Umzimba wethu ufana nefektri eyinkimbinkimbi nemangalisayo. Kuneqembu lezithunywa ezishintshana ngolwazi phakathi kwezingxenye ezahlukene zale fektri futhi zisebenza ngokubambisana. Kalula nje, lezi zithunywa yilokho esikubiza ngokuthi ama-hormone . Umzimba wethu awukwazi ukusebenza ngaphandle kwama-hormone. Kodwa-ke, ngezinye izikhathi la ma-hormone afanayo ondla amanye amangqamuzana omdlavuza, awasize akhule futhi asakazeke. Yilapho ukwelashwa kwama-hormone kuba yinto ebalulekile kithi.
Ngakho-ke kuyini lokhu kwelashwa kwama-hormone?
Kalula nje, ukwelashwa ngama-hormone kuvimbela amangqamuzana omdlavuza ekutholeni ama-hormone awadingayo ukuze akhule. Lapho amangqamuzana omdlavuza encishwa la ma-hormone, alahlekelwa amandla awo okukhula, ukwahlukana, nokusabalala.
Odokotela ngezinye izikhathi basebenzisa lokhu kwelashwa bodwa. Bakusebenzisa futhi kanye nezinye izindlela zokwelapha, njengokuhlinzwa, i-chemotherapy, noma ukwelashwa ngemisebe. Ngezinye izikhathi, ngemva kokuba zonke izindlela zokwelapha eziyinhloko seziqediwe, ukwelashwa ngama-hormone nakho kunikezwa ukunciphisa ingozi yokubuya komdlavuza.
Lokhu kwelashwa kusebenza kanjani?
Kunezindlela ezintathu eziyinhloko lokhu kwelashwa okusebenza ngazo:
1. Ukuvimba ukukhiqizwa kwama-hormone: Kunikezwa imithi yokuvimbela imizimba yethu ekukhiqizeni ama-hormone adingwa amangqamuzana omdlavuza. Kwezinye izimo, izindlala ezikhiqiza lawo ma-hormone (isibonelo, amasende emadodeni) nazo zingasuswa ngokuhlinzwa.
2. Ukuvimba ukusebenza kwama-hormone: Lokhu kuhilela ukuvimba indlela ama-hormone afinyelela futhi anamathele ngayo kumaseli omdlavuza. Uma ama-hormone engakwazi ukufinyelela futhi anamathele esitokisini, iseli alitholi umyalezo wokukhula.
3. Ukufakwa esikhundleni kwama-hormone okwenziwa: Ngezinye izikhathi, ama-hormone afanayo enziwe elebhu anikezwa umzimba. Nakuba la ma-hormone okwenziwa ebukeka njengama-hormone emvelo, amangqamuzana omdlavuza awakwazi ukuwasebenzisa ukuze akhule. Ngakho-ke lapho lawa ethatha indawo yama-hormone emvelo, ukukhula kwamangqamuzana omdlavuza kuyayeka.
Yiziphi izinhlobo zomdlavuza ezisetshenziselwa ukwelashwa ngama-hormone?
Akuwona wonke umdlavuza olashwa ngama-hormone. Lokhu kwelashwa kusetshenziselwa kakhulu umdlavuza oncike kuma-hormone, okusho ukuthi badinga ama-hormone ukuze bakhule.
| Uhlobo lomdlavuza | Incazelo |
|---|---|
| Umdlavuza Wendlala Yesitho Sangasese | Isetshenziselwa ukulawula ukukhula kwamaseli omdlavuza ancike kuma-hormone wesilisa (ama-androgens). |
| Umdlavuza Webele | Isetshenziselwa ukulawula amaseli omdlavuza azwela i-estrogen (ER-positive). |
| Umdlavuza Wesibeletho | Isetshenziselwa ezinye izinhlobo ezingavamile zomdlavuza wesibeletho. |
| Umdlavuza Wesibeletho | Isetshenziselwa ukulawula ukukhula komdlavuza uma ususakazeke noma uphinda uvela. |
Ukwelashwa ngama-hormone omdlavuza we-prostate
Amaseli omdlavuza we-prostate avame ukukhuthazwa ama-hormone wesilisa (ama-androgen) njenge-testosterone. Ngakho-ke umgomo wokwelashwa ukunciphisa amazinga ala ma-hormone noma ukuwavimbela ukuthi angasebenzi. Ngezinye izikhathi, ukususwa kokuhlinzwa kwe-testicle eyodwa noma zombili (i-orchiectomy) kuyenziwa.
Imithi esetshenziswa kakhulu:
- I-Abiraterone acetate: Lo muthi uvimba ukukhiqizwa kwama-hormone wesilisa emangqamuzaneni omdlavuza wendlala.
