Buyini ubudlelwano phakathi kwe-estrogen nomdlavuza? Ake sifunde ngomdlavuza oxhomeke ku-estrogen ngendlela elula!

Sawubona! Cishe uke wezwa nge-hormone i-estrogen. Sivame ukuzwa leli gama maqondana nempilo yabesifazane. Kodwa kungenzeka ungazi ukuthi i-estrogen ingathinta nokukhula kwezinhlobo ezithile zomdlavuza. Yilokho esizokhuluma ngakho namuhla, kalula, ngendlela ongayiqonda.

Iyini i-estrogen? Ake siqonde kuqala!

Kalula nje, i-estrogen iyikhemikhali yemvelo ekhiqizwa yimizimba yethu. Siyibiza nangokuthi i-hormone. Le hormone ye-estrogen ihamba egazini lethu iye emangqamuzaneni nasezicutshini kuyo yonke imizimba yethu.

Abantu abaningi bacabanga ukuthi i-estrogen yinto ekhawulelwe kwabesifazane. Eqinisweni, ama-ovari, ayingxenye yesimiso sokuzala kwabesifazane, akhiqiza i-hormone ye-estrogen eningi kakhulu. Kodwa ngokumangazayo, wonke umuntu, kungakhathaliseki ubulili, ukhiqiza inani elithile le-estrogen emizimbeni yakhe, okuhlanganisa izicubu zamabele nama-fat cell.

Kwabesifazane, ukuthomba kubangelwa inhlanganisela ye-estrogen kanye nenye i-hormone yocansi, i-progesterone. Lokhu kusho izinto ezifana nokukhula kwamabele kanye nokukhula kwezinwele ze-pubic. Futhi yi-hormone i-estrogen elawula umjikelezo wokuya esikhathini wanyanga zonke.

Kodwa-ke, i-hormone i-estrogen idlala indima ebaluleke kakhulu kwabesilisa. Ithinta ukukhula kobuchopho, ukusebenza kahle kocansi, kanye nesifiso sobulili.

Ngakho-ke, iyini imidlavuza encike ku-estrogen?

Manje ake sibheke ukuthi ziyini lezi zinhlanzana ezincike ku-estrogen. Ngezinye izikhathi ungase uzizwe zibizwa ngokuthi i-estrogen receptor-positive , i- hormone-dependent , i-hormone-positive , i-hormone receptor-positive , noma i-hormone-sensitive . Noma ngabe yikuphi, zisho into efanayo.

Kalula nje, lokhu kusho ukuthi i-hormone i-estrogen isiza amangqamuzana omdlavuza ukuba akhule, okungukuthi, akhule futhi asakazeke. Njengoba nje isitshalo sidinga amanzi, i-hormone i-estrogen ibalulekile kulezi zinhlobo zomdlavuza.

Kunezinhlobo eziningana zomdlavuza ezixhomeke kakhulu ku-estrogen. Eziyinhloko yilezi:

• Umdlavuza webele
• Umdlavuza wesibeletho
• Umdlavuza wesibeletho – Lokhu kubizwa nangokuthi umdlavuza we-endometrial.

Ingabe i-estrogen ibangela umdlavuza ngempela? Lokhu kuyadida kancane, akunjalo?

Empeleni lokhu kuyindaba eyinkimbinkimbi kancane. I-hormone i-estrogen ngezinye izikhathi ibizwa ngokuthi i-carcinogen. Lokho kusho ukuthi inamandla athile okubangela umdlavuza. Kodwa sidinga ukuqonda ukuthi lokho kwenzeka kanjani.

Cishe wonke amaseli emzimbeni wethu anohlobo olukhethekile lweprotheyini ebizwa ngokuthi ama-hormone receptors. I-estrogen egazini lethu iyafika futhi ibophezele kula ma-receptor. Lokhu ngokuvamile kubalulekile emisebenzini eminingi emzimbeni wethu. Kumaseli anempilo, i-estrogen isiza amaseli ukuthi asebenze kahle futhi akhule kahle.

Kodwa-ke, ngezizathu ezithile, lapho izici ezithile zihlangana, amangqamuzana anempilo angaphenduka amangqamuzana omdlavuza. Esimweni esinjalo, i-estrogen iqala ukusebenza njengenhlansi. Okusho ukuthi, i-estrogen isiza amangqamuzana omdlavuza asevele akhekile ukuba ahlukane ngokushesha, aphindaphindeke, futhi asakazeke esuka kwenye indawo aye kwenye emzimbeni.

Ngakho-ke, kunokuba sithi i-estrogen yodwa ibangela umdlavuza, kunembile kakhulu ukusho ukuthi i-estrogen, kanye nezinye izici ezifaka isandla ekuthuthukisweni komdlavuza, isiza ukukhula komdlavuza okhona .

