Shin ka san ainihin menene endothelin a jikinka? Yadda yake shafar hawan jininmu!

Shin kun taɓa jin kalmar 'Endothelin'? Wataƙila kun ji likita ya ambaci wannan sunan a gare ku ko wani a cikin iyalinku lokacin da kuke magana game da magani, ko kuma kun taɓa ganinsa a wani wuri lokacin da kuke karantawa game da wata cuta. Ko da yake wannan ƙaramin abu ne da ake samarwa a cikin jikinmu, yana yin babban aiki na kiyaye hawan jininmu, ko 'matsin lamba' kamar yadda muka sani, a matakin da ya dace. Duk da haka, idan wannan endothelin ya ƙaru a cikin jiki fiye da yadda ake buƙata, matsaloli daban-daban na lafiya na iya faruwa. Don haka, a yau za mu yi magana game da menene wannan endothelin da abin da yake yi wa jikinmu ta hanya mai sauƙi da za ku iya fahimta.

To menene wannan endothelin?

A taƙaice dai, endothelin ƙaramin furotin ne wanda ke taimakawa wajen takura jijiyoyin jini a jikinmu. A taƙaice dai, peptide ne. Peptides gajerun sarƙoƙi ne na furotin da aka yi da ƙananan abubuwa da ake kira amino acid. Waɗannan kuma suna taimakawa wajen gina manyan furotin a jikinmu.

Shin kun san wanda ke yin wannan endothelin? Akwai wani Layer na ƙwayoyin halitta a cikin jijiyoyin jininmu. Ana kiransa endothelium. Wannan shine babban wuri a jikinmu wanda ke samar da endothelin.

Menene endothelium? Za ku iya bayyana shi kaɗan?

Ka yi tunanin jijiyoyin jini a cikin jikinmu a matsayin hanyar sadarwa ta bututun da ke ɗauke da ruwa. Cikin waɗannan bututun, a gefen inda jini ke gudana, an rufe shi da siririn Layer na ƙwayoyin halitta. Wannan Layer na ƙwayoyin halitta ana kiransa endothelium . Ko da yake abin mamaki ne, ana kuma ɗaukarsa a matsayin ɗaya daga cikin manyan gabobin jikinmu!

Waɗannan ƙwayoyin endothelial suna fitar da abubuwa daban-daban. Waɗannan abubuwa suna sarrafa faɗaɗa da matsewar jijiyoyin jininmu, wanda ake kira sautin jijiyoyin jini . Wannan sautin jijiyoyin jini yana ƙayyade irin ƙarfin da zuciyarmu ke da shi na fitar da jini da kuma yadda yake da wahalar yin aiki don yaɗa jini a cikin jiki.

Endothelium da endothelin suna aiki tare don yin wasu muhimman ayyuka da dama:

• Yana taimakawa wajen toshewar jini. Wannan yana da matukar muhimmanci don dakatar da zubar jini idan aka samu rauni.
• Yana sarrafa matakan ruwa da gishiri (electrolytes) a cikin jininmu.
• Haka kuma yana taimakawa wajen rage kumburi ta hanyar hana guba shiga kyallen jikinmu.

To me endothelin ke yi wa jiki?

Mun riga mun ambata cewa endothelin wani abu ne da ke taimakawa wajen takaita jijiyoyin jini. A gaskiya ma, endothelin shine mafi ƙarfi a cikin vasoconstrictor a jikinmu. Bari mu ɗan taƙaita wannan kalma kaɗan:

• Bangaren "Vaso" yana nufin jijiyoyin jini a cikin tsarin jijiyoyinmu na zuciya da jijiyoyin jini.
• "Mai ɗaurewa" ko "matsawa"Matsewar jini na nufin cewa jijiyoyin jini sun yi ƙunci ko kuma sun yi tauri. Wannan yana rage kwararar jini, wani lokacin ma yana dakatar da shi.

