Kunzima ukuchaza ngamazwi uloyiko kunye nexhala eliza nokufunyaniswa ukuba unomhlaza webele. Nangona kunjalo, ngokuhambela phambili kwesayensi yezonyango, ngoku kukho unyango oluninzi oluphambili lokunyanga nokulawula umhlaza. I-Orserdu yenye yethemba elitsha, iyeza elikhethekileyo elijolise kwiiseli zomhlaza. Makhe sithethe ngale nto ngokulula nangokucacileyo namhlanje.
Luhlobo luni lonyango i-Orserdu?
Ngamafutshane, i-Orserdu
lunyango olujoliswe kwi-hormone . Ngoku usenokuba uzibuza, "Yintoni leyo?" Kunyango
lwe-chemotherapy esiqhele ukuva ngalo, phantse zonke iiseli ezahlulahlula ngokukhawuleza zinokuchaphazeleka. Oku kuthetha ukuba kungekuphela nje iiseli zomhlaza, kodwa neeseli ezisempilweni emzimbeni wethu zinokonakala. Kodwa kunyango olujoliswe kulo, kwenzeka into eyahlukileyo. La mayeza akrelekrele kakhulu, achonga into ethile, njengeproteni ethile okanye i-gene, enceda iiseli zomhlaza zikhule, kwaye zijolise kuyo. I-Orserdu ivunyiwe ngokukodwa kwi:
- I-Estrogen Receptor -positive (ER-positive ) kunye
- I-receptor ye-2-negative ye-epidermal growth factor receptor yomntu ( HER2-negative ),
- Ngomhlaza webele osasazeke kwamanye amalungu omzimba (oqhubekileyo okanye osasazekileyo).
Ukongeza, olu nyango lunikwa abantu abaneenguqu
kwi-gene (utshintsho kwi-gene) kwi-gene ebizwa ngokuba yi-ESR1 . Eli yeza lidla ngokucetyiswa kubantu abaye bafumana ezinye iindlela zonyango lweehomoni kwaye abanomhlaza ongasabelanga kakuhle kuzo kwaye sele bebuyile. Liza njengepilisi ethathwa kanye ngemini.
Eli yeza lisebenza njani emzimbeni?
Ukuze siqonde oku, masiqale sijonge umhlaza one-ER-positive. Olu hlobo lweseli yomhlaza lufana nesityalo esincinci. Eso sityalo sifuna ihomoni ebizwa ngokuba yi-'estrogen' efana namanzi ukuze sikhule. Ngoko ke, uninzi lonyango lweehomoni luyayithintela le estrogen ukuba ingangeni kwiseli yomhlaza. Kodwa ngamanye amaxesha, xa uthatha olu nyango okwethutyana,
ijini ebizwa ngokuba yi-ESR1 kwiiseli zomhlaza iyatshintsha . Ngenxa yolu tshintsho, amayeza ehomoni awayenikwe ngaphambili awasakwazi ukulawula umhlaza. Umhlaza uqala ukukhula kwakhona.
Khawucinge ukuba iseli yomhlaza ine-receptor ekhethekileyo enokuthi ibanjwe yi-hormone ye-estrogen. I-Orserdu isebenza ngokujolisa kwiiseli zomhlaza ezazingamelani namayeza ngaphambili ngenxa yolo tshintsho lwemfuza.Ingcinga kukuba ufike kuloo mnyango usemngxunyeni, ufike kuwo ngaphambi kokuba i-estrogen ifumaneke, uze uvale loo mnyango. Emva koko i-hormone ye-estrogen ayinalo ithuba lokukhulisa iseli yomhlaza.
Ndingazi njani ukuba i-Orserdu ilungile kum?
Lo ngumbuzo obaluleke kakhulu. I-Orserdu ayiloyeza elinikwa bonke abaguli abanomhlaza webele. Ugqirha wakho we-oncologist ngoyena mntu ufanelekileyo ukwenza esi sigqibo. Ngokubanzi, olu nyango luqwalaselwa kubaguli abahlangabezana nezi mfuno zilandelayo:
Iimeko apho unokucingelwa khona ukuba ufumane unyango lwe-Orserdu
| Imeko yesigulana | Kufuneka ube ngumfazi osele ephezile ukuya exesheni okanye indoda endala. |
| Uhlobo lomhlaza | Umhlaza kufuneka ube ne-ER-positive kwaye ube ne-HER2-negative. |
| Ukusasazeka komhlaza | Umhlaza kufuneka ube sele uqhubele phambili okanye usasazeke kwezinye iindawo zomzimba (i-metastatic). |
| Uvavanyo lwe-genetic | Uvavanyo oluthile kufuneka luqinisekise ukuba umhlaza wakho une -ESR1 gene change . |
| Ngaphambi konyango | Kufuneka ukuba ufumene ubuncinane uhlobo olunye lonyango lwehomoni ngaphambili kwaye umhlaza kufuneka ukuba ubuyile ngexesha okanye emva kolo nyango. |
Ugqirha wakho uya kwenza isigqibo sokugqibela sokuba eli yeza likulungele na emva kokwenza uvavanyo lwemfuza olufunekayo kunye nokuphonononga iirekhodi zakho zonyango ezipheleleyo.
