Dɛn ne nnuru foforo a wɔde sa Alzheimer yare yi? (NMDA Receptor Antagonists) Momma yɛnkasa.

So wo dɔfo, ebia wo maame, wo papa, wo nanabea anaa wo nana, wɔ Alzheimer yare? Yɛn nyinaa nim awerɛhow ne mmoa a wontumi nyɛ ho hwee a ɛba bere a yɛhwere nkae nkakrankakra na yɛn werɛ fi anim a yenim no. Alzheimer yare no yɛ tebea a ebetumi ama obi akae ade, amemene no asɛe na owu mpo aba ankasa. Ɛwom sɛ wonni aduru biara a wɔde sa yare yi de, nanso nnuru bi wɔ hɔ a ebetumi ama yare no ano abrɛ ase na ama ɔyarefo no ho atɔ no kakra. Ɛnnɛ yɛrebɛka nnubɔne kuw titiriw a ɛte saa biako ho asɛm. Ɛno ne NMDA Receptor Antagonists . Ɛwom sɛ edin no yɛ den kakra de, nanso momma yɛnte ase kɛkɛ.

Nnuru ho asɛm ketewaa bi a ɛkɔ so wɔ amemene no mu

Yɛn amemene yɛ beae a ɛyɛ nwonwa. Ntini mu nkwammoaa ɔpepepem pii, anaa `neurons` na ɛwɔ mu. Saa nkwammoaa yi di nsɛm ho dwuma, kae nsɛm, na wɔka nea ɛsɛ sɛ wɔyɛ kyerɛ nipadua no afã afoforo denam anyinam ahoɔden ne nnuru ho nsɛnkyerɛnne a wɔde kɔ anim ne akyi kɔma wɔn ho wɔn ho no so.

Yɛfrɛ abɔfoɔ a wɔsoa saa nnuru nsɛnkyerɛnneɛ yi `neurotransmitters`. Saa abɔfoɔ no mu baako ne `glutamate` .

Susuw glutamate ho kɛkɛ sɛ hyɛmma a ɛde nkrasɛm bi fi ntini mu nkwammoaa biako mu kɔ foforo mu. Saa hyɛmma yi hia hyɛn gyinabea soronko bi na ama watumi akɔ afiase dan foforo no mu na akɔhyɛn gyinabea. Saa hyɛn gyinabea no ne nea yɛfrɛ no NMDA receptor (`N-methyl-D-aspartate` receptor. Sɛ hyɛmma a wɔfrɛ no glutamate no bata NMDA hyɛn gyinabea yi ho a, ɛde ade foforo a ɛho hia a wɔfrɛ no `calcium` kɔ nkwammoaa no mu. Saa calcium yi ne nea ɛwie saa nkrasɛm no na ɛboa yɛn ma yesua na yɛkae biribi.Eyi yɛ adeyɛ a ɛfata wɔ amemene a ɛwɔ apɔwmuden mu.

Enti dɛn na ɛba wɔ Alzheimer yare no mu?

Wɔ obi a ɔwɔ Alzheimer yare amemene mu nkwammoaa mu no , glutamate pii fi ase yɛ . Nea ɛba ne sɛ calcium pii sen kɔ saa ntini mu nkwammoaa no mu. Wo de susuw nea ɛbɛba sɛ wode nsu pii hyɛ nsukorabea bi mu ma ho hwɛ? Ɛyɛ nea ɛboro so. Saa ara na sɛ calcium pii boaboa ano wɔ nkwammoaa no mu a, saa nkwammoaa no fi ase sɛe. Saa ɔsɛe yi ne nea ɛma Alzheimer yare ho sɛnkyerɛnne no yɛ kɛse nkakrankakra.

Sɛnea NMDA Receptor Antagonists boa ni

Nnuru kuw a wɔfrɛ no NMDA receptor antagonists no yɛ adwuma denam mmeae dodow a saa glutamate akorow a ɛboro so no betumi akɔhyɛ NMDA agyefo no so no so. Ɛne sɛ, aduru no siw hyɛn gyinabea ahorow no bi kwan. Nanso nea ɛho hia sen biara ne sɛ saa nnuru yi ma nkrasɛm a ɛho hia sen . Ɛne sɛ, wɔhyɛ calcium a ɛsɛe ade a ɛba no so nkutoo a wɔmfa ɔhaw kɛse biara mma amemene no dwumadi a ɛfata no mu. Eyi ma ntini mu nkwammoaa a ɛsɛe ade no so tew na ɛhwɛ sɛnea yare no tu ntɛmntɛm no so.

NMDA receptor antagonist titiriw a wɔapene so mprempren sɛ wɔmfa nsa Alzheimer yare no ne memantine (ahyɛnsode din `Namenda XR`). Mpɛn pii no, nnuruyɛfo na wɔkyerɛw ma yare no fã a ɛkɔ fam kosi nea emu yɛ den. Ɛtɔ da bi a, wɔde memantine ka `cholinesterase inhibitors` a yɛadi kan aka ho asɛm no ho, a ɛma acetylcholine dodow kɔ soro. Eyi betumi ama nneɛma pa aba ayarefo binom mu.

Nanso kae sɛ, nnuru yi nyɛ adwuma pɛpɛɛpɛ mma obiara.

Momma yɛnhwɛ nsunsuanso bɔne a efi mu ba no nso.

Te sɛ nnuru nyinaa no, eyi betumi anya ɔhaw nketenkete.

• Adwene a ɛyɛ basaa ne sɛnkyerɛnne a ɛtaa ba.
• Nea ɛka ho no, nneɛma te sɛ tiyɛ ne akisikuru nso betumi aba.
• Ɛntaa mma sɛ adwene a ɛyɛ basaa betumi aba amemene no mu .

Sɛ wo anaa wo ɔyarefo no nya eyinom mu biara a, ɛsɛ sɛ wobɔ wo duruyɛfo amanneɛ ntɛm ara . Ɛnyɛ adwene pa da sɛ wubegyae nnuru nom anaasɛ w’ankasa wobɛsesa dodow a wode ma no.

Nnuru afoforo a ɛwɔ abusua yi mu ne sɛnea wɔde di dwuma

Nnuru afoforo wɔ abusua yi mu a wɔfrɛ no NMDA receptor antagonists. Ebinom na yehu wɔn wɔ da biara da asetra mu. Ebinom yɛ nea asiane wom kakra, na wɔde di dwuma ɔkwammɔne so sɛ nnubɔne. Nyansahufo nso reyɛ nhwehwɛmu wɔ mfaso a ɛwɔ nnuru kuw yi so wɔ ntini mu nyarewa afoforo te sɛ Parkinson yare ne ALS (amyotrophic lateral sclerosis) ho.

Momma yensua ho nsɛm pii mfi pon a ɛwɔ ase ha no so.