Isimo esiphuthumayo esihambisana nokwelashwa komdlavuza: Ake sifunde nge-Tumor Lysis Syndrome!

Ukuphila nomdlavuza kuyimpi yangempela. Nakuba ukwelashwa okufana ne-chemotherapy kungasiza ekubhubhiseni amangqamuzana omdlavuza, ngezinye izikhathi lokho kwelashwa kungabangela izinkinga ezingalindelekile. Namuhla, sizokhuluma ngesimo esiphuthumayo esidinga ukunakekelwa okusheshayo futhi esingaba yingozi ngisho nokuphila . Lokhu kubizwa ngokuthi i-Tumor Lysis Syndrome.

Iyini i-Tumor Lysis Syndrome? Masiyiqonde kalula.

Kalula nje, i-Tumor Lysis Syndrome iyiqembu lezimo ezingathi sína ezenzeka lapho inani elikhulu lamangqamuzana omdlavuza lifa ngesikhathi esisodwa futhi okuqukethwe yilawo maseli kukhishwa egazini. Cabanga nje, lesi simo singavela emahoreni ambalwa okuqala ukwelashwa komdlavuza. Singakhula ngokushesha kakhulu futhi sibe yisimo esidinga ukwelashwa okuphuthumayo. Ngakho-ke, odokotela bahlala beqaphile ngalokhu.

Kodwa kunezindaba ezinhle. Odokotela banezindlela zokuvimbela i-Tumor Lysis Syndrome ukuthi ingenzeki . Lokhu bakwenza ngokubona ukuthi obani abasengozini enkulu futhi bathathe izinyathelo zokunciphisa leyo ngozi.

Kwenzekani emizimbeni yethu kulesi simo?

Uma amangqamuzana omdlavuza ebhekene nokucindezeleka, ikakhulukazi ngenxa yokwelashwa okufana nokwelashwa ngamakhemikhali, ayaphuka. Bese kuthi, amakhemikhali kanye nobuthi obungaphakathi kulawo maseli buqongelela ngobuningi egazini. Inkinga iqala lapho umzimba wethu ungakwazi ukususa lokhu ngokushesha. Lesi sifo sokuvuvukala kwezicubu singathinta kakhulu inhliziyo yethu, izinso kanye nemisipha. Ake sibone ukuthi iyini le miphumela:

• I-Hyperuricemia - Lokhu kusho amazinga aphezulu e-uric acid: Uma i-uric acid egazini ikhuphuka, ingafakwa ezinso, okubangela ukungasebenzi kahle kwezinso ngisho nokwehluleka kwezinso. Cabanga ngakho njengokuvaleka kwepayipi lamanzi.
• I-Hyperphosphatemia - okungukuthi, amazinga e-phosphorus akhuphukile: Amazinga e-phosphorus akhuphukile egazini nawo aphazamisa ukusebenza kwezinso.
• I-Hyperkalemia - Lokhu kusho amazinga aphezulu e-potassium: Uma amazinga e-potassium ephezulu, ungase ube nezimpawu ezifana nokucanuzela kwenhliziyo, ukuhlanza, kanye nesifo sohudo. Akukhona lokho kuphela, kodwa izinga lokushaya kwenhliziyo yakho lingashintsha, okubangela ukungasebenzi kahle kwenhliziyo, futhi mhlawumbe ngisho nokuhlaselwa yinhliziyo. Lokhu kuyingozi kancane, akunjalo?
• I-Uremia: Lokhu kwenzeka lapho izinso ziyeka ukuhlunga ubuthi egazini. I-Uremia ingabangela izinkinga ezinkulu ngamathambo, imisipha, inhliziyo kanye nemithambo yegazi.
• I-Hypocalcemia - Amazinga aphansi e-calcium: Amazinga aphansi e-calcium egazini angabangela ushintsho ekushayweni kwenhliziyo, ukuqaqamba kwemisipha, ukudideka, ukungazweli kanye nokuqaqamba kwamalungu. Ngezinye izikhathi, ngisho nokufa ngenxa yokuma kwenhliziyo kungenzeka.

Into ebaluleke kakhulu: I-Tumor Lysis Syndrome yenzeka lapho esinye noma ngaphezulu salezi zimo sihlangana.

Ingabe i-Tumor Lysis Syndrome iyisimo esiphuthumayo?

