Uma sizwa igama elithi 'cholesterol', iningi lethu liyathuthumela kancane, akunjalo? Ikakhulukazi uma udokotela ethi, "I-cholesterol yakho embi, okungukuthi, izinga le-LDL, liphezulu kancane," sesaba kancane. Lokho esikudlayo nesikuphuzayo, kungakhathaliseki ukuthi siyavivinya umzimba noma cha, futhi ngezinye izikhathi izici zofuzo nazo ziyakuthinta lokhu. Ngakho-ke, cishe sonke sike sezwa ngamaphilisi ohlobo lwe-'statin' anikezwa ukulawula i-cholesterol. Kodwa kwabanye abantu, le mithi yodwa ayanele, noma ayikwazi ukusetshenziswa. Namuhla sikhuluma ngohlobo olusha lomuthi oluthuthuke kancane olusetshenziswa ezimweni ezinjalo. Lowo nguRepatha.
Iyini i-Repatha? Inciphisa kanjani i-cholesterol?
Kalula nje, i-Repatha iwumjovo owehlisa amazinga e-cholesterol "embi", noma i-LDL (Low-Density Lipoprotein) emizimbeni yethu. Leli akulona iphilisi esivame ukulithatha, kodwa umjovo ofakwa ngaphansi kwesikhumba.
Manje bheka ukuthi lokhu kusebenza kanjani, kuyamangalisa. Cabanga ukuthi isibindi sethu siyi-filter esusa i-cholesterol embi egazini. Kodwa umzimba wethu uneprotheni ebizwa ngokuthi i-PCSK9 (Proprotein Convertase Subtilisin Kexin uhlobo 9) . Lokhu kufana nomuntu onciphisa ukusebenza kahle kwaleso sihlungi, asiphazamise. Lapho iphrotheni ye-PCSK9 ikhula, ikhono lesibindi lokususa i-LDL egazini liyancipha.
Lokho okwenziwa yiRepatha ukuvimbela umsebenzi waleyo phrotheni ye-PCSK9 'ephazamisayo' . Uma imiswa, isihlungi sesibindi singasebenza kahle kakhulu futhi ngaphandle kokuphazamiseka, sibambe futhi sisuse ngenkuthalo i-cholesterol embi (LDL) egazini. Uyaqonda? Lokhu kusho ukuthi lo muthi usiza inqubo yemvelo yomzimba wethu elawula i-cholesterol.
Ubani onconyelwa lo muthi we-Repatha?
Lo muthi akuwona owawo wonke umuntu. Udokotela uzowuncoma kuphela ezimweni ezimbalwa ezithile.
- Kwabantu abadala abanesifo senhliziyo esikhona: Lo muthi usetshenziselwa ukunciphisa ingozi yokuhlaselwa yinhliziyo, isifo sohlangothi, noma esinye isifo senhliziyo. Ngokuvamile unikezwa kanye neminye imithi ye-cholesterol, njengama-statin.
- Kubantu abane-cholesterol ephezulu ezuzwe ngofuzo: Abanye abantu banamazinga aphezulu e-cholesterol ngenxa yezimo zofuzo ezidluliselwa ezizukulwaneni ngezizukulwane. Lezi zimo zibizwa ngokuthi i-Heterozygous Familyal Hypercholesterolemia (HeFH) kanye ne-Homozygous Familyal Hypercholesterolemia (HoFH) . I-Repatha inconywa kubantu abadala nezingane ezingaphezu kweminyaka eyi-10 ubudala abanalezi zimo ukulawula amazinga e-LDL.
Okubaluleke kakhulu, kubalulekile ukulandela ukudla okunempilo kanye nokuzivocavoca umzimba ngenkathi usebenzisa lo muthi.I-Repatha ayilona umlingo, iyingxenye eyodwa nje yohlelo lokwelashwa.
Yiziphi izinzuzo nemiphumela yalo muthi?
Izifundo zezokwelapha ze-Repatha zibonise imiphumela ethembisayo. Lezi zifundo ziqhathanise i-Repatha ne-placebo (ukwelashwa okungamanga) kanye neminye imithi ye-cholesterol, njenge-statins.
Ake sichaze lokhu kabanzi ngethebula elingezansi.
| Lo muthi unconyelwa bani? | Izinzuzo ezibalulekile ezifakazelwe ukuhlolwa |
|---|---|
| Abantu abadala asebevele benesifo senhliziyo (kanye neminye imithi efana nama-statin) | Kunciphisa kakhulu ingozi yokuhlaselwa yinhliziyo, isifo sohlangothi, kanye nokufa ngenxa yesifo senhliziyo. |
| Abantu abadala nezingane ezingaphezu kweminyaka eyi-10 ubudala abane-cholesterol ephezulu ngenxa yezimbangela zofuzo | Kunciphisa izinga le-cholesterol "embi" (LDL) ngempumelelo enkulu futhi ngokushesha egazini. |
Wazi kanjani ukuthi umuthi uyasebenza?
