Uma uzwa leli gama, cishe ucabanga ngezinkondlo, akunjalo? Kodwa lokhu akuyona indaba ngezinkondlo. I-POEMS syndrome iyisifo segazi esingavamile kakhulu esingathinta izinzwa zomzimba wethu, izitho ezahlukahlukene, uhlelo lwama-hormone, kanye nesikhumba ngesikhathi esisodwa. Kuyinkimbinkimbi kancane ukuxilonga, ngoba izimpawu ezihlobene naso zingafana nezimpawu zezinye izifo eziningi. Yingakho kubaluleke kakhulu ukuqaphela lokhu.
Kungani lokhu kubizwa ngokuthi IZINKONDLO?
Igama layo livela ezincwadini zokuqala zezimpawu ezinhlanu eziyinhloko zesifo. Ake sibone ukuthi ziyini.
| Incwadi | Incazelo kanye nencazelo elula |
|---|---|
| P | I-Polyneuropathy: Lokhu kubhekisela ekulimaleni kwemizwa kuwo wonke umzimba, ikakhulukazi ezithweni. |
| O | I-Organomegaly: Ukwanda kwezitho ezithile emzimbeni, njengesibindi, i-spleen, noma ama-lymph node, ngaphezu kobukhulu obujwayelekile. |
| E | I-Endocrinopathy: Ukuphazamiseka kokusebenza kwezindlala (uhlelo lwe-endocrine) emzimbeni wethu okhiqiza ama-hormone. |
| M | Iphrotheni ye-monoclonal: Ibizwa nangokuthi i-M-protein. Amazinga aphezulu ephrotheni engajwayelekile egazini. |
| S | Izinguquko zesikhumba:Izinto ezifana nokushintsha kombala wesikhumba kanye nokuqina kwesikhumba. |
Kunezikhathi lapho kuthatha izinyanga zokuhlolwa ukuze kutholakale lesi simo, ngoba lezi zimpawu zingadideka kalula nezinye izifo eziningi uma zithathwa zodwa.
Ziyini izimpawu ze-POEMS syndrome?
Manje ake sibheke ngokuningiliziwe izimpawu zengxenye ngayinye yeziNKONDLO okuxoxwe ngazo ngenhla.
- P - Ukulimala kwemizwa (i-Polyneuropathy): Lena yinto yokuqala abantu abaningi abayiqaphelayo. Izinzwane nezinyawo zingase zizwe zingabandi, zihlaba, futhi zingase zizwe ubuhlungu obushisayo noma obubukhali . Ngokuhamba kwesikhathi, lesi simo singasakazekela ezandleni. Amandla ezandleni ayancipha, futhi ungase ungakwazi ukubamba lutho esandleni sakho. Ezimweni ezimbi kakhulu, kungaba nzima ukuma, ukuhamba, ngisho nokuphefumula.
- O - I-Organomegaly: Isibindi sakho, i-spleen, noma ama-lymph node angase avuvuke. Lokhu kungabangela izimpawu ezifana nomuzwa wokugcwala, ubuhlungu besisu noma ukuqunjelwa, kanye nokukhathala okukhulu .
- E - Izinguquko zama-hormone (i-Endocrinopathy): Izinguquko zama-hormone zingabangela izinto ezifana nokuncipha kwesifiso sobulili, ukuphuma koketshezi olufana nobisi emabeleni (kwabesifazane nabesilisa), kanye nokuvuvukala kwezandla nezinyawo .
- I-M - I-M-protein engavamile: Le phrotheni inganqwabelana egazini futhi ibangele ukuba amathambo abe buthaka noma alimale , okungaholela ebuhlungwini bamathambo.
- S - Izinguquko zesikhumba: Isikhumba singaba mnyama kunokujwayelekile. Ngezinye izikhathi isikhumba singaba lukhuni, futhi amabala abomvu angavela esifubeni. Kungase kube nokukhula kwezinwele ebusweni nasemilenzeni, kanti izinzipho zingaba mhlophe .
Kungani kwenzeka into efana nale?
Imbangela eqondile yalokhu ayaziwa okwamanje, kodwa odokotela nabacwaningi bakholelwa ukuthi ihlobene nokusebenza okungajwayelekile kohlobo lweseli emzimbeni wethu olubizwa ngamaseli e-plasma .
Kalula nje, la maseli e-plasma angajwayelekile akhipha i-M-protein esikhulume ngayo egazini. La maseli angajwayelekile kanye ne-M-protein ahlangana ukulimaza izingxenye ezahlukene zomzimba. Ngaphezu kwalokho, laba ziguli banamazinga aphezulu eprotheni ebizwa ngokuthi i-Vascular Endothelial Growth Factor (VEGF) egazini labo. Le phrotheni ye-VEGF ibangela ukuthi uketshezi luphume emithanjeni yegazi luye ezicutshini ezizungezile. Lolu ketshezi olwengeziwe lubangela ukuvuvukala, ukukhulisa izitho zomzimba, kanye nomonakalo wezinzwa.
Ingabe lesi simo singaba sibi kakhulu?
