Ingabe uthatha imithi yokwehlisa i-cholesterol yakho? Uma kunjalo, cishe uthatha uhlobo lwemithi ebizwa ngokuthi 'ama-statin'. Ngemva kokuqala lo muthi, ingabe ngezinye izikhathi uzizwa unesizungu, ukhohlwa izinto, noma unenkinga esibizwa ngokuthi 'i-brain fog'? Lena inkinga abantu abaningi abanayo. Ngakho-ke namuhla, ake sithole ukuthi iyini ngempela.
Okokuqala, ake sibone, iyini le statin?
Kalula nje, i-cholesterol iyinto efana ne-wax, enamafutha egazini lethu. Imizimba yethu iyayidinga le cholesterol ukuze yakhe amangqamuzana futhi ikhiqize ama-hormone, kodwa uma iningi kakhulu ayilungile. Ikakhulukazi uma i-cholesterol "embi", noma i-LDL (Low-Density Lipoprotein) cholesterol , iphezulu, ingakheka ezindongeni zemithambo yegazi yethu futhi iyivale. Lokhu kuyimbangela enkulu yezimo eziyingozi njengokuhlaselwa yinhliziyo kanye nohlangothi.
Imithi ye-statin isebenza ngokunciphisa inani le-cholesterol embi ye-LDL ekhiqizwa yisibindi. Ngakho-ke, bekungeke kube yiphutha ukubiza le mithi ngokuthi ayibalulekile futhi isindisa impilo kulabo abasengozini yesifo senhliziyo.
Ngakho-ke ingabe le ndaba 'yenkungu yobuchopho' iyiqiniso?
Nakuba ama-statin ebhekwa njengephephile kakhulu kubantu abaningi, njenganoma yimuphi umuthi, angabangela imiphumela emibi emincane. Isibonelo, ubuhlungu bemisipha, ukulimala kwesibindi, kanye 'nenkungu yobuchopho', noma izinkinga zokukhumbula nokunaka, ziphakathi kwazo.
'I-Brain Fog' isimo sokudideka okukhulu nokudideka. Cabanga nje, ukhohlwa ukuthi ubekephi okhiye bakho, mhlawumbe uvula ifriji bese ushiya ukhiye kuyo bese uyifuna kamuva. Lezi yizinhlobo zezinto ezenzeka kulesi simo.
Ngisho ne-FDA e-US ifake ukulahlekelwa yinkumbulo kanye nokudideka njengemiphumela emibi "engeyona embi kakhulu futhi engaguquki" kumalebula e-statin. I-cholesterol ibalulekile ekusebenzeni kobuchopho bethu. Eqinisweni, ama-25% e-cholesterol yethu iyonke asebuchosheni. Ngakho-ke kunengqondo ukucabanga ukuthi ukwehlisa i-cholesterol ngama-statin kungaba nomthelela othile ebuchosheni.
Kodwa-ke, ochwepheshe bathi asikho isidingo sokukhathazeka kakhulu ngalokhu. Ucwaningo olunzulu alukakafakazeli ukuxhumana okuqondile phakathi kwalo muthi nokulahlekelwa yinkumbulo.
Ngokuvamile, lezi zimpawu zingaba uphawu lwesinye isimo sezokwelapha esiyisisekelo. Ikakhulukazi uma izinkinga zokukhumbula ezifana nalezi zenzeka kubantu abaseminyakeni ephakathi noma asebekhulile, kungaba uphawu lokuqala lwesifo i-Alzheimer's.
Ngakho into yokuqala udokotela ayicabangayo ukuthi, "Ingabe lokhu kungenxa yemithi ngempela? Noma ingabe kukhona enye inkinga?" Ngenxa yalokho, bangakudlulisela kuchwepheshe wezifo zengqondo ukuze akuhlole.
Kuyamangalisa!
Ngakolunye uhlangothi, olunye ucwaningo lusikisela ukuthi ukusetshenziswa kwe-statin kunganciphisa ingozi yokuwohloka komqondo, noma ukwehla kokuhlakanipha kanye nenkumbulo okwenzeka ngokuguga. Ucwaningo olulodwa olwenziwe eminyakeni eyi-12 luthole ukuthi abantu abathatha imithamo ephezulu yama-statin babenengozi ephansi yokuwohloka komqondo. Ngakho-ke kwenziwa ucwaningo olwengeziwe ngalokhu.
Yini okufanele uyenze uma uhlangabezana nale miphumela emibi?
