Ingaba inani leeplatelet zakho liphezulu? Masithethe ngeThrombocytosis!

Ngaba wakha wayithatha ingxelo yakho yeFull Blood Count waza wajonga izinto ezithethayo? Umele ukuba ubonile ukuba kukho ixabiso elibizwa ngokuba yi "Platelets" phakathi kwezinto ezilapho. Ngamanye amaxesha ugqirha uthi, "Inani leeplatelet zakho liphezulu kancinci." Ngelo xesha, kuyinto eqhelekileyo ukuziva usoyika kwaye ukhathazekile. "Yintoni le? Ingaba inzulu?" Ucinga. Ngoko ke namhlanje, masithethe ngokulula nangobuhlobo malunga nokunyuka kweeplatelet zegazi, okuyimeko ebizwa ngokuba yiThrombocytosis ngokwezonyango.

Okokuqala, masibone, zithini iiplatelets?

Ngamafutshane, iiplatelets luhlobo lweseli encinci egazini lethu. Zicinge njengeqela elincinci 'loncedo' eliza kumisa ukopha xa ufumana isilonda okanye umkrwelo kwindawo ethile emzimbeni wakho. Zifika ngokukhawuleza kwindawo yokwenzakala, zinamathele kunye, kwaye zenze ihlwili, njengeplasta, ukuze zivale inxeba. Le yindlela ukopha okuma ngayo. Ngoko ungabona ukuba iiplatelets yinxalenye ebalulekileyo nebaluleke kakhulu yomzimba wethu.

Kodwa, njengayo nayiphi na into, iingxaki zinokuvela xa ezi platelets ziphezulu kakhulu. I-Thrombocytosis kuxa inani leeplatelets egazini linyuka ngaphezu kwenqanaba eliqhelekileyo. Xa iiplatelets zisanda ngale ndlela, igazi lethu ngamanye amaxesha linokuba ncamathela. Oku kunokukhokelela ekubeni kubekho amahlwili egazi angafunekiyo kwiindawo apho kungekho monakalo, oko kukuthi, ngaphakathi kwemithambo yegazi. Ukuba la mahlwili egazi awanyangwa, anokukhokelela nakwiimeko ezinzima ezifana nokuhlaselwa yintliziyo okanye istroke.

Kukho iintlobo ezimbini eziphambili ze-thrombocytosis:

Ngokuxhomekeke kwisizathu sokuba inani leeplatelet egazini lakho liphezulu, le meko inokwahlulwa ibe ziintlobo ezimbini eziphambili. Kubalulekile ukuqonda ezi zimbini, kuba iindlela zonyango ziya kuxhomekeka kolu hlobo.

Nangona kunjalo, ukuba uvavanyo lwakho lwegazi lubonisa ukuba inani leeplatelet zakho liphezulu, oko kuthetha ukuba kukho into eyenzekayo emzimbeni wakho ekufuneka iphandwe ngugqirha. Ngokuxhomekeke kwisizathu sokufunyaniswa, unokufuna unyango lwexesha elide, unyango lwexesha elifutshane, okanye unganyangwa konke konke.

Ziziphi iimpawu zokuba ne-platelet ephezulu egazini?

Enyanisweni, abantu abaninzi abanazo iimpawu zokuba ne-platelet ephezulu. Oku kufumaneka ngengozi xa uvavanyo lwegazi lwenziwa ngesinye isizathu.

Ukuba une-Reactive Thrombocytosis, unokufumana iimpawu zesifo esisisiseko (umzekelo, umkhuhlane obangelwa lusulelo).

Nangona kunjalo, ukuba ukwanda kweeplatelets kubangela ukuba kubekho amahlwili egazi okanye (kunqabile kakhulu) ukopha ngaphakathi, ezinye iimpawu zinokubakho. Le meko idla ngokubonakala kwi-Essential Thrombocytosis.

