So worehyia mogya mu nkwammoaa fitaa dodow a ɛba fam? Momma yensua Autoimmune Neutropenia (AIN) ho ade!

So woasusuw nea enti a yɛn ankasa nipadua mu tumi a ɛko tia nyarewa no, sɛ́ anka ɛbɛbɔ yɛn ho ban no, etumi fi ase tow hyɛ yɛn ankasa nkwammoaa so pɛn? Ɛno yɛ tebea bi a ɛyɛ den kakra, nanso ntease wom a wɔfrɛ no Autoimmune Neutropenia (AIN) . Nea ɛba ne sɛ yɛn ankasa nipadua mu ahoɔden a ɛko tia nyarewa no tow hyɛ mogya mu nkwammoaa fitaa bi a ɛho hia yiye so wɔ yɛn nipadua mu, a wɔfrɛ no `neutrophils.` Enti momma yɛnka eyi ho asɛm tiawa, wɔ ɔkwan a wubetumi ate ase so.

Enti, dɛn ne Autoimmune Neutropenia (AIN)?

Sɛ yɛbɛka no tiawa a, `Autoimmune Neutropenia` (AIN) yɛ tebea a ɛfa mogya ho. Nea ɛkɔ so wɔ ha ne sɛ yɛn nipadua mu ahoɔden a ɛko tia nyarewa a wɔkyerɛ sɛ ɛbɔ yɛn ho ban no di mfomso tow hyɛ yɛn ankasa mogya mu nkwammoaa fitaa a wɔfrɛ no `neutrophils` so. Fa w’adwene bu eyi, te sɛ asraafo a wɔrebɔ yɛn man ho ban a wodi mfomso tow hyɛ yɛn ankasa nkurɔfo so.

Dɛn ne `Neutrophils`?

Neutrophils yɛ yɛn nipadua mu ahoɔden a ɛko tia nyarewa no afã horow a ɛho hia yiye. Wɔte sɛ asraafo nkumaa wɔ yɛn nipadua mu. Wɔn adwuma titiriw ne sɛ wɔbɛhwehwɛ nneɛma a epira a ɛkɔ nipadua no mu te sɛ mmoawa ne fungi a ɛde nyarewa ba na wɔasɛe no. Enti, wɔ `Autoimmune Neutropenia` asɛm no mu no, yɛn ankasa nipadua mu ahoɔden a ɛko tia nyarewa no sɛe saa `neutrophils` nkwammoaa a ɛsom bo yi, enti `neutrophils` dodow a ɛwɔ mogya no mu no so tew sen sɛnea ɛfata.

AIN ahorow atitiriw abien na ɛwɔ hɔ:

1. Primary Autoimmune Neutropenia (AIN): Wɔtaa hu eyi wɔ nkokoaa ne mmofra nkumaa mu . Nea ɛkɔ so wɔ ha ne sɛ `neutrophils` dodow so tew a ntease foforo biara nni ho. Nanso asɛmpa no ne sɛ mpɛn pii no, tebea yi siesie ne ho wɔ mfe kakraa bi mu.

2. Secondary Autoimmune Neutropenia (AIN): Eyi taa ba mmofra a wɔn mfe akɔ anim ne mpanyimfo mu . Ɛha yi, aduruyɛ mu tebea foforo na ɛde neutrophil dodow a ɛba fam no ba. Sɛ nhwɛso no, ebetumi afi ɔyare mmoawa, mogya mu yare foforo, anaa yare foforo a nipadua no tumi ko tia nyarewa (tebea a nipadua no mu tumi a ɛko tia nyarewa no tow hyɛ n’ankasa nipadua so) mu. Saa AIN tebea a ɛto so abien yi taa yɛ nea enni sabea .

Neutrophils dodow a wɔfrɛ no neutropenia no sua dɛn?

Autoimmune Neutropenia yɛ tebea a ɛtrɛw a wɔfrɛ no Neutropenia no biako pɛ. Wɔkyekyɛ neutropenia mu sɛ ɛnyɛ den, ɛyɛ mmerɛw, anaa emu yɛ den, a egyina neutrophils dodow a ɛwɔ mogya microliter (microL) biara mu so.

• Neutropenia a ɛnyɛ den: Neutrophils 1,000 – 1,500 wɔ microL biara mu.
• Neutropenia a ɛkɔ fam: Neutrophils 500 – 1,000 wɔ microL biara mu.
• Neutropenia a emu yɛ den: Neutrophils a ennu 500 wɔ microL biara mu.

