Kuvamile ukuzizwa wesaba futhi ushaqekile lapho uthola ukuthi ingane yakho noma ilungu lomndeni linesifo esingavamile nesibucayi njenge-primary hemophagocytic lymphohistiocytosis (HLH). Ngesikhathi esinjengalesi, kubalulekile ukwazi ngokugcwele ngokwelashwa okunconywa udokotela wakho. Namuhla, sikhuluma ngomuthi wokugomela okhethekile obizwa ngokuthi i-Emapalumab, osetshenziselwa ukulawula izimpawu zalesi simo.
Kalula nje, iyini i-Emapalumab?
I-Emapalumab uhlobo olukhethekile lomuthi olubizwa ngokuthi i-monoclonal antibody . Cabanga ngayo njengeprotheyini eyenziwe ngokukhethekile elabhorethri ukulawula umsebenzi wengxenye ethile yesistimu yomzimba wethu yokuzivikela.
Manje ake sibone ukuthi lokhu kusiza kanjani nge-HLH. Ku-HLH, amasosha omzimba wethu asebenza ngokweqile bese eqala ukuhlasela amangqamuzana anempilo. I-Emapalumab isebenza ngokuvimbela isignali yamakhemikhali ebizwa ngokuthi i-interferon-gamma ebangela lokhu kusebenza ngokweqile, ithulise amasosha omzimba.
Into ebaluleke kakhulu: Lokhu akulona ikhambi le-HLH, kodwa kuyasiza ukulawula izimpawu ezinzima zesifo futhi kusekele umzimba ekululameni kwawo.
Izinto okudingeka uzitshele udokotela wakho ngaphambi kokuqala lo muthi
Ngaphambi kokuqala lokhu kwelashwa, kubalulekile ukunikeza udokotela umlando wempilo yakho noma wesiguli. Qiniseka ukuthi ukhuluma ngala maphuzu ngokukhethekile.
- Ukutheleleka kwamanje: Uma okwamanje unesifo esifana nomkhuhlane, ukukhwehlela, noma umkhuhlane.
- Mayelana nokugoma: Uma usanda kuthola noma yimuphi umuthi wokugoma, noma uhlela ukuwuthola esikhathini esizayo.
- Isifo Sofuba (TB): Kufanele utshele udokotela wakho uma uke waba nesifo sofuba ngaphambili, uke wahlolwa isikhumba ukuthi une-TB, noma usanda kuxhumana nomuntu onesifo sofuba.
- Ukungezwani komzimba: Uma une-allergy kulo muthi we-Emapalumab noma kunoma yimuphi omunye umuthi, ukudla, noma idayi.
- Ukukhulelwa nokuncelisa: Uma ukhulelwe, uzama ukukhulelwa, noma uncelisa.
Ngokusekelwe kulolu lwazi, udokotela wakho uzonquma ukuthi kufanelekile yini ukukunikeza lo muthi nokuthi yiziphi izinyathelo zokuphepha ezikhethekile okudingeka uzilandele.
Lomuthi unikezwa kanjani?
I-Emapalumab iwumjovo ofakwa emthanjeni (i-infusion). Awukwazi ukuyisebenzisa ekhaya. Inikezwa uchwepheshe wezempilo oqeqeshiwe esibhedlela noma emtholampilo. Bazokuqapha ngokucophelela ngesikhathi sokwelashwa kwakho nangemva kwalokho.
Lo muthi unganikezwa izingane zanoma yimuphi ubudala, kusukela ezinsaneni ezisanda kuzalwa kuya ezinganeni, uma kudingeka. Kodwa-ke, kuthathwa izinyathelo ezikhethekile zokuqapha lapho uwunika izingane. Ungakhuluma nodokotela wezingane ukuze uthole imininingwane eyengeziwe.
Kuthiwani uma ngiphuthelwa umthamo wemithi?
Lokhu kwelashwa kunikezwa ngesheduli ehleliwe. Ngakho-ke, kubaluleke kakhulu ukungaphuthelwa ukubonana nodokotela wakho. Uma ngesizathu esithile ungakwazi ukuya ngosuku oluhleliwe, shayela udokotela wakho noma isibhedlela ngokushesha ubazise.
Kuthiwani uma ngiphuza umuthi omningi kakhulu?
Lokhu kunikezwa esibhedlela ngakho amathuba okuba lokhu kwenzeke mancane kakhulu. Kodwa-ke, uma ucabanga ukuthi kungenzeka ukuthi uthathe umuthi omningi kakhulu, shayela ngokushesha i-National Poisons Information Centre e-Colombo National Hospital , noma uye e- Emergency Treatment Unit (ETU) eseduze.
Izinto okufanele uzicabangele ngesikhathi sokwelashwa
- Ukuhlolwa kwesifo sofuba (TB): Ngaphambi kokuqala lo muthi, uzohlolwa isifo sofuba (TB). Uma udokotela wakho ekunike umuthi wesifo sofuba, kufanele uqale ukuthatha umuthi ngaphambi kokuqala i-Emapalumab bese uwuqeda isikhathi esiphelele esinqunyiwe.
- Ingozi yokutheleleka: Njengoba lo muthi ucindezela amasosha omzimba, ingozi yokutheleleka inganda kancane. Ngakho-ke, uma uba nezimpawu ezifana nomkhuhlane, ukubanda, umphimbo obuhlungu, noma ukukhwehlela , ungaziphilisi futhi wazise udokotela wakho ngokushesha. Zama ukuhlala kude nabantu abagulayo.
- Eminye imithi: Tshela udokotela wakho nganoma yimiphi eminye imithi, amavithamini, noma imithi yamakhambi oyithathayo. Ikakhulukazi, kufanele ugweme ukuthola imijovo yegciwane eliphilayo ngenkathi uthatha lokhu kwelashwa.
Yimiphi imiphumela emibi engingayithola?
Njengayo yonke imithi, i-Emapalumab ingabangela imiphumela emibi, yize kungebona bonke abantu abayitholayo.
| Okuqhamuka uma udla imishanguzo | |
|---|---|
| Imiphumela emibi kakhulu okufanele uyibike kudokotela wakho ngokushesha | |
| Ukusabela kokungezwani komzimba | Ukuqubuka kwesikhumba, ukulunywa, ukuvuvukala kobuso, izindebe noma ulimi. |
| Ubunzima bokuphefumula | Ukuphefumula kanzima, izinga lokuphefumula elikhuphukile. |
| Ukushaya kwenhliziyo | Ukuzizwa sengathi inhliziyo yakho ishaya ngokushesha. |
| Umfutho wegazi ophakeme | Umfutho wegazi ophakeme. |
| Izimpawu zokutheleleka | Umkhuhlane, ukubanda, ukukhwehlela, umphimbo obuhlungu, ubuhlungu lapho uchama. |
| Imiphumela emibi evame ukungabi mibi kakhulu, kodwa okufanele ibikwe kudokotela uma iqhubeka | |
| Izinkinga zesistimu yokugaya ukudla | Ubuhlungu besisu, ukuqunjelwa, uhudo, ukuhlanza. |
| Ezinye izici | Ukukhwehlela, ukungahlaliseki (ikakhulukazi ezinganeni), ubuhlungu, ukubomvu, noma ukuvuvukala endaweni yokujova. |
Lolu hlu aluhlanganisi yonke imiphumela emibi engaba khona. Uma uhlangabezana nanoma yini ehlukile, sicela ufune iseluleko sezokwelapha.
Umlayezo Wokuya Nawe Ekhaya
- I-Emapalumab umuthi okhethekile ofakwa emthanjeni ukulawula izimpawu ze-HLH enzima.
- Nakuba lokhu kungelaphi ngokuphelele lesi sifo, kubaluleke kakhulu ekulawuleni izimpawu.
- Ngaphambi kokuqala ukwelashwa, tshela udokotela wakho yonke imininingwane yakho yezempilo, ikakhulukazi mayelana nezifo ezithathelwanayo, ukungezwani komzimba, kanye nesifo sofuba.
- Ngesikhathi sokwelashwa, qaphela kakhulu izimpawu zokutheleleka njengomkhuhlane, ukukhwehlela, kanye nokusabela kokungezwani komzimba. Uma unezinkinga, yazisa udokotela wakho ngokushesha.
- Njengoba lo muthi unikezwa esibhedlela, qiniseka ukuthi uya kokwelashwa ngezinsuku ezihleliwe.
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