I-Acromegaly: Ingabe izitho zakho nobuso bakho bukhulu ngendlela engavamile? Ake sixoxe!

Wake waphawula ukuthi ukuma kwezingalo zakho, imilenze, noma ubuso kuyashintsha? Mhlawumbe indandatho oyigqokayo ivame ukuzwakala iqinile, noma usayizi wesicathulo sakho ushintshile? Lezi akuzona nje izinto ezingahleliwe, kungaba izimpawu zesimo esingavamile kodwa esingaba sibi esibizwa ngokuthi i-acromegaly . Ungakhathazeki, sizoxoxa ngalokhu ngokuningiliziwe futhi namuhla.

Kuyini i-Acromegaly? Kalula nje...

I-Acromegaly yisimo esibangelwa amazinga aphezulu ekhemikhali ebizwa ngokuthi i-Growth Hormone (GH) emzimbeni wakho. Ngokuvamile, le hormone yokukhula (GH) ikhiqizwa yi -pituitary gland , i-gland engange-pea esisekelweni sobuchopho bethu. Kodwa-ke, ku-acromegaly, le hormone ikhiqizwa ngokweqile ngenxa yesimila ku-pituitary gland noma kwenye indawo emzimbeni.

Ubuwazi ukuthi i-pituitary gland iyi-gland encane kodwa ebaluleke kakhulu. Ikhipha ama-hormone ayisishiyagalombili, elinye lawo yi-growth hormone (GH).

Iyini i-hormone yokukhula (GH) kithi?

I-Growth Hormone, eyaziwa nangokuthi i-Human Growth Hormone (hGH) noma i-Somatotropin , iyi-hormone yemvelo. Ibalulekile ekukhuleni kwezingxenye ezahlukene zomzimba wethu kanye nokuphakama ngesikhathi sobuntwana. Kodwa-ke, njengoba sikhula, ngemva kokuba ama-epiphyses amathambo ethu evaliwe, imizimba yethu isadinga le-GH. Uyazi ukuthi kungani? Isiza ekugcineni isakhiwo esinempilo samathambo ethu, i-cartilage, kanye nezitho zangaphakathi, futhi isiza ngokugaya ukudla, ikakhulukazi ukugcina amazinga ethu kashukela egazini emazingeni afanele.

Ngakho-ke, uma i-hormone yokukhula yomzimba (GH) ikhula kakhulu ngemva kokuba umuntu ekhulile, izinkinga ezinjengokukhubazeka kwamathambo, ukwandiswa kwezitho zomzimba, kanye namazinga kashukela egazini akhuphukayo (i-hyperglycemia) zingavela.

Uyini umehluko phakathi kwe-Acromegaly ne-Gigantism?

Kokubili kubangelwa ukwanda kwe-hormone yokukhula (GH). Kodwa-ke, umehluko usekutheni lesi simo sithinta bani. Abantu abadala bathuthukisa i-acromegaly. Izingane zithuthukisa i-gigantism .

Uma amazinga e-growth hormone (GH) enyuka ezinganeni ngaphambi kokuba ama-growth plates emathanjeni azo avaleke (okungukuthi, ngaphambi kokuba ukuthomba kuphele), zizokhula zibe zinde ngendlela engavamile. Lokhu kubizwa ngokuthi i-gigantism. Kuyivelakancane kune-acromegaly. Abanye odokotela bakubiza nangokuthi "i-pediatric acromegaly."

Kodwa-ke, uma amazinga e-hormone yakho yokukhula (GH) enyuka ngemva kokuba ama-growth plate akho evaliwe, ngeke ukhule ube mude. Kodwa-ke, lelo hormone elidlulele lingathinta ukuma kwamathambo akho, ubukhulu bezitho zakho, kanye nezinye izici zempilo. Leso simo sibizwa ngokuthi i-acromegaly.

Ubani okungenzeka kakhulu ukuthi athole i-acromegaly?

Ingakhula kunoma yimuphi ubudala ngemva kokuthomba. Kodwa-ke, odokotela bavame ukuyixilonga kubantu abaneminyaka ephakathi kuka-40 no-50, okungukuthi, abasebangeni eliphakathi.

Kuvamile kangakanani lokhu?

I-Acromegaly empeleni iyisifo esingavamile . Cishe abantu abangu-31 kwabangu-100,000 kuphela abatholakale benalesi sifo. Ngakho-ke ungesabi ngokungadingekile, kodwa kubalulekile ukuqaphela izimpawu.

I-acromegaly ithinta kanjani umzimba wami?