Iziphumo ebezingalindelekanga ze-Orserdu kunye nendlela yokuzisingatha?
Njengayo nayiphi na iyeza, i-Orserdu inokubangela ezinye iziphumo ebezingalindelekanga. Nangona kunjalo, uninzi lwazo zihlala zilula kwaye zilawuleka.
Eyona nto ibalulekileyo kukuxelela ugqirha wakho kwangoko ngazo naziphi na iimpawu ezintsha ozifumanayo.| Iziphumo ebezingalindelekanga eziqhelekileyo | Iingcebiso zokulawula |
|---|
| Intlungu yemisipha kunye namalungu, intloko ebuhlungu | Thetha nogqirha wakho malunga nokufumana isithomalalisi sentlungu esifanelekileyo koku. |
| Isicaphucaphu, ukuhlanza, isisu esibuhlungu, urhudo, okanye ukuqhina | - Yitya ukutya okuncinci amaxesha amaninzi ngemini. - Kuphephe ukutya okunamafutha nokunamafutha. - Yongeza imifuno neziqhamo ezingaphezulu. |
| I-Anorexia | - Yitya ukutya okuncinci imini yonke xa uziva ulambile. - Zama ii-shakes ezinesondlo okanye ukutya okumanzi. |
| Ukushushu okushushu | - Nxiba impahla ekhaphukhaphu nekhululekileyo. - Nciphisa uxinzelelo. Ukuzilolonga ngokuphefumla nzulu kunokunceda. |
| Ukudinwa | Phumla kangangoko unako. Ukucwangcisa imisebenzi yosuku lwakho kunokukunceda wonge amandla. |
Ukongeza, i-Orserdu inokunyusa amanqanaba e-cholesterol egazini kunye ne-triglyceride. Ingachaphazela nokusebenza kwesibindi kunye nezintso. Ke ngoko, ugqirha wakho uya kuzijonga ezi zinto ngovavanyo lwegazi rhoqo.
I-Orserdu isebenzisana njani nezinye iziyobisi nokutya?
Oku kubaluleke kakhulu. Ngaphambi kokuba uqale ukusebenzisa i-Orserdu, kufuneka uxelele ugqirha wakho we-oncologist malunga
nawo onke amayeza owasebenzisayo ngoku (kuquka amayeza ezinye izifo, iivithamini, kunye neemveliso zezityalo) . Oku kungenxa yokuba amanye amayeza kunye nokutya kunokuchaphazela indlela esebenza ngayo i-Orserdu emzimbeni.
- Izithinteli ze-CYP3A: Olu hlobo lwamayeza okanye ukutya lunokulibazisa ukususwa kwe-Orserdu emzimbeni. Oku kunokunyusa izinga leyeza emzimbeni,Iziphumo ebezingalindelekanga zinokwanda. Imizekelo: Ezinye izibulali-ntsholongwane, izibulali-ntsholongwane, kunye neziqhamo ezifana negrapefruit kunye ne-pomelos.
- I-CYP3A inducers: Olu hlobo lwamayeza lubangela ukuba i-Orserdu isuswe emzimbeni ngokukhawuleza. Oku kunokunciphisa ukusebenza kakuhle kwamayeza. Imizekelo: Amanye amayeza esifo sokuwa, amanye amayeza okubulala iintsholongwane.
Ngoko ke,
qiniseka ukuba uqhagamshelana nogqirha wakho ngaphambi kokuba uqale okanye uyeke naliphi na iyeza elitsha ngelixa usebenzisa i-Orserdu. Umyalezo Wokuya Ekhaya
- I-Orserdu (elacestrant) lunyango olutsha olujolise kwi-hormone kunyango lomhlaza webele ophucukileyo, one-ER-positive, ne-HER2-negative.
- Olu nyango lucetyiswa ngokukodwa kwizigulane ezine-ESR1 gene mutation kwaye ezingaphenduliyo kwezinye iindlela zonyango lweehomoni .
- Uphando lubonise ukuba eli yeza landisa ukusinda ngaphandle kokuqhubela phambili (ixesha apho umhlaza unokulawulwa ngaphandle kokuba mandundu).
- Iziphumo ebezingalindelekanga ezifana nokucaphuka, iintlungu zamalungu, kunye nokudinwa zinokubakho, kodwa zinokulawulwa. Xela ugqirha wakho ngazo naziphi na iziphumo ebezingalindelekanga.
- Kubaluleke kakhulu ukwazisa ugqirha wakho malunga nazo zonke ezinye iziyobisi, iivithamini, kunye nezongezo ozithathayo.
- Ugqirha wakho we-oncologist uza kugqiba ukuba olu nyango lukulungele na emva kovavanyo.
Umhlaza, umhlaza webele, i-Orserdu, i-elacestrant, unyango lweehomoni, unyango olujoliswe kulo, amayeza omhlaza
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