Ingabe kufanele sifunde ngama-H2 Blockers ngesifo sakho sokushisa kwenhliziyo kanye ne-gastritis?

Ingabe ngezinye izikhathi uzizwa ukwanda kwe-asidi esiswini, isilungulela, noma ukungakhululeki esiswini ngemva kokudla? Noma unesifo esifana ne-gastritis? Kungenzeka ukuthi uke wezwa ngohlobo lomuthi olubizwa ngokuthi ama-H2 blockers. Namuhla, ake sixoxe ngokuthi ayini lawa ma-H2 blockers, ukuthi asebenza kanjani, nokuthi asetshenziswa ngaphansi kwaziphi izimo.

Ayini ama-H2 blockers (abaphikisi be-H2)?

Kalula nje, ama-H2 blockers awuhlobo lomuthi onciphisa inani le-asidi ekhiqizwa esiswini sakho. Manje ungase uzibuze ukuthi i-asidi yesisu yenzelwe ini. I-asidi yesisu ibalulekile ekugayeni ukudla esikudlayo. Kodwa-ke, izinkinga ziqala lapho le-asidi iba yiningi kakhulu. Ngemuva kwalokho izicubu ezithambile zesimiso sethu sokugaya ukudla (i-GI - indlela yokugaya ukudla) zingalimala. Yingakho kuvela izimpawu ezifana nobuhlungu besisu kanye nesilungulela. Ngezinye izikhathi, ukudla ukudla okunongwe kungaba nzima kangangokuthi ungase ucabange, "O, kungani ngidle lokho?"

Ngakho-ke, uma ungumuntu onezimpawu ezibangelwa ukwanda kwe-asidi yesisu, ungase uthande ukucabanga ngokusebenzisa i-H2 blocker.

Yiziphi izimo eziphathwa ngama-H2 blockers?

Ama-H2 blocker asetshenziswa kakhulu ukwelapha izimo ezihlobene nokukhiqizwa kwe-asidi eningi esiswini. Kodwa into eyodwa okufanele uyikhumbule: Ngokuqhubeka nokusebenzisa le mithi, ukusebenza kwayo kungase kwehle kancane kancane ngokuhamba kwesikhathi.

Uma unesifo esingamahlalakhona, sesikhathi eside esihilela i-asidi yesisu eningi, ungase uthande ukucabangela uhlobo lomuthi olubizwa ngokuthi i-proton pump inhibitor (PPI) . Nakuba ama-PPI engasebenzi ngokushesha njengama-H2 blockers, anciphisa nokukhiqizwa kwe-asidi yesisu futhi angasetshenziswa isikhathi eside kunama-H2 blockers. Ama-PPI awuhlobo lomuthi onamandla kakhulu ekulawuleni i-asidi kunama-H2 blockers.

Ake sibheke ezinye zezimo eziyinhloko eziphathwa ngama-H2 blockers:

Izilonda zesisu kanye nezilonda ze-duodenal

Uma i-asidi yesisu iba phezulu kakhulu, ingalimaza ulwelwesi lwesisu futhi ibangele izilonda. Ama-H2 blocker anciphisa ukukhiqizwa kwe-asidi yesisu, anikeze lezi zilonda isikhathi sokuphola.

Futhi, i-asidi yesisu ngezinye izikhathi ingahamba iye engxenyeni yokuqala yamathumbu ethu amancane (i-duodenum) futhi ibangele izilonda lapho. Lezi sizibiza ngokuthi izilonda ze-duodenal . Nakuba ama-PPI empeleni eyindlela yokwelapha ephumelela kakhulu kulokhu, ama-H2 blockers nawo angayiphatha le nkinga. I-US Food and Drug Administration (FDA) ivumile ama-H2 blockers okwelashwa kwesikhashana ukuze kuvinjelwe ukwakheka kwezilonda ezintsha. Udokotela wakho angakhuluma nawe mayelana nokwelashwa okufanele kanye nohlelo lokunakekelwa kwakho.

I-reflux ye-asidi kanye ne-GERD

Lena inkinga abantu abaningi abanayo. I-acid refluxKusho ukuthi i-asidi esiswini iyabuya phezulu, okungukuthi, iyakhuphuka, bese ingena emphinjeni nge-esophagus (ipayipi lokudla). Yilokhu okubangela isilungulela. Uma lesi simo siqhubeka, ukuvuvukala kwe-esophagus (esophagitis) nakho kungavela. I-H2 blocker inganikeza impumuzo ekuvuseleleni kwe-asidi ngezikhathi ezithile. Kodwa uma unesifo se-asidi yesikhathi eside, okungukuthi, i-GERD (Gastroesophageal Reflux Disease) , kungcono ukusebenzisa i-PPI.

