Ingabe futhi ulokhu womile futhi uchama cishe izikhathi ezingamashumi amabili ngosuku? Ingabe lokhu kuyi-Arginine Vasopressin Disorders / Diabetes Insipidus?

Ingabe nawe unokoma okungabekezeleleki? Ingabe uzizwa sengathi awukwazi ukuphuza amanzi anele? Ingabe kufanele uye endlini yokugezela izikhathi eziningi ngosuku, ngezinye izikhathi ngisho kanye noma kabili ngehora? Uma kufanele uvuke ebusuku ukuze uchame ngaphandle kokulala kahle, lokhu akuyona into okufanele ithathwe kalula. Namuhla sizokhuluma ngesimo esingavamile kodwa esingelapheka esibonisa izimpawu ezifanayo. Ngaphambilini, lokhu kwakubizwa ngokuthi 'i-Diabetes Insipidus'.

Kuyini i-Arginine Vasopressin Disorder?

Kalula nje, lesi simo sibangelwa ukuthi umzimba wakho ukhiqiza umchamo omningi kakhulu. Lokhu kusho ukuthi umzimba wakho awukwazi ukugcina amanzi anele. Isizathu esiyinhloko salokhu inkinga nge-hormone ebizwa ngokuthi i-Arginine Vasopressin (AVP) . Odokotela babiza le hormone ngokuthi "AVP" ngokuthi i-Antidiuretic Hormone (ADH) . Le hormone "AVP" idlala indima ebaluleke kakhulu ekugcineni inani loketshezi emzimbeni lilingana nezinso zethu.

Kunezinhlobo ezimbili eziyinhloko zalezi zimo:

1. Ukuntuleka kwe-AVP (AVP-D): Lokhu kwenzeka lapho umzimba wakho ungakhiqizi i-hormone i-AVP eyanele.

2. Ukumelana ne-AVP (AVP-R): Lokhu kwenzeka lapho izinso zakho zingasabeli kahle ku-hormone i-AVP. Lokhu kusho ukuthi yize i-hormone ikhona, izinso aziyisebenzisi.

Ziyini izimpawu zalesi simo?

Izimpawu eziyinhloko zokuntuleka kwe-AVP kanye nokumelana ne-AVP yilezi:

• Ukudinga njalo ukuchama: Uphawu oluyinhloko lwalokhu ukuthi kufanele uvuke uyochama hhayi emini kuphela kodwa nasebusuku (Nocturia) .
• Ukuchama okuningi okukhanyayo noma okumanzi: Ngokuvamile, umuntu uchama phakathi kwamalitha angu-1 nama-3 ngosuku. Kodwa-ke, umuntu onalesi simo angachama afinyelela kumalitha angu-20 ngosuku. Cabanga ukuthi kungakanani lokho!
• Ukoma ngokweqile (i-Polydipsia): Ukuzizwa sengathi awukuqedi ukoma kwakho kungakhathaliseki ukuthi uphuza amanzi angakanani.

Lezi zimpawu ziyisibonakaliso esinamandla sokuthi kukhona okungasebenzi kahle emzimbeni wakho. Kubaluleke kakhulu ukufuna iseluleko sezokwelapha ngokushesha okukhulu.

Lezi zimpawu zithinta kanjani izingane ezincane?

Uma lesi simo senzeka ezinganeni ezincane, izimpawu zingase zihluke kancane. Ezinye zazo zifaka:

• Ukuphelelwa ngamanzi emzimbeni okukhulu.
• Ukuqunjelwa.
• Ukuhlanza.
• Umkhuhlane ovamile.
• Ukubonisa isimo sengqondo sokucasuka kakhulu nokucasuka.
• Ukukhula kuyawohloka / Ukwehluleka ukuchuma.

Uma izinsana noma izingane ezincane zinalezi zimpawu, kufanele zibonwe udokotela ngokushesha.

Kungani kwenzeka lezi zinkinga ze-arginine vasopressin?

