Ingabe nawe unesifo esibuhlungu esiswini esingalapheki? Ake sifunde ngesimila se-VIPoma (Vasoactive Intestinal Peptide Secreting)!

Ingabe ngezinye izikhathi uba nesifo sohudo esinzima esihlala izinsuku eziningi, esihambisana nobuhlungu besisu kanye nokuqaqamba? Ungase ungadli noma uphuze lutho, kodwa usazizwa ngale ndlela. Uma unezimpawu ezinjengalezi, imbangela ingase ibe yinto engavamile kakhulu, kodwa kungaba yisimo okudingeka sikhulume ngaso nakanjani. Namuhla sikhuluma ngesinye isimo esinjalo esibizwa ngokuthi i-VIPoma , noma i-`Vasoactive Intestinal Peptide Secreting` tumor . Nakuba igama lingase lizwakale liyinkimbinkimbi kancane, masiligcine lilula.

Iyini i-VIPoma tumor?

Kalula nje, i-VIPoma uhlobo olungavamile kakhulu lwesimila oluvela kuma-pancreas . Ngokukhethekile, lawa ama-tumors akhula kumaseli akhiqiza ama-hormone e-pancreas, abizwa ngamaseli e-endocrine . Odokotela ngezinye izikhathi babiza lesi simo ngokuthi 'i-Verner-Morrison syndrome' .

Amathumba e-VIPoma awavamile kakhulu . Ngisho nasezweni elifana neMelika, lesi simo kuthiwa sivela kubantu abacishe babe yisigidi eziyishumi. Ngakho-ke ungacabanga ukuthi singavamile kangakanani. Ukuphila nesifo esingavamile kangaka kungaba yinselele yangempela, ngoba sinomthelela omkhulu empilweni yakho yansuku zonke. Kodwa, ungakhathazeki . Manje kunezindlela zokwelapha ezingayelapha ngokuphelele lesi simo se-VIPoma ngezinye izikhathi, noma okungenani zilawule izimpawu.

Ziyini izimpawu zesimila se-VIPoma?

Uphawu oluyinhloko nolubaluleke kakhulu olubonakala kulesi simo uhudo olunzima, olunamanzi . Lokhu kukhulu kangangokuthi ungaba nalesi sihudo ngisho noma ungadli (uzilile). Asipheli ezinsukwini ezimbalwa. Lolu uphawu oluhlukile kakhulu lwalesi sifo.

Ngaphandle kwalokho, kungase kube nezinye izimpawu eziningana:

• Ubuhlungu besisu noma izinhlungu: Isisu sakho singase sizizwe sengathi siyaphenduka noma singase sibe buhlungu ukusithinta.
• Ukukhathala: Ukuzizwa ukhathele futhi ungenampilo ngaso sonke isikhathi.
• Ukushawa: Ukubomvu okungazelelwe kobuso nesifuba. Lokhu kungenzeka ngaphandle kwesizathu esibonakalayo.
• Ubuthakathaka bemisipha: Ungase uzizwe sengathi izitho zakho zomzimba ziyaphela amandla, futhi kungaba nzima ukuphakamisa izinsimbi.

Cabanga ukuthi ubungazizwa kanjani uma ubungakhipha amabhodlela amabili noma amathathu amanzi njengendle ngosuku. Lokhu kungaba nzima kakhulu kangangokuthi awukwazi ngisho nokwenza imisebenzi yakho yansuku zonke.

Yini ebangela ukuthi i-VIPoma ikhule?

Ochwepheshe abasazi kahle ukuthi yini ebangela izimila ze-VIPoma, kodwa banokuqonda okucacile kokuthi lezi zimpawu zenzeka kanjani.

Umzimba wethu une -hormone ebizwa ngokuthi i-'Vasoactive Intestinal Peptide' (VIP) . Le hormone ye-VIP inesibopho sokulawula uhlelo lwethu lokugaya ukudla.Kuyasiza kakhulu. Okusho ukuthi, le hormone ilawula ukukhishwa kwamanzi, usawoti, ama-enzyme, kanye ne-asidi yesisu endleleni yokugaya ukudla. Futhi iyasiza ekuphumuzeni eminye yemisipha endleleni yokugaya ukudla.