Don haka, abin da endothelin ke yi shi ne ƙara hawan jininmu. Idan jijiyoyin jini suka taurare, dole ne zuciya ta yi aiki tuƙuru don ta hura jini. Shi ya sa matsin lamba ke ƙaruwa.

Me zai faru idan matakan endothelin suka ƙaru?

Yawanci, endothelin yana aiki ta hanya mai kyau ga jikinmu. Duk da haka, idan saboda wani dalili wannan matakin endothelin ya ƙaru a jiki, yana iya haifar da cututtuka da dama waɗanda ke lalata zuciyarmu da huhu . Ka yi tunanin abin da zai faru idan bututun ruwa ya toshe sosai. Haka ne.

Wasu daga cikin matsalolin da ke iya tasowa sakamakon karuwar matakan endothelin sune:

• Atherosclerosis (cutar jijiya): A cikin wannan, kitse yana taruwa a cikin jijiyoyin jini , yana rage jijiyoyin jini.
• Ciwon zuciya da ya karye: Rauni a zuciya sakamakon damuwa kwatsam.
• Akwai nau'ikan ciwon daji da dama.
• Ciwon zuciya : Rauni a tsokar zuciya.
• Cututtukan zuciya da jijiyoyin jini (zuciya) da kuma gazawar zuciya.
• Ciwon jijiyoyin zuciya , da kuma wata cuta da ake kira rashin aikin endothelial.
• Hawan jini da kuma preeclampsia .
• Ciwon koda da gazawar koda .
• Ciwon huhu da kuma hawan jini a huhu .
• Scleroderma : Kauri a fata da kuma nama mai haɗin kai.

Ka yi tunanin, Nimal ya daɗe yana fama da hawan jini. Likitan ya ce jijiyoyin jininsa sun ɗan yi tsauri, kuma matakan endothelin ɗinsa na iya shafar sa. Ya kuma yi gargaɗin cewa idan bai sha maganin da ya dace ba, zai iya haifar da bugun zuciya. Don haka, ba kyakkyawan ra'ayi ba ne a ɗauki wannan abu na endothelin da wasa.

Akwai nau'ikan endothelin?

Eh, akwai nau'ikan endothelins. Masu binciken lafiya sun fara gano su a shekarar 1987. Akwai manyan nau'ikan endothelins guda uku, waɗanda suka ƙunshi amino acid peptides guda huɗu. Dukansu ukun suna da vasoconstrictors.

Nau'in endothelin da ya fi yawa kuma mafi ƙarfi a jikinmu shine endothelin-1 (ET-1). Masu bincike har yanzu suna koyon yadda sauran nau'ikan guda biyu, endothelin-2 (ET-2) da endothelin-3 (ET-3), ke shafar jikinmu. A halin yanzu, mafi yawan hankali yana kan ET-1.

Mene ne masu karɓar endothelin?

Kowace nama a jikinmu tana da masu karɓar endothelin. Waɗannan masu karɓar kamar maɓallan ƙofa suke. Lokacin da ƙwayoyin endothelin suka zo suka ɗaure ga waɗannan masu karɓar, suna aika saƙo ga waɗannan ƙwayoyin don yin wani abu. Wannan shine yadda endothelin ke sadarwa da ƙwayoyin halitta a cikin jikinmu.

Ta yaya ake auna matakan endothelin?

Idan likitoci suna son sanin menene matakan endothelin ɗin ku, za su yi gwajin jini . Wannan yana auna matakin endothelin-1 (ET-1). Ana samunsa a cikin wani ɓangare na jinin da ake kira plasma. Plasma shine ruwan jinin da ya rage bayan an cire jajayen ƙwayoyin jini, fararen ƙwayoyin jini, da platelets.

Ana iya yin wannan gwajin jini a ofishin likitanka, asibiti, ko dakin gwaje-gwaje. Sauran nau'ikan endothelin suna da wahalar aunawa a cikin jini ta wannan hanyar.

Naúrar auna endothelin ita ce picograms a kowace millilita (pg/mL).

• Matsakaicin matakin plasma na ET-1 a cikin manya shine kusan 1 pg/mL zuwa 2 pg/mL.
• Matakan ET-1 a cikin ƙananan yara sun ɗan fi girma.
• Haka kuma, akwai ɗan bambanci kaɗan a cikin waɗannan matakan tsakanin ƙasashe daban-daban.

Yawanci, mutanen da ke da wasu matsalolin zuciya ko huhu, kamar hawan jini a cikin jijiyoyin huhu, suna da matakan ET-1 masu yawa. Haka kuma, wasu magungunan zuciya, kamar balan-balan angioplasty, na iya ƙara matakan endothelin na ɗan lokaci.

Mene ne masu adawa da Endothelin Receptor Antagonists (ERA)?

Waɗannan nau'in magani ne da ake bayarwa lokacin da matakin endothelin ya ƙaru. Masu hana karɓar Endothelin (ERA) suna aiki ta hanyar rage adadin endothelin a jikinmu.

Waɗannan suna cikin wani nau'in magani da ake kira "maganin da aka yi niyya". Wato, waɗannan magungunan suna tafiya daidai kuma suna kai hari ga ƙwayoyin da ke da matsala kawai, ba tare da haifar da lahani mai yawa ga ƙwayoyin lafiya ba. Kamar maharbi, suna kai hari daidai wurin da aka nufa. Ana amfani da magungunan ERA galibi don magance wasu nau'ikan hawan jini a cikin huhu (hawan jini na huhu).

Akwai wani illa ga waɗannan magungunan ERA?

Kamar kowace magani, magungunan ERA na iya haifar da wasu illa.

• Mata masu juna biyu ko mata da ke ƙoƙarin ɗaukar ciki bai kamata su sha waɗannan magungunan ERA ba. Wannan ya faru ne saboda waɗannan magungunan na iya haifar da lahani ga jaririn da ba a haifa ba. Wannan batu ne mai matuƙar muhimmanci.
• Ba kasafai ake samun wannan maganin ba, yana iya haifar da lalacewar hanta. Saboda haka, likitanka zai iya yin odar gwajin jini don duba lafiyar hanta akai-akai.
• Sauran illolin da ka iya faruwa sune:
• Maƙarƙashiya.
• kumburin fuska (edema) ko kuma kurajen fuska.
• Ciwon kai .
• Tashin zuciya da amai.
• Buga bugun jini da bugun zuciya cikin sauri.

Idan kina jin wani abu makamancin haka, ya kamata ki gaya wa likitanki nan take domin ya ɗauki matakan da suka dace.

To, menene abubuwan da ya kamata mu tuna daga wannan labarin? (Saƙon Gida)

To, mun yi magana sosai game da endothelin. A takaice:

• Endothelin muhimmin furotin ne da ake samarwa a jiki wanda ke taimakawa wajen takaita jijiyoyin jini da kuma daidaita hawan jini.
• Ana yin wannan ne daga wani Layer na ƙwayoyin halitta da ake kira endothelium wanda ke rufe cikin jijiyoyin jininmu.
• Idan matakan endothelin suka yi yawa, tasoshin jini na iya yin tauri sosai, wanda ke haifar da matsaloli kamar hawan jini, cututtukan zuciya, da cututtukan huhu .
• Ana iya auna matakan Endothelin-1 (ET-1) a cikin jini ta hanyar gwajin jini .
• Magungunan hana karɓar Endothelin (ERAs) wani nau'in magani ne da ke rage matakan endothelin. Ana amfani da su musamman don hawan jini a cikin huhu.
• Idan kana shan maganin ERA, ya kamata ka yi taka tsantsan musamman a lokacin daukar ciki da kuma lafiyar hanta.

Don haka, idan kai ko wani da ka sani yana da matsala da Endothelin, ya fi kyau ka nemi shawarar likita. Ina fatan wannan labarin ya ba ka wasu bayanai. Ka kasance cikin koshin lafiya!

Endothelin , hawan jini, cututtukan zuciya, cututtukan huhu, endothelium, peptides