Uma umuntu omdala eba ne-acromegaly, okungukuthi, lapho kuba nokwanda kwe-growth hormone (GH), amathambo, i-cartilage, izitho zomzimba, kanye nezinye izicubu ziqala ukukhula ngobukhulu. Kunezinguquko ezisobala ekubukekeni . Isibonelo:

• Ukwandiswa kwezandla nezinyawo.
• Ukukhulisa izindlebe, izindebe, nekhala.
• Umhlathi ophumile, ibunzi elikhulu.

I-hormone yokukhula (GH) itshela isibindi sethu ukuthi sikhiqize enye i-hormone ebizwa ngokuthi i-Insulin-like Growth Factor 1 (IGF-1) . Le hormone, ebizwa ngokuthi i-IGF-1, empeleni isiza amathambo ethu nezicubu zomzimba ukukhula, futhi ithinta nendlela umzimba wethu olawula ngayo ushukela egazini (i-glucose) namafutha (ama-lipid). Ngakho-ke, lapho amazinga e-GH enyuka, amazinga e-IGF-1 nawo ayanda. Lokhu kungaholela ezimweni ezifana nesifo sikashukela sohlobo 2 , umfutho wegazi ophezulu (umfutho wegazi ophezulu) , kanye nesifo senhliziyo .

Cabanga nje, njengompompi oshiywa ugeleza isikhathi eside uchitha amanzi, la ma-hormone, uma esephezulu kakhulu, anemiphumela ehlukahlukene emzimbeni.

Yiziphi izimbangela ze-acromegaly?

Imbangela evame kakhulu ye-acromegaly yi-tumor e-pituitary gland. Lokhu kubizwa ngokuthi i-pituitary adenoma . Lesi simila sibangela i-pituitary gland ukuthi ikhiphe i-hormone yokukhula (GH) eningi kakhulu.

Okuningi mayelana ne-Pituitary Adenoma...

Lawa ma-adenoma e-pituitary avame ukuba yingozi. Okusho ukuthi, awawona umdlavuza. Iningi lamathumba abangela i-acromegaly likhula kancane kakhulu. Ngakho-ke, ungase ungaboni noma yiziphi izimpawu zalokhu kwanda kwe-GH iminyaka eminingi.

Kuye ngobukhulu nendawo yesimila, singacindezela kwezinye izingxenye zendlala ye-pituitary futhi sithinte amanye ama-hormone akhiqizwa yindlala ye-pituitary. Uma isimila sikhulu, singacindezela nasezingxenyeni eziseduze zobuchopho, okubangela ikhanda elibuhlungu nezinkinga zokubona .

Ziyini izimpawu ze-Acromegaly?

Uma umuntu omdala eba ne-acromegaly, ithinta amathambo nezicubu zomzimba, okubangela ukuba akhule ngendlela engavamile. Lokhu kungabangela izimpawu ezilandelayo:

• Izandla noma izinyawo ezikhulisiwe: Mhlawumbe amasongo akho aqala ukuqina, futhi usayizi wezicathulo zakho, ikakhulukazi ububanzi, uyakhula.
• Izinguquko esimweni sobuso: Ukuvela noma ukwandiswa kwendawo yomhlathi kanye/noma ibunzi.
• Ukukhula kwezindebe, ikhala, kanye/noma ulimi.
• Ukujuluka ngokweqile noma isikhumba esinamafutha.
• Ukujula kwezwi kanye nokushoshozela.

Ezinye izimpawu:

• Ubuhlungu bekhanda
• Ubuhlungu bamalunga
• Izinguquko zombono
• Ukwanda kokubonakala kwamathegi esikhumba amancane
• Ukuba ndikindiki ezandleni
• I-apnea yokulala (i-sleep apnea)
• I-Carpal tunnel syndrome noma izinkinga zomgogodla.

Izimpawu ze-Acromegaly zivame ukukhula kancane kakhulu , ngezinye izikhathi eminyakeni edlule. Ngakho-ke kungaba nzima ukuzibona ekuqaleni. Abanye abantu baqaphela kuphela ukuthi izandla zabo sezinkulu lapho indandatho abayigqokile iba lukhuni noma usayizi wezicathulo zabo ushintsha.

Cabanga nje, kukhona umuntu ogama lakhe linguNilanthi. Ubelokhu ezwa sengathi indandatho yakhe yomshado iqinile isikhathi eside manje. Izicathulo zakhe azisaqinile njengoba zazinjalo ngaphambili, ziqinile kancane. Wayecabanga ukuthi usanda kukhula. Kodwa ngesikhathi esifanayo, abangane bakhe bathi ubuso bakhe buhlukile kancane kunangaphambili, futhi isilevu sakhe sikhulu kancane. Lezi yizinto ezincane eziqashelwa kuqala.

