Masifunde ngeZollinger-Ellison Syndrome ngokulula.

Ngaba wakha weva ngeZollinger -Ellison Syndrome ? Isenokuvakala njengegama elingaqhelekanga, kodwa yimeko enokuchaphazela amathumbu ethu kwaye yinto ekufuneka ixhalatyelwe. Ibangela izilonda zesisu eziqatha kunye norhudo olungapheliyo ngenxa yokuveliswa kakhulu kwe-asidi esiswini sethu. Ngoko ke, masithethe ngayo ngokweenkcukacha namhlanje, akunjalo?

Yintoni kanye kanye iZollinger-Ellison Syndrome?

Ngamafutshane, imbangela ephambili yale meko ebizwa ngokuba yiZollinger-Ellison Syndrome (ZES) luhlobo lwethumba elincinci elikhula emzimbeni wethu, ingakumbi kwi-pancreas okanye kwinxalenye ephezulu yamathumbu amancinci (duodenum). Ezi thumba sizibiza ngokuba yi-gastrinomas . Ezi ngokwenene luhlobo lwethumba le-neuroendocrine .

Ngoku khangela, ezi gastrinomas zivelisa ihomoni ebizwa ngokuba yi-gastrin . Le hormone ye-gastrin yiyo enika isilumkiso esiswini sethu esithi "Kulungile, qala ukwenza i-asidi ngoku." Ngoko ke, xa ezi tumors zivelisa i-hormone ye-gastrin eninzi kakhulu, isisu sivelisa ne-asidi eninzi kakhulu. Khawucinge nje ngayo njengombhobho ovuza amanzi ngaphandle kokuyivala ngokuqinileyo, i-asidi yethu yesisu iyanda ngokungalawulekiyo. Le asidi igqithisileyo yiyo ebangela iingxaki ezifana nezilonda zesisu kunye ne-acid reflux.

Kuyaxhalabisa kancinci ukuba malunga nama-60% ezi gastrinomas zinokuba ngumhlaza . Kodwa ungakhathazeki, njengayo yonke enye into, kukho nonyango lwale meko. Ngamanye amaxesha oogqirha babiza le meko ngokuthi "i-pancreatic ulcerogenic tumor syndrome."

Zithini iimpawu zoku? Siziva njani?

Ngamanye amaxesha, i-Zollinger-Ellison syndrome (ZES) isenokungabangeli zimpawu. Nangona kunjalo, xa kuvela iimpawu, zingabandakanya:

• Ukutsha kwesisu okanye iintlungu: Usenokuziva ngathi kukho into ekutshisayo esiswini sakho, okanye ngathi kukho into ekutyayo. Oku kubangelwa yi-asidi egqithisileyo.
• Ukuhlanza igazi okanye ukuphuma kwegazi kwindle: Oku kubangelwa kukuphuma kwegazi emanxebeni angaphakathi emathunjini (ukopha kwamathumbu).
• Ukudinwa nobuthathaka: Njengoko kukhankanyiwe apha ngasentla, ngenxa yokulahlekelwa ligazi, ungaziva udiniwe kwaye ubuthathaka ngenxa ye-anemia.
• Izitulo ezidadayo nezinamafutha: Abanye abantu banokubona utshintsho kwizitulo zabo, olunokuba lunamafutha kwindlela ezibukeka ngayo.
• Isitshiso sentliziyo: Ngokuchanekileyo, sisitshiso esifubeni esibangelwa yi-asidi ephuma kwi-esophagus.
• Ukudumba, ukungagayi kakuhle kokutya: Oku kunokuvakala ngakumbi emva kokutya ukutya okunamafutha.
• Ukutya akunancasa.
• Isicaphucaphu nokuhlanza.
• Ukuba mncane ngaphandle kwesizathu.

Ubunzima bezi mpawu buxhomekeke kubukhulu kunye nenani lee-gastrinomas. Ii-tumor ezinkulu zivelisa i-gastrin engakumbi, nto leyo ebangela ukuba isisu sivelise i-asidi engakumbi. Oku kunokwenza iimpawu zesifo sesilonda se-peptic zibe mandundu.

Khumbula, ngamanye amaxesha la mathumba anokusasazeka esibindini, nto leyo ekhokelela kumhlaza wesibindi. Ukuba oko kuyenzeka, iimpawu ezinje ngokurhawuzelelwa, ukutyheli kwamehlo amhlophe, kunye nokutyheli kolusu (i-jaundice) nazo zinokuvela.

Kutheni sijamelene nale meko? Zithini izizathu?

Uninzi lwexesha, iZollinger-Ellison Syndrome (ZES) yenzeka ngamaxesha athile , nto leyo ethetha ukuba kunzima ukuchonga unobangela ochanekileyo.

