Momma yensua aduru a wɔfrɛ no Fluorouracil (5-FU) a ɛbɛboa wo wɔ kokoram a wobɛko atia no mu ho ade!

Ɛyɛ ade a ɛfata sɛ wobɛte adesoa kɛse nka bere a wote sɛ wo anaa obi a ɔbɛn wo wɔ kokoram no. Bere koro no ara mu no, sɛ nnuruyɛfo ka eyi ho ayaresa ho asɛm, titiriw bere a wɔte nsɛmfua te sɛ "chemotherapy" a, ebetumi ayɛ hu kakra. Nanso sɛ wɔbɔ wo amanneɛ yiye wɔ saa nneɛma yi ho a, wubenya ahoɔden pii de akɔ saa akwantu yi mu. Ɛnnɛ yɛrebɛka aduru bi a wɔtaa de di dwuma a ɛboa ma wɔko tia kokoram nkwammoaa ho asɛm. Ɛno ne Fluorouracil , ebinom nso frɛ no 5-FU .

Aduru bɛn na ɛyɛ Fluorouracil (5-FU)?

Sɛ yɛbɛka no tiawa a, fluorouracil yɛ aduru a ɛhwɛ ma kokoram nkwammoaa nyin, kyerɛ sɛ, ɛma ɛyɛ brɛoo . Te sɛ nwura ano aduru no, ɛboa ma kokoram nkwammoaa ntrɛw. Ɛyɛ nnuru a wɔde sa yare bi. Nnuruyɛfo de saa aduru yi sa kokoram ahorow pii. Nhwɛso kakraa bi ni:

• Nufu mu kokoram
• Kokoram a ɛwɔ akyi berɛmo mu anaa akyi berɛmo mu
• Kokoram a ɛwɔ dwensɔtwaa mu
• Yafunu mu kokoram

Ɛtɔ da bi a, wobetumi anya saa aduru yi wɔ din afoforo ase, sɛ nhwɛso no `Adrucil`. Afei nso, wo duruyɛfo betumi de saa aduru yi adi dwuma wɔ nneɛma afoforo mu a egyina wo tebea no so. Enti sɛ wowɔ nsɛmmisa bi a, ɛbɛyɛ papa sɛ wubebisa wo duruyɛfo anaa nnuruyɛfo.

Nneɛma bɛn na ɛsɛ sɛ woka kyerɛ wo duruyɛfo ansa na woafi saa aduru yi ase?

Eyi yɛ asɛm a ɛho hia paa. Ansa na wubefi ase anom aduru yi no, ɛho hia sɛ wode w’akwahosan ho nkyerɛkyerɛmu a edi mũ ma wo duruyɛfo. Ɛsɛ sɛ wɔka asɛm ketewaa mpo a wɔmfa nsie. Efisɛ, wogyina saa nsɛm no so si nneɛma te sɛ sɛ ebia aduru yi fata wo ne dodow a wode bɛma ho gyinae. Sɛ wowɔ nea edidi so yi mu biara a, hwɛ hu sɛ wobɛka akyerɛ wo duruyɛfo:

• Sɛ yareɛ anaa ɔhaw bi wɔ mogya no mu a (Mogya mu yareɛ).
• Dihydropyrimidine Dehydrogenase (DPD) a enni nipadua mu no yɛ awosu mu tebea. Ebia ɛbɛyɛ den ama nnipa a wonni saa enzyme yi sɛ wobegyina aduru a wɔfrɛ no fluorouracil a ebetumi de ɔhaw ahorow a emu yɛ den aba no ano . Ɛno nti na ɛho hia sɛ yɛka ho asɛm no.
• Any current infection , titiriw ɔyare mmoawa te sɛ akokɔsrade ne akisikuru`(Virus yareɛ te sɛ akokɔ, atiridiinini , anaa herpes)`.
• Asaabo mu yare .
• Mmɛn mu yare .
• Sɛ wunni aduan pa , kyerɛ sɛ, sɛ wunnya aduan ne anonne a ɛdɔɔso, na w’aduannuru sua a.
• Sɛ woanya mframa a wɔde sa yare nnansa yi ara anaasɛ woreyɛ no mprempren a .
• Sɛ wowɔ adwene a ɛyɛ soronko anaasɛ wo ho yɛ wo hyew wɔ fluorouracil , nnuru afoforo a wɔde sa yare, nnuru foforo biara, aduan, nnuru a wɔde yɛ nneɛma, anaa nneɛma a wɔde sie ho a .
• Sɛ woanyinsɛn anaa worebɔ mmɔden sɛ wubenyinsɛn a , eyi ho hia yiye.
• Sɛ woyɛ ɛna a ɔma nufu a .

Ɛnyɛ saa nneɛma yi nko, na mmom ka akwahosan ho haw biara a wowɔ ho asɛm kyerɛ wo duruyɛfo nso.

Mɛyɛ dɛn ama wo aduru yi?

Wɔtaa de fluorouracil (5-FU) ma wo sɛ nea wɔde gu ntini mu anaasɛ wɔde gu ntini mu, te sɛ nkyene . Eyi nyɛ biribi a wubetumi ayɛ wɔ fie. Akwahosan ho ɔbenfo bi a wɔatete no titiriw sɛ ɔnyɛ eyi na ɔde saa ayaresa yi ma wɔ ayaresabea anaa ayaresabea. Ɛsɛ sɛ wɔhwɛ yiye titiriw bere a wɔde saa aduru yi rema mmofra nkumaa no. Sɛ wɔbɛma wo ba no aduru yi a, wo ne wo mmofra oduruyɛfo nka ho asɛm.

Na sɛ menom nnuru pii nso ɛ? Anaasɛ sɛ mepa dose bi a?

Sɛ wususuw sɛ woanom aduru yi dodo a, frɛ beae a wɔhwɛ awuduru so anaa baabi a wɔhwɛ wɔn a wɔwɔ yare a egye ntɛmpɛ ntɛm ara . Ɛho hia paa sɛ wobɛnom w’aduru no sɛnea wo duruyɛfo akyerɛ wo no pɛpɛɛpɛ. Sɛ biribi nti wuntumi mmra mu mma w’ayaresa da a wɔahyɛ da ayɛ no a, frɛ wo duruyɛfo anaa akwahosan ho ɔyaresafo ntɛm ara na ma wɔnhu .

Nkitahodi afoforo bɛn na ebetumi aba wɔ aduru yi mu?

Nnuru bi wɔ hɔ a ebetumi de ɔhaw aba bere a wɔde fluorouracil ka ho no . Enti, ɛsɛ sɛ woka nnuru a wonom nyinaa ho asɛm kyerɛ wo duruyɛfo, a vitamin, nhabannuru, ne aduannuru a wɔde ma ka ho. Titiriw no, ɛnsɛ sɛ wode fluorouracil ka nnuru a edidi so yi ho :

• Live virus vaccines : Esiane sɛ ebia wo nipadua mu ahoɔden a ɛko tia nyarewa no bɛyɛ mmerɛw bere a wonom saa aduru yi nti, sɛ wunya vaccines a virus a nkwa wom wom a, ebetumi ama woanya ɔyare mmoawa.

Afei nso, nnuru afoforo bi wɔ hɔ a ebetumi ne fluorouracil adi nkitaho . Nhwɛsoɔ:

• Nnuru a esiw mogya a ɛbɛtɔ ano anaasɛ ɛsa (e.g. warfarin, enoxaparin, dalteparin).

Saa list yi nwie pɛyɛ. Enti, ka nnuru a wonom, sigaret a wonom, nsa a wonom, ne nnubɔne a mmara mma ho kwan a wode di dwuma nyinaa kyerɛ wo duruyɛfo . Nneɛma bi betumi ne wo nnuru no adi nkitaho.

Nneɛma bɛn na ɛsɛ sɛ wohwɛ yiye wɔ ho bere a worenom nnuru no?

Ɛsɛ sɛ wohwɛ wo nipadua yiye bere a worenom fluorouracil aduru no.

• Kɔ wo duruyɛfo nkyɛn daa na hwɛ wo tebea no .
• Ebia saa aduru yi bɛma woate nka sɛ wo ho nyɛ wo dɛ na wo ho ayɛ wo yaw sen sɛnea wotaa yɛ no . Eyi yɛ ade a ɛfata. Nea enti a ɛte saa ne sɛ ɛnyɛ kokoram nkwammoaa nko na nnuru a wɔde sa yare no betumi aka, na mmom nkwammoaa a wɔwɔ apɔwmuden nso. Nanso, kɔ so fa ayaresa a wɔakyerɛw ama wo no so kosi sɛ wo duruyɛfo bɛka akyerɛ wo sɛ gyae .
• Sɛ wunya ɔhaw biara a, ka kyerɛ wo duruyɛfo . Ɛtɔ mmere bi a, wobetumi akyerɛw nnuru afoforo ama obi de asiw nea efi mu ba no ano. Di akwankyerɛ a ɛfa aduru no a wode bedi dwuma ho no akyi sɛnea wɔakyerɛ no pɛpɛɛpɛ.
• Sɛ wo ho yɛ wo hyew, wo ho yɛ wo yaw, wo menewa mu yɛ wo yaw, anaa atiridii ho sɛnkyerɛnne afoforo a , ka kyerɛ wo duruyɛfo anaa akwahosan ho ɔyaresafo ntɛm ara . Nnom nnuru biara a wote nka sɛ wobɛnom. Saa aduru yi betumi ama wo nipadua no tumi a ɛko tia nyarewa no so atew. Enti, bɔ mmɔden sɛ wobɛtwe wo ho afi nnipa a wɔyare ho sɛnea wubetumi biara.
• Saa aduru yi betumi ama asiane a ɛwɔ hɔ sɛ mogya bɛtɔ wo anaasɛ wobɛbɔ wo ho akuturuku no ayɛ kɛse . Sɛ wuhu mogya bi a ɛyɛ soronko (sɛ nhwɛso no, mogya a ɛretu wo hwene mu, mogya a ɛretu wo anom, mogya a ɛwɔ wo nsu mu) a, ka kyerɛ wo duruyɛfo.
• Hwɛ yiye paa bere a worebɔ wo sẽ, worebɔ wo sẽ, na wode aduru a wɔde twitwiw sẽ redi dwuma no . Ɛnyɛ den sɛ eyi betumi ama wo sẽ apira, anya ɔyare mmoawa, anaa mogya atɔ wo. Sɛ worekɔyɛ wo sẽ ayaresa biara a, ka kyerɛ wo sẽ ho oduruyɛfo sɛ worenom saa aduru yi.
• Mfa nnuru a wɔde kum ɛyaw te sɛ aspirin, paracetamol, ibuprofen, naproxen, ne ketoprofen a wunnyaa wo duruyɛfo afotu. Saa nnuru yi tumi siw yare no ho sɛnkyerɛnne te sɛ atiridiinini ano.
• Mma nnyinsɛn bere a worenom aduru yi . Sɛ ɔbea a onyinsɛn nya saa aduru yi a, ebetumi apira akokoaa a ɔhyɛ yafunu mu no kɛse. Sɛ worebɔ mmɔden sɛ wubenyinsɛn anaa wususuw sɛ ebia woanyinsɛn a, ka kyerɛ wo duruyɛfo ntɛm ara. Bisa wo duruyɛfo anaa nnuruyɛfo ma ɔmma wo nsɛm pii. Mma mma nufu bere a worenom aduru yi .
• Ɛsɛ sɛ mmarima nso hu eyi . Sɛ worebɔ mmɔden sɛ wobɛwo ba a, ka ho asɛm kyerɛ wo duruyɛfo, efisɛ saa aduru yi betumi atew mmadwoa dodow so.
• Wowɔ atiridiinini (yafunu mu yaw).Sɛ wowɔ atiridiinini a, mma w’ankasa nnom wɔ nnurutɔnbea. Sɛ akisikuru no kyɛ boro nna abien, emu yɛ den yiye, anaasɛ nsu wom a, ka kyerɛ wo duruyɛfo.
• Ebia saa aduru yi bɛma wo honam ani ayɛ mmerɛw kɛse wɔ owia hann ho . Enti, to owia a wobɛbɔ no ano hye sɛnea wubetumi biara. Sɛ wokɔ abɔnten a, hyɛ ntade a ɛkata wo nipadua so yiye, hyɛ ahwehwɛ a wɔde hwɛ owia, na fa aduru a ɛbɔ wo ho ban fi owia ho di dwuma. Mfa owia akanea anaa mpa/ntanning beds nni dwuma.

