Uma sihlola i-cholesterol yethu, sivame ukubheka kuphela "i-cholesterol enhle" (i-HDL) kanye "ne-cholesterol embi" (i-LDL), akunjalo? Kodwa bewazi ukuthi kukhona uhlobo olubaluleke kakhulu lwe-cholesterol abantu abaningi abangakhulumi ngalo, kodwa olufihliwe phakathi? Lena yi-Lipoprotein(a), noma i-Lp(a) ngamafuphi. Into ekhethekile ngalokhu ukuthi inqunywa izakhi zofuzo zethu, okusho ukuthi idluliselwa ezizukulwaneni ngezizukulwane, kunokuba idluliselwe ngalokho esikudlayo nesikuphuzayo noma esikuzivocavocayo. Ungase ube ngumuntu ophilile kakhulu, kodwa izinga lakho le-Lp(a) lingase libe phezulu kakhulu.
Iyini ngempela i-Lipoprotein(a)?
Kalula nje, lokhu kuyisinhlayiya esiqukethe i-cholesterol egazini lethu. Kodwa inkinga ngalokhu ukuthi izinga layo linqunywa kakhulu yizakhi zofuzo zethu. Lokhu kusho ukuthi uma umama wakho, ubaba, noma othile emndenini wakho enalesi simo, nawe unamathuba amaningi okuba naso. Kuthiwa cishe umuntu oyedwa kwabahlanu emhlabeni unamazinga aphezulu e-Lp(a).
Ingozi yalokhu ukuthi ukuba namazinga aphezulu e-Lp(a) kwandisa kakhulu ingozi yokuhlaselwa yinhliziyo kanye nesifo sohlangothi esemncane. Esikhathini esiningi, abantu bathola lokhu kuphela ngemva kokuba behlaselwe yinhliziyo noma isifo sohlangothi. Lokhu kungenxa yokuthi iphaneli ejwayelekile ye-lipid ayibonisi leli nani le-Lp(a). Kudinga ukuhlolwa okuhlukile.
Isibonelo, cabanga ngendaba kaBernadette, owesifazane oneminyaka engu-66 ubudala ohamba amakhilomitha angaba ngu-16 ngosuku futhi adle ukudla okusekelwe ezitshalweni, okuhlanganisa imifino ne-tofu. Amazinga akhe e-cholesterol ngokuvamile ayesezingeni elihle, kodwa izinga lakhe le-Lp(a) laliphakeme ngokuphindwe kahlanu kunezinga lengozi. Lokhu kwakungenxa yofuzo lwakhe. Bobabili unina nogogo wakhe bashone ngenxa yesifo senhliziyo.
"Inselele enkulu kimi ukucindezeleka kokuphila nalokhu. Ngisho noma ngizizwa ngigula kancane, ngicabanga ukuthi, 'Ingabe lokhu ukuhlaselwa yinhliziyo engizobhekana nakho?'" kusho uBernadette.
Inkinga nethemba elisha
Kuze kube manje, akukho muthi othize ovunyelwe ukwehlisa amazinga e-Lp(a). Lokhu kusho ukuthi yize bazi ukuthi ukhona, abantu abaningi kuye kwadingeka baphile ngokwesaba, bengenakwenza lutho ngakho. Kufana nokuba nebhomu eliqhumayo emzimbeni wabo elingaqhuma nganoma yisiphi isikhathi.
Kodwa, manje leso simo sizoshintsha!
Abacwaningi bezokwelapha okwamanje baphenya ngemithi emisha emihlanu eye yabonakala ezifundweni zokuqala ukuthi yehlisa kakhulu amazinga e-Lp(a). Leli yithemba elikhulu ezigidini zabantu abanamazinga aphezulu e-Lp(a). Njengoba umcwaningi oyinhloko uDkt. Steven Nissen esho, " Ungakhathazeki, izixazululo ziyeza. "
Imithi yakamuva esesigabeni socwaningo
Le mithi emisha isesesigabeni sokugcina socwaningo (izivivinyo zemitholampilo). Uma iphumelela, ingaba semakethe maduze nje. Ake sibone ukuthi imiphi leyo mithi nokuthi iphumelela kangakanani.
