Ngaba ungacinga ngemithambo yegazi ethwala igazi esuka entliziyweni yethu ukuya emiphungeni yethu incipha kancinci kancinci, nto leyo ebangela ukuba uxinzelelo lwegazi lunyuke kakhulu? Kufana nokucinezela umbhobho wamanzi kwaye isantya samanzi siyanda. Oku sikubiza ngokuba yi- 'Pulmonary Arterial Hypertension' okanye 'i-PAH' kunyango. Le yimeko eyahlukileyo kancinci kuxinzelelo lwegazi oluqhelekileyo kwaye ifuna ingqalelo ekhethekileyo. Oku kunokubangela iimpawu ezifana nokuphefumla kancinci, iintlungu zesifuba, kunye nokudinwa kakhulu. Ngoko ke namhlanje siza kuthetha ngeyeza elikhethekileyo elisetyenziselwa ukunyanga le meko, eliyi-Treprostinil injection.
Luhlobo luni lweyeza iTreprostinil?
Ngamafutshane, iTreprostinil (igama lophawu: iRemodulin) liyeza elinikwa abantu abane-pulmonary arterial hypertension (PAH) endikhankanyileyo ngaphambili. Eli yeza lisebenza ngokwandisa imithambo yegazi emincinci kancinci, okwenza kube lula ukuba igazi lihambe. Oku kunciphisa umthwalo womsebenzi entliziyweni kwaye kunceda ukulawula iimpawu. Kwakhona kwenza kube lula ukwenza imisebenzi yemihla ngemihla. Eli liyeza elibaluleke kakhulu elinceda ukuphucula umgangatho wobomi.
Ugqirha wakho angakunika eli yeza nakwezinye iimeko, ngoko ke ukuba unemibuzo malunga noku, qiniseka ukuba ubuza ugqirha wakho.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale eli yeza
Ngaphambi kokuba uqalise eli yeza, kubaluleke kakhulu ukunika ugqirha wakho inkcazo epheleleyo yempilo yakho. Qiniseka ukuba ukhankanya oku kulandelayo ngokukodwa:
- Isifo sezintso: Ukuba unesifo esinxulumene nezintso.
- Isifo sesibindi: Ukuba kukho ingxaki ekusebenzeni kwesibindi.
- Ii-Allergy: Qiniseka ukuba uxelele ugqirha wakho ukuba ukhe waba ne-allergy kwi-Treprostinil, i-Epoprostenol, okanye nayiphi na enye iyeza, ukutya, okanye idayi.
- Ukukhulelwa: Ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa, kufuneka uthethe nogqirha wakho ngaphambi kokuba uqale eli yeza.
Ndingayisebenzisa njani le yeza?
Oku akufani nepilisi okanye ikhaphu esidla ngokuyithatha. Inaliti yeTreprostinil inikwa emzimbeni wakho ngepompo encinci esebenza rhoqo (i-continuous infusion) . Iyeza lingena emzimbeni wakho ngetyhubhu encinci, ebizwa ngokuba yi-catheter, eqhagamshelwe kule pompo. Oku kungenziwa ngeendlela ezimbini:
1. I-Subcutaneous: I-catheter ifakwa phantsi kolusu kwaye iyeza liyanikwa.
2. Ngokusebenzisa umthambo (ongena emthanjeni):I-catheter ifakwa ngqo kwimithambo yegazi (umthambo) kwaye iyeza liyanikwa.
Uza kunikwa uqeqesho olucokisekileyo esibhedlele malunga nendlela yokusebenzisa oku, indlela yokulungisa ipompo, kunye nendlela yokufaka i-catheter. Kubaluleke kakhulu ukulandela imiyalelo enikwe ngugqirha kunye nabasebenzi bomongikazi ngokuchanekileyo .
Kubaluleke kakhulu: Musa ukuyeka ukusebenzisa eli yeza nangasiphi na isizathu ngaphandle kokubonisana neqela lakho lezonyango. Ukuliyeka ngequbuliso kunokuyenza imeko yakho ibe mandundu.
Wenza ntoni ngeenaliti neesirinji ezisetyenzisiweyo?
Ungaze ulahle iinaliti neesirinji ezisetyenzisiweyo enkunkuma. Zifanele zibekwe kwisitya esikhethekileyo (isitya esibukhali) esinikiweyo. Ukuba awunaso, cela ugqirha wakho okanye isibhedlele ukuba sikunike sona.
Ngaba eli yeza lifanele linikwe abantwana?
Abantwana banokufuna ukhathalelo olukhethekileyo xa benikwa eli yeza, ngoko ke kubalulekile ukuxoxa ngale nto nogqirha wabantwana ukuze bafumane iingcebiso.
Kuthekani ukuba ndithatha amayeza amaninzi kakhulu?
Ukuba ucinga ukuba uthathe amayeza amaninzi kakhulu, fowunela iZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko. Okanye yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Amanye amayeza anokusebenzisana nalo mayeza (Ukusebenzisana kwamayeza)
Amanye amayeza owasebenzisayo anokusebenzisana neTreprostinil, ngoko ke xelela ugqirha wakho ngawo onke amayeza owasebenzisayo (kuquka iivithamini, amayeza esintu, kunye nezongezo).
| Uhlobo lweziyobisi | Izinto ekufuneka uziqaphele |
|---|---|
| Amanye amayeza oxinzelelo lwegazi oluphezulu | Xa ezi zinto zidibene neTreprostinil, uxinzelelo lwegazi lunokwehla kakhulu. |
| Isithinteli sokugabha kwegazi | Imizekelo: Amayeza afana neWarfarin, iEnoxaparin, iDabigatran, neApixaban. La mayeza anokunyusa umngcipheko wokopha. |
| Iziyobisi zomchamo | Ingabangela uxinzelelo lwegazi oluphantsi. |
| Amanye amayeza | Amayeza afana neGemfibrozil kunye neRifampin anokuchaphazela ukusebenza kakuhle kwale yeza. |
Izinto ekufuneka uzikhumbule xa usebenzisa amayeza
- Ukuhlolwa rhoqo: Hlala unxibelelana nogqirha wakho rhoqo ukuze ujonge inkqubela phambili yemeko yakho. Yiya kwiikliniki rhoqo.
- Ulusu olujikeleze i-catheter: Jonga ulusu olujikeleze i-catheter rhoqo. Ukuba kukho ukubomvu okungaqhelekanga, iintlungu, ukudumba, okanye ukukhupha okufana nobovu, yazisa iqela lakho lezonyango ngoko nangoko. Oku kungaba luphawu losulelo.
- Ukuba imeko yakho iba mandundu: Ngamanye amaxesha imeko yakho inokuba mandundu nasemva kokusela eli yeza. Ukuba uziva ngolu hlobo, njengokuba unengxaki yokuphefumla okanye iintlungu esifubeni, fowunela ugqirha wakho ngoko nangoko. Umthamo wakho unokufuna ukutshintshwa.
Iziphumo ebezingalindelekanga ezinokubakho ngenxa yamayeza
Njengalo naliphi na iyeza, iTreprostinil inokubangela iziphumo ebezingalindelekanga. Ezinye zezi ziyingozi, ngelixa ezinye zixhaphakile.
| Uhlu lweziphumo ebezingalindelekanga | |
|---|---|
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
| Iimpendulo ze-allergy ezifana nokurhawuzelela kwesikhumba, ukurhawuzelela, kunye ne-hives | Ukudumba kobuso, imilebe, okanye ulwimi |
| Ubunzima bokuphefumla | Iintlungu zesifuba |
| Ukubetha kwentliziyo okukhawulezayo ngendlela engaqhelekanga, ukubetheka ngamandla, okanye ukubetha kwentliziyo okungaqhelekanga | Isicaphucaphu, isiyezi, kunye nokuwa |
| Umkhuhlane okanye ukuziva ubanda | Ukudumba, iintlungu, okanye ukudumba kwindawo yokutofa |
| Intlungu, ukungaziva, okanye ukuphelelwa luvakalelo ezandleni nasezinyaweni | Ubuthathaka okanye ukudinwa okungaqhelekanga |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Intlungu yethambo okanye yomhlathi | Urhudo |
| Ukuhlanjwa ngamanzi | Intloko ebuhlungu |
| Isicaphucaphu, ukuhlanza | |
Ungayigcina njani imithi?
Ukuze kugcinwe umgangatho weyeza, kubaluleke kakhulu ukuligcina ngokufanelekileyo.
- Gcina kude nabantwana kunye nezilwanyana zasekhaya.
- Iibhotile ezingavulwanga: Gcina kubushushu obuphakathi kwe-15 kunye ne-25 degrees Celsius.
- Emva kokuvula ibhotile: Emva kokuba idosi yokuqala yeyeza ithathiwe, ibhotile kufuneka isetyenziswe zingadlulanga iintsuku ezingama-30.
- Amayeza aphelelwe lixesha: Musa ukuwasebenzisa nangasiphi na isizathu emva komhla wokuphelelwa.
- Amayeza akwipompo:
- Ukuba inikwa ngaphantsi kwesikhumba: Iyeza elikwisirinji enye lingasetyenziswa ukuya kuthi ga kwiiyure ezingama-72. Emva kweeyure ezingama-72, lahla iyeza eliseleyo.
- Ukuba inikwa ngemithambo: Iyeza elikwisirinji enye lingasetyenziswa ukuya kuthi ga kwiiyure ezingama-48. Lahla iyeza eliseleyo emva kweeyure ezingama-48.
Umyalezo Wokuya Ekhaya
- I-Treprostinil liyeza elibaluleke kakhulu lokulawula uxinzelelo lwegazi oluphezulu lwemithambo yegazi (i-PAH). Lifanele lisetyenziswe kuphela njengoko ugqirha wakho eyalele.
- Ngaphambi kokuba uqale eli yeza, xelela ugqirha wakho ngazo zonke iimeko zakho zempilo kunye nazo zonke ezinye iziyobisi ozisebenzisayo.
- Musa ukuyeka ukuthatha amayeza akho ngaphandle kwengcebiso kagqirha nangasiphi na isizathu. Kunokuba yingozi kakhulu.
- Soloko ujonge iziphumo ebezingalindelekanga ezinje ngokuba bomvu, iintlungu, kunye nokudumba kwindawo ohlatywe kuyo inaliti, kunye nentlungu yesifuba kunye nobunzima bokuphefumla. Ukuba ubona nayiphi na kwezi, yazisa ugqirha wakho ngokukhawuleza.
- Kubaluleke kakhulu ukugcina amayeza ngokufanelekileyo kunye nokulahla iinaliti ezisetyenzisiweyo ngokukhuselekileyo.
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