Wake wazibuza ukuthi uzizwa kanjani uma usuthi? Uma sidla, ngemva kwesikhashana sizizwa "Kulungile, sekwanele." Yini edala lo muzwa? Pho kungani abanye abantu bengazizwa besuthi kungakhathaliseki ukuthi badla malini? I-Leptin ingumdlali obalulekile ngemuva kwakho konke lokhu. Lena i-hormone ebaluleke kakhulu ekulawuleni isisindo somzimba wethu. Ake sixoxe ngayo kalula nangokunembile namuhla.
Kalula nje, iyini i-Leptin?
Kalula nje, i-leptin iyi-hormone ekhiqizwa amaseli amafutha omzimba wakho (izicubu zamafutha). Yaziwa nangokuthi "i-hormone yokugcwala." Umsebenzi wayo oyinhloko ukuthumela isignali ebuchosheni bakho ethi, "Kulungile, usunamandla anele, yeka ukudla." Lena yindlela i-leptin esiza ngayo ukugcina isisindo somzimba esizinzile esikhathini eside.
Ososayensi bathole i-hormone ye-leptin ngo-1994, okusho ukuthi kusenocwaningo oluningi olwenziwayo ngayo. Ukuxhumana kwe-Leptin hhayi nje kuphela nokulawula isisindo, kodwa futhi nezifo ezifana nesifo i-Alzheimer's, impilo yokuzala, kanye nokungabi nabantwana kusaphenywa okwamanje.
Uma uzwa igama elithi "ukulawula isisindo," ungase ucabange, "O... ukuze sikwazi ukulawula i-leptin futhi sehlise isisindo." Kodwa iqiniso liwukuthi, ukulawula le hormone ngendlela esiyifunayo akulula njengoba sicabanga.
I-leptin isebenza kanjani emizimbeni yethu?
Umsebenzi oyinhloko we-Leptin ukusiza ukugcina isisindo somzimba wethu siphilile. Okusho ukuthi, ukudala ibhalansi yesikhathi eside phakathi kwenani lokudla esikudlayo namandla umzimba wethu owasebenzisayo. I-Leptin iyasivimbela ekuzizweni silambile ngokungadingekile. Iyasiza ekuvimbeleni umzimba ekuboniseni indlala lapho ungadingi amandla (amakhalori).
I-Leptin isebenza kakhulu ngokuthinta ingxenye yobuchopho bethu ebizwa ngokuthi i-hypothalamus. Kodwa-ke, kunezitho zokwamukela ezisabela ku-leptin kwezinye izingxenye zomzimba.
Okubaluleke kakhulu, i-leptin ayilawuli indlala yethu kusukela ekudleni okukodwa kuya kokulandelayo. Kunalokho, isebenza ukulawula ukudla okudlayo kanye nokusetshenziswa kwamandla isikhathi eside, igcina isisindo somzimba sizinzile.
Cabanga ukuthi uzama ukwehlisa isisindo. Njengoba amafutha omzimba wakho ehla, amazinga akho e-leptin nawo ayancipha. Lokhu kuthumela isignali ebuchosheni bakho ukuthi ulambile. Lokhu kukwenza uzizwe ulambile kakhulu futhi unezifiso. Lokhu kungaholela ekutheni udle kakhulu ngaphandle kokuqaphela. Lesi ngesinye sezizathu ezenza kube nzima kangaka ukwehlisa isisindo.
Amazinga e-leptin alawulwa kanjani?
I-Leptin ikhiqizwa futhi ikhishwe egazini yizicubu ezimhlophe zamafutha emizimbeni yethu. Ngakho-ke, inani le-leptin egazini lakho lihlobene ngqo nenani lamafutha emzimbeni wakho.
- Uma unamafutha amaningi emzimbeni:Amazinga e-Leptin aphezulu.
- Uma amafutha omzimba ephansi: amazinga e-leptin aphansi.
Ngokuhamba kwesikhathi, uma amafutha omzimba wakho enyuka, amazinga e-leptin ayanda, futhi uma amafutha omzimba wakho ehla, amazinga e-leptin ayancipha.