• Ukudinwa
• Ukopha rhoqo kwempumlo
• Ukopha (ukukrweleka) nangona emva kokwenzakala okuncinci
• Ukopha okulula kwiintsini okanye kwezinye iindawo emlonyeni
• Ukudinwa , ukubona okufipheleyo, kunye nentloko ebuhlungu
• Intlungu, ukudumba, kunye nokubomvu ezandleni nasezinyaweni (uphawu lwesifo esibizwa ngokuba yi-erythromelalgia)
• Intlungu yesisu, ingakumbi kwicala eliphezulu lasekunene lesisu (isenokuba luphawu lwemeko efana ne-Budd-Chiari syndrome)

Kutheni iiplatelets zisanda ngolu hlobo? Zithini izizathu?

Izizathu ziyahluka ngokuxhomekeke kwiintlobo ezimbini esizixubushe ngaphambili.

Izizathu ze-Essential Thrombocytosis (ET)

Oku kubangelwa kukuguquka kwezakhi zofuzo. Kodwa oku akuyonto izalwa nayo, kodwa yinto ekhula ngokuhamba kwexesha. Ngamafutshane, kukho utshintsho kwiizakhi zofuzo ezixelela umzimba wethu ukuba wenze iiplatelets. Ngenxa yoko, umongo wethambo uqala ukwenza iiplatelets ezininzi ngaphandle kolawulo.

Izizathu ze-Thrombocytosis esebenzayo

Le yindlela umzimba osabela ngayo kwenye ingxaki. Nazi ezinye zezizathu eziqhelekileyo zokuba kubekho iiplatelet eziphezulu:

• Ukopha: Xa kukho ukulahleka kwegazi okuninzi ngenxa yengozi okanye utyando.
• Iimeko zomhlaza: Ngenxa yeentlobo ezithile zomhlaza.
• Iintsholongwane: Iintsholongwane okanye iintsholongwane.
• Iimeko zokudumba: Izifo ezibangela ukudumba emzimbeni, ezifana ne-arthritis.
• I-anemia yokunqongophala kwe-iron.
• Amanye amayeza.
• Ukususwa kwespleen ngotyando: Omnye wemisebenzi yespleen kukususa iiplatelet ezindala. Ukuyisusa kunokunyusa inani leeplatelet.

Ziziphi iingxaki ezinokwenzeka ngenxa yale meko?

Abantu abane-Essential Thrombocytosis (ET) basengozini enkulu yokufumana iingxaki. Iingxaki azixhaphakanga kakhulu kwi-Reactive Thrombocytosis.

Eyona ngozi inkulu kukwakheka kwamahlwili egazi . Ukuba la mahlwili egazi anamathela kwimithambo yegazi eya engqondweni, anokubangela isifo sohlangothi , kwaye ukuba anamathela kwimithambo yegazi eya entliziyweni, anokubangela ukuhlaselwa yintliziyo . La mahlwili egazi anokubakho nakwezinye iindawo, njengasemiphungeni nasemilenzeni.

Kunqabile kakhulu, i-ET ingakhula ibe zezinye iintlobo zomhlaza wegazi, ezifana ne-leukemia, okanye ibangele amanxeba kumongo wethambo (i-myelofibrosis). Inganyusa nomngcipheko weengxaki ezithile ngexesha lokukhulelwa.

Kodwa ungakhathazeki. Ukuba une-ET, ugqirha wakho uza kuyijonga impilo yakho ngokusondeleyo aze akunike unyango olufunekayo ukuthintela iingxaki ezinje ngezi.

Oogqirha bakufumanisa njani oku kanye kanye?

I-Thrombocytosis ifunyanwa ikakhulu ngovavanyo lwegazi. Ngokwesiqhelo, inani leeplatelet elingaphezulu kwama-450,000 kwi-microliter yegazi lithathwa njengeliphezulu. Ugqirha wakho unokufuna ukuphinda alivavanye igazi lakho emva kweeveki ezimbalwa ukuze abone ukuba inani leeplatelet zakho lisaphezulu na. Ukuba inani libuyele kwisiqhelo, ngokuqhelekileyo akukho nto ibalulekileyo ekufuneka uyixhalabele.