Uma kuvela isimila se-VIPoma, sikhipha inani elikhulu kakhulu le-hormone ye-VIP emzimbeni. Uma le hormone ye-VIP eningi kakhulu imuncwa emzimbeni, kuvela izimpawu okukhulunywe ngazo ngaphambili, njengohudo olunzima kanye nobuhlungu besisu. Kalula nje, lesi simila sibangela ukuthi i-hormone ye-VIP isebenze ngokweqile.

Yiziphi izinkinga ezingaba khona ngenxa ye-VIPoma?

Inkinga enkulu nge-VIPoma uhudo oluningi. Abanye abantu bangase baphuze ilitha elilodwa kuya kwamathathu (amalitha angu-1-3) endle enamanzi ngosuku. Uma lokhu hudo kuqhubeka, umzimba ulahlekelwa amanzi amaningi kanye namaminerali abalulekile, ikakhulukazi i-potassium.

Lokhu kungaholela ekuphelelweni amanzi emzimbeni kanye nokwehla kwe-kalemia ngokuhamba kwesikhathi. Zombili lezi zimo ziyingozi ngoba zingaholela ezinkingeni zempilo ezinkulu kakhulu. Isibonelo:

• Ukungalingani kwenhliziyo (`Arrhythmia`): Ukushaya kwenhliziyo okungajwayelekile.
• Ukushaqeka kwe-Hypovolemic: Isimo esibangelwa ukwehla kwenani loketshezi emzimbeni.
• Ubuthakathaka bemisipha (`Myopathy`): Ukusebenza kwemisipha okungasebenzi kahle.
• I-Tetany: Ukufinyela okubuhlungu kwemisipha.

Ngenxa yalezi zinkinga, kubaluleke kakhulu ukufuna iseluleko sezokwelapha ngokushesha uma unezimpawu ze-VIPoma.

Odokotela bayixilonga kanjani i-VIPoma?

Uma unezimpawu ezifana nesifo sohudo esinzima noma ubuhlungu besisu obekulokhu kuqhubeka izinsuku eziningana, udokotela uzokwenza ukuhlolwa ngokomzimba futhi akubuze ngezimpawu zakho.

Ukuhlolwa kwendle nakho kungenziwa ukuze kunqunywe ezinye izimo ezivamile ezibangela isifo sohudo (isb., ukutheleleka). Ngaphezu kwalokho, ukuhlolwa okulandelayo kungenziwa:

• Ukuhlolwa kwegazi: Lokhu kuhlola ikakhulukazi izinga le-hormone ye-VIP egazini. Ku-VIPoma, leli zinga liphezulu kakhulu. Bangahlola nezinto ezifana nokuphelelwa amanzi emzimbeni kanye nokuntuleka kwe-potassium.
• Ukuhlolwa kwezithombe: Lokhu kuthatha izithombe zengaphakathi lomzimba ukuze kubonakale ukuthi kukhona yini isimila, uma sikhona, ukuthi sikuphi, nokuthi sikhulu kangakanani. Lokhu kungafaka phakathi ukuhlolwa kwe-`Computed Tomography (CT)` noma ukuhlolwa kwe-`Magnetic Resonance Imaging (MRI)` .

Odokotela baqinisekisa isimo se-VIPoma ngemva kokwenza zonke lezi zivivinyo.

Iphathwa kanjani i-VIPoma?

Ukwelashwa kwe-VIPoma kuvame ukuhilela inhlanganisela yemithi kanye nokuhlinzwa. Udokotela wakho angase akuncome okulandelayo:

• Uketshezi olufakwa emthanjeni (`uketshezi lwe-IV`):Lokhu kunikezwa ukuze kuthathelwe indawo uketshezi namaminerali alahlekayo emzimbeni ngenxa yohudo oluqhubekayo. Lokhu kungasiza ekulawuleni ukuphelelwa amanzi emzimbeni.
• Imithi:
• Uhudo lungalawulwa ngemithi efana ne- "Octreotide (Sandostatin LAR®)" . Le mithi inciphisa ukukhishwa kwe-hormone i-VIP.