I-Zollinger-Ellison syndrome

Lesi yisimo esingavamile kakhulu. Kwenzeka lapho izimila ezithile emizimbeni yethu zibangela ukuthi izisu zethu zikhiqize i-asidi eningi kakhulu. Ama-H2 blocker angasiza ngokuvimbela ukukhiqizwa kwe-asidi yesisu. Kodwa-ke, kulesi simo, udokotela wakho cishe uzokunikeza i-PPI.

Izimpawu ziyancipha ngama-H2 blockers

Le mithi inganikeza impumuzo kulezi zimpawu ezilandelayo:

• Ukuqunjelwa, ukungagayi kahle kokudla
• Ubuhlungu besisu
• Isilungulela kanye ne-reflux
• Isicanucanu nokuhlanza
• Isisu esimuncu, ukunambitheka okumuncu emphinjeni

Ama-blocker e-H2 asebenza kanjani?

Elinye igama lama-H2 blockers yi -histamine-2 (H2) antagonists . Leli gama lisinika umbono omncane wokuthi le mithi isebenza kanjani. Kungenzeka ukuthi uke wafunda ngendima 'yomphikisi' ekilasini lesiNgisi ngesikhathi usesikoleni. Emshweni, umphikisi uyinto ebangela ukuvinjelwa. Ngendlela efanayo, abaphikisi be-H2 bavimba ukukhiqizwa kwe-asidi yesisu.

Cabanga ngale ndlela. Ngemva kokudla, umzimba wakho ukhipha ikhemikhali ebizwa ngokuthi i-H2. Le H2 iyahamba inamathele ezindaweni ezithile (ama-H2 receptors) emaseli asezindongeni zesisu sakho. Lokhu kuhlanganiswa yikona okubangela ukuthi isisu sakho sikhiphe i-asidi.

Uma uthatha i-H2 antagonist, noma i-H2 blocker, umuthi uya kulawo ma-H2 receptors ngaphambi kokuba i-H2 ikwazi ukubopha kuwo. Kalula nje, ama-H2 blockers "avimba" i-H2 ekubopheni kulawo ma-receptor. Lokhu kunciphisa ukukhiqizwa kwe-asidi esiswini.

Lokhu ngeke kuphazamise inqubo yakho yokugaya ukudla. Kodwa kuzonciphisa inani le-asidi eyengeziwe ebangela lezo zimpawu ezibuhlungu. Uyaqonda?

Yiziphi izinhlobo zama-H2 blockers? (Imithi iyatholakala emakethe)

Kunezinhlobo eziningana zama-H2 blockers. Amanye ungawathenga ngaphandle kwemithi kadokotela (OTC) ekhemisi ngaphandle kwemithi kadokotela (Rx). Amanye adinga imithi kadokotela evela kudokotela. Lokhu kuyahlukahluka kuye ngohlobo lomuthi kanye nomthamo.

Izinhlobo zama-blocker e-H2 atholakalayo njengamanje yilezi:

• I-Cimetidine ( igama lomkhiqizo, isibonelo, i-Tagamet®) - Lokhu kuyatholakala kokubili i-OTC kanye ne-Rx.
• I-Famotidine(Igama lomkhiqizo, isibonelo, i-Pepcid®) - Lokhu kuyatholakala kokubili i-OTC kanye ne-Rx.
• I-Nizatidine (igama lomkhiqizo, isibonelo, i-Axid®) - Lokhu kungatholakala kuphela nge-Rx.

Kungenzeka ukuthi uke wezwa ngeRanitidine ( eyaziwa ngegama lomkhiqizo iZantac®). Kwakuyi-H2 blocker yokuqala eyavunywa yi-FDA ngo-1983. Kodwa-ke, ngo-Ephreli 2020, i-FDA yayala abakhiqizi ukuthi basuse iRanitidine emakethe. Isizathu salokhu ukuthi ukuhlolwa kwe-FDA kwathola ukuthi lapho iRanitidine igcinwa isikhathi eside, amazinga e-carcinogen engaba khona (i-nitrosodimethylamine, noma i-NDMA) akhuphuka afinyelela emazingeni angaphephile. Abacwaningi bathole nokuthi amazinga e-NDMA akhuphuka lapho iRanitidine igcinwa emazingeni okushisa aphezulu.