Izizathu ziyahlukahluka, kuye ngohlobo okukhulunywe ngalo ekuqaleni.

Izimbangela zokuntuleka kwe-AVP `(AVP-D)`

Ngaphambilini okwakubizwa ngokuthi i-central diabetes insipidus , lokhu kubangelwa ukuntuleka kwe-hormone i-arginine vasopressin (AVP). Lolu uhlobo oluvame kakhulu.

Lokhu kungase kube ngenxa yalokhu:

• Ukulimala kwe -hypothalamus noma i-pituitary gland (lezi yizingxenye ezibalulekile zobuchopho ezilawula ama-hormone). Lo monakalo ungavela ngokuhlinzwa noma ukulimala ekhanda.
• Ezinye izinhlobo zofuzo (Ukwehluka kwezakhi zofuzo okuzuzwe njengefa)
• Ukwakheka kwezimila .
• Ukuvuvukala/ama-granuloma abangelwa yizimo ezithile zezokwelapha, njenge-sarcoidosis noma isifo sofuba.
• Ngezinye izikhathi, imbangela ingase ingatholakali (idiopathic) . Lokhu kusho ukuthi cishe ingxenye yeziguli, imbangela ayaziwa.

Izimbangela zokumelana ne-AVP (AVP-R)

Lolu hlobo lwalubizwa ngokuthi i-nephrogenic diabetes insipidus ngaphambilini. Kulokhu, i-pituitary gland ikhiqiza i-hormone i-AVP, kodwa izinso aziphenduli kahle kuyo.

Kunezizathu eziningana zalokhu:

• Ezinye izinguquko zofuzo.
• Umgudu womchamo ovalekile .
• Ukusetshenziswa isikhathi eside kwemithi ethile, ikakhulukazi i-lithium .
• Ukwanda kwamazinga e-calcium egazini (i-Hypercalcemia) .
• Amazinga aphansi e-potassium egazini (i-Hypokalemia) .

Uhlobo olukhethekile oluvela ngesikhathi sokukhulelwa

Lokhu kubizwa ngokuthi i-Gestational Arginine Vasopressin Disorder (gAVP-d) . Lokhu akuvamile kakhulu. Ngesikhathi sokukhulelwa, i-placenta ikhiqiza i-enzyme eningi kakhulu ephula i-hormone i-AVP.

Kungenzeka kakhulu ukuthi ube nalesi simo, ngesizathu esithile :

• Uma uthwele amawele noma izingane ezingaphezulu .
• Uma unesifo esithinta ukusebenza kwesibindi, njenge- preeclampsia noma i-HELLP syndrome .

Izindaba ezinhle ukuthi lesi simo se-'gAVP-d' sivame ukuphela emasontweni amabili kuya kwamathathu ngemva kokubeletha.

Yiziphi izinkinga zalesi simo?

Inkinga eyinhloko ye-AVP-D kanye ne-AVP-R ukuphelelwa amanzi emzimbeni , okuwukulahlekelwa uketshezi kanye nama-electrolyte adingekayo ukuze umzimba usebenze.

Ngokuvamile ungalawula ukuphuma komchamo wakho ngokuphuza amanzi amaningi kunalawo owadingayo, kodwa uma ungakwenzi lokho, ungaphelelwa amanzi emzimbeni ngokushesha okukhulu.

Ukuphelelwa amanzi emzimbeni kungaba yingozi empilweni. Uma unezimpawu zokuphelelwa amanzi emzimbeni, njengokuzungeza, isicanucanu, noma ukukhathala okukhulu, hamba uye esibhedlela esiseduze ngokushesha okukhulu.

Odokotela bakuthola kanjani lokhu?

Ngenxa yokuthi izimpawu zokoma njalo kanye nokuchama zingabangelwa ezinye izimo ezivamile, odokotela baqale bakhiphe ezinye izimo lapho bexilonga i-'AVP-D` noma i-'AVP-R`. Uma unalezi zimpawu, udokotela wakho cishe uzoyala ukuhlolwa okuningana.