Yiziphi izinto ezandisa ingozi yokuthola umdlavuza oncike ku-estrogen njengalona?

Kunezici eziningana ezandisa ingozi yokuba nomdlavuza oncike ku-estrogen ngezinga elithile. Ake sibheke ukuthi ziyini:

• Ukuba namazinga aphezulu e-estrogen emzimbeni: Abanye abantu banezinga eliphezulu le-estrogen ngokwemvelo.
• Ukuthatha Ukwelashwa Kokushintsha Ama-hormone (HRT): Lokhu ukwelashwa okuvame ukunikezwa ukwelapha ukungakhululeki ngokomzimba (isib. ukushisa okukhulu, ukujuluka ebusuku) okwenzeka ngemva kokunqamuka kokuya esikhathini. Cabanga ukuthi umama noma u-anti wakho banikezwe umuthi wama-hormone ngudokotela ngenxa yezimpawu zakhe zangemva kokunqamuka kokuya esikhathini. Yilokho i-HRT eyikho.
• Ukukhuluphala: Njengoba amafutha omzimba enyuka, ukukhiqizwa kwe-estrogen nakho kunganda.
• Ukuba nesimo esibizwa ngokuthi i-Polycystic Ovary Syndrome (PCOS): Lokhu kuhlotshaniswa nokungalingani kwama-hormone.
• Ukusetshenziswa kwe-Diethylstilbestrol (DES): Lena i-estrogen yokwenziwa eyanikezwa abesifazane abakhulelwe ukuvimbela ukuphuphuma kwesisu kusukela ngo-1938 kuya ku-1971. Uma umama esebenzise i-DES phakathi nalesi sikhathi, noma uma umama evezwe ku-DES ngesikhathi sokukhulelwa futhi wazala umntwana, ingane isengozini yokuthola lolu hlobo lomdlavuza kamuva ekuphileni.

Buyini ubudlelwano phakathi kwe-estrogen nomdlavuza webele?

Uma kukhulunywa ngomdlavuza webele, cishe umdlavuza webele ongu-8 kwabayishumi une-hormone receptor-positive . Kalula nje, lo mdlavuza udinga i-estrogen, i-progesterone, noma womabili la ma-hormone ukuze ukhule.

Ingozi yomdlavuza webele iyanda uma ukuvezwa isikhathi eside ku-estrogen ngamanani aphezulu. Izizathu eziyinhloko zalokhu yilezi:

• Ukwelashwa kokushintsha ama-hormone (HRT) kokunqamuka kokuya esikhathini.
• Ukuba namazinga aphezulu ngokwemvelo e-estrogen emzimbeni.
• I-Klinefelter syndrome yisimo sofuzo esithinta amadoda (amadoda analesi simo anamazinga aphezulu e-estrogen).

Esikhathini esidlule, amanye amadoda ayenikwa i-hormone i-estrogen njengokwelashwa komdlavuza wendlala yesitho sangasese sowesifazane. Kodwa manje odokotela abavamile ukuncoma lokho kwelashwa ngoba kwandisa nengozi yomdlavuza webele kwabesilisa.

Buyini ubudlelwano phakathi kwe-estrogen nomdlavuza wesibeletho?

Ukuchayeka ku-estrogen impilo yonke kungandisa ingozi yokuba nomdlavuza wesibeletho. Izici eziyingozi zifaka:

• Ukuqala ukuya esikhathini ngaphambi kweminyaka eyi-12 (okusho ukuthomba kwasekuqaleni).
• Ungalokothi ukhulelwe.
• Ukunqamuka kokuya esikhathini (okusho ukuthi unesikhathi eside) ngemva kweminyaka engu-55.
• Ukuthatha ukwelashwa ngama-hormone ahlanganisiwe (ukwelashwa ngama-hormone) ngemva kokunqamuka kokuya esikhathini, okuqukethe ama-hormone i-estrogen ne-progesterone.

Buyini ubudlelwano phakathi kwe-estrogen nomdlavuza wesibeletho?

Umdlavuza wesibeletho, noma njengoba sishilo ngaphambili, umdlavuza we-endometrial, ukhula olwelwesini lwesibeletho sakho. Abesifazane banamathuba amaningi okuthola lo mdlavuza ngemva kokunqamuka kokuya esikhathini.

