Ua ʻike anei ʻoe e pili ana i kēia ʻelele liʻiliʻi i loko o kou kino? (Adrenocorticotropic Hormone - ACTH)

Ua noʻonoʻo paha ʻoe i ka mea e hana ana i loko o kou kino ke kaumaha ʻoe a i ʻole ke kaumaha nui nei? He hoaaloha liʻiliʻi ko ko kākou kino a ʻike ʻole ʻia e kōkua mai ana iā kākou i nā manawa e like me kēia. Ua kapa ʻia ʻo ia ʻo ACTH. I kēia lā, e kamaʻilio kākou e pili ana i kēia ACTH.

He aha ka ACTH?

I ka ʻōlelo maʻalahi, ʻo ACTH kahi hormone i hana ʻia e kou kelepa pituitary. He kuleana nui ia i ke ʻano o ka pane ʻana o kou kino i ke kaumaha . Ke hoʻokuʻu ʻia ʻo ACTH, hōʻailona ia i kāu mau kelepa adrenal e hana i ka cortisol, ka mea a mākou e ʻike ai ʻo ka "hormone stress," a me kahi hui o nā hormones wahine i kapa ʻia ʻo androgens.

I kēia manawa ke noʻonoʻo nei paha ʻoe i ke ʻano o kēia mau hormones, ʻeā? ʻO nā hormones he mau kemika e hoʻonohonoho i nā hana like ʻole i loko o kou kino. Ua like lākou me nā ʻelele. Hele kēia mau leka ma o kou koko i kou mau ʻōpū, ʻili, ʻiʻo, a me nā ʻiʻo ʻē aʻe. Hōʻike kēia mau hōʻailona i kou kino i ka mea e hana ai a me ka wā e hana ai.

He ʻāpana liʻiliʻi kou pituitary gland, e like me ka nui o ka pī, aia ma ke kumu o kou lolo, ma lalo pono o ka hypothalamus. He ʻāpana ia o kāu ʻōnaehana endocrine. ʻElua ʻāpana o ka pituitary gland: ka lobe mua a me ka lobe hope. ʻO kou pituitary gland mua ka mea e hana a hoʻokuʻu iā ACTH.

He aha ka mea e hana maoli me ka ACTH?

ʻO ka hana nui o ACTH ka hoʻoulu ʻana i kāu mau kelepa adrenal e hoʻokuʻu i ka hormone cortisol. E noʻonoʻo iā ia e like me ACTH e like me ke kauoha e haʻi ana i kāu mau kelepa adrenal e hana i ka cortisol.

He hormone koʻikoʻi loa ka Cortisol e pono ai ko kākou kino. Hoʻopilikia ia i kēlā me kēia ʻōkana a me nā ʻiʻo o ke kino. Ua kapa ʻia ʻo Cortisol ʻo ka "hormone stress," akā he nui nā hana koʻikoʻi ʻē aʻe i loko o ko kākou kino.

Eia kekahi mau mea nui e pili ana i ka cortisol:

• Hoʻokele ʻoe i ke ʻano o ka pane ʻana o kou kino i ke kaumaha .
• Kōkua ia i ka kaohi ʻana i ke ʻano o ka hoʻohana ʻana o kou kino i nā momona, nā protein, a me nā kalapona, ʻo ia hoʻi, kāu metabolism .
• Ua hoʻemi ʻia ka mumū , ʻo ia hoʻi ka pehu a me ka ʻulaʻula ma nā wahi like ʻole o ke kino.
• Hoʻoponopono i ke kaomi koko .
• Hoʻoponopono i nā pae kō koko .
• Kōkua nō hoʻi ia i ka hoʻoponopono ʻana i kāu pōʻaiapuni hiamoe-ala .

ʻAʻole wale kēia, hana ʻo ACTH i kekahi mea ʻē aʻe. ʻO ia hoʻi, hoʻoulu ia i nā kelepa adrenal e hoʻokuʻu i nā hormones wahine i kapa ʻia ʻo androgens. Eia kekahi, kōkua ʻo ACTH i ka hana ʻana i nā kemika e hoʻoulu ai i ka hana ʻana o nā hormones hou aʻe, e like me ka adrenaline a me ka noradrenaline.

