So woate pɛn sɛ obi nan ho ahonhon na ɛyɛ yaw mpofirim na oduruyɛfo bi ka kyerɛɛ no sɛ mogya atɔ ne nan mu? Anaasɛ aberante bi a ɔwɔ apɔwmuden a ɛyɛ den ma no sɛ ɔbɛhome mpofirim na ne koko ayɛ no yaw na wɔde no akɔ ayaresabea? Sɛ yɛte nsɛm a ɛte sɛɛ a, ebia yebesusuw nea ɛrekɔ so no ho. Mpɛn pii no, yehu nneɛma te sɛ onyin ne kɛseyɛ mmoroso sɛ ɛno na ɛde eyi ba. Nanso, ɛtɔ mmere bi a nea ɛde ba no betumi ayɛ biribi te sɛ yɛn aniwa kɔla, sɛnea yɛn ti nhwi te, anaa awosu mu abɔde bi a yenya fi yɛn awofo hɔ. Ɛnnɛ yɛrebɛka awosu mu tebea a ɛte saa a ɛma asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no yɛ kɛse ho asɛm. Wɔfrɛ eyi
Prothrombin Gene Mutation .
Sɛ yɛbɛka no tiawa a, dɛn ne saa Prothrombin Gene Mutation yi?
Ebia eyi bɛyɛ te sɛ nyansahu mu din, nanso asɛm no yɛ mmerɛw yiye. Momma yenni kan nhwɛ sɛnea mogya a ɛtwetwe no taa ba yɛn nipadua mu. Sɛ wupira kakra a, mogya kakra sen na afei egyae bere tiaa bi akyi, ɛnte saa? Nea enti a ɛte saa ne sɛ mogya a ɛma mogya tu wɔ yɛn nipadua mu no yɛ adwuma. Protein ahorow pii boa wɔ eyi mu. Yɛfrɛ saa protein ahorow yi Clotting Factors.
Prothrombin yɛ protein a ɛte saa no mu biako. Edin foforo a wɔde frɛ eyi ne
Factor II . Mpɛn pii no, yɛn nipadua no yɛ Prothrombin dodow a ehia nkutoo. Nanso, wɔ obi a ɔwɔ awosu mu nsakrae a wɔfrɛ no Prothrombin Gene Mutation nipadua mu no, wɔyɛ protein a wɔfrɛ no Prothrombin yi
dodow kɛse sen sɛnea wɔhwehwɛ . Wo de susuw ho hwɛ, sɛ obi de asikre nkaribo anum anaa asia ka tii kuruwa biako ho sen sɛ ɔde asikre nkaribo abien bɛka ho a, dɛn na ɛbɛba? Sɛnea tii yɛ dɛ dodo no, sɛ prothrombin dodow kɔ soro a, yɛn mogya no "yɛ nnam" kakra, anaasɛ
ɛyɛ mmerɛw sɛ ɛbɛtwetwe. Eyi ma asiane a ɛwɔ hɔ sɛ mogya a ɛbɛtɔ ntini no mu no yɛ kɛse , a opira biara mpo. Saa mogya a ɛretu yi ba wɔ nan no ntini a emu dɔ no mu. Yɛfrɛ tebea yi
Deep Vein Thrombosis (DVT) . Ɛtɔ mmere bi a, mogya a ɛtɔ yi fã bi betumi abubu na asiw ntini bi a ɛwɔ ahurututu no mu. Eyi yɛ tebea a asiane wom yiye, a wɔfrɛ no
Pulmonary Embolism (PE) .
Yɛbɛyɛ dɛn anya saa awosu mu abɔde yi? Dɛn ne homozygous ne heterozygous?
Eyi yɛ mmerɛw yiye sɛ yɛbɛte ase. Yenya awosu mu abɔde biara sɛ biako fi yɛn maame hɔ na biako fi yɛn papa hɔ. Susuw saa awosu mu abɔde a ɛma Prothrombin yi ho hwɛ. 1.
Heterozygous: Wunya saa awosu mu abɔde a asɛe yi fi wo maame
anaa wo papa hɔ, kyerɛ sɛ, efi w’awofo no mu biako pɛ hɔ. Onipa foforo no nya awosu mu abɔde a ɛwɔ apɔwmuden na ɛteɛ no. Nnipa pii a wɔwɔ Sri Lanka ne wiase nyinaa wɔ saa tebea yi. Wɔ eyi mu no, asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no dɔɔso kakra sen sɛ wɔkyekyem pɛpɛɛpɛ a, onipa biara. Sɛ yɛbɛka no tiawa a, nnipa 1,000 biara a wɔwɔ saa yare yi mu baanu anaa baasa wɔ asiane mu sɛ wobenya mogya a ɛbɛtɔ. 2. 2. .
