Nā ʻike hou loa e pili ana i ka maʻi ʻaʻai umauma holomua - E kamaʻilio kākou

Inā ʻoe a i ʻole kekahi āu i ʻike ai e hakakā nei me ka maʻi ʻaʻai umauma holomua, hiki iā ia ke lilo i kumu ikaika nui e noho mau ai i ka ʻike e pili ana i ka ʻike hou a me nā mea i ʻike ʻia. Ke hoʻāʻo mau nei nā kānaka ʻepekema a me nā kauka e hoʻomaopopo maikaʻi i kēia maʻi a loaʻa nā lāʻau lapaʻau hou a ʻoi aku ka maikaʻi. No laila e nānā kākou i ke ʻano o kēia manaʻolana hou.

Nā lāʻau lapaʻau i ʻāpono hou ʻia

Ua hoʻolauna mua ʻia kekahi mau lāʻau lapaʻau hou i hōʻike i nā hopena holomua loa no ka maʻi ʻaʻai umauma holomua. Hana kekahi o kēia mau mea ma ka hoʻopili ʻana i nā protein kikoʻī e kāohi ana i ka ulu ʻana o nā hunaola kanesa.

I ka ʻōlelo maʻalahi, ua hoʻoikaika ʻia kekahi mau ʻano maʻi ʻaʻai umauma e nā hormones i loko o ke kino e ulu. Kāhea mākou i kēia mau maʻi ʻaʻai "hormone-receptor positive". Eia kekahi, ʻaʻohe protein i kapa ʻia ʻo `HER2` ma luna o ko lākou ʻili i kekahi mau cell kanesa. Ua kapa ʻia kēia mau maʻi ʻaʻai `HER2` maikaʻi ʻole. Inā loaʻa iā ʻoe kēia ʻano maʻi ʻaʻai, he koho maikaʻi paha nā lāʻau hou nāu.

E nānā kākou i kekahi o kēia mau lāʻau lapaʻau hou ma ka papa ma lalo nei.

Nā manaʻolana hou e mau ana i ke kahua noiʻi

Ma waho aʻe o nā lāʻau lapaʻau i ʻāpono ʻia i kēia manawa, aia kekahi mau lāʻau lapaʻau hoʻohiki ʻē aʻe e noiʻi ʻia nei. ʻOiai ʻaʻole i hoʻohana nui ʻia kēia mau mea, hiki iā lākou ke lilo i mea pōmaikaʻi nui iā mākou i ka wā e hiki mai ana.

Nā mea pale PARP

Hana kēia mau lāʻau lapaʻau ma ke ālai ʻana i ka hiki o nā hunaola maʻi kanesa ke hoʻoponopono iā lākou iho (hoʻoponopono DNA). Ua ʻike ʻia he mea pono loa lākou no ka poʻe me nā mutations i loko o nā genes BRCA1 a i ʻole BRCA2, i pili i ka maʻi kanesa o ka umauma.

Nā mea pale Tyrosine Kinase

ʻO kēia kekahi mau lāʻau lapaʻau e ālai ana i nā enzymes e kōkua i ka ulu ʻana o nā hunaola kanesa. Ua ʻae mua ʻia ʻo Lapatinib (Tykerb) no nā maʻi kanesa HER2-positive. Ua hōʻike ʻia kekahi lāʻau lapaʻau ʻē aʻe, ʻo Neratinib, ma kahi noiʻi hou e kōkua i nā mea maʻi e ola lōʻihi ke hāʻawi ʻia ma hope o ka chemotherapy.

Nā lāʻau lapaʻau HER2 i hoʻolālā hou ʻia

Ma kahi o hoʻokahi o kēlā me kēia ʻelima poʻe me ka maʻi ʻaʻai umauma he nui loa ka protein i kapa ʻia ʻo HER2, kahi e kōkua ai i ka ulu ʻana o nā hunaola maʻi ʻaʻai umauma. Ke hoʻomohala ʻia nei nā lāʻau lapaʻau e kuhikuhi ana i kēia protein i kēlā me kēia lā. No ka laʻana, ua hōʻike ka lāʻau Margetuximab i nā hopena hoʻohiki i ka hoʻemi ʻana i nā puʻupuʻu, a ua hōʻike ka lāʻau ONT-380 i ka hoʻohiki i ka mālama ʻana i ka maʻi ʻaʻai umauma me nā hopena ʻaoʻao liʻiliʻi.

ʻO nā immunotherapy ʻē aʻe

Hana kēia mau lāʻau lapaʻau ma ka hoʻoulu ʻana i ko kākou ʻōnaehana pale ponoʻī e hakakā i ka maʻi kanesa. