Ngaba unamaqhuma kufutshane namalungu akho? Masithethe ngeTumoral Calcinosis!

Ngaba ngamanye amaxesha uziva ngathi uneqhuma okanye indawo eqinileyo phantsi kolusu kufutshane nelungu elifana nengqiniba yakho, igxalaba, okanye idolo? Isenokungabi buhlungu xa uyicinezela, kodwa inokuba nkulu kancinci. Kuqhelekile ukuba uzive usoyika kancinci xa ubona into efana nale. Kodwa ayizizo zonke ezi qhuma ziyingozi kumhlaza. Namhlanje siza kuthetha ngemeko ebonisa ezi mpawu, kodwa ingenguwo umhlaza, kwaye inqabile kodwa kubalulekile ukuyazi. Yiyo loo 'Tumoral Calcinosis' .

Yintoni iTumoral Calcinosis?

Ngamafutshane, i-tumor calcinosis yimeko yemfuza . Oku kwenzeka xa amanqanaba egazi lakho ekhemikhali ebizwa ngokuba yi-phosphate ephezulu kakhulu. I-Phosphate yi-particle etshajiweyo ngombane, okanye i-ion, equlethe i-phosphorus yeminerali. Ngoko ke, kumntu one-tumor calcinosis, zombini i-phosphorus kunye ne-calcium ziyaqokelelana emzimbeni, nto leyo ebangela ukuba kubekho amaqhuma phantsi kolusu, ingakumbi ajikeleze amalungu.

Zombini i-phosphorus kunye ne-calcium zibalulekile emizimbeni yethu ukuze sakhe amazinyo namathambo aphilileyo, aqinileyo. Kodwa xa ziphezulu kakhulu, ukukhula okungenamhlaza (okungengobungozi), oko kukuthi, akuyongozi, kodwa okufana neethumba, kuqala ukwakheka kwizicwili. Oku sikubiza ngokuba yi-tumoral calcinosis.

Ngaba likho elinye igama lale nto?

Ewe, igama elipheleleyo lezonyango lale meko yi -'Hyperphosphatemic Familyal Tumoral Calcinosis' (HFTC) . Igama elide kancinci, akunjalo? Abanye oogqirha babiza ngokuba yi-'Teutschlaender disease'. Oko kukukhumbula u-Otto Teutschlaender, ugqirha waseJamani owafunda esi sifo ukususela ngeminyaka yoo-1930 ukuya kweyoo-1950.

Lithetha ukuthini eli gama lide lezonyango?

Ngaba singalihlulahlula eli gama libe ziinxalenye size siliqonde? Oko kuya kuba lula.

• I-Hyperphosphatemic: Oku kuthetha ukuba inqanaba le-phosphate egazini liphezulu.
• Usapho: Oku kuthetha ukuba le yimeko eyenzeka kwiintsapho kwaye idluliselwa kwilifa.
• I-Tumoral: Eli gama lisetyenziswa kuba ezi zityalo zifana ne-tumor zifana ne-tumor enomhlaza.
• I-Calcinosis: Oku kuthetha ukuba i-calcium ifakwa kwizicubu zemisipha yakho kunye nenkqubo ye-musculoskeletal.

Ngaba uyayiqonda intsingiselo yelo gama lide ngoku?

I-Tumoral Calcinosis ichaphazela njani umzimba?

La maqhuqhuva, abizwa ngokuba yi-tumoral calcinosis , adla ngokwakheka phantsi kolusu, kufutshane namalungu . Angakhula kumalungu angaphezu kwelinye, kodwa angakhula nakumalungu amaninzi. Iindawo ezixhaphakileyo zezi:

• Amalungu esinqe
• Iingqiniba
• Amagxa
• Ezantsi
• Amalungu esinqeni
• Inxulumene nentambo yomqolo
• Indawo yomhlathi

Ixhaphake kangakanani le meko?

Iingcali zonyango aziqinisekanga ukuba bangaphi abantu abane-tumor calcinosis. Ngenxa yokuba yimeko engaqhelekanga , ixhaphake kakhulu kubantu baseAfrika nakuMbindi Mpuma. Ingachaphazela amadoda nabafazi.

Ziziphi iintlobo eziphambili zeTumoral Calcinosis?