Ungayisebenzisa kanjani le mithi?

Ama-H2 blocker amaningi eza ngesimo samaphilisi noma ama-capsule owaphuza ngomlomo. Ngezinye izikhathi afika ngesimo sempuphu ongayixuba noketshezi bese uyiphuza kubantu abanenkinga yokugwinya amaphilisi.

Amanye ama-H2 blocker nawo anganikezwa ngemithambo yegazi (IV) , ikakhulukazi uma usesibhedlela futhi ungakwazi ukuthatha imithi ngomlomo.

Yisiphi isikhathi esingcono kakhulu sokuthatha i-H2 blocker?

Uma wazi ukuthi uzodla into ongayithandi, njengokudla okubabayo, kungumqondo omuhle ukuthatha i-H2 blocker cishe imizuzu engama-30 kuya kwengama-60 ngaphambi kokuba uyidle. Ngaleyo ndlela, umuthi unesikhathi sokuqala ukusebenza. Kulungile ukuwuthatha ngemva kokuqeda ukudla, kodwa kungathatha isikhathi esingafika ehoreni ukuthi izimpawu zakho ziphele.

Njengokwelashwa kwesikhashana kwesimo esifana nesilonda esiswini, udokotela wakho angakutshela ukuthi uthathe lo muthi kanje:

• Kanye ngosuku, ngaphambi kokulala ebusuku.
• Noma kanye ekuseni kanye kanye ebusuku.

Into ebaluleke kakhulu ukuthi uma udinga ukusebenzisa i-H2 blocker isikhathi esingaphezu kwamasonto amabili ukulawula izimpawu zakho, kufanele nakanjani ubone udokotela. Akuyona into enhle ukuthembela kuma-H2 blocker isikhathi eside ngaphandle kokukhuluma nodokotela.

Kuthatha isikhathi esingakanani ukuthi ama-H2 blockers asebenze? Ihluke kanjani kweminye imithi?

Ngokuvamile kuthatha cishe ihora ukuzwa impumuzo ezimpawini ngemva kokuthatha i-H2 blocker. Imiphumela ivame ukuhlala emahoreni amane kuya kwayishumi . Lesi senzo esisheshayo senza kube ukukhetha okuhle uma udinga impumuzo ngokushesha noma uma unesilungulela ngezikhathi ezithile.

Uma udinga usizo olusheshayo, ungazama umuthi oqeda i-asidi . Ama-antacid aqeda i-asidi esiswini sakho. Azoqala ukusebenza ngokushesha kune-H2 blocker, kodwa imiphumela yawo ngeke ihlale isikhathi eside njenge-H2 blocker.

Uma izimpawu zakho zihlala isikhathi eside, ikakhulukazi uma i-H2 blocker ingakuniki impumuzo eyanele, kungadingeka ukuthi uthathe i-PPI. I-PPI ingathatha usuku olulodwa kuya kwezine ukuze isebenze ngokugcwele, kodwa ihlala isikhathi eside kakhulu kune-H2 blocker.

Ingabe ama-H2 blockers anemiphumela emibi?

Ama-H2 blocker anikeza impumuzo ngengozi ephansi yemiphumela emibi. Kodwa-ke, njenganoma yimuphi umuthi, imiphumela emibi emincane ingaba khona.

Imiphumela emibi evamile

• Ubuhlungu besisu
• Ubuhlungu bemisipha
• Ukuqunjelwa
• Uhudo (ukuqunjelwa)
• Umlomo owomile
• Ukukhathala
• Ikhanda elibuhlungu

Izinto okufanele uzinake ngokukhethekile

Nakuba kungavamile kakhulu, ama-H2 blocker angabangela izimpawu zezinzwa (isib. ukudideka, ukukhuluma okungaqondakali) kwamanye amaqembu asengozini enkulu. Kungenzeka kakhulu ukuthi ube nalezi zimpawu uma uneminyaka engaphezu kwengu-50 futhi ungasebenzi kahle kwezinso noma isibindi . Kodwa-ke, lezi zimpawu zivame ukuphela zingakapheli izinsuku ezimbalwa ngemva kokuyeka imithi.

