Dɛn ne Acetylcholine (ACh)? Momma yɛnhwehwɛ nea ɛyɛ yɛn nipadua no pɛpɛɛpɛ!

So woate acetylcholine , anaa (ACh) ho asɛm pɛn? Ebia wo duruyɛfo aka ho asɛm akyerɛ wo, anaasɛ woakenkan ho asɛm wɔ baabi. Ɛyɛ nnuru ketewaa bi nanso ɛho hia yiye wɔ yɛn nipadua mu. Ɛte sɛ posɔfese sohwɛfo ketewaa bi a ɔde nkrasɛm kɔ yɛn nipadua mu. Enti, ɛnnɛ yɛbɛka acetylcholine ho asɛm wɔ ɔkwan a ɛyɛ mmerɛw so a wubetumi ate ase.

Dɛn ankasa ne Acetylcholine?

Sɛ yɛbɛka no tiawa a, acetylcholine yɛ ntini mu nkwaadɔm . Susuw ho hwɛ, ɛsɛ sɛ w’amemene no de anyinam ahoɔden nkrasɛm nketenkete mena na ama woatumi akanyan wo nsa, susuw ho, kae biribi, saa nneɛma yi nyinaa. Acetylcholine yɛ nnuru a ɛboa ma wɔde saa nkrasɛm no fa ntini mu nkwammoaa mu .

Wɔsan frɛ eyi sɛ " excitatory " neurotransmitter . Wunim nea ɛno yɛ? Ɛ "nyane" ntini mu nkwammoaa bi, kyerɛ sɛ, ɛkanyan no, na ɛma "ɛsoma" nkrasɛm ntɛmntɛm. Ɛte sɛ nea worebɔ obi a wada pon mu na woaka sɛ, "Hwɛ, fa krataa yi."

Edin acetylcholine no fi nneɛma abien a ɛma ɛyɛ no mu. Baako ne acetyl kuw bi . Eyi fi aduru bi a wɔfrɛ no acetyl coenzyme A a wɔde asikre glucose na ɛyɛ no mu. Ɔfoforo no yɛ aduannuru bi a wɔfrɛ no choline . Wohu choline fi awosu mu wɔ nkesua a wɔayam, soya, mmerɛbo, nhabannuru, ne atoko mu. Wɔyɛ choline nso wɔ yɛn mmerɛbo mu.

Acetylcholine ka yɛn nipadua mu dwumadi atitiriw pii ho, titiriw ntini a yefi yɛn pɛ mu keka ne ho.Eyi di dwuma titiriw wɔ yɛn adwene mu nneyɛe te sɛ yɛn akwaa a yɛde tu ne nantew mu. Ɛkanyan ntini mu nkwammoaa a ɛwɔ yɛn ntini mu no, na ɛma ɛtwetwe. Ɛnyɛ ɛno nko, na mmom ɛho hia kɛse ma ntini nkwammoaa a ɛwɔ yɛn amemene mu, ne nneɛma te sɛ nkae, nsusuwii, ne adesua nso.

Ɔkwan bɛn so na acetylcholine (ACh) yɛ adwuma?

Wɔde acetylcholine sie ntini mu nkwammoaa no awiei, kosi sɛ ɛho behia sɛ wɔde nkrasɛm bi mena. Sɛ “sɛnkyerɛnne” bi ba sɛ ɛde nkrasɛm bɛmena a, acetylcholine a wɔakora so yi fi adi. Sɛ wogyae a, etu kwan kɔ ɔkwan ketewaa bi a ɛda ntini mu nkwammoaa abien ntam mu. Wɔfrɛ saa nsonsonoe yi sɛ synaptic cleft .