Pehea e kāohi ʻia ai nā pae ACTH?

Hoʻokele ʻia nā pae ACTH o kou kino e kahi ʻōnaehana hoihoi loa. Ua kapa ʻia ʻo ia he ʻōnaehana feedback. Pili ia i kou hypothalamus, ka pituitary gland, nā adrenal glands, a me kekahi mau hormones. Kāhea mākou i kēia ʻōnaehana holoʻokoʻa ʻo ka Hypothalamic-Pituitary-Adrenal (HPA) axis . He paʻakikī iki ke kani, ʻeā? Akā, he maʻalahi ia.

E noʻonoʻo ʻoe ua pili kāu kelepa pituitary i kou hypothalamus e kahi ʻōpala liʻiliʻi o nā kīʻaha koko a me nā aʻalolo. Ua kapa ʻia kēia ʻo ke koʻokoʻo pituitary. Ma o kēia ʻōpala e kamaʻilio ai ka hypothalamus i ka kelepa pituitary a haʻi iā ia e hoʻokuʻu i kekahi mau hormones. ʻO kou hypothalamus kahi ʻāpana o kou lolo e kaohi ana i nā mea e like me ke koko, ka helu o ka puʻuwai, ka mahana o ke kino, a me ka ʻai ʻana.

ʻO nā kelepa adrenal ʻelua mau kelepa liʻiliʻi, triangular aia ma luna o kou mau puʻupaʻa.

I kēia manawa, e nānā kākou pehea e hana ai kēia ʻōnaehana manaʻo e kāohi ana i nā pae ACTH:

• Ke hāʻule ka nui o ka cortisol o kou kino, hoʻokuʻu kou hypothalamus i kahi hormone i kapa ʻia ʻo Corticotrophin-Releasing Hormone (CRH) .
• Hoʻoulu kēia CRH i kou lobe pituitary mua e hoʻokuʻu iā ACTH.
• A laila hoʻoulu ʻo ACTH i kāu mau kelepa adrenal, ʻoi aku ka adrenal cortex, e hoʻokuʻu i ka cortisol a me nā androgens.
• Ke piʻi aʻe nā pae cortisol e like me kēia, hoʻouna ia i kahi hōʻailona i ka hypothalamus e hoʻohaʻahaʻa i nā pae CRH. A pēlā e pau ai ke kaʻina hana. Ua like ia me kahi 'on-off switch' .

ʻAʻole wale kēia, ke kaumaha ʻoe, ʻo ia hoʻi, ke kaumaha noʻonoʻo, hoʻoulu ʻia ka hana ʻana o ACTH a piʻi aʻe nā pae cortisol.

Eia nō naʻe, inā he pilikia me kou hypothalamus, pituitary gland, a i ʻole nā ​​​​gland adrenal, ʻo ke kaulike o nā hormones e pili ana i kēia kaʻina hana, ʻo ia hoʻi ʻo ACTH, e hoʻopilikia ʻia paha.

Pehea e nānā ai i nā pae ACTH?

Hana ʻia kahi hoʻāʻo koko e nānā i kāu mau pae ACTH. Pili kēia i ka lawe ʻana i kahi hāpana koko liʻiliʻi mai kahi aa koko ma kou lima.

Hoʻomaʻamaʻa pinepine nā kauka i kahi hoʻāʻo cortisol me kahi hoʻāʻo ACTH e hoʻoholo ai inā he mau pilikia me ka pituitary gland a i ʻole nā ​​​​gland adrenal.

Eia kekahi, i kekahi manawa, hana paha nā kauka i kahi mea i kapa ʻia he hoʻāʻo hoʻoulu ACTH . Hoʻāʻo kēia i ka maikaʻi o ka pane ʻana o kāu mau kelepa adrenal i ka ACTH. Hiki i kēia ke kōkua i ka ʻike ʻana i nā pilikia me nā kelepa pituitary a/a i ʻole nā ​​​​kelepa adrenal.

