Ngaba uqala usuku lwakho ngomqolo oqinileyo kunye nentlungu xa uvuka kusasa? Ngaba udiniwe ziintlungu ezivela kumalungu akho xa uhamba okanye uhambahamba? Ezi zinokuba ziimpawu ze- ankylosing spondylitis , okanye i-AS ngamafutshane. Le yimeko yokudumba ehlala ixesha elide eyenzeka kumqolo nakwamanye amalungu. Ngoko ke ukuba unale meko, ugqirha wakho usenokuba uthethe ngohlobo oluthile lwamayeza abizwa ngokuba yi-TNF Inhibitors. Makhe sithethe ngale nto ngokulula nangokucacileyo namhlanje.
Kutheni amalungu ebuhlungu kwi-AS? Yintoni i-TNF?
Kulungile, masiyibeke ngokulula le nto. Sonke sinenkqubo yokuzikhusela emizimbeni yethu. Yiyo esikhuselayo ngokulwa neentsholongwane ezibangela izifo. Kodwa kwiimeko ezifana ne-AS, le nkqubo yokuzikhusela iba namandla kakhulu. Ifana nomlindi ohlala ephaphile.
Xa oku kusenzeka, imizimba yethu iqala ukuvelisa iproteni ekhethekileyo ebizwa ngokuba yiTumor Necrosis Factor, okanye i-TNF . Le protein ye-TNF yiyo ebangela ukudumba kwamalungu ethu, oko kuthetha ukudumba, ukudumba, ukuba bomvu, kunye nentlungu. Yiyo loo nto amalungu anjengomqolo wakho kunye nezinqe eqina, evuvukile, kwaye ebuhlungu.
Ngoko ke ziintoni ezi TNF Inhibitors?
Ngamafutshane, ii-TNF inhibitors luhlobo lwamayeza 'avimba' iproteni ye-TNF esithethe ngayo ngaphambili, ebangela ukudumba. Ezi azifani neentlungu eziqhelekileyo. Ii-painkillers zicinezela iintlungu okwethutyana kuphela. Kodwa ii-TNF Inhibitors zisebenza nzulu kakhulu kunoko.
La mayeza aya ngqo kwiproteni ye-TNF ebangela ukudumba kwaye ayimise ukusebenza. Oku kunciphisa ukudumba kwamalungu, kulawula iintlungu, ukudumba, kunye nokuqina. Akwanceda ukuthintela ukonakala kwamalungu ngokuhamba kwexesha.
Oogqirha bakwabiza la mayeza ngokuthi 'zii-TNF blockers', 'biologics', okanye 'i-anti-TNF drugs'. Kukho iintlobo ezahlukeneyo ze-TNF inhibitors ezivunyiweyo kwi-AS:
- I-Adalimumab
- I-Certolizumab pegol
- I-Etanercept
- IGolimumab
- I-Infliximab
Ugqirha wakho uhlala ecinga ngolu nyango xa iimpawu zakho zingalawulwa zii-painkillers (NSAIDs). Ayizizo zonke izithinteli ze-TNF ezisebenzela wonke umntu. Iyeza elinye lisenokusebenza kakuhle kwabanye abantu, kodwa alisebenzi kakuhle kwabanye. Ngoko ugqirha wakho unokuzama amayeza ahlukeneyo de afumane elilungele wena.
Zisetyenziswa njani ezi ziyobisi?
Kukho iindlela ezimbini eziphambili zokunika eli yeza , eziya kwahluka ngokuxhomekeke kuhlobo lwamayeza owanikwe wona.
1. Njengomjovo phantsi kolusu (Injection)
Amanye amayeza eza njengeenaliti. Eyona nto ilungileyo kukuba ungawanika ekhaya. Ugqirha wakho okanye umongikazi oqeqeshiweyo uza kukubonisa indlela yokuwanika ngokuchanekileyo. Ahlala enikwa eluswini lwesisu okanye ethangeni lakho. Into ebalulekileyo kukujikeleza indawo ofakelwe kuyo inaliti, hayi leyo ifanayo ngalo lonke ixesha.
2. Njengesisombululo setyuwa esifakwe emthanjeni (Intravenous Infusion)
Amayeza anjengeGolimumab kunye ne-Infliximab anikwa njengesicombululo setyuwa emthanjeni. Oku kufuna ukuba uye esibhedlele okanye kwiziko lokufumana amayeza. Olu nyango lungathatha iiyure ezininzi. Ugqirha uya kukunika amayeza kangangeeyure ezimbini aze akugcine ujongiwe ezinye iiyure ezimbini ukuze abone ukuba unayo na i-allergy enzulu. Usenokufuna ukuthatha olu nyango rhoqo kwiiveki ezimbini ekuqaleni, kodwa eli xesha lisenokuncitshiswa ngokuhamba kwexesha.
Zithini iingenelo ze-TNF Inhibitors?
Izifundo zibonise ukuba abantu abane- AS bafumana iingenelo ezibalulekileyo kolu nyango.
- Intlungu iyancipha kakhulu.
- Ukusebenza kwamalungu kunye nokuguquguquka kwawo kuyaphucuka.
- Iimpawu ezinje ngokuqina kwamalungu ekuseni kunye nokudumba kunokwenzeka ukuba zinciphe.
- Inciphisa ukudumba okujikeleze umqolo kunye namanye amalungu.
- Inciphisa umonakalo osisigxina wamalungu ngokuhamba kwexesha.
