Ngaba wakha waba nesicaphucaphu esikhulu nokuhlanza emva kotyando okanye ngexesha lolunye utyando olukhulu? Okanye ngaba wakha waba nesicaphucaphu sasekuseni esinganyamezelekiyo ngexesha lokukhulelwa? Kunokuba nzima kangangokuba kunokwenza ubomi bethu bube nzima. Nangona kunjalo, kukho udidi olusebenzayo lwamayeza olusetyenziswa ngoogqirha ukulawula olu hlobo lwesicaphucaphu nokuhlanza. Yiloo nto siza kuthetha ngayo namhlanje.
Ngamafutshane, yintoni le nto ichasene ne-serotonin?
Eli ligama elinikwa udidi lwamayeza. Ngamafutshane, la ngamayeza anikwa ukuthintela nokunyanga isicaphucaphu nokuhlanza. Ngokwezonyango, la abizwa ngokuba yi-'antiemetics'. Nokuba ugqirha wakho akalikhankanyanga eli gama ngokuthe ngqo, kusenokwenzeka ukuba unikwe amayeza kweli klasi.
Amanye amagama aliqela asetyenziswa kolu hlobo lwamayeza:
- Abachasi be-serotonin-receptor
- Ii-receptor antagonists ze-5HT3
- Izithinteli zeSerotonin
Nangona la magama esenokuvakala ngathi antsonkothile, onke athetha into enye. Oko kukuthi, la mayeza athintela ukusebenza kwekhemikhali emzimbeni wethu ebizwa ngokuba yi-serotonin . Makhe sijonge ngokweenkcukacha ezithe vetshe.
Kukho iintlobo ezahlukeneyo zamayeza kolu didi ezisetyenziswa kakhulu eSri Lanka nakwihlabathi liphela:
- I-Ondansetron - Le yeyona yaziwa kakhulu. Iza phantsi kwegama lophawu lweZofran®.
- IGranisetron - ifumaneka phantsi kwegama lophawu lweKytril®.
- I-Palonosetron - ifumaneka phantsi kwegama lebrendi i-Aloxi®.
- I-Dolasetron - Nangona yayisaziwa njenge-Anzemet® ekuqaleni, ngoku ayisetyenziswa kumazwe afana ne-United States.
Eli yeza lifumaneka kwifomu yepilisi kunye neyokujova.
Lisetyenziselwa ntoni kanye kanye eli yeza?
La mayeza avunyiwe kakhulu ukuthintela isicaphucaphu nokuhlanza kwiimeko ezithile.
- Unyango lomhlaza (iKhemotherapy): Olu nyango lubalulekile ekulawuleni isicaphucaphu esinzima abantu abaninzi abasifumanayo ngexesha lekhemotherapy.
- Unyango ngemitha: Unyango ngemitha yomhlaza lunokubangela isicaphucaphu.
- Emva kwe-Anesthesia: Abantu abaninzi bafumana ukuhlanza kunye nesicaphucaphu xa bebuya engqondweni emva kokuhlinzwa. Eli yeza linikwa ukuthintela oku.
Ezi zinikwa ngoogqirha njengoko kufanelekile kubantu abadala nakubantwana.
Ngamanye amaxesha oogqirha basebenzisa la mayeza kwezinye iimeko. Oku kubizwa ngokuba kukusetyenziswa "ngaphandle kweleyibhile". Oko kukuthi, bayawanika kuba oogqirha bayazi ukuba ayasebenza kuloo meko, nangona engavunywanga kuloo meko ithile.
Le ilandelayo yimizekelo yokusetyenziswa kwale mithi ngaphandle kweleyibhile:
- Ukunyanga (hayi nje ukuthintela) isicaphucaphu nokuhlanza emva kotyando.
- Ukulawula isicaphucaphu esinzima kunye nokuhlanza (isicaphucaphu sasekuseni) ngexesha lokukhulelwa okunzima ukukulawula ngezinye iindlela zonyango.
Eli yeza lisebenza njani emzimbeni wethu?
Ukuze sikuqonde oku, masiqale siqonde ukuba yintoni i-'serotonin'.
I-Serotonin yi -neurotransmitter emizimbeni yethu. Ifana 'nesithunywa'. Esi sithunywa silawula izinto ezininzi, kuquka isimo sethu sengqondo, ukulala, kunye nokugaya ukutya. I-90% ye-serotonin emizimbeni yethu ifumaneka kwiiseli zenkqubo yethu yokugaya ukutya (amathumbu).
Khawucinge nje, xa sifumana into efana ne-chemotherapy, iiseli ezisemathunjini ethu zonakele. Emva koko, ezo seli zikhupha isixa esikhulu se-serotonin egazini ngequbuliso. Le serotonin igqithisileyo ithumela umyalezo engqondweni ithi, "Kukho into engalunganga apha!" Loo myalezo yiwo osenza sizive 'sinesicaphucaphu' .
Ukuze ezi miyalezo ze-serotonin zifikelele ebuchotsheni, kufuneka zibophelele kwi-'receptors' ezithile emathunjini ethu nasebuchotsheni. Ezi zifana 'nemingxuma yesitshixo' apho isitshixo singena khona. I-Serotonin sisitshixo, kwaye i-receptor ngumngxuma wesitshixo. Xa isitshixo sifakwe ngokuchanekileyo, ucango luyavuleka (oko kukuthi, umyalezo wokucaphuka uyathunyelwa).