Nangona kunjalo, malunga nama-25% abantu abanale meko bafunyenwe benemeko yemfuza ebizwa ngokuba yi -MEN Type 1 (Multiple Endocrine Neoplasia Type 1) . I-MEN Type 1 yimeko engaqhelekanga, ezuzwe njengelifa apho iithumba zinokukhula kwiindlala ezininzi ze-endocrine emzimbeni wethu.

Zeziphi iingxaki ezinokuvela ngenxa yale meko? Ngaba kufuneka ndixhalabe?

Ewe, iZollinger-Ellison Syndrome (ZES) yimeko enokuba yingozi ebomini ngamanye amaxesha . Umzekelo, ukuba i-gastrinoma ivala inxalenye ephezulu yamathumbu amancinci (i-duodenum), inokuqhuma. Inokusasazeka nakwisibindi. Ukopha kakhulu kwesisu kunokwenzeka ngenxa ye-asidi egqithisileyo esiswini.

Nangona kunjalo, musa ukoyika xa usiva ezi zinto. Ukuba isifo sifunyenwe kwangethuba kwaye sinyangwa ngokufanelekileyo, ezi ngxaki zinokuthintelwa kakhulu.

Oogqirha bayixilonga njani le sifo? (Ukuxilongwa)

Ukuba unale mpawu, ugqirha uza kuqala akuhlole, akubuze ngeempawu zakho nokuba kukho mntu kusapho lwakho okhe waba nazo na ezi meko. Emva koko, banokwenza uvavanyo olufana nolu:

• Uvavanyo lwegazi: Olu vavanyo lunokujonga ukuba amanqanaba e-gastrin hormone egazini lakho aphezulu kakhulu na (hypergastrinemia).
• Uvavanyo lwemifanekiso: I-CT scan okanye i-MRI scan ingenziwa ukuze kubonwe ukuba kukho iithumba ze-gastrinoma kwi-pancreas okanye kwi-duodenum.
• Uvavanyo lwe-asidi yesisu: Kolu vavanyo, ugqirha ufaka umbhobho omncinci esiswini ngempumlo okanye ngomlomo aze athathe isampuli ye-asidi apho.

Ukuba ezi mvavanyo zokuqala zichonga iithumba, ugqirha unokwenza ezinye iimvavanyo ezininzi:

• I-Endoscopy: Kolu vavanyo, kufakwa ityhubhu encinci enekhamera eqhotyoshelweyo ngomlomo kwaye kuhlolwa umphimbo, isisu, inxalenye engentla yamathumbu amancinci (i-duodenum), kunye nepancreas.
• I-ultrasound ye-Endoscopic: Le yindibaniselwano ye-ultrasound kunye ne-endoscopy. Inokwenza imifanekiso ecacileyo.
• I-ERCP (Endoscopic Retrograde Cholangiopancreatography): Le ikwayi-scan ekhethekileyo. Ijonga ngaphakathi kwimibhobho yenyongo kunye nemibhobho ye-pancreatic.
• Ukufunxwa ngenaliti encinci: Ukuba kukho ithumba, le ndlela isetyenziselwa ukuthatha iqhekeza elincinci lalo kwaye livavanywe ukuba alinazo na iiseli zomhlaza (i-biopsy).

Zithini iindlela zokunyanga oku? (Unyango)

Iindlela zonyango zixhomekeke ekubeni iimpawu zakho zinzima kangakanani na kunye nokuba i-gastrinoma inomhlaza na. Kukho iintlobo ezintathu eziphambili zonyango:

1. Amayeza:

• Amayeza aphambili adla ngokunikwa zii- proton pump inhibitors (PPIs) . La mayeza asebenza ngokunciphisa ubungakanani be-asidi eveliswa esiswini. Ngamafutshane, alawula i-asidi egqithisileyo eveliswayo.

2. Utyando:

• Ugqirha wakho angacebisa utyando lokususa ithumba. Kukho iintlobo ezahlukeneyo zotyando:
• Ukususwa kwethumba: Ithumba lisuswa ngokusikwa okuncinci kwinxalenye ephezulu yamathumbu amancinci (i-duodenum).
• Ukususwa kwesisu: Ukususwa kwenxalenye okanye sonke isisu.
• Utyando lwesibindi: Ukuba kukho iithumba esibindini, ziyasuswa.
• Ukususwa kwePancreatectomy: Ukususwa kwenxalenye okanye yonke ipancreas.
• Ukuphuma kwethumba: Ukuba kukho iithumba entlokweni yepancreas, kuphela ezo zisuswa ngononophelo.

3. Unyango lomhlaza:

• Ukuba ithumba linesifo somhlaza, ugqirha wakho angacebisa unyango olufana ne -chemotherapy . Olu nyango lunokunceda ekunciphiseni iimpawu kunye nokucothisa ukusasazeka kwethumba.