Abantu abaninzi baqala ukubona umahluko emva kweedosi ezimbini okanye ezintathu zeyeza. Nangona kunjalo, ngamanye amaxesha kungathatha ukuya kwiinyanga ezintathu ukubona iziphumo ezipheleleyo zeli yeza. Kungoko ke, kubalulekile ukuba nomonde ngonyango.
Siyazazi neziphumo ebezingalindelekanga.
Njengayo nayiphi na iyeza, eli linokuba nemiphumo emibi. Nangona kunjalo, uninzi lwabantu lufumana iziphumo ezingephi kuphela. Eyona nto ibalulekileyo kukwazi oku kwaye wazise ugqirha wakho ngokukhawuleza ukuba uneengxaki.
Ngenxa yokuba la mayeza athintela ukusebenza kwenkqubo yethu yokuzikhusela komzimba, amandla ethu okulwa neentsholongwane anokuncipha kancinci. Oku kwandisa kancinci umngcipheko wosulelo .
Kukho umngcipheko wokuba isifo sephepha (TB) sibuye. Ungakhathazeki, ugqirha wakho uza kukuvavanya isifo sephepha kunye nezinye izifo ngaphambi kokuba uqale eli yeza.
Apha ngezantsi kukho ezinye zeziphumo ebezingalindelekanga eziqhelekileyo ezinokubakho.
| Imiphumela | Inkcazo kunye noko kufuneka ukwazi |
|---|---|
| Iimpendulo kwindawo yokujova | Kusenokubakho ukubomvu, ukurhawuzelela, kunye nokudumba kwindawo efakwe kuyo inaliti. Oku kudla ngokuphela kwisithuba seveki. |
| Ingozi yokosuleleka | Umngcipheko wokufumana izinto ezifana nomkhuhlane, umkhuhlane, inyumoniya, kunye nosulelo lolusu unokwanda. Xelela ugqirha wakho ukuba unesifo esifana nomkhuhlane okanye ukukhwehlela. |
| Ezinye iingxaki eziqhelekileyo | Intloko ebuhlungu, amaqhuqhuva eluswini, isicaphucaphu, iintlungu zesisu, urhudo, i-sinusitis, njl. |
| Iimpendulo ezinzulu (ezingaqhelekanga) | Izinto ezinje ngokudumba kwemilebe, ubunzima bokuphefumla, uxinzelelo lwegazi oluphantsi, njl. Ukuba kukho into efana nale, funa ingcebiso yezonyango ngokukhawuleza okanye uye kwiSebe leeNgxamiseko (ETU) elikufutshane. |
Kwezinye iimeko, eli yeza linokunyusa kancinci umngcipheko wokuba nomhlaza wolusu (umhlaza wolusu ongengomelanoma), ngoko ke ugqirha wakho uya kukwazi oko.
Ngubani ongafanele asebenzise eli yeza?
Ii-TNF Inhibitors azifanelekanga kuye wonke umntu. Ugqirha wakho akanakukunika ii-TNF Inhibitors ukuba unenye yezi meko zilandelayo:
- Ukuba ungumama oncancisayo .
- Okwangoku unentsholongwane esebenzayo.Ukuba kukho usulelo olusebenzayo.
- Ukuba unembali yezifo ezifana ne -lupus okanye i-multiple sclerosis .
- Ukuba unesifo somhlaza okanye iiseli ezingaphambi komhlaza (oku kunokwahluka ngokuxhomekeke kwisigqibo sikagqirha kwiimeko zomhlaza ezineminyaka engaphezu kwe-10 ubudala kwaye ezinyangiweyo kwaye zanyangwa).
- Ukuba unembali yesifo sentliziyo esibi kakhulu .
Ngaba ezi zingasetyenziswa ngexesha lokukhulelwa?
Lo ngumbuzo obalulekileyo kubantu abaninzi. Izifundo zibonise ukuba uninzi lwala mayeza lukhuselekile ukuwasebenzisa ngexesha lokukhulelwa. Nangona kunjalo, amanye amayeza, ingakumbi kwikota yesibini okanye yesithathu yokukhulelwa, anokuwela i-placenta aye kumntwana.
Ngoko ke ukuba ulindele umntwana, ngokuqinisekileyo thetha nogqirha wakho wamathambo ngale nto. Usenokukwazi ukukucebisa iyeza elikulungeleyo, elifana neCertolizumab, elingaweliyo kwi-placenta.
Umyalezo Wokuya Ekhaya
- Ii-TNF Inhibitors ziluhlobo oluthile, olunamandla lwamayeza alawula ukudumba, unobangela oyintloko we-ankylosing spondylitis (AS).
- Ezi azifani neepilisi zokudambisa iintlungu eziqhelekileyo; ziphazamisana nenkqubo yomzimba yokuzikhusela esisiseko sesifo.
- Ngenxa yomngcipheko ophezulu wokosuleleka, ugqirha wakho uza kukujonga ngononophelo ngaphambi nangexesha lonyango.
- Xelela ugqirha wakho ngoko nangoko malunga nazo naziphi na iimpawu ezintsha ozifumanayo, ingakumbi umkhuhlane okanye iimpawu zosulelo.
- Ukuba uceba ukukhulelwa okanye ukhulelwe, kubalulekile ukuthetha nogqirha wakho malunga nale mithi.
- Ungaze utshintshe idosi okanye uyeke ukuthatha amayeza ngaphandle kwengcebiso kagqirha.
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