Uma unalezi zimpawu, kubaluleke kakhulu ukukhuluma nodokotela.

I-Acromegaly itholakala kanjani?

Ngenxa yokuthi izimpawu zivela kancane kakhulu, eminyakeni eminingi, kungaba nzima ukuzibona.

Udokotela wakho angakuthumela kudokotela we-endocrinologist , udokotela ogxile ezifweni ezihlobene nama-hormone. Uzokwenza ukuxilongwa ngokusekelwe emlandweni wakho wezokwelapha, ukuhlolwa kwezokwelapha, kanye nokuhlolwa okukhethekile (njengokuhlolwa kwegazi kanye nokuhlolwa kwezithombe).

Yiziphi izivivinyo zokuxilonga?

Uma kutholakale ukuthi une-acromegaly, udokotela wakho angase akucele ukuthi kwenziwe olunye ucwaningo ukuze abone ukuthi lesi simo sithinte yini ezinye izingxenye zomzimba wakho. Lokhu kungafaka:

• Ukuhlolwa kwe-echocardiogram ukuhlola izinkinga zenhliziyo.
• Ukuhlolwa kocwaningo lokulala ukuze kubonakale ukuthi uyacinana yini ngesikhathi ulele.
• I-Colonoscopy ukuhlola impilo ye-colon.
• Hlola impilo yamathambo nge-X-ray noma i-DEXA scan .

Iphathwa kanjani i-Acromegaly?

Kunezindlela eziningana zokwelapha i-acromegaly. Kuye ngezimpawu nesimo sakho, udokotela wakho uzosikisela ukwelashwa okufanele wena.

Izindlela zokwelapha ezisetshenziswa kakhulu yilezi:

• Ukuhlinzwa
• Imithi
• Ukwelashwa ngemisebe

Ukuhlinzwa kwe-Acromegaly

Ezimweni eziningi, ukuhlinzwa kunganciphisa kakhulu noma kuphulukise ngokuphelele izimpawu ze-acromegaly. Odokotela abahlinzayo bavame ukusebenzisa inqubo ebizwa ngokuthi i-transsphenoidal surgery , ehilela ukwenza ukuhlinzwa ngekhala nange-sphenoid sinus (isikhala esingenalutho ngemuva kwemigudu yamakhala, ngaphansi kobuchopho).

Imininingwane yokuhlinzwa incike ngobukhulu nendawo yesimila. Umgomo oyinhloko wokuhlinzwa ukususa ngokuphelele isimila esibangela ukukhiqizwa kwe-hormone yokukhula ngokweqile (GH). Uma udokotela ohlinzayo ekwazi ukususa ingxenye enkulu yesimila, ungase ungadingi olunye ukwelashwa. Kodwa-ke, uma kususwa ingxenye kuphela yesimila, ungase udinge imithi noma ukwelashwa ngemisebe ukulawula izimpawu nokunciphisa ukukhiqizwa kwe-hormone yokukhula (GH).

Imithi ye-Acromegaly

Udokotela wakho angase akunike umuthi owodwa noma inhlanganisela yemithi. Le mithi isebenza ngezindlela ezahlukene ukuze kulungiswe amazinga e-hormone yokukhula (GH) emzimbeni wakho futhi kuncishiswe izimpawu. Kwezinye izimo, umuthi unikezwa kuze kube yilapho isimila sincipha, ukuze udokotela ohlinzayo akwazi ukusisusa ngokuphephile. Abanye abantu kungadingeka bathathe umuthi isikhathi eside ukuze balawule amazinga nezimpawu ze-hormone yokukhula (GH).

Ingabe i-acromegaly ingelapheka ngokuphelele?

I-Acromegaly ngezinye izikhathi ingelapheka, kodwa hhayi njalo. Uma isimila se-pituitary esibangela i-acromegaly sisuswa ngokuhlinzwa, izinga lokuphulukiswa lingaba ngu-85% wezimila ezincane . Kuzimila ezinkulu, liphakathi kuka-40% no-50%.

Imithi ayikwazi ukwelapha ngokuphelele i-acromegaly, kodwa inganikeza ukwelashwa okuphephile nokuhlala isikhathi eside .

Ingabe i-acromegaly ingavinjelwa?

Ngeshwa, akukho ongakwenza ukuvimbela i-acromegaly. Ososayensi abakaqiniseki ukuthi yini ebangela izimila ze-pituitary ezibangela i-acromegaly. Kodwa-ke, bakholelwa ukuthi ezinye izici zofuzo zingadlala indima.