Uma uthatha i-statin futhi uzwa 'inkungu yobuchopho', ubuhlungu bemisipha, noma ezinye izimpawu ezingavamile, into ebaluleke kakhulu futhi okuwukuphela kwayo okufanele uyenze ukwazisa udokotela wakho.
Ungalokothi uyeke ukuthatha imithi yakho ngokuzumayo ngaphandle kokukhuluma nodokotela wakho. Khumbula, le mithi ikuvikela ezingozini ezinkulu njengokuhlaselwa yinhliziyo kanye nohlangothi.
Udokotela wakho uzohlola isimo sakho futhi ashintshe uhlelo lwakho lokwelashwa uma kudingeka. Angenza okulandelayo:
- Ukuyeka okwesikhashana imithi ye-statin oyithathayo njengamanje.
- Ukushintshela kolunye uhlobo lwe-statin.
- Ukunciphisa umthamo wemithi.
Yiziphi ezinye izindlela zokuthatha ama-statin?
Kwezinye izimo, uma ama-statin eqhubeka nokubanga imiphumela emibi, udokotela wakho angase ancome eminye imithi. Eminye yalena ibhalwe ngezansi.
| Isigaba sezidakamizwa | Ukusebenza kahle | Izibonelo (amagama emikhiqizo) |
|---|---|---|
| Izithibi ze-ACL | Kunciphisa ukukhiqizwa kwe-cholesterol yisibindi. Eminye imithi inciphisa nokumuncwa kwe-cholesterol emathunjini amancane. | I-Nexletol (i-bempedoic acid), i-Nexlizet (i-bempedoic acid kanye ne-ezetimibe) |
| Ama-PCSK9 Inhibitors | Lezi yimijovo. Azingeni ebuchosheni. Ziphula i-cholesterol embi ye-LDL egazini futhi zisheshise ukususwa kwayo. | I-Alirocumab (Praluent), i-Evolocumab (i-Repatha) |
Le mithi ingabiza kakhulu kunemithi yama-statin futhi ingase ingafaneleki kuwo wonke umuntu, ngakho-ke lesi yisinqumo esizothathwa udokotela wakho.
Yini enye okudingeka uyiqaphele lapho uthatha ama-statin?
Ukuze unciphise imiphumela emibi, nanka amaphuzu alandelayo:
- Qaphela i-grapefruit: Amanye amakhemikhali atholakala kujusi we-grapefruit angaphazamisa ikhono lomzimba lokuphula imithi ye-statin. Akudingeki uyeke ngokuphelele i-grapefruit, kodwa buza udokotela wakho ukuthi ungadla/uphuze okungakanani.
- Tshela udokotela wakho ngayo yonke eminye imithi oyithathayo: Eminye imithi ingasebenzisana nama-statin futhi ibangele imiphumela emibi. Izibonelo:
- Imithi yokwelapha izinkinga zesigqi senhliziyo (isb. i-Amiodarone)
- Eminye imithi ye-cholesterol (isib., i-Gemfibrozil)
- Imithi esetshenziswa ukwelapha i-HIV
- Amanye ama-antibiotic kanye nemithi yokulwa namagciwane (isib. i-Clarithromycin, i-Itraconazole)
- Imithi yokuvimbela amasosha omzimba (isib. i-Cyclosporine)
- Isexwayiso Sokuzivocavoca: Umphumela ovamile wemithi ye-statin ubuhlungu bemisipha. Uma uqala ngokuzumayo ukwenza ukuzivocavoca okunzima ngenkathi usebenzisa yona, ungase wandise ingozi yakho yokulimala kwemisipha. Uma usanda kuqala ukuzivocavoca, yandisa ukuqina kancane kancane.
Umlayezo Wokuya Nawe Ekhaya
- Ama-statin ayisidakamizwa esibaluleke kakhulu, esisindisa impilo esinciphisa ingozi yokuhlaselwa yinhliziyo kanye nesifo sohlangothi.
- 'I-Brain fog' ingumphumela ongavamile kakhulu. Ngokuvamile ayibi yingozi futhi iyanyamalala uma umuthi uyekwa noma ushintshwa.
- Izinkinga zokukhumbula obhekene nazo cishe zibangelwa ezinye izici (ubudala, ezinye izimo zezokwelapha) kunemithi ye-statin.
- Uma uhlangabezana nanoma yimiphi imiphumela emibi, into engcono kakhulu ongayenza ukukhuluma nodokotela wakho.
- Ungayeki ukuthatha ama-statin nganoma yisiphi isizathu ngaphandle kweseluleko sezokwelapha. Izinzuzo zidlula kakhulu izingozi.
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