Uma othile emndenini wakho, mhlawumbe umama wakho othandekayo, ubaba, noma ugogo, ehlushwa yisifo i-Alzheimer's Disease, siyazi ukuthi kungaba buhlungu kangakanani. Kuyadabukisa kakhulu ukubona inkumbulo yomuntu omthandayo inyamalala kancane kancane. Kodwa-ke, phakathi nalesi simo esinzima, sikhuluma ngendaba eletha ithemba elincane. Lokhu akulona ikhambi eliphelele lalesi sifo, kodwa kungaba yisinyathelo esibalulekile sokuqhubekela phambili.
Zithini lezi zindaba ezintsha?
Muva nje, iphaneli yokweluleka ye-US Food and Drug Administration (FDA) ngazwi linye inikeze imvume yokwelashwa okusha kwe-Alzheimer's. Igama lomuthi yi
-donanemab . Kunconywa iziguli
ezisesigabeni sokuqala salesi sifo. Ukuvunyelwa kwaleli phaneli yokweluleka kusho ukuthi kunethuba elikhulu lokuthi i-FDA izowunikeza imvume ephelele lo muthi maduze. Lokhu kuyinto enkulu ngempela, ngoba ukufika kokwelashwa okusha kwesifo esibi njenge-Alzheimer's kuyithemba elikhulu.
Isebenza kanjani i-Donanemab?
Kulungile, manje ake sibone ukuthi lo muthi usebenza kanjani. Lokhu kuyinkimbinkimbi kancane, kodwa ngizokuchaza kalula. I-Donanemab uhlobo lomuthi olubizwa ngokuthi
i-monoclonal antibody . Kalula nje, iyiprotheni ekhethekile eyenziwe elebhu ukuhlasela isisulu esithile kusetshenziswa izingxenye zesimiso sethu somzimba sokuzivikela. Iyini isisulu salo muthi? Yi
-amyloid plaques , okucatshangwa ukuthi iyimbangela enkulu yesifo i-Alzheimer's. Njengoba nje ukugqwala kwakheka emapayipini ethu amanzi, lawa ma-plaques akheka phakathi kwamangqamuzana ezinzwa ebuchosheni futhi aphazamise ukusebenza kwawo. Lokho i-Donanemab ekwenzayo ukuhlonza la ma-plaques nokusiza ukuwasusa.
Into ebalulekile ukuthi lokhu akulona ikhambi lalesi sifo. Kodwa-ke, kunganciphisa izinga lesi sifo esiba sibi ngalo. Lokhu kusho ukuthi kungasiza isiguli ukuba silondoloze inkumbulo yaso kanye nekhono lokwenza imisebenzi yansuku zonke isikhathi eside.
Lo muthi usebenza kangakanani?
Ngokwemiphumela yokuhlolwa kwemitholampilo eyanyatheliswa ngonyaka odlule, lokhu kwelashwa
kunganciphisa izinga lesi sifo esiba sibi ngalo phakathi nezinyanga ezimbalwa.Bekungenzeka. Lokhu kulinganiswa ngokuhlolwa okulinganisa amakhono engqondo eziguli (isib. inkumbulo, ukuxazulula izinkinga) nokuthi zenza kahle kangakanani imisebenzi yokuphila kwansuku zonke (isib. ukushayela, ukuphatha imali). Abanye ochwepheshe babiza le miphumela ngokuthi imiphumela ephansi noma "ejwayelekile". Lokho kusho ukuthi awukwazi ukulindela umehluko omkhulu kulokhu. Kodwa futhi kuhle ukuthi lesi sifo singancishiswa ngezinyanga ezimbalwa nje, kunokuba sibe sibi kakhulu ngaphandle kokwelashwa. Ngokuqondene nendlela yokwelashwa enikezwa ngayo, umuthi unikezwa iziguli nyanga zonke ngomthambo (i-infusion). Labo abahlanganyele ezivivinyweni banikezwe lokhu kwelashwa cishe unyaka nesigamu.
Kunezinzuzo kanye nezingozi ezinkulu.