Ingozi yokuchayeka ku-estrogen ingandiswa yizici ezifana nalezi:

• Ukwelashwa kokufaka esikhundleni se-estrogen: I-estrogen isiza ekunciphiseni ukungakhululeki kokunqamuka kokuya esikhathini, njengokushisa okukhulu, ukujuluka ebusuku, kanye nokomisa kwesitho sangasese sowesifazane. Kodwa-ke, ukuthatha ukwelashwa kwe-estrogen kuphela kwandisa ingozi yokuba nomdlavuza wesibeletho. Lokhu kungenxa yokuthi i-estrogen ikhuthaza ukukhula kolwelwesi lwesibeletho. Yingakho i-estrogen ivame ukunikezwa ne-hormone ebizwa ngokuthi i-progesterone (ukwelashwa ngama-hormone ahlanganisiwe). Lokhu kunciphisa ingozi yomdlavuza wesibeletho. Kodwa-ke, uma uke wahlinzwa i-hysterectomy, ngeke ube nalo mdlavuza ngoba awunawo isibeletho.
• Ukusetshenziswa kweTamoxifen: I-Tamoxifen umuthi obaluleke kakhulu osetshenziselwa ukwelapha umdlavuza webele nokuvimbela umdlavuza ukuthi ungabuyi. Isebenza njenge-Selective Estrogen Receptor Modulator (SERM) futhi ivimba imiphumela ye-estrogen ezicutshini zebele. Kodwa-ke, kwabesifazane asebekhulile, i-tamoxifen isebenza njenge-estrogen esibelethweni. Lokhu kukhuthaza ukukhula kolwelwesi lwesibeletho, okwandisa ingozi yomdlavuza we-endometrial ngezinga elithile. Kodwa ungakhathazeki, ingozi yokuthola umdlavuza we-endometrial ngenxa ye-tamoxifen ivame ukuba ngaphansi kuka-1% ngonyaka. Kukhona futhi ingozi encane kakhulu yokuthola i-uterine sarcoma, uhlobo olungavamile lomdlavuza olukhula emisipheni noma kwezinye izicubu zesibeletho.

Umdlavuza oxhomeke ku-estrogen utholakala kanjani? Odokotela bakuthola kanjani lokhu?

Uma usola ukuthi unomdlavuza, into yokuqala udokotela wakho azokwenza ukuthatha ingxenye encane yezicubu ezivela esimila (lokhu sikubiza ngokuthi i-tumor biopsy) ayithumele elabhorethri. Lapho, bazosebenzisa izivivinyo ezikhethekile ukuhlola ukuthi lawo maseli anama-hormone receptors.

Uma umphumela wokuhlolwa ubuya njenge -hormone receptor positive (HR+) , kusho ukuthi i-estrogen, i-progesterone, noma womabili lawa ma-hormone asiza umdlavuza wakho ukuba ukhule, okungukuthi, uwupha ukudla.

Umdlavuza ofana nalo oxhomeke ku-estrogen welashwa kanjani?

Kubalulekile ukuthi odokotela bazi isimo se-hormone receptor yomdlavuza, njengoba ezinye izindlela zokwelapha zisebenza kuphela kumdlavuza one-hormone. Ezinye zezindlela zokwelapha eziyinhloko zalezi zinhlobo zomdlavuza yilezi:

• Ama-Aromatase inhibitors: Le mithi isebenza ngokuvimbela umzimba ekuguquleni ama-androgens, i-hormone, abe yi-estrogen. Lokhu kwelashwa kusebenza kuphela kwabesifazane asebedlule esikhathini sokunqamuka kokuya esikhathini (okungukuthi, ama-ovari abo ayeke ukukhiqiza i-estrogen).
• Ezinye izindlela zokwelapha ngama-hormone: Lokhu kunciphisa noma kumisa ukukhiqizwa kwe-estrogen emzimbeni.
• I-Tamoxifen kanye neminye imithi ye-SERM: Njengoba sesixoxile ngaphambili, lokhu kusebenza ngokuvimbela ama-receptor ama-hormone ukuthi angabophani ne-estrogen.
• Ukususwa Kwama-Oophorectomy: Kwezinye izimo, ama-ovari, izitho eziyinhloko ezikhiqiza i-estrogen, asuswa ngokuhlinzwa. Lokhu kunganciphisa kakhulu amazinga e-estrogen emzimbeni.

Ingabe amaphilisi okuvimbela inzalo angayinciphisa ngempela ingozi yalo mdlavuza?

Impendulo yalokhu ingaba 'yebo' kanye 'nocha'. Kwenzeka kanjani lokho?

Ezinye izifundo zibonise ukuthi abesifazane abasebenzisa izindlela zokuvimbela inzalo zama-hormone, njengephilisi, bangase babe nengozi encane kakhulu (cishe u-7%) yokuba nomdlavuza webele .