Nea ɛho hia sen biara ne sɛ ɛsɛ sɛ oduruyɛfo si saa gyinapɛn ahorow yi so dua. Sɛ w’adwene mu yɛ wo naa wɔ eyi ho a, ɛho hia paa sɛ wohwehwɛ aduruyɛ mu afotu.

Ɔkwan bɛn so na AIN ka me nipadua?

Ɔkwan a AIN fa so ka wo no betumi ayɛ soronko wɔ onipa biara ho. Egyina nneɛma ahorow bi so, enti ɛbɛyɛ papa sɛ wo ne wo duruyɛfo bɛkasa afa eyi ho. Sɛ wo neutrophil dodow so tew dodo a, ɛda adi sɛ wubenya nyarewa . Ɛtɔ mmere bi a, saa nyarewa yi betumi de wo nkwa ato asiane mu, titiriw sɛ woankɔ aduruyɛ mu ntɛm a.

Nanso, wɔ tebea horow bi mu no, autoimmune neutropenia betumi de ɔyare mmoawa a emu nyɛ den nkutoo aba. Anaasɛ ebetumi ayɛ nea enni sɛnkyerɛnne biara. Ɛno nti na ɛho hia sɛ wo ne oduruyɛfo yɛ adwuma de hu nea ɛde wo neutropenia no ba no. Ɛdenam nea ɛde ba so no, wo duruyɛfo betumi ahwɛ wo tebea no na waboa wo ma woadi ɔyare no so.

Hena na onya Autoimmune Neutropenia (AIN)?

• AIN Titiriw: Eyi ka nkokoaa ne mmofra nkumaa titiriw . Wɔtaa hu sɛ ɛyɛ bɛyɛ asram 8.
• AIN a ɛto so abien: Eyi taa ba wɔ yare foforo a nipadua no tumi ko tia nyarewa te sɛ lupus anaa ntini mu yare ho. Wɔtaa hu mmofra a wɔwɔ AIN a ɛto so abien no bɛyɛ mfe 10. Wɔtaa hu mpanyimfo a wɔwɔ AIN no bere a wɔadi fi mfe 40 kosi 60.

Autoimmune neutropenia abu so dɛn?

Primary AIN yɛ tebea a ɛntaa nsi koraa . Ɛka mmofra a wonnii mfe 100,000 biara mu bɛyɛ 100,000 biara mu biako pɛ. Enti wubetumi ahu sɛnea ɛho yɛ na no.

Dɛn ne Autoimmune Neutropenia ho sɛnkyerɛnne ahorow?

Ɛnyɛ bere nyinaa na Autoimmune Neutropenia de sɛnkyerɛnne atitiriw ba. Nanso, ɛtɔ da a, ebia wubehu sɛnkyerɛnne ahorow a ɛkyerɛ sɛ woanya ɔyare mmoawa. Nhwɛsoɔ:

• Aso mu yare: Eyi yɛ sɛnkyerɛnne a ɛtaa ba no mu biako. Fa no sɛ w’aba kumaa no kɔ so nya aso mu yaw, na sɛ wokɔ oduruyɛfo nkyɛn a, wɔka kyerɛ wo sɛ ɛyɛ aso mu yare foforo.
• Ɔhome mu nyarewa: Atiridii, ɔfe, ne atiridii a ɛtaa ba.
• Ano mu yare: Nneɛma te sɛ ano mu akisikuru ne anom akisikuru.
• Honam ani nyarewa.
• Ahurututu mu yare.
• Meningitis a ɛma obi ho yɛ hyew.
• Nsuo mu yareɛ (UTIs).
• Sepsis: Eyi yɛ ɔyare mmoawa a emu yɛ den yiye a ɛde nkwa to asiane mu.

Mpɛn pii no, nyarewa a ɛbata AIN titiriw ho no nyɛ den, nanso nyarewa a emu yɛ den te sɛ ahurututu mu yare, ahurututu mu yare, ne sepsis abu so wɔ AIN a ɛto so abien mu.

Dɛn na ɛde autoimmune neutropenia ba?

Wɔkyekyɛ AIN mu sɛ nea edi kan anaa nea ɛto so abien a egyina nea ɛde neutrophil dodow a ɛba fam ba no so.

Neutropenia a Ɛma Nkwammoaa a Ɛko Tia Nyarewa a Ɛho Hia (AIN Titiriw) .

