Ngokuxhomekeke kwingcebiso kagqirha wakho, ungalifumana kwiikhemesti ezikhethekileyo okanye mhlawumbi ngekhemesti yakho yasekuhlaleni.
Ungaze uqale, uyeke, okanye utshintshe umthamo walo naliphi na iyeza ngaphandle kwengcebiso kagqirha. Soloko uqhagamshelana nogqirha wakho ngaphambi kokuba wenze naziphi na izigqibo.
Umyalezo Wokuya Ekhaya
- I-Repatha yinaliti efakwa ngaphantsi kwesikhumba ehlisa amanqanaba aphezulu e-LDL ("amabi") e-cholesterol.
- Oku kucetyiswa ngakumbi kwabo basengozini enkulu yesifo sentliziyo kunye nabo baneengxaki ze-cholesterol yemfuza.
- Ithintela iproteni ebizwa ngokuba yi-PCSK9, enceda isibindi ukuba sisuse i-LDL cholesterol egazini.
- Oku kungafumaneka kuphela ngomyalelo kagqirha. Kubaluleke kakhulu ukulandela imiyalelo kagqirha wakho.
- Iziphumo ezinje ngokuba bomvu kunye neempawu ezifana nokubanda kwindawo efakwe kuyo inaliti zinokubakho, kwaye kufuneka wazise ugqirha wakho ngazo.
- Iziphumo ezilungileyo zinokufumaneka ngokusebenzisa iRepatha kunye nendlela yokuphila enempilo.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho