Dɛn ne Felty Syndrome? Eyi ho hia ma mo a mowɔ ntini mu yare no!

Ebia wo nkwaa nso bɛyɛ wo yaw, wo hohoro, na wo nsa ne wo nan ase ayɛ wo den kakra anɔpa, ɛnte saa? Mpɛn pii no, eyinom betumi afi ntini mu yare mu. Nanso so wunim sɛ ɔhaw foforo bi wɔ hɔ a ebetumi de ntini mu yare yi aba, nanso wonnim no yiye saa, nanso ɛho hia yiye sɛ wuhu ho asɛm? Ɛno ne Felty Syndrome a ɛyɛ yare no. Momma yɛnka eyi ho asɛm nkɔ akyiri kakra nnɛ.

Dɛn ankasa ne Felty Syndrome?

Sɛ yɛbɛka no tiawa a, Felty Syndrome yɛ tebea abiɛsa a wɔaka abom a ɛbom ba. Wɔne:

• Rheumatoid Arthritis - Ntini a ɛyɛ hyew a mo mu pii nim.
• Neutropenia - Eyi yɛ neutrophils dodow a ɛso tew, mogya mu nkwammoaa fitaa bi a ɛwɔ mogya mu.
• Splenomegaly - Wei kyerε sε spleen, akwaa bi a εwכ nipadua no mu no yε kεseε sene sεdeε εteε.

Ɛtaa fi ase wɔ ntini mu yare (RA) mu. Tebea abien a aka no ba sɛ RA ho nsɛnnennen. Nnuruyɛfo frɛ eyinom ‘extra-articular manifestations’. Ɛne sɛ, ɛnyɛ nkwaa no nkutoo mu na ntini mu yare, na mmom ɛka nkwaa a ɛwɔ akyi no. Eyi te saa esiane ɔfe a ɛde ntini mu yare no ba nti. Bere a ɛtaa ba sɛ saa nsunsuanso ahorow yi ba wɔ nkwaa a ɛwɔ RA ​​no akyi no, Felty Syndrome yɛ tebea a ɛntaa nsi kakra.

Eyi ka wo dɛn?

Felty yare no fi ase wɔ Rheumatoid Arthritis so. Afei wote ɛyaw a emu yɛ den na wo nkwaa mu ahonhon. Afei, sɛ tebea horow te sɛ Neutropenia ne Splenomegaly ba a, ɛka wo nipadua mu ahoɔden a ɛko tia nyarewa no . Neutropenia yɛ mogya mu nkwammoaa fitaa bi a wɔfrɛ no neutrophils a ɛso tew. Saa neutrophils yi yɛ nkwammoaa bi a ɛho hia paa a ɛbɔ yɛn nipadua ho ban fi nyarewa ho. Enti sɛ ɛso tew a, hokwan a ɛwɔ hɔ sɛ obi benya nyarewa no yɛ kɛse. Akisikuru a ɛtrɛw nso betumi ayɛ ade foforo a ɛma neutrophils so tew yi.

Saa tebea yi abu so dɛn?

Felty yareɛ no ba nnipa a wɔwɔ ntini mu yareɛ bɛyɛ 2% mu . Te sɛ RA no, Felty yare no abu so wɔ mmea mu bɛyɛ mpɛn abiɛsa sen mmarima. Nea ɛyɛ anigye no, ɛkame ayɛ sɛ nnipa a wɔwɔ RA ​​a wonya Felty yare no nyinaa yɛ ‘seropositive’. Eyi kyerɛ sɛ nhwehwɛmu ahorow si so dua sɛ wɔwɔ biribi a wɔfrɛ no rheumatoid factor antibodies wɔ wɔn mogya mu. nnipa a ‘seronegative’, a ɛkyerɛ sɛ nnipa a wonni saa nnuru a ɛko tia nyarewa no ntaa nnya Felty yare no.

Dɛn ne eyi ho sɛnkyerɛnne?

Mpɛn pii no, sɛnkyerɛnne a edi kan a ɛda adi ne ntini mu yare. Eyinom bi ne:

• Nkwaa mu yaw
• Nkwaa a ɛho ahonhon
• Nkwaa a ɛyɛ den, titiriw anɔpa

Nnipa binom betumi anya sɛnkyerɛnne afoforo a ɛka RA ho wɔ wɔn nkwaa mu. Nhwɛsoɔ:

• Akuru a ɛba honam ani a ɛbɛn nkwaa no (wɔfrɛ eyinom rheumatoid nodules) .
• Ntini a ɛho ahonhon wɔ mmeae te sɛ kɔn ne abasa
• Ebia mmerɛbo no ahonhon na sɛ woka a, ɛbɛyɛ yaw.
• Aniwa ne ano a ɛyɛ mmerɛw (wɔfrɛ eyi Sjogren yare) .
• Aniwa kɔkɔɔ a ahonhon (wɔfrɛ eyi episcleritis) .
• Honam ani akuru, titiriw wɔ nan no so
• Nsɛnkyerɛnne a ɛkyerɛ sɛ mogya retu wɔ honam ani
• Ɔhome a ɛyɛ den esiane ahurututu a ɛho ahonhon nti
• Koko mu yaw esiane koma no ho ahonhon nti
• Huraeɛ
• Ɔbrɛ ne ɔbrɛ
• Aduan ho akɔnnɔ a ɛyera anaasɛ ne mu duru a ɛso tew a wontumi nkyerɛkyerɛ mu

Eyinom akyi no, Felty Syndrome nso wɔ sɛnkyerɛnne afoforo. Ɛtɔ mmere bi a, saa sɛnkyerɛnne ahorow yi betumi ada adi ansa na RA sɛnkyerɛnne ahorow no afi ase.

• Nyarewa a ɛtaa nya, a ɛtra hɔ kyɛ. Nhwɛso bi ne atiridiinini, yafunu mu yaw, ne honam ani yare.
• Akisikuru a ɛho ahonhon. Ebia wɔbɛte nka wɔ nsa mu na ebetumi ayɛ yaw.
• Wora kɔla a ɛsakra (te sɛ nsensanee).

Nanso nea ɛyɛ nwonwa ne sɛ, ɛtɔ mmere bi a wobetumi ahu sɛ wowɔ Felty Syndrome a wunhu sɛnkyerɛnne biara. Mogya mu nhwehwɛmu ne scan betumi akyerɛ sɛ wowɔ tebea abiɛsa no nyinaa ansa na woate yare no ho sɛnkyerɛnne biara mpo.

Mfe bɛn mu na eyi taa fi ase?

Felty Syndrome taa ba nnipa a wɔn mfe akɔ anim, a wɔadi fi mfe 50 kosi 70. Wɔ nnipa dodow no ara fam no, Felty Syndrome da adi bere a wɔanya ntini mu yare ho sɛnkyerɛnne bɛyɛ mfe 10 kosi 15 akyi.

Dɛn nti na Felty Syndrome ba?

Ntini mu yare yɛ ‘autoimmune yare’. Eyi kyerɛ sɛ yɛn ankasa nipadua mu tumi a ɛko tia nyarewa no tow hyɛ yɛn ankasa nipadua no afã horow so te sɛ nea ɛyɛ ɔtamfo. Nyansahufo pii gye di sɛ Felty Syndrome yɛ RA ho haw a emu yɛ den. Wɔ saa nyarewa a nipadua no tumi ko tia nyarewa yi mu no, yɛn nipadua no yɛ ‘antibody’ a ɛko tia protein ahorow bi. Saa nnuru a ɛko tia nyarewa yi kɔfa saa protein ahorow no na ɛkyerɛ sɛ wɔbɛsɛe. Eyi ne ɔkwan a ɔfe no kɔ soro.

Ebia ɛnyɛ bere nyinaa na saa nnuru a ɛko tia nyarewa yi wɔ RA ​​mu. Nanso, wɔ nnipa a wɔwɔ Felty Syndrome mu no, akyinnye biara nni ho sɛ saa nnuru a ɛko tia nyarewa yi wɔ hɔ. Saa nnuru a ɛko tia nyarewa yi a ɛwɔ hɔ no yɛ nea enti a RA mu yɛ den kɛse na nsunsuanso afoforo a ɛwɔ nkwaa no akyi (extra-articular manifestations) no kɔ soro. Wɔfrɛ RA a ɛwɔ nnuru a ɛko tia nyarewa no ‘seropositive RA’. Nhwehwɛmu kyerɛ sɛ seropositive RA ne Felty Syndrome nyinaa ne ‘awosu mu nneɛma’ bi wɔ abusuabɔ. Eyi kyerɛ sɛ wobetumi de akɔ awo ntoatoaso ahorow mu akodu baabi.

Ɔkwan bɛn so na ntini mu yare (RA) de neutropenia ne splenomegaly ba?

Sɛnea Neutropenia Ba

Neutropenia yɛ mogya mu nkwammoaa fitaa a wɔfrɛ no neutrophils dodow a ɛso tew. Nneɛma atitiriw abien nti na ɛte saa. Biako ne sɛ wo nnompe mu ntini no ntumi nyɛ neutrophils a ɛdɔɔso. Anaasɛ, wɔresɛe neutrophils a ɛwɔ wo nipadua mu no. Wɔ Felty Syndrome mu no, eyinom abien nyinaa betumi asi. Autoimmune kwan a yɛadi kan aka ho asɛm no betumi asiw neutrophils a ɛba nnompe mu ntini mu no kwan, na neutrophils a wɔayɛ dedaw no betumi asɛe. Afei nso, akyi berɛmo a ɛtrɛw yɛ ade foforo nti a neutrophils so tew.

Sɛnea Splenomegaly Ba

Wo dwensɔtwaa adwuma ne sɛ ɛbɛyi mogya mu nkwammoaa dedaw a mfaso nni so afi wo mogya mu. Nanso sɛ w’akyi yɛ kɛse dodo (splenomegaly) a, ɛyɛ adwuma boro so na efi ase yi mogya mu nkwammoaa pa pii fi hɔ. Ɛtɔ mmere bi a, ntini mu yare betumi ama akyi berɛmo no ayɛ kɛse. Wonnya nhuu nea ɛde ba ankasa. Afei nso, ahurututu no betumi ayɛ kɛse a neutropenia nni mu. Afei nso, ɛntaa mma koraa sɛ Felty Syndrome betumi aba a akyi berɛmo no ntrɛw.

Dɛn ne nsɛnnennen a asiane wom a efi Felty Syndrome mu ba?

Esiane sɛ Felty Syndrome ma wo nipadua mu tumi a ɛko tia nyarewa no yɛ mmerɛw nti, wowɔ asiane kɛse mu sɛ wobɛtaa anya nyarewa a emu yɛ den . Sɛ wotaa nya yare ketewaa bi a ɛnyɛ den sɛ wobɛsa mpo a, saa tebea yi betumi ayɛ den araa ma ɛbɛkɔ so atra hɔ na ɛtɔ mmere bi a ɛde wo nkwa to asiane mu. Yare mmoawa a wontumi nni so no betumi de tebea bi a ɛyɛ hu a wɔfrɛ no sepsis aba. Nnipa a wɔwɔ Felty Syndrome nso wɔ asiane kɛse mu sɛ wobenya kokoram ahorow bi te sɛ lymphoma.

Nanso sɛ wote saa nsɛm yi a, nsuro. Asiane ahorow yi wɔ hɔ, nanso wobetumi adi so denam ayaresa ne adwene a ɛfata so.

Ɔkwan bɛn so na yebetumi ahu eyi?

Nnuruyɛfo hu Felty Syndrome bere a wohu sɛ ntini mu yare, neutropenia, ne splenomegaly nyinaa wɔ hɔ no. (Ɛntaa mma sɛ wobetumi ahu yare no a wɔn akyi berɛmo ntrɛw.)

Sɔhwɛ ahorow a wɔtaa yɛ ne:

• Mogya mu nhwehwɛmu: Mogya dodow a wɔkan koraa, titiriw de hwɛ sɛnea neutrophils no te.
• X-ray a wɔde yɛ nkwaa: Hwɛ sɛ ebia ntini mu yare bi wɔ hɔ anaa.
• Spleen scans: Sɛ nhwɛso no, ultrasound anaa CT scan.
• Nnompe mu ntini mu nhwehwɛmu:Eyi boa ma wɔhwɛ hu sɛ aduruyɛ mu tebea foforo biara nni hɔ.

Dɛn ne ayaresa a wɔde sa eyi?

Botae atitiriw abiɛsa na ɛwɔ hɔ bere a wɔresa Felty Syndrome no:

• Tebea a ɛwɔ Rheumatoid Arthritis no ase a wobedi so.
• Sɛ neutropenia mu yɛ den a, sa no tẽẽ.
• Nyarewa a wobesiw ano na sɛ ɛba a, wɔbɛsa.

Felty syndrome betumi afi ntini mu yare (RA) a wɔansa anaasɛ wontumi nni so yiye mu aba. Wɔ nnipa pii fam no, neutropenia tu mpɔn bere a wɔn RA tu mpɔn no. Enti, nnuruyɛfo di kan hwɛ sɛ wɔbɛpaw nnuru a etu mpɔn a ɛsakra yare (DMARD) a wɔde sa RA. Wɔbɔ mmɔden nso sɛ wɔbɛkwati nnuru a ɛma nipadua no tumi ko tia nyarewa sɛnea wobetumi biara.

DMARD ahorow pii wɔ hɔ a wobetumi de adi dwuma ama Felty Syndrome:

• Methotrexate ne folic acid (ɛtew methotrexate ho nsunsuanso bɔne so) .
• Abatacept a wɔde di dwuma
• Rituximab a wɔde di dwuma
• Leflunomide a wɔde yɛ aduru

Nanso sɛ wo neutropenia no ankɔ yiye wɔ DMARD ahorow yi mu, anaasɛ wo neutropenia no mu yɛ den yiye, anaasɛ wowɔ ɔyare mmoawa dedaw a, wo duruyɛfo bɛsɔ ayaresa afoforo ahwɛ na ama wo neutrophil dodow akɔ soro. Ebia eyinom bi ne:

• Nnuru a wɔde bɔ nkurɔfo ho ban a wɔfrɛ no G-CSF (granulocyte colony-stimulating factor).
• Nnuru a wɔde yɛ corticosteroid a wɔde di dwuma bere tiaa bi.
• 'Splenectomy' - Wei kyerε sε wobεyε oprehyɛn ayi spleen a εyε adwuma boro so no.