Wɔ AIN titiriw mu no, nipadua mu nkwammoaa a ɛko tia nyarewa de wɔn ani si neutrophils so na wɔsɛe no. Nkwammoaa a ɛko tia nyarewa yɛ protein bi a ɛwɔ yɛn nipadua mu ahoɔden a ɛko tia nyarewa no mu. Wɔn adwuma a wɔtaa yɛ ne sɛ wɔbɛsɛe nneɛma a epira te sɛ mmoawa ne mmoawa a wɔhyɛn nipadua no mu. Nanso saa bere yi de, nhwehwɛmufo da so ara nnim nea enti a yɛn ankasa nipadua mu nkwammoaa a ɛko tia nyarewa no tow hyɛ saa neutrophils yi so no ankasa.

Autoimmune Neutropenia a Ɛto so Abien (AIN a Ɛto so Abien) .

Wɔ AIN a ɛto so abien mu no, neutrophils dodow so tew esiane ade foforo a ɛde ba anaa tebea foforo nti. Eyi ma nipadua no mu tumi a ɛko tia nyarewa no sɛe neutrophils no.

Nneɛma bi a ebetumi de eyi aba ne:

• Nyarewa afoforo a nipadua no tumi ko tia nyarewa: Nhwɛso bi ne ntini mu yare, lupus, ne mogya a ɛtɔ kɔ nipadua mu a nipadua no tumi ko tia nyarewa.
• Kokoram: Sɛ nhwɛso no, `granular lymphocyte leukemia kɛse`.
• Nyarewa: Nyarewa te sɛ `HIV`, `Parvovirus`, `hepatitis B`.
• Akisikuru: Te sɛ `Wilms akisikuru`, `Hodgkin yare`.
• Ntini mu nyarewa: Sɛ nhwɛso no, ntini mu yare.
• Asaabo anaa nnompe mu ntini a wɔde si ananmu.
• Nnuru bi: Titiriw nnuru bi a wɔde sa kokoram.

Ɔkwan bɛn so na wohu sɛ obi anya Autoimmune Neutropenia? (Nyare a Wɔahu) .

Sɛ wowɔ atiridiinini anaa ɔyare mmoawa bi a, ebia wo duruyɛfo behu sɛ wo neutrophil dodow sua bere a woreyɛ mogya adwuma de ahu nea ɛde ba no. AIN a wobehu no betumi ayɛ anifere kakra, efisɛ nneɛma pii wɔ hɔ a ebetumi de aba. Ebia wo duruyɛfo behu AIN bere a wapo tebea afoforo a ebetumi ama wo neutrophil dodow so atew akyi.

Sɛ wobɛhunu anaa wobɛhwɛ `Autoimmune Neutropenia` a, wo duruyɛfoɔ bɛtumi ayɛ nhwehwɛmu a ɛdidi soɔ yi:

• Mogya dodow a edi mũ (CBC): CBC betumi ahwɛ sɛnea neutrophils dodow a ɛwɔ wo mogya mu no te. Esiane sɛ saa dodow yi betumi ayɛ soronko nti, mpɛn pii no wo duruyɛfo no bɛyɛ CBC bɛboro biako de asi neutropenia so dua na wahwɛ wo neutrophil dodow so. CBC a wɔyɛ no daa nso betumi aboa ma woahu sɛ ebia wo AIN no yɛ nea enni sabea anaa.
• Mogya a wɔde gu nipadua no akyi: Wɔde afiri a wɔde hwɛ nneɛma nketenkete hwehwɛ mogya bi mu de hwɛ sɛnea neutrophils no te ne sɛnea ɛte. Eyi nso boa ma wohu yare no.
• Vitamin B12, folate, ne kɔbere mu nhwehwɛmu: Saa nhwehwɛmu yi betumi ahwɛ sɛ aduannuru yi nni hɔ anaa. Nipadua no hia eyinom na ama ayɛ neutrophils.
• Mmɛn dwumadi ho nhwehwɛmu: Eyinom nso betumi ahwɛ mmerɛbo no dwumadi ne sɛ ebia mmerɛbo mu yare a efi ɔyare mmoawa mu wɔ hɔ anaa.
• HIV ne mmoawa ho nhwehwɛmu afoforo: Yare mmoawa te sɛ HIV nso betumi ama mogya mu nkwammoaa fitaa so atew.
• Flow cytometry: Eyi yɛ nhwehwɛmu a wɔyɛ wɔ aduruyɛdan mu a ɛhwɛ nkwammoaa no mu hwɛ sɛ ebia yare ho sɛnkyerɛnne bi wɔ hɔ anaa. Wɔde kyerɛ sɛ ebia tebea bi a nipadua no tumi ko tia nyarewa na ɛde neutropenia ba anaa.
• Mfoninitwa: Sɛ wosusuw sɛ kokoram te sɛ lymphoma na ɛde AIN ba a, wobetumi ayɛ MRI anaa CT scan.
• Bone marrow aspiration ne biopsy: Ɛha yi, oduruyɛfo no fa nnompe mu ntini ketewaa bi na ɔhwehwɛ mu hwɛ sɛ ebia yare ho sɛnkyerɛnne bi wɔ hɔ anaa. Eyi betumi aboa ma wɔahu sɛ ebia mogya mu kokoram te sɛ mogya mu kokoram na ɛde neutropenia ba anaa.