Iyeza elithi `Serotonin Antagonist` lisebenza ngokuya kwezi hole zezitshixo (ii-receptors ze-5-HT3) lize lizivale. Kufana nokufaka isitshixo sobuxoki kumngxuma wesitshixo. Emva koko isitshixo sokwenyani (i-serotonin) asikwazi ukungena. Umyalezo awuyi engqondweni. Isiphumo? Isicaphucaphu nokuhlanza kuyaphela.
Iziphumo ebezingalindelekanga kunye neengozi zamayeza
Eli yeza lihlala likhuselekile kakhulu. Nangona kunjalo, njengalo naliphi na iyeza, linemiphumo emibi kunye nezinto ezimbalwa ekufuneka uzazi.
Iziphumo ebezingalindelekanga eziqhelekileyo
- Intloko ebuhlungu
- Ukudinwa
- Ukuqhinwa
Ezi azisoloko zimbi kangako, kodwa ukuba ziyakukhathaza, thetha nogqirha wakho.
Iingozi ekufuneka ziqwalaselwe ngokukodwa
| Imeko yomngcipheko | Yintoni ekufuneka uyazi |
|---|---|
| Iimeko zentliziyo | Ukuba uneengxaki zesingqisho sentliziyo ezifana ne -Long QT syndrome , i-Ventricular arrhythmia , okanye ezinye iimeko zentliziyo, qiniseka ukuba uxelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza. Abanye abantu banokutshintsha izinga lentliziyo yabo ngenxa yale yeza. |
| Isifo seSerotonin | Le yeyona meko iyingozi kakhulu nekhawulezileyo. Xa isetyenziswa kunye namanye amayeza anyusa amanqanaba e-serotonin (umz., ii-SSRI, ii-SNRI zokudakumba), amanqanaba e-serotonin emzimbeni anokuba phezulu kakhulu. Kubaluleke kakhulu ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo. |
| Ukukhulelwa | Nangona eli yeza lingenawo umngcipheko omkhulu wokuzalwa neziphene, kuye kwaxelwa ukuba kukho ukwanda okuncinci kweziganeko zeziphene zentliziyo kunye ne-cleft palate. Ke ngoko, kufuneka lisetyenziswe kuphela ngexesha lokukhulelwa ngokwengcebiso kagqirha ukuba iingenelo zingaphezulu kweengozi. |
Okungakumbi malunga neSerotonin Syndrome
Le yimeko embi kakhulu enokuba yingozi nakubomi. Lumka kakhulu ngezi mpawu zilandelayo. Ukuba ufumana enye okanye ezingaphezulu kwezi, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele ngoko nangoko.
- Ukungazoli, ixhala
- Isicaphucaphu nokuhlanza
- Urhudo
- Ukwandiswa kwamehlo
- Ukungcangcazela komzimba
- Ukushukuma kwemisipha, ukuqina
- Ukubila, ukuziva ubanda
- Ukudideka, ukulahlekelwa zingqondo
- Ukubetha kwentliziyo
- Igazi elonyukayo
- Ubushushu bomzimba obuphezulu (ngaphezulu kwe-101.3°F / 38.5°C)
- Ukuxhuzula
- Ukulahlekelwa yingqondo
Ndifanele ndiphinde ndimbone ugqirha kwakhona?
Ukuba uthatha eli yeza ixesha elide, kubalulekile ukuba uhlale unxibelelana nogqirha wakho rhoqo. Qiniseka ukuba uthetha nogqirha wakho kwezi meko zilandelayo:
- Ukuba iziphumo ebezingalindelekanga ziqala ukukukhathaza.
- Ukuba isicaphucaphu sakho kunye nokuhlanza akuphucuki okanye kuya kuba mandundu.
- Ukuba ucinga ngokuyeka amayeza (ungaze uyeke ukuwasela ngaphandle kokubuza ugqirha wakho).
Isicaphucaphu siyinto engathandekiyo. Kodwa iindaba ezimnandi zezokuba kukho amayeza asebenzayo kakhulu akhoyo namhlanje ukulawula ezi meko. Ukuba unale ngxaki, thetha nogqirha wakho ngayo ngokukhululekileyo uze ufumane unyango olulungele wena.
Umyalezo Wokuya Ekhaya
- I-Serotonin Antagonist liyeza elisebenza kakuhle kakhulu elilawula isicaphucaphu nokuhlanza okubangelwa lunyango lomhlaza, unyango ngemitha, kunye notyando.
- Ezi zisebenza ngokuthintela isenzo sesithunywa esibizwa ngokuba yi-serotonin emzimbeni.
- Ukuba unesifo sentliziyo okanye usela amanye amayeza (ingakumbi amayeza okudakumba), qiniseka ukuba wazise ugqirha wakho ngaphambi kokuba uwasebenzise la mayeza.
- Qaphela iimpawu zeSerotonin Syndrome (ukuxhalaba, ukubila kakhulu, ukuqina kwemisipha, ukubetha kwentliziyo ngokukhawuleza) kwaye uye kwiSebe lezeMpilo eziNgxamisekileyo (ETU) esibhedlele ngoko nangoko ukuba urhanela imeko enjalo.
- Soloko ufumana kwaye usebenzise la mayeza kuphela phantsi kwengcebiso kagqirha.
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