Homozygous: Eyi ho yɛ na kakra. Nea ɛkɔ so wɔ ha ne sɛ wunya awosu mu abɔde a asɛe no fi wo maame ne wo papa nyinaa hɔ. Eyi kyerɛ sɛ wunya awosu mu abɔde a asɛe no abien no nyinaa
fi awofo baanu no nyinaa hɔ . Wɔ saa tebea yi mu no, asiane a ɛwɔ hɔ sɛ mogya bɛtɔ
no boro wɔn a wɔyɛ `Heterozygous` no so mpɛn pii. So me mma benya eyi afi me hɔ?
Eyi yɛ ɔhaw a awofo pii wɔ.
- Sɛ wowɔ homozygous tebea no (a ɛkyerɛ sɛ awosu mu abɔde no mfonini abien no nyinaa asɛe) a, akyinnye biara nni ho sɛ wode awosu mu abɔde biako a asɛe ama wo mma no mu biara .
- Sɛ woyɛ heterozygous (a ɛkyerɛ sɛ wowɔ awosu mu abɔdeɛ baako pɛ a ɛtɔ sin) a, ɛyɛ 50% sɛ wo mma no mu baako bɛnya saa awosuo mu nkwaadɔm no. Ɛte sɛ nea worebɔ sika bi; ebia wubenya anaasɛ worennya bi.
Dɛn ne tebea yi ho sɛnkyerɛnne?
Ade a ɛho hia sen biara ni.
Nsɛnkyerɛnne biara nni hɔ a ɛfa awosu mu nsakrae a wɔfrɛ no Prothrombin Gene Mutation ho pɔtee. Ɛne sɛ, sɛ wowɔ saa awosu yi wɔ wo nipadua mu mpo a, worente nsonsonoe anaa ɔhaw biara nka. Nnipa pii nnim mpo sɛ wɔwɔ saa awosu mu abɔde yi, na wɔtra ase wɔn nkwa nna nyinaa a mogya mu ntini biara nni hɔ. Enti ɛhe na ɔhaw no wɔ? Sɛ mogya a ɛtɔ esiane saa awosu mu abɔde yi nti nkutoo na ɔhaw no ba. Afei yehu sɛnkyerɛnne ahorow a ɛfa saa mogya a ɛretu no ho.
| Beae a mogya no tu no | Nsɛnkyerɛnne a ɛsɛ sɛ yɛhwɛ kwan |
|---|
| Ntini a emu dɔ a ɛma mogya tu (DVT) wɔ nan anaa abasa mu | - Ɛyaw a ɛba mpofirim, titiriw bere a wogyina hɔ anaa wɔnantew no.
- Nan anaa abasa a ɛho ahonhon.
- Wora yɛ kɔkɔɔ anaa kɔkɔɔ.
- Sɛ wode wo nsa ka a, saa beae no yɛ hyew sen mmeae afoforo.
|
| Wɔ ahurututu mu (Pulmonary Embolism - PE) . | |
Nea ɛho hia: Ahurututu mu ntini a ɛma mogya tu no yɛ aduruyɛ mu tebea a egye ntɛmpɛ . Enti, ɛho hia paa sɛ wobɛkɔ ayaresabea ntɛm ara sɛ atifi hɔ sɛnkyerɛnne ahorow no ba a.
So nneɛma afoforo wɔ hɔ a ɛka awosu mu nkwaadɔm ho a ɛma asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no yɛ kɛse?
Yiw, koraa. Yɛkae sɛ ɛnyɛ obiara a ɔwɔ saa awosu mu abɔde yi na obenya mogya mu ntini. Nanso, sɛ nneɛma a edidi so yi mu biako anaa nea ɛboro saa wɔ hɔ a, asiane no betumi ayɛ kɛse. Ɛte sɛ nea wode pɛtro agu ogya so.
- Sigaretnom: Sigaretnom sɛe mogya ntini na ɛma asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no yɛ kɛse .
- Oprehyɛn a wɔreyɛ: Sɛ woyɛ oprehyɛn kɛse wie a, ebia wobɛda mpa so nna pii, na ɛno betumi ama mogya no so atew na woatɔw.
- Kɛse mmoroso : Bere a nipadua mu duru kɔ soro no, asiane yi kɔ soro bere a wɔde nhyɛso kɛse ba ntini no so no.
- Nyinsɛn: Wɔ nyinsɛn mu no, asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no kɔ soro fi awosu mu esiane nkwaadɔm mu nsakrae a ɛba nipadua no mu ne nhyɛso a ɛba ntini no so a akokoaa a ɔrenyin no de ba nti.
- Awo ano aduru anaa hormone ayaresa a wɔnom: Asiane no betumi ayɛ kɛse denam estrogen hormone a ɛwɔ awo ano aduru ne hormone ayaresa bi mu no so.