Yebo, impela! I-Tumor Lysis Syndrome iyisimo esiphuthumayo sezokwelapha esidinga ukwelashwa okusheshayo. Ngakho-ke, kubaluleke kakhulu ukuqaphela lokhu.

Ubani ongaba yisisulu salesi simo?

Akuwona wonke umuntu othola ukwelashwa komdlavuza othola i-Tumor Lysis Syndrome. Uma uthola ukwelashwa komdlavuza, kuwumqondo omuhle ukubuza udokotela wakho ngalokhu. Ngokuvamile, abantu abathola ukwelashwa ngamakhemikhali ngenxa yalezi zinhlobo zomdlavuza basengozini enkulu yokuthola lesi simo:

• I-Acute Lymphocytic Leukemia
• I-Aggressive Non-Hodgkin's Lymphoma, njenge-Burkitt Lymphoma kanye ne-Diffuse Large B-cell Lymphoma
• I-Acute Myeloid Leukemia (AML)
• I-B-cell Acute Lymphoblastic Leukemia (YONKE)
• Umdlavuza Wamaphaphu Wamangqamuzana Amancane

Futhi, kunezinye izinhlobo zomdlavuza, lapho welashwa, zisengozini encane yokuba nalesi simo. Kodwa asikapheli ngokuphelele. Izibonelo:

• I-Anaplastic Large Cell Lymphoma - Lona umdlavuza ongavamile, okhula kancane wesimiso somzimba sokuzivikela.
• I-Chronic Lymphocytic Leukemia (CLL)
• I-Neuroblastoma
• Umdlavuza Webele
• I-Sarcoma Yezicubu Ezithambile
• I-Medulloblastoma
• I-Merkel Cell Carcinoma

Yiziphi ezinye izimbangela ze-Tumor Lysis Syndrome?

Odokotela bayazi ukuthi abanye abantu basengozini enkulu yokuthola lesi simo. Kuthathwa izinyathelo zokuphepha ezikhethekile ngaphambi kokunikeza abantu abanjalo ukwelashwa ngamakhemikhali. Nazi ezinye izinto ezandisa ingozi:

• Ukuba nenani eliphezulu kakhulu lamaseli amhlophe egazi.
• Amazinga e-uric acid egazini asevele ephezulu.
• Ukuba nezinkinga zezinso.
• Ukwehla kokuqukethwe kwamanzi emzimbeni (Ukuphelelwa amanzi emzimbeni).
• Ukuba nomdlavuza esigabeni esibi kakhulu (umdlavuza wesigaba esilandelayo).
• Ukuba nezimila ezinkulu.

Ingabe lesi simo singaba khona ngaphandle kwe-chemotherapy?

Yebo, kodwa akuvamile kakhulu . Uma kwenzeka, odokotela bakubiza ngokuthi yi-Spontaneous Tumor Lysis Syndrome.

Ziyini izimpawu ze-Tumor Lysis Syndrome?

Lezi zimpawu zivame ukuvela zingakapheli amahora ayi-12 kuya kwangu-72 kusukela ziqale ukwelashwa ngamakhemikhali. Nakhu ukuthi ziyini:

• Isicanucanu nokuhlanza.
• Uhudo.
• Izinguquko enanini lomchamo odlulayo (zinganda noma zinciphe).
• Ubuthakathaka kanye nokudinwa.
• Igazi emchameni (i-Hematuria).
• Izimo zesifo sokuwa, okungukuthi, ukuxhuzula.
• Ukuqaqamba Kwemisipha.
• I-Syncope.
• Ukushaya kwenhliziyo okungajwayelekile.
• Umfutho wegazi ophansi (i-Hypotension).
• Ubuhlungu Bamalunga.

Uma uhlangabezana nesinye noma ngaphezulu salezi zimpawu ngenkathi welashwa umdlavuza, kufanele wazise udokotela ngokushesha.

Kungani kwenzeka i-Tumor Lysis Syndrome?

Kalula nje, lesi simo senzeka lapho ukwelashwa komdlavuza kubangela inani elikhulu lamangqamuzana omdlavuza ukuba afe ngokuzumayo nangokushesha. Izinto ezingaphakathi kwamangqamuzana afayo (njenge-potassium, i-phosphorus, ne-uric acid) ziqongelela egazini ngokuzumayo.