He aha ka pae ACTH maʻamau?

E like me ka cortisol, ʻo ke kiʻekiʻe loa o ka ACTH i loko o kou koko i ke kakahiaka nui. E emi mālie ana ia i ka hala ʻana o ke ao, a hiki i kona pae haʻahaʻa loa ma kahi o ke aumoe. Eia nō naʻe, inā ʻoe e hana i ka hoʻololi pō a hiamoe i nā manawa like ʻole o ka lā, e loli paha kēia ʻano.

No laila, koi pinepine ʻia ke koko e huki ʻia i ke kakahiaka no nā hoʻokolohua ACTH. Ma ke ʻano laulā, ʻo ka pae maʻamau no nā pae ACTH ma waena o 7:00 a.m. a me 10:00 a.m. he 7.2 a 63.3 picograms no ka milliliter (7.2 a 63.3 pg/mL) .

Akā e hoʻomanaʻo i hoʻokahi mea. Hiki ke ʻokoʻa kēia mau pae maʻamau mai ka lab a i ka lab, mai kēlā manawa a i kēia manawa, a mai ke kanaka a i ke kanaka. Inā loaʻa iā ʻoe kahi hoʻāʻo ACTH, ʻo kāu kauka ka mea nāna e heluhelu i kāu mau hopena a haʻi iā ʻoe inā pono a ʻaʻole paha he hoʻāʻo hou aʻe.

He aha ka mea e hana ai inā piʻi aʻe ka nui o ka ACTH?

Inā kiʻekiʻe kou mau pae ACTH, he mea hiki nō hoʻi ke kiʻekiʻe kou mau pae cortisol. Ma muli o ka hoʻopilikia ʻana o ka cortisol i ke kino ma nā ʻano he nui, hiki iā ʻoe ke ʻike i nā hopena ʻaoʻao o ka cortisol kiʻekiʻe ma mua o nā hōʻailona o ka ACTH kiʻekiʻe. I kekahi mau hihia, ke hana ʻole kāu mau kelepa adrenal i ka cortisol lawa, hiki ke piʻi aʻe nā pae ACTH. I kēlā mau hihia, hiki iā ʻoe ke ʻike i nā hōʻailona o ka cortisol haʻahaʻa, ʻaʻole ka ACTH kiʻekiʻe.

Aia kekahi mau kumu no ka hoʻonui ʻia ʻana o ka ACTH:

• ʻO ka maʻi Cushing: ʻO kēia ke kumu maʻamau o nā pae ACTH kiʻekiʻe. Hoʻokumu ʻia kēia e kahi puʻupuʻu ʻaʻole cancerous (adenoma) i loko o ka pituitary gland e hana nui ana i ka ACTH. A laila hoʻonui kēia i nā pae cortisol. He mea nui e hoʻomaopopo i ka ʻokoʻa ma waena o ka maʻi Cushing a me ka maʻi Cushing . ʻO ka maʻi Cushing kekahi o nā kumu he nui o ka maʻi Cushing.
• ʻO ka puʻupuʻu hormone adrenocorticotropic ectopic: He mea kākaʻikahi loa, hiki i kahi puʻupuʻu e ulu ana ma waho o kou gland pituitary ke hoʻokuʻu i ka nui o ka ACTH. ʻO nā puʻupuʻu e hiki ke hana i ka ACTH ma kēia ʻano (ʻoiai he mea kākaʻikahi loa) e komo pū me nā puʻupuʻu carcinoid noncancerous o nā māmā, nā puʻupuʻu cell islet o ka pancreas, medullary carcinoma o ka thyroid, nā puʻupuʻu cell liʻiliʻi o ka māmā, a me nā puʻupuʻu o ka thymus gland .
• ʻO ka lawa ʻole o ka adrenal mua: Hana ʻia kēia kūlana ke hōʻino kekahi mea i kāu mau kelepa adrenal a ʻaʻole hiki iā lākou ke hana pono i ka cortisol. ʻO ka maʻi ʻo AddisonʻO kēia ke kumu maʻamau o ka nele o ka adrenal mua. ʻO ka hopena, hoʻokuʻu kāu pituitary gland i ka ACTH hou aku no ka mea makemake ia e hoʻoulu i nā adrenal glands.