Njenganoma yimuphi umuthi onamandla, i-donanemab inezinzuzo kanye nemiphumela emibi kanye nezingozi ezinkulu. Kubalulekile ukuqonda izinhlangothi zombili ngaphambi kokwenza isinqumo.
| Izinzuzo | Izingozi Nokungahleleki |
|---|
| Ukunciphisa izinga lesi sifo esiba sibi ngalo. | Imiphumela emibi kakhulu: Kukhona ingozi yokuvuvukala kobuchopho noma ukopha kobuchopho. |
| Kusiza ukugcina inkumbulo kanye nekhono lokwenza imisebenzi yansuku zonke isikhathi eside. | Ngesikhathi sokuhlolwa kwemitholampilo, kubikwe ukufa kwabantu abathathu okuhlobene nalokhu kwelashwa. |
| Ukuqondisa ama-plaque ebuchosheni abangela lesi sifo. | Izindleko eziphezulu: Ngokusho kwezilinganiso zaseMelika, izindleko zonyaka zokwelashwa zingaba cishe amaRandi ayizigidi ezingu-6,600 (cishe amaRandi ayizigidi ezimbili aseSri Lanka). |
| Ukuletha ithemba elisha ezigulini ezine-Alzheimer kanye nemindeni yazo. | Ukuthi kufanele ngifike esibhedlela njalo ngenyanga ukuze ngithole ukwelashwa futhi ngifakwe umuthi ngemithambo yegazi. |
Naphezu kwakho konke lokhu okucatshangelwayo, iphaneli yokweluleka ye-FDA ekugcineni yanquma ukuthi
izinzuzo zalo muthi zidlula izingozi zawo.Okusho ukuthi, uma inikezwa iziguli ezifanele, ngaphansi kokuqashwa okufanele, izinzuzo ziba zinkulu.
Ingabe lo umuthi omusha kuphela otholakalayo?
Cha. Kukhona omunye umuthi osebenza ngendlela efanayo. Ubizwa ngokuthi
i-lecanemab . Lowo muthi usebenza nangokubhekisa ama-platelet aqoqana ebuchosheni. Wathola imvume ye-FDA ngoJulayi 2023. I-Donanemab ingenye isinyathelo kulolo hambo. Izinhlangano ze-Alzheimer's ezihamba phambili emhlabeni zinethemba elikhulu lokwelashwa okusha okufana nalokhu. Zithi, "Uma ukwelashwa okuvunyelwe okufana nalokhu kuvela kaningi, amathuba eziguli ezifanelekela lokhu ayanda. Kwenziwa intuthuko ecacile maqondana nokwelashwa." Njengamanje, izigidi zabantu emhlabeni wonke zihlushwa yisifo se-Alzheimer's. Akukabikho ndlela yokuvimbela noma yokwelapha ngokuphelele lesi sifo. Ngakho-ke, imithi efana ne-donanemab iyizinyathelo ezibalulekile kakhulu kulolo hambo olude.
Umlayezo Wokuya Nawe Ekhaya
- I-Donanemab umuthi omusha osuzovunyelwa ukwelapha izigaba zokuqala zesifo i-Alzheimer's .
- Lokhu akukwazi ukwelapha lesi sifo, kodwa kunganciphisa izinga lapho izimpawu ziba zimbi khona izinyanga ezimbalwa .
- Kanye nezinzuzo zalokhu kwelashwa, kukhona nezingozi ezinkulu , njengokuvuvukala kobuchopho kanye nokopha kwegazi .
- Isinqumo sokuthatha lo muthi noma cha kufanele senziwe ngemuva kokuxoxa kabanzi nodokotela wakho ngesimo sesiguli kanye nezingozi zaso, kanye nangemva kokuhlola ngokucophelela izinzuzo nezingozi.
- Kuhle ukuqaphela izindlela ezintsha zokwelapha ezifana nalezi, kodwa qiniseka ukuthi ucela iseluleko kudokotela ofanelekayo ngaphambi kokwenza noma yiziphi izinqumo.
Isifo sika-Alzheimer, i-donanemab, isifo sobuchopho, ukulahlekelwa yinkumbulo, i-dementia, ukwelashwa okusha, i-antibody ye-monoclonal
💬 Comments (0)
Awekho amazwana athunyelwe okwamanje. Faka amazwana akho lapha okokuqala ngqa.
Engeza amazwana akho