Iyini iphrojekthi ye-acromegaly?

Umbono walokhu uncike ebunzimeni besifo nokuthi izimpawu zilawulwa kahle kangakanani ngokwelashwa. Abantu abaningi babona ukwehla okukhulu kwezimpawu ngemva kokwelashwa.

Uma ingelashwa, i-acromegaly ingashintsha kakhulu ukubukeka kwakho kanye nesimo samathambo akho. Lezi zimpawu zingaba nomthelela omkhulu ekuzihlonipheni kwakho kanye nekhwalithi yokuphila. Amaqembu okusekela asiza abanye abantu ukuthi babhekane nezinselele ze-acromegaly.

I-Acromegaly ingadala nezinkinga zempilo, njengesifo senhliziyo noma isifo sikashukela sohlobo 2, okunganciphisa ikhwalithi yokuphila futhi kunciphise isikhathi sokuphila. Ngakho-ke, kubalulekile ukubona udokotela uma unezimpawu futhi, uma kutholakala ukuthi une-acromegaly, ulandele uhlelo lokwelashwa eduze.

Yiziphi izinkinga ezingaba khona uma zingelashwa?

Uma ingelashwa, i-acromegaly ingaholela ezinkingeni ezifana nalezi:

• Isifo sikashukela sohlobo 2
• Umfutho wegazi ophezulu (i-Hypertension)
• Isifo senhliziyo
• Isifo semisipha yenhliziyo (i-Cardiomyopathy)
• Isifo samathambo
• Ama-polyp ekholoni - Lawa angaba umdlavuza uma engelashwa.
• Ukwehluleka kwezitho zomzimba

Iyini isikhathi sokuphila somuntu one-acromegaly?

Lokhu kuncike ebunzimeni besifo nokuthi ngabe zikhona yini ezinye izimo zempilo, ezivame ukubangelwa yi-acromegaly engelashwa.

Uma amazinga akho e-growth hormone (GH) engalawulwa kahle futhi unezinye izimo ezifana nesifo senhliziyo nesifo sikashukela, isikhathi sakho sokuphila singancishiswa cishe ngeminyaka eyi-10.

Kodwa-ke, uma une-acromegaly, welashwa kahle, futhi une-hormone yokukhula evamile (GH) kanye namazinga e-IGF-1, cishe uzophila isikhathi esijwayelekile sokuphila.

Kufanele ngimbone nini udokotela mayelana ne-acromegaly?

Uma unezimpawu ze-acromegaly, kubaluleke kakhulu ukukhuluma nodokotela.

Uma utholakale une-acromegaly, kuzodingeka ubone udokotela wakho njalo ukuqinisekisa ukuthi ukwelashwa kwakho kusebenza kahle.

I-Acromegaly yisimo esingavamile kodwa esibucayi. Izindaba ezinhle ukuthi ingelashwa ngokuhlinzwa, imithi, kanye/noma ukwelashwa ngemisebe. Uma uqaphele ukuthi izandla zakho, izinyawo, kanye/noma izici zobuso ziyakhula, khuluma nodokotela wakho. Angenza izivivinyo ezimbalwa ezilula ukuze abone ukuthi amazinga akho e-growth hormone (GH) ayimbangela yezimpawu zakho.

Ekugcineni, umyalezo okufanele uwuthathe uye nawo ekhaya

• I-Acromegaly yisimo esingavamile kubantu abadala esibangelwa ukwanda kwe-hormone yokukhula (GH).
• Izimpawu zingase zihlanganise ukuvuvukala kwezingalo nobuso, ukujuluka ngokweqile, kanye nokushintsha kwezwi . Lokhu kungabonakala kancane, ngakho ungase ungaziboni.
• Imbangela eyinhloko yalokhu isimila, ngokuvamile esingesona umdlavuza, esikhula endlaleni ye-pituitary.
• Ukutholwa kusenesikhathi kanye nokwelashwa kungavimbela izinkinga eziningi futhi kuthuthukise ikhwalithi yokuphila.
• Uma unalezi zimpawu, ungangabazi ukufuna iseluleko sezokwelapha. Yilokho okuhlakaniphe kakhulu ongakwenza.

Sicela ukhumbule, lolu lwazi lungolwezinjongo zolwazi kuphela. Akufanele lusetshenziswe esikhundleni seseluleko sezokwelapha. Uma unezinkinga zempilo, sicela uxhumane nochwepheshe wezokwelapha ofanelekayo.

I- Acromegaly, i-Growth Hormone, i-Pituitary Gland, i-Gigantism, i-IGF-1, ukuphazamiseka kwama-hormone, i-Endocrine