Ingabe uvame ukuzizwa ukhathele noma ulunywa ngaphandle kwesizathu? Ngezinye izikhathi singase singazinaki kakhulu lezi zinto njengezinto ezivamile ekuphileni kwethu kwansuku zonke. Kodwa-ke, lezi ngezinye izikhathi zingaba uphawu oluyisixwayiso oluvela ngaphakathi emzimbeni wethu. Ikakhulukazi, zingaba izimpawu zokuqala zenkinga ngesibindi sethu. Namuhla sizokhuluma ngesifo esingathinta umzimba buthule. Leso yi-Primary Biliary Cholangitis, noma i-PBC ngamafuphi.
Kalula nje, iyini i-Primary Biliary Cholangitis (PBC)?
Cabanga ukuthi ngaphakathi kwesibindi sakho kukhona uhlelo lwamapayipi amancane kakhulu, amancane. Kufana namagatsha esihlahla akhula. Lawa yilokho esikubiza ngokuthi amapayipi enyongo. Umsebenzi oyinhloko wale misele ukuthwala uketshezi olubizwa ngokuthi 'inyongo' olukhiqizwa yisibindi luphume esibindini, okungukuthi, lungene ohlelweni lwethu lokugaya ukudla. Lenyongo ibaluleke kakhulu kithi, ngoba yilenyongo esiza ekuncibilikiseni amafutha ekudleni esikudlayo.
Manje, esifweni esibizwa ngokuthi i-Primary Biliary Cholangitis (PBC), amasosha ethu omzimba ahlasela ngephutha lawa ma-bile ducts. Lokhu kubangela ukuvuvukala, noma ukuvuvukala, kuma-bile ducts. Ngokuhamba kwesikhathi, lokhu kuvuvukala konakalisa ama-bile ducts futhi kuyawabhubhisa kancane kancane.
Kwenzekani-ke? Njengepayipi lamanzi elivalekile, i-bile ayikwazi ukugeleza bese inamathela ngaphakathi kwesibindi. I-bile ebambekile iqala ukulimaza amangqamuzana esibindi. Njengoba lo monakalo uqhubeka, izicubu zesilonda ziqala ukwakheka esikhundleni sezicubu zesibindi ezinempilo. Ekugcineni, isibindi siba nzima kancane kancane futhi umsebenzi waso uyehla. Lesi simo sisibiza ngokuthi i-cirrhosis . Esikhathini esidlule, lesi sifo sasibizwa nangokuthi i-Primary Biliary Cirrhosis.
Ingabe lesi sifo sibi ngempela?
I-PBC iyisifo esiqhubekayo nesingapheli. Lokhu kusho ukuthi ayibi ngcono ngobusuku obubodwa, futhi izimpawu zingase zibe zimbi kakhulu ngokuhamba kwesikhathi. Ezigabeni zokuqala, kungase kungabi nazimpawu nhlobo. Kodwa-ke, uma lesi sifo singalawulwa, singagcina siholele ekuhlulekeni kwesibindi. Ngaleso sikhathi, singaba yingozi empilweni uma ukufakelwa kwesibindi kungenziwa.
Kodwa ungesabi lapha. Ngenhlanhla, kunemithi eminingi emihle namuhla enganciphisa ijubane futhi ilawule isivinini salesi sifo. Ngakho akuwona wonke umuntu ofinyelela esigabeni sokugcina salesi sifo. Into ebaluleke kakhulu ukuxilonga lesi sifo kusenesikhathi bese uqala ukwelashwa.
Ubani onamathuba amaningi okuthola lesi sifo?
Into eyodwa evelele uma kukhulunywa ngalesi sifo ukuthi sivame kakhulu kwabesifazane.Kuwo wonke amadoda athola lesi sifo, abesifazane ababalelwa kwabayi-10 bayasithola. Kukhona igebe elinjalo.
- Lesi sifo sivame ukutholakala ngemva kweminyaka engama-40.
- Futhi, uma othile emndenini wakho enezinye izifo ezibangelwa ukuzivikela komzimba , ungase ube sengozini enkulu yokuthola esinye, okuphakamisa ukuthi kungase kube nokuxhumana kwezakhi zofuzo.
Yiziphi izimpawu nezinkinga ze-PBC?
Abantu abaningi ababi nazo izimpawu ezigabeni zokuqala zalesi sifo. Ngezinye izikhathi kutholakala ngengozi lapho kwenziwa ukuhlolwa kwegazi ngesinye isizathu. Kodwa njengoba lesi sifo siqhubeka, izimpawu ziqala ukuvela.
Izimpawu ezivamile eziza kuqala
- Ukukhathala: Lolu uphawu oluvame kakhulu. Kungakhathaliseki ukuthi ulala noma uphumule kangakanani, ukukhathala okuzwayo akupheli.