Ingabe kungaba nezinkinga ngeminye imithi?

Amanye ama-H2 blocker (isibonelo, i-cimetidine) angavimbela eminye imithi oyithathayo ukuthi isebenze kahle. Isibonelo, i-cimetidine inganciphisa ukusebenza kahle kwamanye ama-SSRI (uhlobo lomuthi osetshenziselwa ukwelapha izifo zengqondo njengokucindezeleka) kanye ne-warfarin (umuthi ovimbela ukuqhekeka kwegazi).

Ngakho-ke, ngaphambi kokuqala umuthi omusha, kubaluleke kakhulu ukukhuluma nodokotela wakho ukuze uthole ukuthi kukhona yini ukuhlangana okungekuhle nemithi osuvele uyithatha.

Ingabe kuphephile ukusebenzisa ama-H2 blockers ngesikhathi sokukhulelwa nokuncelisa?

Kudingeka ucwaningo olwengeziwe ukuze kutholakale ukuphepha kokusebenzisa ama-H2 blockers ngesikhathi sokukhulelwa, kodwa abacwaningi bayazi ukuthi umuthi udlulela obisini lwebele .

Uma uthatha i-H2 blocker futhi ukhulelwe, qiniseka ukuthi ukhuluma nodokotela wakho. Mbuze ukuthi kuphephile yini ukuthatha lo muthi ngesikhathi sokukhulelwa noma ngenkathi uncelisa.

Kunini lapho udinga ukubonana nodokotela?

Njengoba sishilo ekuqaleni, uma kufanele usebenzise ama-H2 blockers isikhathi esingaphezu kwamasonto amabili ukulawula izimpawu zakho, kufanele nakanjani ubone udokotela. Kubalulekile ukuthola ukuthi yini ngempela ebangela izimpawu zakho. Ungadinga ikhambi lesikhathi eside, njenge-PPI.

Futhi, tshela udokotela wakho uma unezinkinga ngemithi noma uqaphela noma yimiphi imiphumela emibi. Kungase kudingeke ukuthi umthamo wakho ushintshwe noma kungadingeka ukuthi ushintshele komunye umuthi.

Iyiphi i-H2 blocker ephephile? Yikuphi okungcono kakhulu kwe-GERD?

Ama-blocker e-H2 avunyelwe yi-FDA afana kakhulu ngokuphepha kwawo kanye nokusebenza kwawo kahle.

Kodwa-ke, uma uthatha eminye imithi futhi ucabanga ukusebenzisa i-H2 blocker, kungcono ukukhuluma nodokotela wakho. Kubalulekile ukukhetha umuthi ongeke uphazamise ukusebenza kahle kwemithi osuvele uyisebenzisa.

Ku-GERD, noma yimuphi umshini wokuvimba i-H2 ungasiza ekunciphiseni izimpawu ze-acid reflux. Kodwa-ke, uma i-acid reflux yakho ingamahlalakhona (njengaku-GERD), kungcono ukweqa ngokuphelele ama-H2 blockers bese ukhetha i-PPI. Khuluma nodokotela wakho ngalokhu futhi.

Okokugcina, izinto okufanele uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, ngakho-ke sikhulume kakhulu ngama-H2 blockers namuhla, akunjalo?

Ama-H2 blockers, ama-antacid, nama-PPI konke kusetshenziselwa ukwelapha izimo ezibangelwa yi-asidi eningi esiswini. Ngezinye izikhathi, ngezinketho eziningi kangaka, kungaba ukudideka ukwazi ukuthi iyiphi okufanele uyikhethe.

Cabanga ngalokhu ngale ndlela: Uma ufuna impumuzo yesikhashana ehlala amahora ambalwa, ama-H2 blockers angaba yindlela engcono kakhulu kuwe. Ikakhulukazi uma wazi ukuthi kungenzeka ukuthi uhlaselwe yisisu ngemuva kokudla okuthile okubabayo, kuwumqondo omuhle ukuthatha i-H2 blocker kusengaphambili.

Khumbula, uma uneminye imibuzo mayelana nalomuthi, ungesabi ukubuza udokotela wakho. Kubaluleke kakhulu ukwaziswa ngempilo yakho!

Ama - H2 blocker, i-gastritis, ukuvuvukala kwesisu, i-asidi yesisu, ukuvuvukala kwesifuba, izilonda zesisu, izihloko zezokwelapha zesiSinhala