Uma kutholakala lesi simo, kubalulekile ukunquma ukuthi ngabe ``AVP-D`` noma ``AVP-R`` nokuthi siyini imbangela.

Ukuhlolwa kokuxilonga

• Ukuhlolwa kokuntuleka kwamanzi: Lena yindlela ethembekile kakhulu yokuxilonga i-AVP-D noma i-AVP-R. Uzoqashwa ngokucophelela phakathi nalolu vivinyo, njengoba lokhu kungabangela ukuphelelwa amanzi emzimbeni. Lolu vivinyo luhilela ukungaphuzi noma yiluphi uketshezi amahora amaningana nokubona ukuthi umzimba wakho usabela kanjani. Uma unalesi simo, uzoqhubeka nokuphuma umchamo omningi wamanzi, onombala okhanyayo. Uma ungenaso lesi simo, uzophuma umchamo omncane ophuzi ogxilile, omnyama.
• Ukuhlolwa kwegazi le-Copeptin: I-Copeptin ingumkhiqizo olandelanayo we-hormone i-AVP.
• Ukuhlolwa kweglucose egazini: Lokhu kwenzelwa ukuhlola isifo sikashukela, esinazo izimpawu ezifanayo.
• Ukuhlolwa komchamo: Lokhu kuhlola i-osmolality ( ukuhlushwa komchamo) kanye nama-ketone emchameni.
• Ukuhlolwa kwezithombe okufana nokuskena kwe-MRI (MRI - Magnetic Resonance Imaging): Lokhu kwenziwa ukuze kubonakale ukuthi kukhona yini umonakalo ku-pituitary gland noma ku-hypothalamus.

Ziphathwa kanjani lezi `AVP-D` kanye ne`AVP-R`?

Ukwelashwa kuncike ekutheni une-`AVP-D` noma i-`AVP-R`. Kungakhathaliseki ukuthi ukwelashwa kunjani, kubalulekile ukuphuza amanzi amaningi ukuze ugweme ukuphelelwa amanzi emzimbeni.

Ukwelashwa kwe-AVP-D (Ukuntuleka)

I-Desmopressin iyindlela yokwelapha eyinhloko ye-AVP-D. Iwumuthi osebenza ngendlela efanayo ne-hormone i-AVP. Ingathathwa ngezindlela ezahlukene (isib., njengesifutho sekhala, njengephilisi).

I-Desmopressin ngezinye izikhathi isetshenziselwa isimo sokukhulelwa esingavamile ``(gAVP-d)''. Kodwa-ke, ngezinye izikhathi ngesikhathi sokukhulelwa, ingalawulwa ngokuphuza amanzi amaningi.

Ukwelashwa kwe-AVP-R (Ukumelana)

Ukwelapha i-`AVP-R` kuyinkimbinkimbi kancane. Ngezinye izikhathi izindlela eziningana zidinga ukusetshenziswa ndawonye. Isibonelo:

• Imithi yokukhipha isisu i-Thiazide(Nakuba lokhu kuwuhlobo lwemithi ekhulisa ukuchama, isebenza ngendlela ehlukile kulesi simo)
• Imithi engeyona eye-steroidal elwa nokuvuvukala (ama-NSAID)

Uma isimo se-`AVP-R` sibangelwa umuthi owuthathayo, udokotela wakho angase akwazi ukwelapha lesi simo ngokukushintshela komunye umuthi.

Kufanele ngimbone nini udokotela?

Uma une-`AVP-D` noma i-`AVP-R`, kubaluleke kakhulu ukubona udokotela wakho njalo ukuze uthole iseluleko. Ngale ndlela, udokotela wakho angenza izivivinyo zokuqapha isimo sakho futhi aqinisekise ukuthi ukwelashwa kwakho kusebenza kahle.