Uhlobo oluqhelekileyo lwale nto yiHyperphosphatemic Familyal Tumoral Calcinosis, esixoxe ngayo ngaphambili. Ukongeza, kukho nezinye iintlobo ezingaqhelekanga:

• I-Hyperphosphatemia-hyperostosis syndrome (HHS): Le yimeko ebangela ukukhula kwamathambo ngokugqithisileyo kunye nophuhliso lwezilonda zamathambo ezingezizo ezomhlaza.
• I-Normophosphatemic tumoral calcinosis: Olu hlobo ludla ngokubonakala kubantu abaneengxaki zezintso. Lunokubangela imeko ebizwa ngokuba yi-hyperparathyroidism, eyi-parathyroid gland esebenza kakhulu.

Yintoni ebangela iTumoral Calcinosis?

I-tumor calcinosis sisifo se-metabolic esifunyanwa njengelifa . Malunga nesithathu sabantu abanale meko banotshintsho, okanye utshintsho, kwi-gene yabo ye-FGF23. I-gene ye-FGF23 inceda iiseli zethu zamathambo ukuba zenze iproteni ebizwa ngokuba yi-fibroblast growth factor (FGF) 23. Abanye abantu banale meko ngenxa yotshintsho kwi-gene ye-GALNT3 kunye ne-KL. Ezi gene zilawula ukuveliswa kwe-FGF23. Abantu abane-nomophosphatemic tumor calcinosis banotshintsho kwi-gene ye-SAMD9.

Ngokwesiqhelo, iproteni ethi `FGF23` ixelela izintso zethu ukuba ingakanani i-phosphate ekufuneka ifunxwe kwakhona egazini. Kodwa xa kukho utshintsho lwemfuza, le nkqubo iyaphazama. Emva koko izintso zifunxwe kwakhona i-phosphate engaphezulu kunokuba kufanele. Ngokwesiqhelo, izintso zikhupha i-phosphate engaphezulu kumchamo. Kodwa kwi-tumoral calcinosis, le phosphate ibopha kwi-calcium kwaye yenze i-tumor kwizicubu ezithambileyo.

Ngubani osengozini yokufumana le meko?

I-Tumorous calcinosis sisifo esibizwa ngokuba yi-autosomal recessive disease . Oku kunzima ukukuqonda, kodwa ngamafutshane, ukuze ube nesi sifo, kufuneka uzuze i-gene mutation kubazali bakho bobabini. Abazali bakho banokuba ngabathwali be-mutation, kodwa basenokungabi naso esi sifo.

Ukuba bobabini abazali banesi sifo, ngamnye kubantwana babo unamathuba alandelayo:

• Kukho ithuba eli-1 kwabane lokungabi nayo i-gene eguquliweyo (akukho mngcipheko wokufumana esi sifo).
• Kukho ithuba eli-1 kwabane lokufumana i-tumor calcinosis.
• Kukho ithuba eli-1 kwaba-2 lokuba ngumntu onesifo esingabangeli esi sifo.

Zithini iimpawu zeTumoral Calcinosis?

Le meko ibangela ukuba kubekho amaqhuma anobukhulu obahlukeneyo kufutshane nelungu elinye okanye ngaphezulu. La maqhuma adla ngokuvela ebuntwaneni okanye ebusheni . Nangona kunjalo, anokuvela nakwiintsana nakubantu abadala. Ngamanye amaxesha, ambalwa kuphela amaqhuma akhula ebomini. Okanye, amaninzi amaqhuma anokuvela ngaxeshanye.

Usenokuba neempawu ezifana nezi:

• Ubunzima bokushukumisa okanye ukugoba ilungu elichaphazelekileyo ngokufanelekileyo.
• Amaqhuma aqinileyo, angenabuhlungu (amanye amaqhuma anokuba buhlungu kancinci xa uwachukumisa).
• Intlungu yemisipha.

Ifunyanwa njani iTumoral Calcinosis?

Ingcali yamathambo ngugqirha ogxile kwiingxaki zamathambo namalungu. Uza kukuhlola aze akubuze ngeempawu zakho. Emva koko angenza enye okanye ngaphezulu kwezi X-reyi zilandelayo ukujonga ezi thumba kunye nezinye iingxaki zamathambo:

• Uvavanyo lwe-X-reyi `(X-reyi)`
• Iskeni ye-CT
• Iskeni se-MRI `(MRI)`

Ziziphi ezinye iimeko ezibonisa iimpawu ezifanayo neTumoral Calcinosis?