- Mpanyinyɛ: Asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no kɔ soro fi awosu mu bere a obi nyin no.
- Gyinabea koro no ara a wobɛtra bere tenten dodo:
- Mpa a wɔda so wɔ ayaresabea nna pii.
- Cast a wobɛhyɛ bere a woabubu nan bi no.
- Wimhyɛn, bɔs, anaa kar a wɔde tu kwan nnɔnhwerew pii wɔ bere koro mu.
Mɛyɛ dɛn ahu sɛ mewɔ saa tebea yi anaa?
Wontumi mfa mogya mu nhwehwɛmu a wɔyɛ no daa (te sɛ mogya dodow a edi mũ) nhu eyi. Awosu
mu nhwehwɛmu pɔtee bi ho hia ma eyi. Wɔnam mogya a wɔfa so na ɛyɛ eyi. Nanso, oduruyɛfo nka nkyerɛ obiara sɛ ɔnyɛ nhwehwɛmu yi. Mpɛn pii no, oduruyɛfo bi susuw eyi ho na ɔhyɛ sɛ wɔnyɛ nhwehwɛmu wɔ nsɛm a edidi so yi mu:
- Sɛ woanya mogya a ɛtɔ bɛboro biako pɛn a.
- Sɛ mogya tu bere a woyɛ abofra, wowɔ apɔwmuden, na wunni nyarewa foforo biara a.
- Sɛ wo busuani bi a ɔbɛn wo wɔ w’abusua mu (ɛna, agya, anuanom) wɔ mogya a ɛtwetwe ho haw a ɛte sɛɛ a.
Ɔkwan bɛn so na wɔsa?
Ɛha yi, ɛsɛ sɛ yɛka nsɛm abien a emu da hɔ. 1.
Awosu mu nkwaadɔm mu nsakrae ho ayaresa: Sɛnea mprempren aduruyɛ ho nyansahu kyerɛ no,
ɔkwan biara nni hɔ a yɛbɛfa so asa yɛn awosu mu nkwaadɔm anaasɛ yɛbɛsesa. Wei kyerɛ sɛ Prothrombin Gene Mutation no bɛka wo ho wo nkwa nna nyinaa. 2.
Mogya a ɛtwetwe no Ayaresa: Nanso, yebetumi
adi asiane a ɛwɔ hɔ sɛ mogya a ɛtɔ a saa awosu mu abɔde yi de ba no so na yɛasa mogya a ɛtɔ a ayɛ . Sɛ wowɔ DVT anaa PE a, wo duruyɛfo no bɛtaa afi ayaresa ase denam aduru bi a esiw mogya a ɛbɛtɔ (nea yɛtaa frɛ no mogya a ɛma mogya tu) a ɔbɛma wo no so. Wɔ aduruyɛ mu no, wɔfrɛ eyinom
nnuru a ekum mogya a ɛtwetwe mogya . Wɔ tebea horow bi a egye ntɛmpɛ mu no, wɔde nnuru a wɔfrɛ no
thrombolytics ma denam aduru a wɔde twitwiw nipadua no mu ma ɛpete na wɔayi mogya a ɛretu no afi hɔ. Ɛntaa mma koraa sɛ wobetumi de catheter anaa oprehyɛn ayi mogya a ɛretu no afi hɔ. Bere tenten a wɔde sa yare no gu ahorow wɔ onipa biara mu. Wɔ nnipa binom fam no, sɛ wɔnom aduru no bɛyɛ asram abiɛsa a, ɛdɔɔso. Ebia ɛho behia sɛ afoforo nom nnuru a ɛma mogya tu wɔn nkwa nna nyinaa. Wo duruyɛfo no begyina wo tebea no ne asiane ahorow a ɛwɔ hɔ so asi saa gyinae no.
Ɔkwan bɛn so na saa tebea yi ka nyinsɛn?
Eyi yɛ asɛm a ɛho hia ma mmea pii.
- Sɛ wowɔ Prothrombin Gene Mutation yi na woanya mogya a ɛtɔ bere bi a atwam no a , ebia wo duruyɛfo bɛkamfo akyerɛ sɛ fa aduru a wɔde siw mogya ano a ɛba fam (a wɔde siw ano) da biara da (te sɛ heparin) wɔ wo nyinsɛn no nyinaa mu ne adapɛn kakraa bi wɔ wo ba no awo akyi. Saa nnuru a wɔde twitwiw wo ba no mu no nyɛ asiane mma wo ba no.
- Nanso, sɛ wowɔ saa awosu mu abɔde yi mpo a, sɛ woannya mogya a ɛtɔ da wɔ w’asetra mu a , mpɛn pii no wunhia ayaresa biara wɔ nyinsɛn mu.