- Isikhumba esilumayo: Ukuluma kungenzeka, ikakhulukazi ezintendeni zezandla nasematheni ezinyawo. Kodwa-ke, kungenzeka noma kuphi emzimbeni. Kwabanye abantu, ukuluma kungaba nzima ukukuthwala.
Lezi zimpawu azibonakali ngendlela efanayo kuwo wonke umuntu. Kwabanye, zivela ekuqaleni kwesifo, kanti kwabanye, zivela kamuva kakhulu.
Izinkinga ezingase zenzeke njengoba isifo siqhubeka
Uma inyongo ingakwazi ukugeleza kahle, iqala ukuqongelela egazini lethu. Futhi, kuvela izinkinga ngoba uhlelo lokugaya ukudla aluyitholi inyongo. Njengoba izibazi zesibindi zanda, ingcindezi nayo iyakhula emithanjeni yegazi edlula esibindini. Lokhu kungaholela ezinkingeni ezahlukahlukene. Ake sibheke lokhu etafuleni.
| Uhlobo lwenkinga | Izimpawu nezinkinga ezingaba khona |
|---|---|
| Ukumuncwa Kwamafutha Ukungakwazi ukugaya uwoyela ekudleni ngenxa yokuntuleka kwenyongo. |
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| Umfutho wegazi ophezulu we-Portal Ukwanda kwengcindezi emthanjeni wegazi oyinhloko odlula esibindini ngenxa yezibazi zesibindi. |
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Iyini imbangela yangempela ye-PBC?
Njengoba sishilo ngaphambili, i-PBC iyisifo esibangelwa ukuzivikela komzimba . Kalula nje, "ibutho" lomzimba wethu (amasosha omzimba) lihlasela ngephutha amangqamuzana ethu amahle. Kufana nokuhlasela abantu bakithi, sicabanga ukuthi bayizitha. Ku-PBC, lokhu "kuhlasela" kwenzeka emigudwini ye-bile esibindini.
Odokotela abakakazi kahle ukuthi kungani lokhu kwenzeka, kodwa bakholelwa ukuthi kunezimbangela eziningana ezingaba khona:
1. Isici sezakhi zofuzo: Uma othile emndenini enalezi zifo, abanye banamathuba amaningi okuzithola.
2. Izici zemvelo: Lapho igciwane, amabhaktheriya, noma amakhemikhali kungena emzimbeni, isimiso somzimba sokuzivikela somuntu onesifo sofuzo singase sibangele ukuba singasebenzi kahle.
Lesi sifo sitholakala kanjani? (Ukuxilongwa)
Uma utshela udokotela wakho ngezimpawu zakho, uzokuhlola bese eyalela ukuhlolwa okuningana ukuqinisekisa ukuxilongwa.
1. Ukuhlolwa Kwegazi: Lokhu ukuhlolwa okubaluleke kakhulu. Kunezinto ezimbili ezibhekwa ngqo.
- Ama-antibodies: Cishe ama-95% abantu abane-PBC bane-antibody ethile ebizwa ngokuthi i-Antimitochondrial Antibody (AMA) egazini labo.
- Ama-Enzyme Esibindi: Uma isibindi sonakele, ama-enzyme athile (ikakhulukazi i-Alkaline Phosphatase - ALP ) ayanda egazini.
2. Ukuhlolwa Kwezithombe: Uma ukuhlolwa kwegazi kubonisa i-PBC, udokotela wakho angase akucele ukuthi kuhlolwe isibindi sakho kanye nenyongo. Lokhu kungasiza futhi ekususeni ezinye izimbangela zezimpawu zakho. Ukuskena kwe-ultrasound kuvame ukuba ukuhlolwa kokuqala okwenziwayo. Ukuskena kwe-MRI kungenziwa ukuze kutholakale izithombe ezicacile.Ungabhekisela futhi kwenye.
3. Ukuhlolwa Kwesibindi: Ngezinye izikhathi (ikakhulukazi kubantu abangenawo ama-antibodies e-AMA egazini labo), kuthathwa ingxenye encane kakhulu yezicubu zesibindi bese ihlolwa ngaphansi kwe-microscope ukuqinisekisa ukuxilongwa nokunquma izinga eliqondile lomonakalo wesibindi.
Yiziphi izindlela zokwelapha i-PBC?
Akukho ukwelashwa kwe-PBC okwamanje. Kodwa-ke, kunezindlela zokwelapha eziphumelela kakhulu zokunciphisa umonakalo esibindini obangelwa yilesi sifo, ukulawula ukuqhubeka kwesifo, nokuphatha izimpawu.