Kwenzekani uma amazinga e-leptin ephakama kakhulu? - Ukumelana ne-Leptin
Umuntu okhuluphele unamafutha amaningi emzimbeni wakhe. Ngenxa yalokho, amazinga akhe e-leptin egazini nawo aphezulu kakhulu. Lesi simo sibizwa ngokuthi i-hyperleptinemia .
Manje ungase ucabange, "Uma i-leptin iphezulu, kufanele uzizwe usuthi, ngakho-ke kufanele ulawule ukudla kwakho?" Kodwa okuphambene nalokho kuyiqiniso. Lapho amazinga e-leptin emzimbeni ephakeme isikhathi eside, ubuchopho buqala ukungasabeli kulowo mbonakaliso we-leptin. Kufana nomuntu ohlala esimemeza futhi siba yizithutha ngemva kwesikhashana. Lokhu kubizwa ngokuthi ukumelana ne-leptin .
Kalula nje, ukumelana ne-leptin kusho ukuthi noma ngabe kune-leptin eyanele emzimbeni, ubuchopho abutholi isignali "egcwele".
Kwenzekani ngenxa yalokhu?
1. Ukungazizwa usuthi: Ngisho noma unamafutha anele emzimbeni wakho, ubuchopho bakho bucabanga ukuthi usalambile. Ngakho-ke uyaqhubeka nokudla.
2. Umzimba ungena "emodini yendlala": Ngenxa yokuthi ubuchopho abutholi isignali ye-leptin, ubuchopho bucabanga ukuthi umzimba awunawo amandla anele nokuthi siyalamba. Ngakho-ke, ukuze kulondolozwe amandla, izinga lomzimba eliyisisekelo (i-BMR) liyancipha. Lokhu kusho ukuthi inani lamakhalori owashisa ngenkathi uhleli nje liyancipha.
Ngale ndlela, ukumelana ne-leptin, ngakolunye uhlangothi, kwandisa indlala futhi kwandisa inani lokudla okudliwayo, kanti ngakolunye uhlangothi, izinga lokushisa komzimba amakhalori liyancipha. Uma lezi zinto ezimbili zihlangana, umphumela uba ukwanda kwesisindo.
| Izici Eziyinhloko Zokumelana Ne-Leptin |
|---|
| Ukuzizwa ulambile kakhulu njalo (hyperphagia) naphezu kokuba namafutha amancane emzimbeni noma ungenawo nhlobo. |
| Ubunzima bokulawula ukudla okudlayo kanye nokudla okwandisiwe. |
Lezi zimpawu zingabangelwa ezinye izici, ngakho-ke uma ubhekene nalezi zimpawu, kungcono ukukhuluma nodokotela wakho.
Kwenzekani uma amazinga e-leptin ehla?
Ukuntuleka kwe-Leptin kuyisimo esingavamile kakhulu . Ngokuvamile kwenzeka ngesimo sofuzo esibizwa ngokuthi ukuntuleka kwe-leptin kokuzalwa . Umuntu onalesi simo unesifo lapho amaseli akhe amafutha engakwazi ukukhiqiza i-leptin.
Uma i-leptin ingekho, umzimba ucabanga ukuthi awekho amafutha emzimbeni. Lokhu kubonisa ukuthi ubuchopho buyalamba futhi abukwazi ukuwalawula. Ngenxa yalokho, izingane ezincane ezinalesi simo ziba nesifiso sokudla esingalawuleki. Ngenxa yalokho, ziba nokukhuluphala kakhulu (ukukhuluphala kwesigaba sesi-3) zisencane kakhulu futhi zibhekana nokuthomba okulibazisekile.
| Izimo ezingase zihlotshaniswe namazinga aphezulu e-leptin (i-Hyperleptinemia) | Izimo ezingase zihlotshaniswe namazinga aphansi e-leptin (i-Hypoleptinemia) |
|---|---|
| Ukucindezeleka | Amazinga aphezulu e-insulin (i-Hyperiinsulinemia) |
| Umlutha wokudla | Ukungalingani kwamafutha egazini (i-Dyslipidemia), isibonelo, i-cholesterol, ama-triglycerides |
| Isifo sesibindi esinamafutha esingadakwanga | Isifo sesibindi esinamafutha |
| Izinkinga ze-Neurodegenerative | Ukutheleleka njalo kwamagciwane |
Ingabe amazinga e-leptin angalinganiswa egazini?