Ungase ukuthole kuwusizo ukubuza udokotela wakho le mibuzo:

• Ingabe ngine-`AVP-D` noma `AVP-R`?
• Iyini imbangela yalokhu?
• Ingabe lesi yisimo esingamahlalakhona (esihlala isikhathi eside) noma esesikhashana?
• Yiziphi izindlela zokwelapha enginazo?
• Kufanele ngiphuze amanzi angakanani ngosuku?
• Yini enye engingayenza ukuze ngiphathe lesi simo?
• Ingabe umndeni wami nawo usengozini yokuthola isifo se-arginine vasopressin?

Yini engingayilindela uma ngine-`AVP-D` noma i-`AVP-R`?

Umbono (umphumela) wezimo ze-`AVP-D` kanye ne-`AVP-R` ngokuvamile muhle. Uma uthatha ukwelashwa okufanele futhi uphuza amanzi anele, akufanele ube nezinkinga ezinkulu.

Kodwa-ke, laba bantu basengozini enkulu yezinkinga:

• Izingane
• Abantu abangaphezu kweminyaka engama-65 ubudala
• Abantu abanezimo ezithile zempilo yengqondo noma ukukhubazeka kokukhula

Laba bantu bangase babe nobunzima bokubona ukoma kwabo, noma bangase bangakwazi ukuthatha isinyathelo ngakho.

Kungani lokhu kungabizwa ngokuthi 'i-Diabetes Insipidus' manje?

Ngo-2022, izinhlangano eziningana zezokwelapha zanquma ukushintsha igama elithi 'Diabetes Insipidus' laba yi-'Arginine Vasopressin Deficiency' kanye ne-'Arginine Vasopressin Resistance'. Isizathu esiyinhloko salokhu kwakuwukudideka okubangelwe igama elithi 'diabetes' kanye nemiphumela emibi yezempilo ebangelwe yilo.

Uma abantu abaningi bethi nje "isifo sikashukela", basho isifo sikashukela . Sibangelwa amazinga aphezulu kashukela egazini. Siphinde sibe nezimpawu ezifana nokoma njalo nokuchama. Kodwa-ke, sivame kakhulu kunezimo ezithi `AVP-D` kanye nethi `AVP-R` (ezaziwa ngokuthi `Diabetes Insipidus`). Futhi, ukwelashwa kwesifo sikashukela kuhluke ngokuphelele ekwelashweni kwe-`AVP-D` kanye nethi `AVP-R`.

Igama elithi "isifo sikashukela" livela egameni lesiGreki elithi "diabetesine," elisho "ukudlula." Lelo gama lisetshenziswa ngoba, njengasesifo sikashukela, uketshezi ludlula emzimbeni ngokushesha kakhulu, okuyikho okwenzeka kulezi zinkinga ze-arginine vasopressin.

Ekugcineni, kufanele ngikutshele... (Umyalezo Wokuya Ekhaya)

Uma une-`AVP-D` (ukuntuleka kwe-arginine vasopressin) noma i-`AVP-R` (ukumelana ne-arginine vasopressin), ungase uzizwe sengathi uchitha ingxenye enkulu yempilo yakho endlini yokugezela, awukwazi ukuqeda ukoma kwakho kungakhathaliseki ukuthi uphuza amanzi angakanani. Kodwa izindaba ezinhle ukuthi lezi zimo zingalawulwa.

Udokotela wakho uzokwakha uhlelo lokwelashwa oluzokusebenzela, futhi uzokutshela nokuthi udinga ukuphuza amanzi angakanani ngosuku ukuze uhlale unamanzi. Ungesabi. Thola ukwesekwa nesiqondiso sikadokotela wakho. Khumbula, lokhu akusikho "isifo sikashukela." Yingakho kubalulekile ukuthola ukuxilongwa okufanele nokwelashwa. Awuwedwa, hlala unolwazi, futhi uhlale uqinile.

Izinkinga ze - Arginine Vasopressin, Isifo Sikashukela i-Insipidus, i-AVP, i-ADH, Ukoma Okudlulele, Ukuchama Okuvamile, Ukuphelelwa Amanzi Emzimbeni, i-Polydipsia, i-Nocturia, i-Desmopressin, Izinso, Ama-Hormones