Ngaba unyango lungayinyanga ngokupheleleyo?

Ukuba i-gastrinoma enomhlaza inokususwa ngokupheleleyo ngotyando, imeko inokunyangeka ngokupheleleyo . Nangona kunjalo, oku kufuna ukususa zonke iiseli zomhlaza emzimbeni. Nokuba utyando luphumelele, kuya kufuneka usele amayeza okulawula i-asidi yesisu ubomi bakho bonke.

Ukuba ndinale meko, ndimele ndilindele ntoni? (Ingqikelelo)

Isiqinisekiso sokuba uza kuba nale meko sixhomekeke kuhlobo lwethumba. I-gastrinomas ezingezizo umhlaza azisongeli ubomi. Nangona kunjalo, kuya kufuneka unyango oluqhubekayo ukulawula amanqanaba e-asidi esiswini.

Nangona kunjalo, imeko iyatshintsha ukuba unezimila ezinomhlaza. Kwimeko enjalo, unokufuna utyando kunye nonyango lomhlaza olulandelayo.

Amanani okusinda kwabantu abane-Zollinger-Ellison syndrome (ZES) ayahluka. Ngokwedatha, emva kokuba zonke ii-gastrinomas zisusiwe ngotyando, abantu abangaphezu kwama-90% baphila iminyaka emi-5 ukuya kweli-10 . Nangona kunjalo, ukuba zonke ii-tumor azinakususwa, izinga lokusinda leminyaka emi-5 liyehla liye kuma-43%. Kubalulekile ukukhumbula ukuba ezi zizibalo nje. Ukuba unale meko, thetha nogqirha wakho malunga noko unokukulindela.

Ndingazinyamekela njani? Ndingenza ntoni?

Kuxhomekeke kwimeko yakho. Abantu abaninzi kufuneka bathathe amayeza okunciphisa i-asidi yesisu ubomi babo bonke. I-Zollinger-Ellison syndrome (ZES) ibangelwa yi-gastrinomas. Uninzi lwala mathumba lunokuba ngumhlaza. Ngoko ke, ukuba ukhe waba namathumba anomhlaza, kufuneka uqhubeke ubona ugqirha wakho ukuze afumane unyango olulandelayo ukuze ubone ukuba abuye na.

Ndifanele ndiphinde ndimbone ugqirha kwakhona?

Emva konyango, ukuba iimpawu zakho zeZollinger-Ellison Syndrome (ZES) ziya zisiba mandundu okanye kuvela iimpawu ezintsha, kufuneka ubone ugqirha ngoko nangoko.

Xa ufumanisa ukuba unesifo esingaqhelekanga, unokumangaliswa kwaye woyike kancinci. Kunokuba nzima ukuva into efana nale ngequbuliso, nangona usenokungabi nazimpawu. Usenokuba nemibuzo emininzi malunga nendlela i-ZES eza kukuchaphazela ngayo. Iimpendulo zale mibuzo zinokuhluka kakhulu ngokuxhomekeke kwimeko yakho.

Eyona nto ibalulekileyo kukuxoxa ngayo yonke imibuzo yakho kunye namathandabuzo akho nogqirha. Baza kukuchazela yonke into baze bakunike inkxaso oyifunayo.

Umyalezo Wokuya Ekhaya:

Kulungile, masikhumbule ezinye zezona ngongoma zibalulekileyo koko sithethe ngako:

• I-Zollinger-Ellison Syndrome (ZES) yimeko ebangelwa sisisu esibizwa ngokuba yi-gastrinoma, esibangela izilonda zesisu kunye norhudo ngenxa ye-asidi egqithisileyo esiswini.
• Iimpawu ezinje ngentlungu yesisu, ukuhlanza igazi, iintlungu zesifuba, kunye nokuncipha komzimba zinokubakho.
• Uninzi lwezi thumba zinokuba ngumhlaza.
• Esi sifo sichongwa ngovavanyo olufana novavanyo lwegazi, iiskeni, kunye ne-endoscopy.
• Unyango luquka amayeza (ii-PPI), utyando, kunye ne-chemotherapy.
• Ukufunyanwa kwangoko kunye nonyango kunokuthintela iingxaki kwaye kukhuthaze ukuchacha.
• Ukuba unale meko, landela imiyalelo kagqirha wakho ngokuchanekileyo, vavanywa ngexesha, kwaye uthethe nogqirha wakho ngaphandle kokuzibamba.

Ndiyathemba ukuba olu lwazi luluncedo kuwe. Hlala usempilweni!

Isifo sikaZollinger -Ellison, i-gastrinoma, i-asidi yesisu, izilonda zesisu, urhudo, iihomoni, umhlaza