Ngokuvamile, izinso zethu yizo ezihlunga lezi zinto ezingafuneki. Kodwa, lapho inani elikhulu lamaseli lifa ngesikhathi esisodwa, izinso azikwazi ukwenza lo msebenzi. Kufana nomsele ovalekayo lapho inani elikhulu likadoti lingena ngesikhathi esisodwa. Bese lobu buthi buqala ukuqongelela emzimbeni.

Odokotela bakuthola kanjani lesi simo?

Ukugxila okukhulu kodokotela ukuvimbela i-Tumor Lysis Syndrome. Ukuze benze lokhu, bazokwenza njalo ukuhlolwa kwegazi nomchamo ukuqinisekisa ukuthi izinso zakho zisebenza kahle nokuthi ubuthi buyasuswa emzimbeni wakho.

Yiziphi izindlela zokwelapha i-Tumor Lysis Syndrome?

Umzamo wokuqala wodokotela ukuvimbela lokhu. Lokhu bakwenza ngokubona labo abasengozini enkulu nokuthatha izinyathelo zokuphepha ezikhethekile. Kodwa, uma isimo sivela, ukwelashwa kuqala ngokushesha.

Izinto okufanele uzenze ukuze uvimbele:

• Ukumanzisa Ngemithambo Yegazi (IV): Lokhu kusiza ukugcina amazinga amahle okumanzisa, kukhuthaze ukuchama, futhi kusize ekususeni ubuthi emzimbeni ngokushesha.
• Ukunikeza imithi evimbela ukubekwa kwamakristalu e-uric acid ezinso: Kunemithi ethile esiza ukulawula amazinga e-uric acid.

Ukwelashwa uma lesi simo sivela:

• Ukunikeza imithi yokukhipha isisu: Lokhu kusiza ukususa ubuthi emzimbeni ngokushesha.
• I-GLISH: Ukunikeza imithi esusa i-potassium ne-phosphorus eningi.
• Ukunikeza imithi encibilikisa amakristalu e-uric acid akheke ezinso.
• I-Dialysis: Uma izinso zakho zingasebenzi kahle, ungase udinge i-dialysis ukuze ususe ubuthi egazini lakho. Lokhu kufana nokwenza umsebenzi wezinso zakho ngokwenziwa.

Ingabe i-Tumor Lysis Syndrome ingelapheka?

Yebo, impela! Cishe amaphesenti angama-90 abantu abathola lesi simo bayalulama. Into ebaluleke kakhulu ukuxilonga kusenesikhathi bese uqala ukwelashwa kusenesikhathi.

Kwenzekani ngemva kokuba lesi simo seselashwe?

I-Tumor Lysis Syndrome ingabangela umonakalo othile ezinso zakho. Ngakho-ke, uma unalesi simo, kubaluleke kakhulu ukubuza udokotela wakho uma udinga ukwelashwa okwengeziwe noma ukunakekelwa okukhethekile kuze kube yilapho izinso zakho zilulama.

Ukwelashwa komdlavuza kuyathuthuka usuku nosuku, okusivumela ukuthi sibhubhise amangqamuzana omdlavuza ngokushesha. Kodwa-ke, ngezinye izikhathi, lapho lawa maseli efa, amakhemikhali kanye nobuthi ababukhiphayo kungabangela isimo esiyingozi esibizwa ngokuthi i-Tumor Lysis Syndrome. Lokhu kungaba nomthelela omkhulu enhliziyweni nasezinso.

Okokugcina, okufanele ukukhumbule (Umyalezo Wokuya Ekhaya)

Ukwelashwa komdlavuza kuyinselele. Phakathi nalesi sikhathi, kubalulekile ukuqaphela izimo eziphuthumayo ezifana ne-Tumor Lysis Syndrome. Uma welashwa umdlavuza, qiniseka ukuthi ubuza udokotela wakho ukuthi usengozini yalesi simo. Bazokuchazela izingozi futhi benze konke okusemandleni abo ukuvimbela noma ukwelapha lesi simo uma sivela. Ungazinaki izimpawu, futhi utshele udokotela ngokushesha uma ubona noma yini engavamile. Ukunakekela impilo yakho kuyinto ebaluleke kakhulu!

Isifo se - Tumor lysis, ukwelashwa komdlavuza, i-chemotherapy, isifo sezinso, i-hyperkalemia, i-hyperuricemia, isimo esiphuthumayo sezokwelapha