Oku kubaluleke kakhulu. Kuba kubalulekile ukufumana uxilongo oluchanekileyo . Isizathu kukuba kukho ezinye iimeko ezibonisa iimpawu ezifanayo, kodwa zinzima ngakumbi. Ezinye zezi meko zezi:

• Iithumba ezithambileyo ezingeyongozi kunye neethumba ezithambileyo ezinobungozi
• I-Calcific myonecrosis (ithumba le-calcium deposits kwimisipha yemilenze)
• I-Calcific tendonitis (i-calcium deposits ene-tendonitis)
• I-Calcinosis circumscripta (i-calcium deposits eluswini nakwizicwili zezandla neenyawo)
• I-Calcinosis yokungasebenzi kakuhle kwezintso (izintso) okungapheliyo (iidiphozithi zecalcium kubantu abakwi-dialysis)
• I-Calcinosis universalis (ukufakwa kwetyuwa ye-calcium eluswini, kwizicubu, kwimisipha, nakwimisipha)
• Izifo zezicubu ezidibeneyo
• Igawuthi
• I-Myositis ossificans (imisipha eguquka ibe lithambo)
• I-Osteosarcoma kunye ne-sarcoma (umhlaza wamathambo)
• I-Synovial chondromatosis (iiqhuqhuva ze-cartilage ezidityanisweni)

Uyabona? Nangona iimpawu zifana, unobangela unokwahluka kakhulu. Yiyo loo nto kubalulekile ukufumanisa ukuba kwenzeka ntoni kanye kanye.

Ziziphi iindlela zonyango ezingasebenzisi utyando?

Ugqirha wakho unokunciphisa ubungakanani be-phosphate egazini lakho.Amayeza okubopha i-phosphate anganikwa. Xa la mayeza okubopha i-phosphate edityaniswe neyeza elibizwa ngokuba yi-acetazolamide (elisetyenziswa rhoqo kwi-epilepsy kunye ne-glaucoma), anokuthintela amandla omzimba okufunxa i-phosphorus. Kusenokufuneka utye ukutya okune-phosphorus encinci .

Yintoni ukutya okune-phosphorus ephantsi?

Ukuba une-tumor calcinosis, ugqirha wakho unokucebisa ukutya okune-phosphorus encinci. I-phosphorus ifumaneka ngokwemvelo kwinyama, intlanzi, kunye neemveliso zobisi. I-phosphorus ikwafakwa kwezinye ukutya njengesigcini okanye isinongo.

Zama ukunciphisa ukutya neziselo ezine-phosphorus eninzi, ezifana nezi:

• Ibhiya, ii-cola, iti ebandayo kunye neziselo zetshokholethi.
• Iintlobo zetshokholethi kunye nekharameli.
• Ukutya kobisi (ubisi, itshizi, i-ayisikhrim, iiyogathi ezingezizo ezamaGrike, iisuphu ezikhrim).
• Ukutya kwaselwandle okufana neeoyster kunye neesardine, kunye namalungu angaphakathi anjengesibindi senkomo kunye nenkukhu.
• Inyama elungisiweyo (ii-hot dog, inyama yasemini, i-bacon, iisoseji).
• Iimveliso ezenziwe nge-oat bran.

Kungcono ukuthetha nogqirha wakho okanye ingcali yesondlo ngale nto ukuze ufumane ulwazi oluthe kratya.

Zithini iindlela zonyango zotyando?

Usenokufuna utyando ukuze ususe iithumba ezinkulu kakhulu ukuba zingasebenzi kakuhle. Nangona kunjalo, ezi thumba zinokukhula kwakhona . Ugqirha wakho usenokuthatha isampuli yezicubu ezisusiweyo aze enze i-biopsy ukuqinisekisa ukuxilongwa.

Ziziphi iingxaki ezinokubakho zeTumoral Calcinosis?

Kunqabile kakhulu, le meko inokuchaphazela imithambo yegazi okanye ingqondo yakho, nto leyo eyonyusa umngcipheko wakho weengxaki zempilo ezinzulu ezifana nokuhlaselwa yintliziyo kunye nokubetha.

Ukongeza, le meko inokubangela oku kulandelayo:

• Ii-calcifications ze-corneal okanye i-angioid streaks (i-red streaks) kwi-cornea yamehlo.
• Iingxaki zamazinyo.
• Ukukhula kwamathambo ngokugqithisileyo (hyperostosis).
• Ukudumba kwamathambo amade (i-diaphysis) emilenzeni okanye ezingalweni zakho.

Ngaba i-Tumoral Calcinosis ingathintelwa?