Kodwa-ke, ngakolunye uhlangothi, ukuphuza amaphilisi okuvimbela inzalo kunganciphisa nengozi yokuthola izinhlobo ezilandelayo zomdlavuza:

• Umdlavuza wesibeletho
• Umdlavuza we-Colorectal
• Umdlavuza wesibeletho
• Umdlavuza wesibeletho

Ngakho-ke, njengoba ubona, lokhu kuyinkimbinkimbi kancane. Ngakho-ke, kungcono ngaso sonke isikhathi ukukhuluma nodokotela wakho bese unquma ukuthi iyiphi indlela yokuvimbela inzalo engcono kakhulu kuwe, nokuthi iyiphi ephephile kakhulu.

Yini esingayenza ukuvimbela ukuthuthukiswa komdlavuza oxhomeke ku-estrogen?

Iningi lomdlavuza likhula ngaphandle kwesizathu esicacile. Lokhu kusho ukuthi ngezinye izikhathi umdlavuza ungakhula kungakhathaliseki ukuthi siqaphile kangakanani. Kodwa-ke, kunezinto ezilula esingazenza ukunciphisa ingozi yomdlavuza ngezinga elithile.

• Uma kungenzeka, ncelisa izingane zakho. Ukuncelisa kuye kwatholakala ukuthi kunciphisa ingozi yomdlavuza webele.
• Nciphisa ukusetshenziswa kotshwala ngangokunokwenzeka futhi ugweme ukubhema ngokuphelele. Lezi yizinto ezibangela umdlavuza omningi.
• Zama ukudla ukudla okunempilo. Yidla imifino nezithelo eziningi. Futhi, vivinya umzimba nsuku zonke futhi ube matasa ngokomzimba.
• Uma ukhuluphele ngokweqile, okungukuthi, ukhuluphele ngokweqile, zama ukunciphisa isisindo.
• Khuluma nodokotela wakho ngendlela yokuvimbela inzalo ephephile kakhulu kuwe.
• Uma ufuna ukulawula ukungakhululeki kokunqamuka kokuya esikhathini, funa iseluleko sezokwelapha mayelana nokwelashwa ngama-hormone ahlanganisiwe noma ukwelashwa okungekhona ngama-hormone.

Yimiphi imibuzo ebaluleke kakhulu okufanele ngiyibuze udokotela wami?

Uma unenkinga ngalesi simo, noma ngengozi yomdlavuza ohlobene ne-estrogen, ungalokothi unqikaze ukubuza udokotela wakho. Kubalulekile ukususa ukungabaza kwakho. Nansi eminye imibuzo ongayibuza:

• Ingabe umdlavuza enginawo/enginawo uncike ku-estrogen noma i-hormone-receptor?
• Yiziphi izindlela zokwelapha ezingcono kakhulu ezitholakalayo njengamanje zalolu hlobo lomdlavuza?
• Ziyini izingozi nemiphumela emibi yalezi zindlela zokwelapha?
• Yiziphi izinguquko engingazishintsha endleleni yami yokuphila ukuze ngivikele impilo yami futhi nginciphise ingozi yami yokuba nomdlavuza?
• Ingabe kufanele ngishintshe indlela yokuvimbela inzalo engiyisebenzisayo njengamanje? Iyiphi indlela engcono kakhulu kimi?
• Ingabe kufanelekile kimi ukuthatha ukwelashwa ngama-hormone? Ingabe zikhona izingozi kimi?

Okokugcina, okufanele ukukhumbule (Umyalezo Wokuya Ekhaya)

Esikhathini esiningi, i-hormone i-estrogen idlala indima enenzuzo emizimbeni yethu, iyisize isebenze kahle. Kodwa-ke, umdlavuza oxhomeke ku-estrogen uhlukile. Kulezi zimdlavuza ezithile, i-estrogen empeleni iyasiza umdlavuza ukuthi ukhule, okungukuthi, uyondla umdlavuza.

Uma kutholakala ukuthi unomdlavuza futhi udokotela wakho esola ukuthi ungase uzwele kuma-hormone, nakanjani uzokwenza izivivinyo ezidingekayo ukuze athole ukuthi uhlobene yini ne-estrogen. Ngokusekelwe kulolo lwazi, udokotela wakho uzokwazi ukukhetha ukwelashwa okusebenzayo nokufanelekile kakhulu kuwe.

Ngakho-ke, ngaphandle kokwesaba noma ukufihla noma yini, xoxa ngokukhululekile ngayo yonke imibuzo yakho nokungabaza kwakho nodokotela wakho. Kubaluleke kakhulu empilweni yakho nasenhlalakahleni yakho yengqondo.

I- Estrogen, umdlavuza, ama-hormone, umdlavuza webele, umdlavuza wesibeletho, umdlavuza wesibeletho, impilo yabesifazane