Nneɛma bɔne bɛn na ɛsɛ sɛ meka kyerɛ oduruyɛfo no ntɛm ara sɛnea metumi?

Te sɛ nnuru nyinaa no, fluorouracil betumi de ɔhaw ahorow aba. Ebinom nyɛ aniberesɛm, nanso sɛ wunya saa nsunsuanso bɔne yi bi a, ɛsɛ sɛ woka kyerɛ wo duruyɛfo . Eyinom bi ne:

• Allergic reactions : honam ani akisikuru, ɛyaw, akisikuru, anim, anofafa, anaa tɛkrɛma a ɛho ahonhon.
• Mogya dodow a ɛso tew : Saa aduru yi betumi ama mogya mu nkwammoaa fitaa (nkwaboaa a ɛko tia nyarewa), mogya mu nkwammoaa kɔkɔɔ (nkwaboaa a ɛde mframa pa kɔ), ne mogya mu nkwammoaa (nkwaboaa a ɛboa ma mogya tu) no so tew. Eyi betumi ama asiane a ɛwɔ hɔ sɛ wubenya ɔyare mmoawa ne mogya a ɛbɛtɔ wo no ayɛ kɛse .
• Nsɛnkyerɛnne a ɛkyerɛ sɛ obi anya ɔyare no : atiridii anaa atiridiinini, ɔfe, menewam yaw, ɛyaw anaa ɛyɛ den sɛ ɔbɛtow.
• Nsɛnkyerɛnne a ɛkyerɛ sɛ mogya nkwammoaa a ɛba fam anaasɛ mogya tu : akisikuru wɔ mmeae bi wɔ nipadua no so, nsensanee kɔkɔɔ nketenkete a ɛwɔ honam ani (te sɛ nea wɔde pin abɔ), nsu tuntum a ɛyɛ tar, mogya a ɛwɔ nsu mu.
• Mogya mu nkwammoaa kɔkɔɔ a ɛba fam ho sɛnkyerɛnne : ɔbrɛ a ɛyɛ soronko, te nka sɛ wo ho totɔ wo bere a ogyina hɔ, te nka sɛ wo ho ayɛ wo hyew.
• Ɔhome a ɛyɛ den .
• Anisoadehu sesa (e.g. anisoadehu a ɛyɛ kusuu).
• Koko mu yaw .
• Ano mu akuru (ano mu, anofafa so).
• Akisikuru ne ɔfe (a ɛtaa ba anaasɛ ɛyɛ den).
• Ɛyaw, ɔfe, ne kɔkɔɔ wɔ baabi a wɔde aduru no guu no .
• Ɛyaw, akisikuru, anaasɛ nsa anaa anan a ɛyɛ den .
• Nsateaa anaa nan ase a ɛyɛ kɔkɔɔ, ɛho ahonhon, anaasɛ ɛyɛ yaw (wɔsan frɛ no `Hand-Foot Syndrome`).
• Yafunu mu yaw (a emu yɛ den).
• Mogya a ɛtɔ a ɛnyɛ ne kwan so .