Ebia wo duruyɛfo nso bɛhyɛ sɛ wɔnyɛ mogya mu nhwehwɛmu mfa nhwɛ sɛ nipadua mu nkwammoaa a ɛko tia nyarewa wɔ wo mogya mu a ɛtow hyɛ neutrophils so. Nhwehwɛmu a wɔtaa yɛ ne I-GIFT (Indirect granulocyte immunofluorescence test) ne GAT (Granulocyte agglutination test).

Nea ɛyɛ awerɛhow no, ɛnyɛ bere nyinaa na wotumi de ho to sɔhwɛ ahorow yi so wɔ AIN a wobehu mu. Ebia nhwehwɛmu ahorow yi renhu nnuru a ɛko tia nyarewa a egyina nea ɛde wo neutropenia ba ne bere a wobɛyɛ no so. Nea efi mu ba a ɛnyɛ nokware ne bere a sɔhwɛ no kyerɛ sɛ nnuru a ɛko tia nyarewa wɔ hɔ bere a enni hɔ no.

Sɛ oduruyɛfo no susuw sɛ tebea pɔtee bi na ɛde neutropenia ba a, obetumi ahyɛ sɛ wɔnyɛ nhwehwɛmu foforo.

Ɔkwan bɛn so na wɔsa Autoimmune Neutropenia?

Ayaresa no gyina sɛnea wo tebea no mu yɛ den so. Sɛ nhwɛso no, ebia ɛho behia sɛ akokoaa a ɔwɔ neutropenia a enni sɛnkyerɛnne biara no nya CBC ne neutrophil dodow daa nkutoo, nanso ebia ɛho renhia ayaresa ntɛm ara. Sɛ wo ba no taa nya ɔyare mmoawa a, ebia wo duruyɛfo bɛkyerɛw nnuru a ekum ɔyare mmoawa a wɔde siw ano de asiw ɔyare mmoawa ano. Wɔtaa de nnuru a ekum ɔyare mmoawa ma de sa ɔyare mmoawa, nanso wɔde nnuru a ekum ɔyare mmoawa yi ma sɛnea ɛbɛyɛ a ɔyare mmoawa no rensi.

Wɔ obi a ɔwɔ AIN a ɛto so abien fam no, oduruyɛfo no bɛsa tebea a ɛda adi a ɛde neutrophil dodow a ɛba fam ba no. Wobetumi nso akyerɛw:

• Granulocyte colony-stimulating factor (G-CSF): Eyi ne ayaresa titiriw a wɔde sa nsɛm a emu yɛ den a ɛfa neutropenia ho. Ɛboa nipadua no ma ɛyɛ neutrophils pii. G-CSF nso betumi asiw nyarewa a ɛtaa ba a ɛbata AIN titiriw ho no ano.
• Corticosteroids: Corticosteroids te sɛ prednisone siw wo nipadua no tumi a ɛko tia nyarewa no ano, na ɛtew nipadua mu nkwammoaa a ɛko tia nyarewa a ɛtow hyɛ neutrophils so no so.
• Ayaresa afoforo: Wɔde nnuru afoforo te sɛ IVIG, rituximab, ne alemtuzumab nso adi dwuma wɔ ayarefo a wɔn yare mu yɛ den a autoimmune neutropenia a emu yɛ den no mu.

So wobetumi asiw Autoimmune Neutropenia ano?

Wontumi nsiw Primary AIN anaa Secondary AIN biara ano . Nanso, wubetumi asiw nsɛnnennen a ɛbata `Autoimmune Neutropenia` ho, kyerɛ sɛ, ɔyare mmoawa a ɛba no ano. Sɛ wobɛyɛ eyi a, ɛsɛ sɛ woyɛ nneɛma a ɛho hia de bɔ wo ho ban fi nyarewa ho. Sɛ nhwɛso no, kwati a wobɛkwati mmeae a nnipa ahyɛ hɔ ma, wo nsa a wobɛhohoro wo ho mpɛn pii, na wobɛtwe wo ho afi nnipa a wɔyare ho.

Daakye bɛn na obi a ɔwɔ Autoimmune Neutropenia betumi ahwɛ kwan?