Ukuba inani leeplatelet liyaqhubeka liphezulu, inyathelo elilandelayo kukufumanisa ukuba ingaba yiReactive okanye yiEssential. Oku kuya kufuna uvavanyo oluninzi.

• Ezinye iimvavanyo zegazi: Ezi zijonga izinto ezifana namanqanaba esinyithi kunye neempawu zokudumba, kwaye zijonga iimilo ezingaqhelekanga zeeplatelet phantsi kwemakroskopu.
• Uvavanyo lwe-genetic: Olu vavanyo lunokubona utshintsho lwe-genetic olufana ne -JAK2 , i-CALR1 , okanye i-MPL1, oluqhele ukubonwa kwi-Essential Thrombocytosis.
• Uvavanyo lwe-bone marrow biopsy: Oku kuquka ukuthatha isampuli encinci kakhulu yomongo kwindawo efana nethambo lesinqe phantsi kwe-anesthesia kwaye uyivavanye kwilebhu. Oku kunokuqinisekisa ngokuqinisekileyo imeko ye-ET.

Iphathwa njani?

Iindlela zonyango zixhomekeke kuhlobo lwe-thrombocytosis onayo kunye neempawu zakho.

Kwi-Reactive Thrombocytosis:

Kulapho iiplatelet zinyuka khona xa kusenzeka esinye isifo. Ngoko ke, unyango lujoliswe kwisizathu esiyintloko . Umzekelo, ukuba inani leeplatelet liyanda ngenxa yosulelo, xa kunikwa amayeza okubulala iintsholongwane kuloo sulelo, inani leeplatelet liza kubuyela esiqhelweni njengoko usulelo luphola.

Kwi-Essential Thrombocytosis (ET):

I-ET ayisosifo esinokunyangeka. Nangona kunjalo, inokulawulwa kakuhle ukunciphisa umngcipheko wokuqhekeka kwegazi. Kukho iindlela ezahlukeneyo zonyango:

• Ukulinda ngononophelo: Ukuba awunazo iimpawu kwaye umngcipheko wakho wokuba namahlwili egazi uphantsi, ugqirha wakho unokujonga imeko yakho ngokwenza uvavanyo lwegazi rhoqo ngaphandle kokukunika amayeza.
• I-aspirin enesilinganiselo esiphantsi: Unganikwa ipilisi ye-aspirin yemihla ngemihla ukunceda ukuthintela ukuqhekeka kwegazi. Kodwa khumbula, ungaze uqale ukuyithatha wedwa i-aspirin ngaphandle kokubonisana nogqirha.
• Amayeza anciphisa amanqanaba eeplatelet: Amayeza afana neHydroxyurea, iAnagrelide, kunye neInterferon alfa alawula ukuveliswa kweeplatelet.
• Inkqubo yokususa iiplatelet: Ukuba kukho umngcipheko okhawulezileyo wokuba nehlwili legazi elisongela ubomi, igazi lakho linokudluliselwa ngomatshini ukuze kuhluzwe iiplatelet ezigqithisileyo.

Ufanele uye nini kugqirha?

Ukuba ufunyaniswe une-thrombocytosis, kubalulekile ukuba uhlolwe igazi rhoqo njengoko ugqirha wakho ekuyalele. Kwakhona, buza ugqirha wakho ukuba zeziphi iimpawu omele uzixele ngoko nangoko ukuba ziyavela.

Ngokukodwa, ukuba ubonakalisa iimpawu zestroke okanye ukuhlaselwa yintliziyo (umz. iintlungu zesifuba ngequbuliso, ubunzima bokuthetha, ubuthathaka kwelinye icala lomzimba, ukugoba kobuso), yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele ngoko nangoko.