Sɛ wuhu saa sɛnkyerɛnne ahorow yi bi a, nsɛe bere na ka kyerɛ wo duruyɛfo anaa ayaresabea a wɔresa wo yare no ntɛm ara .

Dɛn ne nsunsuanso bɔne a mpɛn pii no ɛnyɛ aniberesɛm sɛ wobɛka akyerɛ oduruyɛfo no , nanso sɛ ɛkɔ so anaasɛ ɛhaw adwene a, ɛsɛ sɛ wɔbɔ ho amanneɛ?

Nneɛma bɔne bi wɔ hɔ, ɛnyɛ aniberesɛm saa, nanso sɛ ɛkɔ so anaasɛ ɛhaw wo a, ɛbɛyɛ papa sɛ wobɛka akyerɛ wo duruyɛfo.

• Nsakrae a ɛba nsateaa anaa nansoaa nnadewa mu (sɛ nhwɛso no, kɔla a ɛsakra, ɛnyɛ den sɛ ebebubu).
• Atiridiinini (ɛnyɛ den, ano brɛ ase wɔ nna kakraa bi mu).
• Wora a ayow anaasɛ ɛyɛ wo yaw .
• Nwi a ɛtɔ . Eyi to nnipa pii, nanso ti nhwi no san nyin bere a wɔawie ayaresa no.
• Tipaeɛ .
• Aduan yɛ nea ɛnyɛ dɛ .
• Aniwa a ɛte owia hann nka .
• Yafunu a ɛyɛ yaw kakra, te sɛ aduan a ɛnyɛ dɛ .
• Nusu a ɛyɛ soronko a efi aniwa mu reba .

Saa nsɛm a wɔahyehyɛ yi nka nsunsuanso bɔne a ebetumi aba nyinaa ho. Sɛ wuhu biribi foforo a ɛyɛ soronko a, wo ne wo duruyɛfo nka ho asɛm.

Ɛhe na wode aduru yi sie?

Eyi nyɛ aduru a wubetumi de asie wɔ fie. Wɔde fluorouracil (5-FU) ma wɔ ayaresabea anaa ayaresabea, enti ɛnsɛ sɛ wohaw wo ho sɛ wode besie.

Awiei koraa no, kae (Take-Home Message) .

Saa asɛm yi yɛ aduru a wɔde ko tia kokoram a wɔfrɛ no fluorouracil (5-FU) no mu nsɛm tiawa kɛkɛ. Yɛwɔ anidaso sɛ eyi bɛma woanya aduru yi ho adwene bi. Nanso, ɛnyɛ nea wode besi wo duruyɛfo, nnuruyɛfo, anaa akwahosan ho ɔyaresafo foforo a wo ne wo bɛkasa ananmu .

Sɛ wowɔ nsɛmmisa bi fa aduru yi, sɛnea ɛyɛ adwuma, nea efi mu ba, anaa biribi foforo biara ho a, ntwentwɛn wo nan ase sɛ wubebisa w’aduruyɛfo kuw no . Wɔwɔ ha sɛ wɔrebɛboa wo.

Kokoram ayaresa betumi ayɛ akwantu a emu yɛ den. Nanso sɛ wunya nimdeɛ a ɛfata, akwankyerɛ a efi wo duruyɛfo hɔ, ne mmoa a efi w’abusua hɔ a, wubetumi ahyia saa asɛnnennen yi. Kae sɛ ɛnyɛ wo nkutoo na wowɔ hɔ .

---

` Fluorouracil, 5-FU, kokoram, nnuru a wɔde sa yare, kokoram nnuru, nea efi mu ba, kokoram ayaresa