Mpɛn pii no AIN titiriw no ankasa siesie . Mmofra a wɔwɔ AIN no mu bɛyɛ 95% ma wɔn neutrophil dodow san kɔ sɛnea na ɛte kan bere a wɔadi mfe abien kosi abiɛsa no. Ɛkame ayɛ sɛ mmofra a wɔwɔ AIN titiriw nyinaa ho tɔ wɔn koraa bere a wɔadi mfe 11. Eyi ma awerɛhyem ankasa, ɛnte saa?

Wɔ tebea afoforo mu a wɔfrɛ no AIN a ɛto so abien no, sɛnea wo ho bɛtɔ wo no gyina nneɛma pii so, titiriw tebea a ɛde wo neutropenia bae no. Saa tebea no a wobɛsa na woasiw nyarewa ano no betumi aboa ma wo neutrophil dodow asan aba sɛnea na ɛte kan no.

Bere bɛn na ɛsɛ sɛ mehwehwɛ aduruyɛ mu afotu?

Sɛ wowɔ autoimmune neutropenia a emu yɛ den na wunya atiridii a, kɔ oduruyɛfo nkyɛn ntɛm ara . Ɛtɔ da bi a, ebia wo duruyɛfo adi kan akyerɛw nnuru a ekum ɔyare mmoawa a sɛ wo ho tɔ wo a, ɛsɛ sɛ wonom. Mpɛn pii no, ɛho behia sɛ wɔsa wo yare wɔ ayaresabea.

Sɛ wowɔ autoimmune neutropenia a emu yɛ den a ɛtra hɔ kyɛ a, wo duruyɛfo bɛkyerɛkyerɛ sɛnkyerɛnne ahorow a ɛsɛ sɛ wuhu ne nea wubetumi ayɛ de asiw nsɛnnennen ano mu akyerɛ wo.

Kae: Sɛ wohu sɛ wo anaa wo ba no anya AIN a, wo ne wo duruyɛfo nkasa mfa sɛnea ɛka wo no ho asɛm. Bere a ɛsono sɛnkyerɛnne ne nea ɛde ba no, asɛmpa no ne sɛ ayaresa te sɛ G-CSF tu mpɔn kɛse wɔ neutrophil dodow a ɛkɔ soro no mu.

Sɛ wo ba no wɔ AIN a, yɛ mogya mu nhwehwɛmu daa sɛnea wo duruyɛfo kyerɛ no. Hwɛ yiye sɛ wubehu sɛnkyerɛnne ahorow a ɛkyerɛ sɛ woanya ɔyare mmoawa, na sɛ wuhu bi a, hwehwɛ ayaresa ntɛm ara sɛnea wubetumi, na amma woasiw nsɛnnennen a ebetumi aba ano.

Nsɛm a Wɔaboaboa Ano (Nkrasɛm a Wɔde Kɔ Fie) .

Okay, enti mewɔ anidaso sɛ seesei woanya ntease pa wɔ `Autoimmune Neutropenia` (AIN) a yɛkaa ho asɛm no ho.

• AIN yɛ tebea a yɛn ankasa nipadua mu ahoɔden a ɛko tia nyarewa no sɛe yɛn mogya mu nkwammoaa fitaa a wɔfrɛ no `neutrophils`.
• Eyi betumi aba mmofra nkumaa (Primary AIN) anaa mpanyimfo (Secondary AIN). Mpɛn pii no, AIN titiriw a ɛwɔ mmofra nkumaa mu no ankasa siesie.
• Asiane titiriw ne ɔyare mmoawa a wɔtaa nya.
• Mogya mu nhwehwɛmu ne nhwehwɛmu afoforo wɔ hɔ a wɔde hu yare no.
• Nea ɛka ayaresa ho ne hwɛ a wɔhwɛ, nnuru a ekum ɔyare mmoawa, G-CSF, ne corticosteroids.
• Nea ɛho hia sen biara ne sɛ woremmɔ hu anaasɛ woremmɔ hu na sɛ wo anaa wo ba wɔ saa sɛnkyerɛnne ahorow yi a, hwehwɛ aduruyɛfo afotu. Sɛ wohu ntɛm na wodi ho dwuma yiye a, wubetumi atra ase pa wɔ AIN mpo mu.

Sɛ wowɔ nsɛmmisa foforo bi fa eyi ho a, hwɛ hu sɛ wo ne wo duruyɛfo bɛkasa. Wɔn na wobetumi de afotu a eye sen biara ama wo.

` Neutropenia, Autoimmune Neutropenia, Mogya Nkwammoaa Fitaa, Nkwammoaa a ɛko tia nyarewa, Nyarewa, Mogya mu Nyarewa, Mmofra Nyarewa