Wake wazibuza ukuthi umzimba wakho ugcina kanjani amazinga kashukela egazini lakho elinganisela kahle? Isidlali esibalulekile kule nqubo yinto ebizwa ngokuthi i-glucagon. Cabanga ngayo njengeqhawe elincane ngaphakathi ohlelweni lwakho, elisebenza ngokungakhathali ukuqinisekisa ukuthi ushukela wakho wegazi awunciphi kakhulu. Namuhla, sizohlola ukuthi i-glucagon isebenza kanjani, ngamazwi acacile nalula, lapha eNirogi Lanka.
Kuyini i-Glucagon?
Kalula nje, i-glucagon iyi-hormone yemvelo ekhiqizwa umzimba wakho . Ikakhulukazi, idalwa amaseli e-alpha atholakala kuma-pancreas akho. Umzimba wakho ukhipha i-glucagon noma nini lapho amazinga akho e-glucose (ushukela) egazini ehla—njengalapho uzila ukudla isikhathi eside, uvivinya umzimba kakhulu, noma ngemva kokudla ukudla okunamaphrotheni amaningi.
Cabanga nge-glucose njengomthombo oyinhloko kaphethiloli womzimba wakho, owuthola kuma-carbohydrate ekudleni okudlayo. Njengophethiloli wemoto, le glucose inikeza amandla abalulekile adingekayo ukuze izitho zakho, imisipha, kanye nesistimu yezinzwa zisebenze. Umzimba wakho ugcina ibhalansi eyinkimbinkimbi nebucayi ukuze ugcine la mazinga kashukela esezingeni elifanele; uma ekhuphuka kakhulu noma ephansi kakhulu, kungaholela ezinkingeni ezahlukahlukene zempilo.
Imijovo ye-Glucagon kanye ne-Sprays yekhala
Ngaphezu kwe-glucagon eyenziwa ngumzimba wakho, kunezinhlobo zokwenziwa ezitholakalayo njengemijovo noma izifutho zomlomo ezomile. Kungenzeka ukuthi uke wazibona zisetshenziswa, ikakhulukazi ngabantu abanesifo sikashukela sohlobo 1 , njengokwelashwa okuphuthumayo kwe-hypoglycemia enzima (ushukela wegazi ophansi kakhulu). Uma inikezwa, le glucagon isebenza ngokukhuthaza isibindi sakho ukuthi sikhiphe ushukela ogciniwe egazini lakho, okuhlinzeka ngempumelelo 'ngokukhulisa' amazinga kashukela akho ngendlela esindisa impilo.
I-Glucagon Ithinta Kanjani Umzimba Wakho?
Uma i-pancreas yakho isebenza kahle, ilawula ngokucophelela ushukela wegazi lakho isebenzisa ama-hormone amabili ayinhloko: i-glucagon kanye ne-insulin . Lapho amazinga kashukela egazini lakho eqala ukwehla kakhulu (i-hypoglycemia), i-pancreas yakho ikhipha i-glucagon eyengeziwe ukuze ibuyise amazinga ngezindlela eziningana:
- Okokuqala, i-glucagon iya esibindini sakho bese iguqula i-glucose egciniwe—eyaziwa ngokuthi i-glycogen —ibe yindlela esebenzisekayo, bese isibindi siyikhipha egazini lakho.
- Okwesibili, i-glucagon itshela isibindi sakho ukuthi siyeke ukugcina i-glucose, okuqinisekisa ukuthi kusele okuningi egazini lakho.
- Okwesithathu, i-glucagon isiza umzimba wakho ukuthi wakhe i-glucose entsha evela kweminye imithombo, njengama -amino acid .
Khumbula, lokhu kufana ne-seesaw: uma ushukela wegazi uphansi, i-glucagon iyasebenza; uma ushukela wegazi uphezulu, i-insulin iyahola!
Yiziphi Izimo Ezithinta Umsebenzi We-Glucagon?
Uma umzimba wakho unenkinga yokuphatha i-glucagon ngempumelelo, kungaholela ezinkingeni zempilo.
Uma unesifo sikashukela, umzimba wakho ungase ube nenkinga yokukhipha i-glucagon eyanele lapho ushukela wegazi wehla. Lokhu kukubeka esimweni esibucayi.ingozi ephezulu ye-hypoglycemia evame kakhulu noma enzima, ikakhulukazi uma uthatha i-insulin noma imithi ethile efana ne-sulfonylureas.
Kwabanye abantu abanesifo sikashukela sohlobo 2, amazinga e-glucagon angase abe phezulu kunokuvamile, okungabangela ushukela wegazi ophakeme.