Ngemva kokulawula izimpawu zakho ngale ndlela, udokotela wakho angase asikisele ezinye izindlela zokwelapha ukususa noma ukulawula isimila:

• Ukuhlinzwa: Uma isimila singakasabalali kwezinye izingxenye zomzimba (sesivele sigugile) , ukuhlinzwa kungasetshenziswa ukususa isimila. Lokhu kungenziwa ngokuhlinzwa okubizwa ngokuthi i-distal pancreatectomy, okususa umsila nomzimba we-pancreas. Uma isimila sisusiwe ngokuphelele, lesi sifo singase selapheke.
• Ukwelashwa ngamakhemikhali: Uma isimila sisakazeke noma singenakususwa ngokuphelele ngokuhlinzwa, kunikezwa i-chemotherapy ukuze kubhujiswe amangqamuzana omdlavuza.
• Ukwelashwa okuqondiwe: Lezi yizidakamizwa eziqondisa izingxenye ezithile zamaseli omdlavuza.

Ithimba lakho lezokwelapha lizonquma ukwelashwa okufanele kakhulu kuwe ngemva kokuhlola ngokucophelela isimo sakho.

Yini umuntu one-VIPoma angayilindela?

Lokhu kuyahlukahluka ngempela kumuntu nomuntu. Ukuhlinzwa kungayilapha ngokuphelele i-VIPoma. Imithi ingalawula izimpawu ngezinga elikhulu.

Kodwa-ke, akuzona zonke izimo ezifanayo . Okuhlangenwe nakho kwakho kungase kuhluke kakhulu kokwabanye abantu nge-VIPoma. Udokotela wakho ohlinzayo kanye nethimba lezokwelapha yibona abangakunikeza ulwazi olungcono kakhulu kanye nesiqondiso. Bakwazi kangcono wena kanye nesimo sakho, ngakho-ke babuze noma yini okudingeka uyazi.

Kufanele ngimbone nini udokotela?

Uma usuvele uthola ukwelashwa kwe-VIPoma, shayela udokotela wakho ngokushesha uma izimpawu zakho zingathuthuki noma zingabi zimbi kakhulu.

Futhi, iya ekamelweni eliphuthumayo uma unezinye zalezi zimpawu:

• Uma unezinhlungu zesisu ezinzima .
• Uma usube nohudo olumanzi izinsuku eziningana .
• Uma ubonisa izimpawu zokuphelelwa ngamanzi emzimbeni , njengokuzizwa unesizungu, ukuzizwa unesizungu, noma umchamo ophuzi noma onsundu omnyama.

Uhudo olungapheli olubangelwa yi-VIPoma lungaphazamisa imisebenzi yakho yansuku zonke ngisho nokulala kwakho ebusuku. Ukwazi ukuthi yini ebangela lezi zimpawu kungaba impumuzo. Kodwa-ke, ngenxa yokuthi i-VIPoma iyisifo esingavamile, bambalwa abantu abaziyo ngaso. Lokhu kungakwenza uzizwe unesizungu futhi ukhungathekile. Ungase uzizwe unamahloni ngisho nangezimpawu ze-VIPoma.

Ithimba lakho lezokwelapha liyayiqonda kahle le mizwa, ngakho ungangabazi ukubacela noma yiluphi usizo oludingayo, kungaba mayelana nokulawula izimpawu zakho noma ukuphila nesifo esingavamile kangaka.

Izinto ezibaluleke kakhulu okudingeka sizikhumbule (Umyalezo Wokuya Ekhaya)

I-VIPoma iyisimila esingavamile esikhula ku-pancreas. Sibangela ukukhiqizwa ngokweqile kwe-hormone ebizwa ngokuthi i-VIP, ebangela izimpawu ezifana nohudo olunzima kanye nobuhlungu besisu. Uma lezi zimpawu ziqhubeka, kubalulekile ukufuna iseluleko sikadokotela. Ukwelashwa okusheshayo kubalulekile njengoba izinkinga ezifana nokuphelelwa amanzi emzimbeni kanye nokuntuleka kwe-potassium zingase zenzeke. Kunezindlela zokwelapha ezifana nokuhlinzwa, imithi, kanye ne-chemotherapy. Nakuba lesi kuyisifo esingavamile, awuwedwa. Thola ukwesekwa eqenjini lakho lezokwelapha.

I- VIPoma, i-Vasoactive Intestinal Peptide, umdlavuza we-pancreatic, isifo sohudo, i-Verner-Morrison syndrome, ukungalingani kwama-hormone, izifo ezingavamile