Yebo, i-POEMS syndrome ngezinye izikhathi ingaba yingozi ngokushesha, okuholela ezinkingeni ezisongela ukuphila.
Ezinye zazo yilezi:
- I-Capillary Leak Syndrome: Ukwehluleka kwezitho zomzimba kungenzeka ngenxa yokuvuza ngokweqile koketshezi oluvela emithanjeni yegazi.
- Isifo Samaphaphu Esivimbelayo: Ubunzima bokuphefumula ngenxa yokuthi amaphaphu awakwazi ukukhula kahle.
- Umfutho wegazi ophezulu wamaphaphu: Ukucindezeleka okukhulu emithanjeni yegazi ethwala igazi liye emaphashini.
Ngakho-ke, uma unezimpawu, kubaluleke kakhulu ukufuna iseluleko sezokwelapha bese uqala ukwelashwa ngokushesha okukhulu.
Udokotela ukuthola kanjani lokhu?
Uma uya kudokotela, uzolalela ngokucophelela izimpawu zakho. Uzobe esehlola umzimba wakho futhi akuncomele ukuhlolwa okuningana ukuqinisekisa ukuthi unesifo.
| Ukuhlolwa | Uhlola ini? |
|---|---|
| Ukuhlolwa kwegazi nomchamo | Amazinga e-M-protein noma e-VEGF ayahlolwa ukuze kutholakale amaseli e-plasma angajwayelekile. |
| Ukuhlolwa kwezithombe (i-X-ray, i-CT scan) | Bafuna ukubona ukuthi i-M-protein ibangele yini umonakalo emathanjeni. |
| I-biopsy yomnkantsha wethambo | Ukuhlola amaseli e-plasma angajwayelekile emnkantsheni wethambo. |
| I-Electromyogram (EMG) | Umsebenzi wakho wezinzwa uyalinganiswa. |
Ngaphezu kwalokho, ukuhlolwa kokuphefumula, ukuhlolwa kwe-echocardiogram, kanye nokuhlolwa kwama-hormone kungenziwa kuye ngezimpawu zakho.
Yiziphi izindlela zokwelapha lokhu?
Umgomo oyinhloko wokwelashwa ukulawula izimpawu kanye namaseli e-plasma angajwayelekile. Kunezindlela ezahlukene zokwelapha lokhu.
- Ukwelashwa ngamakhemikhali: Lokhu kwelashwa kubhubhisa amangqamuzana e-plasma angajwayelekile noma kumise ukukhula kwawo.
- Ukwelashwa Ngezifo Ezingajwayelekile: Le mithi isiza ukusebenzisa amasosha omzimba wakho ukubhubhisa amaseli e-plasma angajwayelekile.
- Ukwelashwa ngemisebe: Ukwelashwa ngemisebe kubhubhisa amaseli e-plasma angajwayelekile.
- Ukufakelwa kweseli le-Autologous stem: Lokhu kuhilela ukususa amangqamuzana e-plasma angajwayelekile emzimbeni wakho bese uwafaka esikhundleni sawo amangqamuzana e-stem anempilo.
- Ukwelashwa ngokomzimba: Ukulimala kwemizwa kungenza kube nzima ukuhamba nokwenza imisebenzi yansuku zonke. Ukuzivocavoca umzimba kungakusiza ukuthi uthole amandla kabusha.
- Ukusekelwa ngokwengqondo: Ukuphila nesifo esingavamile nesingelapheki njengalesi kungaba nzima kakhulu ngokwengqondo. Lokhu kungaholela ezimweni ezifana nokukhathazeka nokucindezeleka. Ukufuna usizo lomeluleki kungasiza ekulawuleni lokhu kucindezeleka.
Ungaphila isikhathi esingakanani nalesi sifo?
Lena inkinga abantu abaningi abanayo. Uma lesi sifo sitholakala kusenesikhathi futhi selashwa kahle, abantu abaningi bangaphila iminyaka eyi-10 noma ngaphezulu ngemva kokuxilongwa. Imithi emisha isiyatholakala manje yokwelapha lesi sifo. Kodwa-ke, lokhu kungahluka kumuntu nomuntu. Umuntu ongcono kakhulu ongathola incazelo engcono kakhulu nokuqonda isimo sakho udokotela wakho. Ngakho khuluma naye ngokukhululekile ngaso.
Umlayezo Wokuya Nawe Ekhaya
- I-POEMS syndrome iyisifo segazi esingavamile kodwa esibi kakhulu esithinta izinhlelo eziningana zomzimba.
- Leli gama lisuselwa ezinhlamvini zokuqala zezici zalo eziyinhloko: i-Polyneuropathy , i-Organomegaly , i-Endocrinopathy , i-M -protein, kanye nezinguquko zesikhumba .
- Uma une-numbness eqhubekayo, ukuvuvukala, noma izinguquko zesikhumba emilenzeni yakho, ungazinaki.
- Ukuxilonga lesi sifo kungaba nzima futhi kudle isikhathi, kodwa manje kunezindlela zokwelapha eziphumelela kakhulu zokulawula lesi simo.
- Uma unezimpawu ezisolisayo, bona udokotela wakho ngokushesha ukuze akunike iseluleko.
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