Udokotela wakho uzo-oda ukuhlolwa kwegazi (ukuhlolwa kwephrofayili yamafutha) ngezikhathi ezijwayelekile. Ngemva kokuqala i-Repatha, ungase uqaphele ukwehla okukhulu kwamazinga akho e-cholesterol e-LDL zingakapheli amasonto ayi-12 .
Ake sifunde futhi ngokusetshenziswa kanye nemiphumela emibi ye-Repatha.
Ungayisebenzisa kanjani lokhu?
I-Repatha iza njengesirinji egcwaliswe kusengaphambili noma ipeni lomjovo. Ifakwa ngaphansi kwesikhumba njalo emavikini amabili noma kanye ngenyanga, kuye ngokuthi umthamo owubekelwe wona ungakanani.
Okubaluleke kakhulu: Kubaluleke kakhulu ukufunda ngqo ukuthi ungayisebenzisa kanjani kudokotela wakho kuqala. Ngaphambi kokuyisebenzisa okokuqala, cela ukuboniswa okucacile kokuthi ungayenza kanjani.
Yiziphi imiphumela emibi?
Njenganoma yimuphi umuthi, i-Repatha ingabangela imiphumela emibi emincane, yize kungebona bonke abantu abayitholayo.
| Imiphumela emibi evamile | Amathiphu okuvimbela noma okuphatha |
|---|---|
| Ubomvu, ubuhlungu, kanye nokudumba endaweni yokujova. | - Jikelezisa njalo indawo yomjovo (isib., uhlangothi olulodwa lwesisu, ngesikhathi esilandelayo kolunye uhlangothi). - Khipha umuthi wokugoma esiqandisini, uwuyeke uhlale imizuzu engama-30-45 , bese uwufaka uma usufinyelele izinga lokushisa legumbi. |
| Izimpawu ezifana nomkhuhlane (umkhuhlane, izinhlungu zomzimba). | Lezi zivame ukuba zesikhashana. Uma unenkinga ethile, khuluma nodokotela wakho. |
| Ubuhlungu emhlane, amazinga aphezulu kashukela egazini. | Tshela udokotela wakho uma kukhona imiphumela emibi ekukhathazayo noma eqhubekayo. |
Amaphuzu okufanele uwaqaphele ngokukhethekile:
- Ukungezwani Ne-Latex: Ezinye izinaliti zomjovo zingase zibe ne-latex emagodleni azo. Uma une-latex allergy, qiniseka ukuthi utshela udokotela wakho ngalokhu.
- Ukukhulelwa nokuncelisa: Uma ukhulelwe, uzama ukukhulelwa, noma uncelisa, kubalulekile ukutshela udokotela wakho ngaphambi kokusebenzisa lo muthi, njengoba kungekho datha eyanele ngokuphepha kwawo kulezi zimo.
Ngingawuthola kanjani lo muthi?
Lona akuyona imithi ongayithenga ekhemisi. Kudingeka incwadi kadokotela.
Ngokuvamile, umhlinzeki wakho wokunakekelwa okuyinhloko noma udokotela wenhliziyo uzonquma ukuthi uyawudinga yini lo muthi futhi awuncome. Kuye ngeseluleko sikadokotela wakho, ungase ukwazi ukuwuthola kumakhemisi akhethekile noma mhlawumbe ngekhemisi yangakini.
Ungalokothi uqale, uyeke, noma ushintshe umthamo wanoma yimuphi umuthi ngaphandle kweseluleko sezokwelapha. Njalo xhumana nodokotela wakho ngaphambi kokwenza noma yiziphi izinqumo.
Umlayezo Wokuya Nawe Ekhaya
- I-Repatha iwumjovo ongaphansi kwesikhumba owehlisa amazinga aphezulu e-LDL ("amabi") e-cholesterol.
- Lokhu kunconywa kakhulu kulabo abasengozini enkulu yesifo senhliziyo kanye nalabo abanezinkinga ze-cholesterol ezihambisana nofuzo.
- Ivimba iphrotheni ebizwa ngokuthi i-PCSK9, esiza isibindi ukususa i-cholesterol ye-LDL egazini.
- Lokhu kungatholakala kuphela ngomuthi kadokotela. Kubaluleke kakhulu ukulandela imiyalelo kadokotela wakho.
- Imiphumela emibi efana nokubomvu kanye nezimpawu ezifana nomkhuhlane endaweni yokujova ingase ivele, futhi kufanele wazise udokotela wakho ngazo.
- Imiphumela emihle kakhulu ingatholakala ngokusebenzisa i-Repatha kanye nendlela yokuphila enempilo.
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