Uma othile emndenini wakho, mhlawumbe umama wakho, ubaba, noma othandekayo wakho, ehlushwa yisifo i-Alzheimer's, siyazi ukuthi kunzima kangakanani. Amazwi awakwazi ukuchaza usizi nokungabi namandla ozizwayo njengoba inkumbulo yakho iphela kancane kancane futhi ungasabazi abathandekayo bakho. Kodwa-ke, manje sekukhona inhlansi yethemba kulobu bumnyama. Muva nje, i-US Food and Drug Administration (FDA) ivumile umuthi omusha wesifo i-Alzheimer's.
Uyini lomuthi omusha?
Igama lalo muthi osanda kuvunyelwa yi- donanemab . Utholakala emakethe ngaphansi kwegama elithi Kisunla. Lo muthi akuwona umuthi onikezwa bonke abantu abane-Alzheimer's. Uqondiswe ngqo kubantu abasesigabeni sokuqala salesi sifo. Okusho ukuthi, labo abasanda kuqala ukubonisa ukukhubazeka okuthile ememori namakhono okucabanga. Ngokwezokwelapha, ulungele iziguli ezinokukhubazeka okuncane kwengqondo noma i-dementia encane .
Kalula nje, isifo i-Alzheimer's sibangelwa ukunqwabelana kohlobo lweprotheni engafuneki ebizwa ngokuthi i-amyloid ebuchosheni. Kufana nokuvaleka kwepayipi lamanzi okubangelwa ukungcola. Ngaphambi kokuba lo muthi omusha unikezwe, kudingeka kwenziwe ukuhlolwa ukuze kuqinisekiswe ukuthi isiguli sinawo ngempela lawa ma-amyloid ebuchosheni baso.
Yini ekhethekile kakhulu ngalo muthi?
Into enkulu nebaluleke kakhulu ngalo muthi ukuthi awusiwo umuthi wokuphila konke. Cabanga nje, imithi eminingi yamanje efana nalena kufanele ithathwe njalo. Kodwa umehluko omkhulu nge-donanemab ukuthi ukwelashwa kungamiswa ngemva kokuba kususwe lawo ma-amyloid angafuneki ebuchosheni.
Lesi yisinyathelo esikhulu sokuqhubekela phambili. Lokhu kuvunyelwa kunikeza iziguli izinketho ezengeziwe, kanye nethuba lokuchitha isikhathi esengeziwe nabathandekayo babo, nezinkumbulo ezengeziwe.
Ochwepheshe bakholelwa ukuthi ngokuyeka ukwelashwa ngale ndlela, inani lezikhathi isiguli esidinga ukuvakashela ngazo esibhedlela, ukungakhululeki esikuzwayo, kanye nezindleko zokwelashwa kungancishiswa kakhulu.
Azikho yini izingozi noma imiphumela emibi?
Vele, njengayo yonke imithi, kunezingozi ezithile. Asikwazi ukuzishaya indiva. Ingozi enkulu ehlotshaniswa nalo muthi yisimo esibizwa ngokuthi i-ARIA (Amyloid-Related Imaging Abnormalities) .
Kalula nje, lokhu kungabangela ukuvuvukala okuncane ngaphakathi kobuchopho (i-brain edema) noma ukuphuma kwegazi okuncane kakhulu (ukuphuma kwegazi ebuchosheni) . La magama angase azwakale esabisa, kodwa ochwepheshe bathi le ngozi ingalawulwa . Yingakho kubalulekile ukuqaphela ngesikhathi sokwelashwa.Ubuchopho buqashelwa eduze ngokwenza ama-MRI scan njalo. Uma kukhona izinguquko ezibonakala, udokotela uzothatha izinyathelo ezidingekayo.
Ngakho-ke, uma ucabangela lokhu kwelashwa, kubaluleke kakhulu ukukhuluma ngokukhululekile nodokotela wakho mayelana nezinzuzo nezingozi zalo muthi, okungukuthi, izinzuzo nezingozi, ngaphandle kokufihla lutho.
| Izinzuzo ze-Donanemab | Izingozi kanye nokungalungi kwe-Donanemab |
|---|---|
| Isusa ama-amyloid deposits ebuchosheni abangela isifo i-Alzheimer's. | Ingozi ye-ARIA (ukuvuvukala kobuchopho noma ukopha). |
| Yehlisa izinga lokuwohloka kwenkumbulo kanye nekhono lokucabanga. | Kubalulekile ukuqapha ubuchopho ngokuskena kwe-MRI njalo. |
| Kungenzeka ukuyeka ukwelashwa uma i-amyloid isiphelile. | Imiphumela emibi evamile efana nekhanda elibuhlungu kanye nesicanucanu ingase ivele. |
| Ukunciphisa isikhathi sokwelashwa kanye nezindleko ngokuhamba kwesikhathi. | Lona akuwona umuthi owelapha ngokuphelele lesi sifo, ulawula kuphela ukuwohloka kwesifo. |
Ingabe lolu hlobo lokwelashwa luyatholakala ezweni lethu?
Okwamanje, i-donanemab ivunyelwe e-United States kuphela. Ngakho-ke kuzothatha isikhathi ukuthi lokhu kwelashwa kutholakale ezibhedlela zaseSri Lanka. Futhi, kuyabiza kancane. Kodwa-ke, uma lo muthi ufika eSri Lanka esikhathini esizayo, kungenzeka ukuthi iziguli zizothola impumuzo ngokungenelela kukahulumeni kanye nomshuwalense.
Kodwa-ke, izinto ezintsha ezitholakele njengalezi zibonisa ukuthi isayensi ithuthuka kancane kancane ekulweni nesifo i-Alzheimer's. Lokho ngokwako kusinika ithemba elikhulu.
Umlayezo Wokuya Nawe Ekhaya
- I-Donanemab umuthi omusha ovunyelwe ezigabeni zokuqala zesifo i-Alzheimer's.
- Lokhu kususa amaprotheni e-amyloid ayingozi aqoqana ebuchosheni futhi kunciphise ukuqhubeka kwesifo.
- Kubalulekile ukuqonda ukuthi lokhu akulona ikhambi lazo zonke izinkinga.
- Inzuzo enkulu yalokhu kwelashwa ukuthi kungamiswa uma i-amyloid isisusiwe ebuchosheni.
- Ngenxa yokuthi kungenzeka ukuthi kube nezimo eziyingozi njenge-ARIA, ukuqapha udokotela kanye nokuskena kwe-MRI kubalulekile phakathi nesikhathi sokwelashwa.
- Ngaphambi kokwenza noma yiziphi izinqumo mayelana nempilo yakho noma yothandekayo wakho, xoxa njalo ngazo zonke izinketho, izinzuzo kanye nezingozi nodokotela wakho.
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