Ukuba wena neqabane lakho nobabini ninotshintsho lwezakhi zofuzo olubangela i-tumor calcinosis, ningathetha nomcebisi wezakhi zofuzo malunga neendlela zokunciphisa umngcipheko wokuba abantwana benu bafumane olu tshintsho. Abanye abantu bakhetha inkqubo ebizwa ngokuba yi- Preimplantation Genetic Diagnosis (PGD) . Oku kubandakanya ukuchonga ii-embryo ezingenalo utshintsho. Emva koko ugqirha wakho usebenzisa inkqubo ebizwa ngokuba yi-In Vitro Fertilization (IVF) ukuhambisa ii-embryo eziphilileyo kwinkqubo yokuzala yomfazi. Ngale nkqubo, umntwana wakho akayi kuzuza utshintsho lwezakhi zofuzo olubangela esi sifo.

Injani imbono yomntu one-Tumoral Calcinosis?

Uninzi lwabantu abane-tumor calcinosis baphila ubomi obupheleleyo nobusebenzayo . Le meko ayibangeli iingxaki zempilo ezinzulu. Nangona kunjalo, kuya kufuneka ubone ugqirha wakho rhoqo ukuze ujonge ukuba ingaba isifo siphinde sibuye na.

Ndifanele ndimbone nini ugqirha?

Bona ugqirha ukuba unale mpawu:

• Ukuncipha komgama wokuhamba kwelungu.
• Intlungu yamalungu, intlungu yamathambo, okanye intlungu yemisipha.
• Ukubonakala kwethumba okanye iqhubu phantsi kolusu.

Ndimele ndibuze ntoni kugqirha wam?

Ungabuza ugqirha imibuzo efana nale:

• Kutheni ndifumene i-tumor calcinosis?
• Yeyiphi indlela engcono yonyango kum?
• Ngaba kufuneka ndityandwe?
• Ziziphi iintlobo zokutya endifanele ndizinciphise?
• Ngaba kufuneka ndixhalabele iingxaki?
• Ngaba intsapho yam yonke kufuneka iye kuvavanyo lwemfuza?

Ngaba i-Tumoral Calcinosis ingaba ngumhlaza?

Nangona igama elithi "tumoral" lisetyenziswa kweli gama, iithumba ezikhula ngenxa ye-tumoral calcinosis azingomhlaza ngokwenene . Akukho mngcipheko wokuba ezi thumba zibe yingozi. Ngoko ke ungakhathazeki ngayo.

Liyinyaniso elokuba iithumba ezingaphantsi kolusu ngenxa ye-tumoral calcinosis zinokuba yinto engathandekiyo neyoyikisayo. Kodwa kubantu abaninzi, ezi thumba azibangeli ngxaki zinkulu. Amayeza anokunciphisa amanqanaba e-phosphorus egazini. Ugqirha wakho unokucebisa ukuba ubonane nengcali yesondlo ukuze akuncede utye ukutya okune-phosphorus encinci. Ukuba unentlungu emalungwini akho, emathanjeni, okanye kwimisipha ethintela ukuhamba kwakho, xelela ugqirha wakho. Nangona iithumba zinokususwa ngotyando, khumbula ukuba zinokubuya.

Umyalezo Omele Uwuthathe Uhambe Nawo Ekhaya (Izinto Omele Uzikhumbule)

Kulungile, masiphinde sichaze amanqaku abalulekileyo esiwathethe namhlanje malunga neTumoral Calcinosis:

• Le yimeko engaqhelekanga, efunyanwa njengelifa. Amanqanaba aphezulu e-phosphate egazini abangela ukuba idibane ne-calcium ukuze yenze amaqhuma kufutshane namalungu.
• Ezi thumba azinawo umhlaza .
• Ezi zihlala zingenabuhlungu, kodwa zinokuphazamisana nokuhamba kwamalungu.
• Unyango luquka amayeza okunciphisa i-phosphate, ukutya okune-phosphorus ephantsi, kwaye, ukuba kuyimfuneko, utyando.
• Ukuba ubona iqhuma elinje, musa ukoyika kwaye ufune ingcebiso kugqirha. Ukuxilongwa ngokuchanekileyo kubaluleke kakhulu.
• Abantu abaninzi baphila ubomi obuqhelekileyo nobusebenzayo benesi simo.

Ngoko ke, ukuba wena okanye umntu omaziyo unezi mpawu, kungcono ukubona ugqirha ukuze akunike icebiso.

I- Tumorous calcinosis, ii-joint cysts, i-phosphate, i-calcium, izifo zemfuza, ii-skin nodules, izifo zamathambo