Imithi
- I-Ursodeoxycholic acid (UDCA): Lona umuthi oyinhloko we-PBC. Uyi-bile acid eyenzeka ngokwemvelo. Lo muthi usiza ukususa i-bile esibindini futhi unciphise ukulimala kwesibindi. Ungasebenza kahle kakhulu uma uqalwa ekuqaleni kwalesi sifo.
- Eminye imithi: Kulabo abangasabeli kahle ku-UDCA, udokotela wakho angase ancome eminye imithi, njenge- obeticholic acid . Ngaphezu kwalokho, imithi emisha, njenge -seladelpar kanye ne -elafibrinor, manje isetshenziswa.
- Imithi yezimpawu:
- Kwesikhumba esilumayo: Kusetshenziswa imithi efana ne-Cholestyramine, ama-antihistamine, kanye nokwelashwa ngokukhanya kwe-ultraviolet.
- Uma untula amavithamini: Kunikezwa izithasiselo eziqukethe amavithamini A, D, E, kanye no-K.
- Ngokukhathala: Abanye abantu bangathola impumuzo emithini evuselelayo njenge-modafinil.
Ukuhlinzwa
Uma ukusebenza kwesibindi sakho kuqhubeka nokwehla futhi kungalawulwa ngemithi, udokotela wakho angakubeka ohlwini lokulinda ukufakelwa isibindi . Ukufakelwa isibindi se-PBC kuyaphumelela kakhulu. Ungaphila impilo evamile ngemva kokufakelwa. Nakuba kungenzeka ukuthi i-PBC ibuyele esibindini esisha, akuvamile kakhulu.
Yini okufanele ngiyazi ngokuphila nalesi sifo?
I-PBC ivame ukuqhubeka kancane kakhulu. Kungathatha iminyaka eyi-15-20 ukuthi lesi sifo sifinyelele ezigabeni zaso zokugcina. Uma lesi sifo sitholakala futhi selashwa kusenesikhathi, amacala abucayi alesi sifo angavinjelwa noma abambezeleke. Abantu abaningi baphatha izimpawu zabo ngemithi futhi baphile iminyaka eminingi ngaphandle kokuphazamiseka okukhulu empilweni yabo yansuku zonke.
Kodwa-ke, abanye abantu bangase babe nokuqhubeka okusheshayo kwalesi sifo. Ukukhathala ngokweqile kanye namazinga aphezulu e-bilirubin egazini kungaba izimpawu zokuthi lesi sifo siqhubeka ngokushesha.
Izinto ongazenza ukuze uvikele isibindi sakho
Ukulandela indlela yokuphila enhle kanye nemikhuba yokudla kuzosiza ukugcina isibindi sakho siphilile isikhathi eside ngangokunokwenzeka.
- Yeka ngokuphelele ukubhema, utshwala, nokusebenzisa izidakamizwa ngokungadingekile.Lezi ziyingozi kakhulu esibindini.
- Yidla ukudla okuphelele okwengeziwe njengemifino emisha, izithelo, namakhambi esikhundleni sokudla okucutshungulwe, okupakishwe emaphaketheni.
- Nciphisa amafutha agcwele bese ukhetha ukudla okuqukethe amafutha agcwele noma "amahle" (isib. ukwatapheya, amantongomane, uwoyela womnqumo).
- Zivocavoce nsuku zonke. Ngisho nento elula njengokuhamba kahle. Ukuzivocavoca okuthwala isisindo kusiza ekugcineni amathambo eqinile.
Ukuphila nesifo esingamahlalakhona esinjengalesi kungaba yinto ekhathazayo engqondweni. Khuluma nodokotela wakho ngezindlela zokunciphisa ukucindezeleka kwakho ngokomzimba, ngokwengqondo nangokomzwelo. Funa ukwelulekwa uma kudingeka. Khumbula, impilo yakho iyonke inkulu kakhulu kunalesi sifo.
Umlayezo Wokuya Nawe Ekhaya
- I-Primary Biliary Cholangitis (PBC) yisifo esingamahlalakhona esilimaza imigudu ye-bile encane esibindini.
- Lokhu kubangelwa ukuthi amasosha ethu omzimba ahlasela ngephutha imigudu ye-bile (isifo sokuzivikela komzimba).
- Izimpawu zokuqala zingase zihlanganise ukukhathala kanye nokulunywa kwesikhumba, noma kungase kungabi nazimpawu nhlobo.
- Ukutholwa kusenesikhathi kubalulekile. Lesi sifo singatholakala ngokuhlolwa kwegazi.
- Imithi ingalawula ngempumelelo umonakalo esibindini obangelwa yilesi sifo kanye nesivinini sokuqhubeka kwalesi sifo.
- Ukugwema utshwala nokubhema nokulandela indlela yokuphila enempilo kubaluleke kakhulu empilweni yesibindi.
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