Bere a wɔatwa synaptic cleft no akyi no, nneɛma ahorow abien na ɛwɔ hɔ a acetylcholine tumi kyekyere ho. Wɔne:

• Nneɛma a ɛma nicotine
• Muscarinic a ɛma nipadua no nya ntini

Bere a ɛkyekyere saa ntini ahorow yi akyi no, nnuru nkrasɛm no kɔ ntini mu nkwammoaa a edi hɔ no mu. Sɛ wɔde nkrasɛm no mena wie a, acetylcholine a ɛka wɔ synaptic cleft no mu no nsɛe kɛkɛ. Enzyme foforo bi a wɔfrɛ no acetylcholinesterase ba na ɛpaapae saa acetylcholine yi mu kɔ ne afã horow a ɛka bom no mu, choline ne acetate. Afei wɔsan twetwe afã horow a abubu yi, wɔsan de di dwuma bio, na wɔde di dwuma de nnuru ho nkrasɛm foforo kɔ. Nhyehyɛe a etu mpɔn yiye!

Dɛn na ɛba acetylcholine (ACh) so?

Acetylcholine wɔ mfaso pii ma yɛn nipadua. Momma yɛnhwɛ emu atitiriw no.

Nkwammoaa ahorow abien no nyinaa ka yɛn nkae ho . Ɛne sɛ, ɛho hia ma bere tenten nkae, bere tiaa mu nkae, nkae a wɔhyehyɛ, nea wɔhyɛ mu den, ne nea wogye. Wɔ amemene no mu no, acetylcholine ka nneɛma afoforo ho. Ɛhyɛ nkannyan, anigye/adwene, adesua, ne REM nna (nna fã a yɛda dae) ho nkuran.

Tebea horow bɛn na ɛba bere a acetylcholine (ACh) dodow so tew no?

Acetylcholine a ɛba fam, anaasɛ nea enni nipadua no mu no betumi de nyarewa pii aba. Eyinom mu nea ɛho hia sen biara ne:

• Alzheimer yare : Nnipa a wɔwɔ Alzheimer yare no nni acetylcholine a ɛdɔɔso wɔ wɔn amemene mu. Ne saa nti, nkae a wɔhwere no yɛ sɛnkyerɛnne titiriw.
• Lambert-Eaton myasthenic syndrome : Saa yare yi fi acetylcholine a efi ntini mu nkwammoaa mu no so tew.
• Myasthenia gravis : Eyi yɛ yare a nipadua no tumi ko tia nyarewa a ɛma nnompe mu ntini no yɛ mmerɛw ntɛmntɛm bere a wɔde adi dwuma mpɛn pii akyi no.

Nnuru bɛn na ɛde n’ani si acetylcholine (ACh) so?

Cholinesterase inhibitors yɛ nnuru kuw bi a ɛyɛ adwuma denam enzyme a ɛpaapae acetylcholine a ɛmma ɛnyɛ adwuma na ɛma acetylcholine agyefo no dwumadi yɛ kɛse no so. Wɔde sa Alzheimer yare ne myasthenia gravis. Donepezil (Aricept®), Rivastigmine (Exelon®), ne Galantamine (Razadyne®) yɛ nnuru yi bi.

Nnuan bɛn na choline a ɛboa ma wɔyɛ acetylcholine (ACh) wom?

Choline, aduannuru bi a ɛdan acetylcholine, wɔ nnuan pii mu. Nhwɛsoɔ:

• Nantwinam mmerɛbo
• Nkwaa (titiriw no, nkesua) .
• Nantwinam top kurukuruwa
• Soyabean a wɔayam, asaabo a wɔde ahyɛ toa mu
• Akokɔ nufu a wɔayam
• Cod mpataa `(Cod)`
• Quinoa a wɔanoa
• Shiitake nsenia a wɔanoa, broccoli a wɔanoa ne Brussels sprouts
• Nufusu (1%) `(Nufusu (1%))`, vanilla yogurt a srade nnim `(vanilla yogurt a srade nnim)`

Bɔ mmɔden sɛ wode saa nnuan yi bɛka w’aduan ho. Aduan a ɛkari pɛ ho hia yiye ma asetra a ahoɔden wom.