Afei nso, nnuruyɛfo bɛyɛ nneɛma titiriw bi de abɔ wo ho ban afi nyarewa ho, titiriw sɛ w’ayaresa no ka wo nipadua mu tumi a ɛko tia nyarewa no a. Ebia wɔbɛkamfo nneɛma te sɛ:

• Nnuru a ekum ɔyare mmoawa a ɛtrɛw a wɔnom.
• Nnuru a wɔde bɔ nkurɔfo ho ban a ɛho hia a wobenya.
• Hwɛ w’ano ne wo sẽ akwahosan so titiriw.

Sɛ obi a ɔwɔ Felty Syndrome nya ɔyare mmoawa a, nnuruyɛfo bu no aniberesɛm kɛse. Sɛ eyi to wo a ɛsɛ sɛ wunya ayaresa ntɛm ara . Wo duruyɛfo bɛkyerɛw nnuru a ano yɛ den ama wo.

Dɛn ne nkwa nna a wɔhwɛ kwan wɔ Felty Syndrome ho?

Mprempren akontaabu biara nni hɔ a ɛfa nnipa a wɔwɔ Felty Syndrome nkwa nna ho. Nanso, mpɛn pii no, ayaresa a wɔpaw no anya nkɔso kɛse wɔ nnansa yi mfe mu. Enti hokwan kɛse wɔ hɔ sɛ ayaresa biara bedi nkonim ama wo. Asiane titiriw a ɛwɔ owu mu wɔ Felty Syndrome mu da so ara fi nyarewa a emu yɛ den mu . Enti, sɛ woyɛ nneɛma bi de bɔ wo ho ban fi nyarewa ho a, ebetumi ama nsakrae kɛse aba w’akwahosan a ɛtra hɔ kyɛ no mu.

Felty Syndrome yɛ ɔhaw a ɛntaa nsi na wɔtaa bu ani gu so a ɛfa ntini mu yare (RA) ho. Sɛ wowɔ RA ​​a wuntumi nni so bere tenten, anaasɛ wo nnuru no gyae adwumayɛ sɛnea na ɛte kan no a, wubetumi anya Felty Syndrome. Nnipa binom nya bi a enni sɛnkyerɛnne biara. Ebetumi ayɛ basaa kakra sɛ wubehu sɛ yare bi a ɛka wo nkwaa nso betumi aka wo mogya mu nkwammoaa.

Sɛ woredi RA ho dwuma dedaw, ne ebia sɛnkyerɛnne afoforo a, ebetumi ayɛ den sɛ wubehu sɛ wowɔ yare foforo. Nanso Felty Syndrome mfa sɛnkyerɛnne foforo pii mma, na ebia ɛho renhia ayaresa foforo biara. Nea ɛho hia ne sɛ wubehu asiane ahorow a ɛwom. Sɛ wo ne wo duruyɛfo bɛyɛ adwuma de asa wo RA na wɔasiw nyarewa ano a, wubetumi adi Felty Syndrome no ho dwuma.

Nea etwa to no, nneɛma a ɛsɛ sɛ yɛkae

Felty Syndrome yɛ tebea a ebetumi aba nnipa binom a wɔwɔ ntini mu yare (RA) mu. Nea ɛda nsow ne sɛ mogya mu nkwammoaa fitaa a wɔfrɛ no neutrophils a ɛwɔ wo mogya mu no so tew (neutropenia) ne akyi berɛmo a ɛyɛ kɛse (splenomegaly).

• Asiane titiriw ne ɔyare mmoawa a wɔtaa nya, enti ɛho hia yiye sɛ wobɛbɔ wo ho ban afi nyarewa ho.
• Ɛwom sɛ ebia eyi bɛyɛ te sɛ nea ɛyɛ hu kakra de, nanso wobetumi adi tebea yi so yiye denam ayaresa ne afotu a ɛfata so .
• Sɛ wowɔ RA ​​a, hwɛ yiye wɔ sɛnkyerɛnne afoforo yi ho. Sɛ wowɔ biribi a ɛhaw wo a , hwɛ hu sɛ wo ne wo duruyɛfo bɛkasa. Wɔbɛtumi aboa wo.

` Felty Syndrome, Ntini mu Yare, Neutropenia, Splenomegaly, Ntini mu Yare, Ntini mu Ɔhaw, Neutrophils, Akisikuru, Ntini a ɛko tia nyarewa