Nakuba izinkinga ngokukhiqizwa kwe-glucagon ngaphandle kwesifo sikashukela zingavamile, zingabangelwa yilokhu okulandelayo:
- I-Pancreatitis: Uma ukuvuvukala okungapheli kwe-pancreas kubangela isifo sikashukela, ungase ubhekane nokuntuleka kwe-glucagon, okwandisa ingozi yakho yokuba noshukela wegazi ophansi.
- I-Glucagonoma: Isimila esingavamile kakhulu se-pancreas esikhiqiza i-glucagon eningi, okuholela kushukela ophezulu egazini, ukuqubuka kwesikhumba okuthile, kanye nokwehla kwesisindo.
- I-Multiple Endocrine Neoplasia (MEN): Isimo esingavamile sofuzo lapho izindlala eziningi ohlelweni lwakho lwe-endocrine zikhula khona izimila, okungase kuhlanganise ne-pancreas.
- Ukususwa Kwe-Pancreat: Uma ingxenye noma wonke ama-pancreas akho esuswa ngokuhlinzwa, ungase ulahlekelwe amaseli akhiqiza i-glucagon kanye ne-insulin.
Izimpawu Zezinkinga Ezihlobene Ne-Glucagon
Njengoba kuxoxiwe, ukungalingani kwe-glucagon kungaholela ku-hypoglycemia (ushukela ophansi egazini) noma i-hyperglycemia (ushukela ophezulu egazini). Nansi indlela ongazibona ngayo lezi zimpawu.
Izimpawu ze-Hypoglycemia (Ushukela Ophansi Egazini)
Uma wena noma othandekayo wakho niphatha isifo sikashukela, kubalulekile ukuqaphela izimpawu zokwehla koshukela egazini. Ungase uzizwe uqhaqhazela, ujuluka, noma udidekile, futhi ube nobunzima bokukhuluma noma ukugxilisa ingqondo. Lokhu kungaba uphawu loshukela ophansi egazini.
Izimpawu ezivamile zifaka:
- Ukuthuthumela noma ukuthuthumela
- Ukujuluka nokuzizwa kubanda
- Isiyezi noma ikhanda elibuthakathaka
- Ukushaya kwenhliziyo okusheshayo
- Indlala engazelelwe
- Ukudideka noma ubunzima bokugxila
Okubalulekile: Uma uhlangabezana nalezi zimpawu, kubalulekile ukuthi udle okuthile okunoshukela noma ama-carbohydrate ngokushesha . Lokhu kusiza ukubuyisela amazinga kashukela egazini lakho. Uma lokhu kwenzeka njalo, kufanele uthintane nodokotela wakho ngokushesha.
Izimpawu Zoshukela Ophezulu Egazini (i-Hyperglycemia)
Ushukela ophezulu egazini (i-hyperglycemia) uvame ukubangelwa ukuntuleka kwe-insulin, kunokuba kube yinkinga eyinhloko nge-glucagon. Kodwa-ke, izinkinga ezingavamile ezihlobene ne-glucagon nazo zingaholela ekuphakameni koshukela egazini. Izimpawu zokuqala zifaka:
- Ukoma okwandayo kanye/noma indlala eqhubekayo
- Umbono ofiphele
- Ukuchama njalo
- Ubuhlungu bekhanda
Uma ubhekene nalezi zimpawu, kubaluleke kakhulu ukubona uchwepheshe wezempilo.
Yiziphi izivivinyo ezisetshenziswa ukuhlola amazinga e-Glucagon?
Uma ubonisa izimpawu ezithile, udokotela wakho angase akucele ukuba uhlolwe igazi ukuze kuhlolwe amazinga akho e-glucagon. Phakathi nale nqubo, udokotela noma umhlengikazi uzoqoqa isampula yegazi emthanjeni esebenzisa inaliti, bese ithunyelwa elabhorethri ukuze ihlaziywe.
Ayini amazinga ajwayelekile e-Glucagon?
Ngokuvamile, izinga elijwayelekile le-glucagon egazini lakho liphakathi kwama -picogram angu-50 no-100 nge-milliliter (pg/mL) . I-picogram iyi-trillionth eyodwa yegremu—inani elincane ngempela!
Khumbula ukuthi la mabanga okubhekisela angahluka kancane phakathi kwama-laboratory ahlukene. Ngaphezu kwalokho, imiphumela yakho ingathonywa ukuthi usuzilile isikhathi esingakanani kanye namazinga akho kashukela egazini ngesikhathi sokuhlolwa. Ngakho-ke, qhathanisa njalo imiphumela yakho namazinga okubhekisela anikezwe embikweni wakho we-laboratory othize . Uma unemibuzo, xoxa ngayo nodokotela wakho eNirogi Lanka.
Kufanele ubonane nini nodokotela mayelana namazinga akho e-Glucagon?