Nanso, eyi yɛ biribi a ɛsɛ sɛ oduruyɛfo gyina w’ankorankoro tebea so si ho gyinae. Sɛ woreyɛ nhyehyɛe sɛ wubenyinsɛn anaa wuhu sɛ woanyinsɛn a, ɛho hia sɛ wobɔ wo mmea ho ɔyaresafo ne nnuruyɛfo afoforo amanneɛ sɛ wowɔ saa awosu mu tebea yi.
Bere bɛn na ɛsɛ sɛ wokɔ oduruyɛfo nkyɛn?
Eyi ho hia paa. Sɛ wohu sɛnkyerɛnne ahorow no na woyɛ ho biribi ntɛm a, ebetumi asiw tebea horow a emu yɛ den ano.
| Nsɛnkyerɛnne a worehyia | Adeyɛ a ɛsɛ sɛ wɔyɛ |
|---|
| DVT ho sɛnkyerɛnne bi ne ɛyaw, ɔfe, kɔkɔɔ, ne ɔhyew wɔ nan anaa nsa bi mu. | Frɛ w’abusua oduruyɛfo ntɛm ara, anaa kɔ ayaresabea Emergency Department (ETU) a ɛbɛn wo . |
| PE ho sɛnkyerɛnne ahorow bi ne koko mu yaw, ahome a ɛyɛ den, ne koma a ɛbɔ ntɛmntɛm. | Kɔ Emergency Department (ETU) a ɛbɛn wo no hɔ ntɛm ara a ntwentwɛn wo nan ase. Eyi yɛ tebea a egye ntɛmpɛ a ɛde nkwa to asiane mu. |
| Sɛ wode nnuru a ɛma mogya yɛ mmerɛw (anticoagulants) redi dwuma dedaw a. | Hwɛ hu sɛ wobɛkɔ mogya mu nhwehwɛmu ne ayaresabea ahorow sɛnea wo duruyɛfo ayɛ nhyehyɛe no. |
Awiei koraa no, sɛ wuhu sɛ wowɔ Prothrombin Gene Mutation no a, mma wo ho nnyɛ wo hu. Kae sɛ nnipa dodow no ara a wɔwɔ saa awosu mu abɔde yi betumi atra ase yiye a ɔhaw biara nni ho. Ade a ɛho hia sen biara ne sɛ wubehu eyi, twe wo ho fi nneɛma a ɛde asiane ba (te sɛ sigaretnom, kɛseyɛ mmoroso), tra ase a ahoɔden wom, na sɛ wunya mogya a ɛretu ho sɛnkyerɛnne biara a, hwehwɛ aduruyɛ mu afotu ntɛm ara.
Nkrasɛm a Wɔde Kɔ Fie
- Prothrombin Gene Mutation yɛ awosu mu tebea a wɔde ma awo ntoatoaso ahorow. Ɛnyɛ wo mfomso.
- Sɛ obi wɔ saa awosu mu abɔde yi a, esiw mogya a ɛbɛtɔ no kwan. Nnipa dodow no ara nhyia ɔhaw biara.
- Nsɛnkyerɛnne biara nni hɔ a ɛbata saa awosu mu abɔde yi ho. Sɛ mogya a ɛtɔ te sɛ DVT anaa PE ba nkutoo a, na sɛnkyerɛnne ahorow no ba.
- Hwɛ yiye bere nyinaa sɛ wobɛhu sɛnkyerɛnne ahorow a ɛkyerɛ sɛ wo nan ho ahonhon, ɛyaw (DVT), ne wo koko mu yaw mpofirim ne ahome a ɛyɛ tiaa (PE).
- Pulmonary Embolism (PE) yɛ aduruyɛ mu tebea a egye ntɛmpɛ a ɛsɛ sɛ wɔsa no ntɛm ara.
- Sigaretnom a wɔkwati, nipadua mu duru a wodi so, ne asetra kwan a ɛyɛ nnam a wobɛtra ase no betumi atew asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no so.
- Sɛ wunim sɛ wowɔ saa yare yi a, ɛho hia paa sɛ wobɔ oduruyɛfo biara amanneɛ bere a woahu wɔn, ansa na wɔayɛ wo oprehyɛn, anaa bere a woanyinsɛn no.
- Sɛ wo ne wo duruyɛfo di nkitaho daa na wudi n’afotu akyi a, so wɔ mfaso kɛse ma w’akwahosan.
Prothrombin Gene Mutation, Factor II mutation, Mogya a ɛtwetwe, Deep Vein Thrombosis, Pulmonary Embolism, DVT, PE, Awosu mu nyarewa, Mogya a ɛma mogya tu, Nnuru a ɛma mogya tu
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