Yebo, ukuhlolwa kwegazi okulula kungalinganisa amazinga e-leptin. Kodwa-ke, lokhu akusikho ukuhlolwa odokotela abavame ukukuyalela. Kwenziwa kuphela ezimweni ezikhethekile. Isibonelo:
- Uma ingane encane kakhulu ikhuluphele kakhulu.
- Uma umuntu okhuluphele eqhubeka nokulamba okungalawuleki.
Ngokuvamile, amazinga e-leptin anempilo angahluka kusuka ku:
- Abesifazane: 0.5 - 15.2 ng/mL (ama-nanogram ngemililitha ngayinye)
- Owesilisa: 0.5 - 12.5 ng/mL
Lezi zindinganiso zingahluka kancane kusukela elabhorethri kuya kwelebhu, ngakho-ke uma unokungabaza ngezindinganiso ezisembikweni wakho, buza udokotela wakho.
Siwalungisa kanjani amazinga e-leptin?
Ayikho indlela yokwandisa amazinga e-leptin ngokwenziwa ukuze unciphise indlala, ngoba amazinga e-leptin ahlobene ngqo nenani lamafutha emzimbeni wakho.
Kodwa-ke, kunezinto eziningana ezingasiza ekusebenzeni kwe-leptin kanye nokulinganisela kwama-hormone:
1. Lala ngokwanele: Ucwaningo olulodwa luthole ukuthi ukungakwazi ukulala kwandisa i-hormone yendlala i-ghrelin futhi kunciphisa i-hormone yokusutha i-leptin. Ngakho-ke, ukulala ngokwanele nsuku zonke kubaluleke kakhulu ekulinganiseni kwama-hormone.
2. Yidla ukudla okunempilo: Ezinye izifundo zisikisela ukuthi amazinga aphezulu e-triglycerides, uhlobo lwamafutha egazini, angaphazamisa i-leptin efinyelela ebuchosheni. Nakuba kusenemibono ehlukene ngalokhu, kungcono njalo ukudla ukudla okulinganiselayo okuhlanganisa imifino, izithelo, i-fiber, amaprotheni amahle, namafutha anempilo, kuyilapho unciphisa ushukela, ufulawa, nokudla okucutshunguliwe .
3. Vivinya umzimba njalo: Ucwaningo luye lwabonisa ukuthi ukuzivocavoca kungasiza ekunciphiseni ukumelana ne-leptin. Okusho ukuthi, ukuzivocavoca kungathuthukisa ukuzwela kwe-leptin ebuchosheni.
Into ebalulekile ukuthi, i-leptin ayiyona into etholakala ekudleni. Iyi-hormone ekhiqizwa yimizimba yethu. Ngakho-ke ayikho into efana "nokudla i-leptin eningi kakhulu."
Uma ukhathazekile ngesisindo sakho, noma udinga isiqondiso sendlela yokwehlisa isisindo ngendlela enempilo, kungcono ukukhuluma nodokotela wakho. Uma kudingeka, angakudlulisela kudokotela we-endocrinologist.
Umlayezo Wokuya Nawe Ekhaya
- I-Leptin iyi-hormone "yokugcwala" ekhiqizwa amaseli amafutha emizimbeni yethu. Itshela ubuchopho ukuthi sesidle ukudla okwanele.
- Njengoba amafutha omzimba wakho enyuka, amazinga e-leptin nawo ayanda.
- Inkinga enkulu ngokukhuluphala akuyona ukuntuleka kwe-leptin, kodwa isimo esibizwa ngokuthi "ukumelana ne-leptin," lapho ubuchopho bungasabeli khona ku-leptin.
- Ukumelana ne-leptin kwandisa indlala futhi kunciphisa ukushiswa kwama-calories emzimbeni, okungaholela ekukhuleni kwesisindo okwengeziwe.
- Ukulala ngokwanele, ukudla okunempilo, kanye nokuzivocavoca kusiza ukugcina ukusebenza kwe-leptin kanye nokulinganisela kwama-hormone.
- Uma unenkinga ngesisindo sakho noma izindlela zokudla, xhumana nodokotela wakho njalo ukuze akunike iseluleko.
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