He aha ka mea e hana ai inā e emi iho nā pae ACTH?

Inā haʻahaʻa nā pae ACTH ma muli o kahi pilikia me ka pituitary gland, e haʻahaʻa pinepine nā pae cortisol. Eia nō naʻe, inā kiʻekiʻe nā pae cortisol ma muli o kahi pilikia me ka adrenal gland, hiki ke haʻahaʻa nā pae ACTH.

Aia kekahi mau kumu e haʻahaʻa ai nā pae ACTH:

• ʻO ka maʻi Cushing: ʻO ka maʻi Cushing, hiki ke hana ʻia e kahi puʻupuʻu adrenal gland a i ʻole ma ka hoʻohana lōʻihi ʻana i nā lāʻau corticosteroid no nā kūlana ʻē aʻe, hiki ke hana i nā pae ACTH haʻahaʻa. ʻO kēia no ka mea ʻaʻole hiki i kāu pituitary gland ke hoʻokuʻu iā ACTH ma ke ʻano maʻamau ma muli o ka cortisol keu.
• Hypopituitarism: He kūlana kakaikahi loa kēia. ʻO kēia ka wā e hana ai kāu gland pituitary i ka liʻiliʻi o hoʻokahi, he nui, a i ʻole nā ​​​​hormone āpau. ʻO ACTH kekahi o nā hormones i hiki ke hoʻopilikia ʻia. ʻO kēlā me kēia hōʻino i kāu gland pituitary, e like me ka puʻupuʻu, ke ʻoki kino, a i ʻole ka radiation therapy, hiki ke hana i ka hypopituitarism.

I kēia manawa, ua maopopo paha iā ʻoe he mea nui ka ACTH no ka hoʻoponopono ʻana i kāu mau pae cortisol. Inā ʻike ʻoe i nā hōʻailona o nā pae cortisol kiʻekiʻe a haʻahaʻa paha, e like me ka piʻi ʻana o ke kaumaha a i ʻole ka emi ʻana o ke koko, ke koko kiʻekiʻe a haʻahaʻa paha, e ʻike pono i kāu kauka. Hiki iā ia ke hana i nā hoʻokolohua koko cortisol a me ACTH e hoʻoholo ai inā ʻo kāu mau kelepa adrenal a i ʻole ka pituitary gland ke kumu o kāu mau hōʻailona.

No laila he aha nā mea e pono ai mākou e hoʻomanaʻo?

He hormone koʻikoʻi loa ka ACTH i hana ʻia e ka pituitary gland e kōkua ai i ka kaohi ʻana i ke kaumaha i loko o ko mākou kino.

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- ʻO kēia ka mea e hoʻoulu ai i nā kelepa adrenal e hana i ka "hormone stress" cortisol .

- Hoʻokele ʻo Cortisol i nā mea he nui, e like me ko kākou metabolism, ke koko, a me nā pae kō koko.

- Hoʻomalu ʻia nā pae ACTH e kahi ʻōnaehana paʻakikī e pili ana i ka hypothalamus, ka pituitary gland, a me nā adrenal glands .

- Inā piʻi a emi paha nā pae ACTH, hiki iā ia ke alakaʻi i ka maʻi Cushing, ka maʻi Addison.Hiki ke loaʻa nā pilikia olakino like ʻole.

- Inā loaʻa iā ʻoe kekahi mau hōʻailona ma kēia ʻano, ʻoi aku ka maikaʻi o ka ʻike ʻana i ke kauka me ka makaʻu ʻole a ʻimi i ka ʻōlelo aʻo.

ʻAʻole hiki ke hoʻoponopono ʻia kēia mau mea . ` ACTH, Adrenocorticotropic Hormone, Cortisol, Pituitary gland, Adrenal glands, Hormones, Stress