Uma unesifo sikashukela futhi uvame ukubhekana neziqephu zoshukela wegazi ophansi noma ophezulu, kubalulekile ukubonisana nodokotela wakho. Nakuba amazinga e-glucagon engahlolwa njalo kubo bonke abanesifo sikashukela, uhlelo lwakho lokuphatha isifo sikashukela lungadinga ukulungiswa ukuze kuncishiswe lokhu kushintshashintsha.
Nakuba ezinye izinkinga ezihlobene ne-glucagon zingavamile, uma ubhekene nezimpawu, ukuthola imbangela eyinhloko kubalulekile. Njalo beka phambili ukubhukha i-aphoyintimenti nomhlinzeki wakho wezempilo.
Uyini umehluko phakathi kweGlucagon neGlycogen?
Lezi ezimbili zihlukile. I-Glycogen uhlobo olugciniwe lwe-glucose (ushukela). Umzimba wethu ugcina i-glycogen esibindini nasemisipheni.
I-Glucagon iyi-hormone. Isebenza njenge-ejenti yokubonisa, itshela isibindi ukuthi siguqule i-glycogen egciniwe ibe yi-glucose, bese ikhishwa egazini ukuze inikeze umzimba wakho amandla.
Kwenzekani ku-Glucagon uma uzila ukudla?
Uma uzila ukudla, i-glucagon ibalulekile ekuvimbeleni ukuthi ushukela wegazi lakho wehle kakhulu, njengoba umzimba wakho ungatholi ushukela ekudleni.
Ngesikhathi sokuzila ukudla isikhathi eside, i-glucagon ivuselela ukukhiqizwa kwe-glucose emithonjeni engeyona i-carbohydrate, njenge-lipids, ama-amino acid, namaprotheni. Le nqubo ibizwa ngokuthi i-gluconeogenesis .
Umyalezo Wokugcina Wokuya Nasekhaya
Njengoba ubona, i-glucagon iyi-hormone ebalulekile esebenza ngasese ukugcina amazinga kashukela egazini enempilo. Uma ungenaso isifo sikashukela, izinkinga nge-glucagon azivamile.
Kodwa-ke, uma uvame ukuzwa izimpawu zoshukela wegazi ophansi noma ophezulu, sicela uxhumane nodokotela wakho. Bangakwazi ukubona imbangela eyinhloko bese bekunikeza ukwelashwa okudingekayo. Ukubeka impilo yakho phambili kuyisinyathelo esibaluleke kakhulu ongasithatha.
👩🏽⚕️ Imibuzo Evame Ukubuzwa (Imibuzo Evame Ukubuzwa)
💬 Ingabe i-glucagon iyimithi efana ne-insulin eyehlisa ushukela egazini?
Cha, kuphambene kakhulu! I-Glucagon iyi-hormone etholakala ngokwemvelo emzimbeni wakho esebenza njengomlingani we-insulin. Nakuba i-insulin yenzelwe ukwehlisa ushukela wegazi lakho, i-glucagon isebenza njengendlela yokutakula; lapho ushukela wegazi lakho wehla uye emazingeni aphansi kakhulu (hypoglycemia), i-glucagon itshela isibindi sakho ukuthi sikhiphe i-glucose egciniwe (glycogen) egazini lakho, okuholela amazinga akho emuva ezingeni eliphephile.
💬 Kungani i-glucagon igcinwa njengokwelashwa okuphuthumayo?
Uma umuntu onesifo sikashukela eba ne-hypoglycemia enkulu—okuholela ekudidekeni noma ekulahlekelweni yingqondo—akakwazi ukudla ushukela ngokuphephile, njengoba engase aminze. Kulezi zikhathi ezibucayi, umjovo we-glucagon (noma ipeni) ofakwa ethangeni noma engalweni yangaphandle ungakhuphula amazinga kashukela egazini ngemizuzu embalwa, kusize isiguli ukuthi siphinde siqonde. Uma lokhu kwenzeka, xhumana njalo nezinsizakalo eziphuthumayo (911) ngokushesha ngemva kokuthatha umuthi.
💬 Kulula yini ukufaka umjovo we-glucagon ekhaya?
Yebo. Njenge-EpiPen esetshenziselwa ukungezwani komzimba okukhulu, lawa makhithi ezimo eziphuthumayo enzelwe amalungu omndeni noma abanakekeli ukuthi bawasebenzise kalula ekhaya. Ezinye izifunda zinikeza nama-spray ekhaleni (njenge-Baqsimi). Uma othile ekhaya lakho esebenzisa i-insulin, ukugcina ikhithi yezimo eziphuthumayo ye-glucagon itholakala kalula kuyindlela ebalulekile yokuphepha engasindisa impilo. Njalo xhumana nomhlinzeki wakho wezempilo waseNirogi Lanka mayelana nokusetshenziswa okufanele.
Amagama angukhiye: i-glucagon, ushukela egazini, i-hypoglycemia, i-hyperglycemia, isifo sikashukela, i-pancreas, i-hormone