- Ama-agonist e-LHRH: Le mithi itshela i-pituitary gland ebuchosheni bethu ukuthi iyeke ukukhiqiza enye i-hormone (i-luteinizing hormone) esiza ukukhiqiza i-testosterone.
- Ama-antiandrogens: Lawa avimbela ngqo i-hormone testosterone ekubopheni amangqamuzana omdlavuza.
Okubalulekile: Imiphumela emibi yalokhu kwelashwa iyahlukahluka kumuntu nomuntu. Xoxa ngalokhu ngokukhululekile nodokotela wakho.
Imiphumela emibi evame ukubonwa:
- Ukwanda kwesisindo.
- Ukuncipha noma ukuphelelwa yisifiso socansi.
- Ukungasebenzi kahle kwe-Erectile.
- Ukwehla kobuningi bamathambo (i-Osteoporosis).
Ukwelashwa ngama-hormone omdlavuza webele
Cishe u-80% womdlavuza webele uzwela kuma-hormone. Lokhu kusho ukuthi amangqamuzana omdlavuza asabela ku-estrogen yehomoni yabesifazane. Lawa abizwa ngokuthi umdlavuza we-ER-positive . Ngakho-ke umgomo wokwelashwa ukunciphisa izinga le-estrogen emzimbeni noma ukuvimbela i-estrogen ekubopheni amangqamuzana omdlavuza.
Lokhu kwelashwa kuvame ukunikezwa ngemva kokuhlinzwa ukuze kuncishiswe ingozi yokubuya komdlavuza. Kodwa-ke, kusetshenziswa nangaphambi kokuhlinzwa ukunciphisa isimila noma ukwelapha umdlavuza osusakazekele kwezinye izingxenye zomzimba.
| Uhlobo lwesidakamizwa | Ukusebenza kahle |
|---|---|
| Ama-Inhibitors e-Aromatase | Ivimba i-enzyme (i-Aromatase) ekhiqiza i-estrogen emzimbeni, yehlisa amazinga e-estrogen (avame ukunikezwa abesifazane ngemva kokunqamuka kokuya esikhathini). |
| Ama-Selective Estrogen Receptor Modulators (ama-SERM) | I-hormone i-estrogen ivimbela amangqamuzana omdlavuza webele ukuthi anganamatheli kuyo. |
| Ama-Downregulators e-Estrogen Receptor (ama-ERD) | Lezi zivimba ama-receptor e-estrogen futhi zinciphise inani lawo. |
Imiphumela emibi evame ukubonwa:
- Ubuhlungu bomzimba, noma ukuqina kwamalunga.
- Ngikhathele.
- Isicanucanu nokuhlanza.
- Ukwanda kwesisindo.
- Ukuncipha kwesifiso sobulili.
- Ukuzwa ukushisa okweqile emzimbeni (ukushisa okukhulu).
- Ubuhlungu bebele noma ukuvuvukala.
Kunikezwa kanjani lokhu kwelashwa? Yiziphi izinzuzo nezingozi?
Ukwelashwa ngama-hormone kuvame ukunikezwa njengephilisi oliphuza nsuku zonke. Eminye imithi iyatholakala futhi njengomjovo owuthatha ngezikhathi ezithile. Lokhu kunqunywa udokotela wakho.
Inzuzo enkulu ukuthi, uma ihlanganiswa nezinye izindlela zokwelapha, inganciphisa noma imise ngokuphelele ukukhula kwamangqamuzana omdlavuza.
IngoziLezi yimiphumela emibi. Kodwa khumbula, akuwona wonke umuntu oyithola yonke. Kukhona nezindlela zokuphatha le miphumela emibi. Kubalulekile ukutshela udokotela wakho nganoma yikuphi ukungakhululeki okutholayo. Imiphumela emibi ingahluka kuye ngesimo sakho sempilo kanye nokwelashwa okutholayo.
Umlayezo Wokuya Nawe Ekhaya
- Ukwelashwa ngama-hormone kuyindlela yokwelapha enciphisa ukutholakala kwama-hormone adingekayo ukuze akhule ngamaseli omdlavuza.
- Lokhu kwelashwa kusetshenziselwa umdlavuza oxhomeke kuma-hormone njengomdlavuza we-prostate, webele, we-ovarian, kanye nowesibeletho.
- Izindlela zokwelapha, imithi, kanye nemiphumela emibi kuyahlukahluka kumuntu nomuntu futhi kuye ngohlobo lomdlavuza.
- Lokhu kwelashwa kungase kubangele imiphumela emibi, kodwa ungathola usizo lokuyilawula.
- Kubaluleke kakhulu ukukhuluma ngokukhululekile nangokucacile nodokotela wakho mayelana nokuthi iyiphi indlela yokwelapha engcono kakhulu kuwe nokuthi yiziphi izinzuzo nezinkinga zayo.
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