| Igama Lomuthi | Isici / Indlela yokuhlinzeka | Umphumela olindelekile |
|---|---|---|
| I-Pelacarsen | Umjovo onikezwa kanye ngenyanga | Amazinga e-Lp(a) angancishiswa cishe ngo-80%. |
| I-Olpasiran | Umuthi wokugoma onikezwa njalo ezinyangeni ezi-3 | Amazinga e-Lp(a) angancishiswa ngaphezu kwama-95%. |
| I-Lepodisiran | Umuthi wokugoma owodwa ohlala usebenza cishe unyaka wonke | Amazinga e-Lp(a) angancishiswa cishe ngo-94% futhi agcinwe isikhathi eside. |
| I-Zerlasiran | Umuthi wokugoma ongavamile | Amazinga e-Lp(a) angancishiswa cishe ngo-86%. |
| I-Muvalaplin | Iphilisi lansuku zonke | Amazinga e-Lp(a) angancishiswa cishe ngo-86%. |
Yini ekhethekile ngephilisi le-Muvalaplin?
Kulaba, abacwaningi banethemba elikhulu ngomuthi obizwa ngokuthi ``(Muvalaplin)'' ngoba yize eminye imithi emine kufanele inikezwe njengomjovo, lo ungathathwa njengephilisi lansuku zonke . Ngakho-ke, kungaba lula kakhulu ezigulini, futhi kungaba okungabizi kakhulu.
Eminye imithi isebenza ngokuthulisa i-gene ebangela ukukhiqizwa kwe-Lp(a). Kodwa leli philisi lisebenza ngendlela ehlukile. Limisa ukukhiqizwa kwezinhlayiya ze-Lp(a) phakathi. Lokhu kuvumela ukuthi lisebenze ngaphandle kokuthinta isibindi futhi lisuswe emzimbeni ngokushesha uma kuvela noma yimiphi imiphumela emibi.
Kungani sidinga ukuhlola i-Lp(a)?
Njengoba ufunda lesi sihloko, ungase uzibuze, 'Ingabe kufanele ngihlolwe nalokhu?' Impendulo ithi, yebo! Kufanele nakanjani ucabangele lokhu, ikakhulukazi uma othile emndenini wakho eke waba nesifo senhliziyo noma isifo sohlangothi esemncane .
I-National Lipid Association manje isincoma ukuthi wonke umuntu ahlolwe izinga lakhe le-Lp(a) okungenani kanye empilweni yakhe . Ngenxa yokuthi kuyinto yofuzo, izinga alishintshi kakhulu empilweni yakhe yonke. Ukulihlola kanye nje kwanele.
Lokhu ukuhlolwa kwegazi okulula kakhulu. Kodwa-ke, njengoba kungafakwanga embikweni ojwayelekile we-cholesterol, kufanele ubuze udokotela wakho ngqo ngalokhu ngaphambi kokwenza lokhu kuhlolwa.
Ukwazi izinga lakho le-Lp(a) kuyisinyathelo sokuqala. Uma liphezulu, ungesabi. Njengoba le mithi emisha iza maduze, uzokwazi ukulawula ingozi yakho yokuhlaselwa yinhliziyo kanye nesifo sohlangothi. Kuze kube yileso sikhathi, kubalulekile ukugcina ezinye izici eziyingozi, njengomfutho wegazi ophakeme, isifo sikashukela, ukubhema, kanye namazinga e-cholesterol e-LDL, zilawulwa kahle.
Umlayezo Wokuya Nawe Ekhaya
- I-Lipoprotein(a), noma i-Lp(a), uhlobo lwe-cholesterol olulawulwa ngofuzo futhi lwandisa ingozi yesifo senhliziyo.
- Lokhu akufakiwe ekuhlolweni okuvamile kwe-cholesterol (iphrofayili ye-lipid), ngakho-ke kufanele ubuze udokotela wakho ngalokhu bese uhlola ngokuqondile.
- Uma kukhona emndenini wakho oke waba nesifo senhliziyo esemncane, kubaluleke kakhulu ukwenza lokhu kuhlolwa.
- Nakuba okwamanje kungekho muthi othize we-Lp(a), imithi eminingana ekhombisa imiphumela ethembisayo isesigabeni sokugcina socwaningo. Lokhu kuthembisa kakhulu.
- Uma uthola ukuthi izinga lakho le-Lp(a) liphezulu, ungesabi, xoxa nodokotela wakho ngakho, bese ulawula ezinye izinto ezibangela isifo senhliziyo.
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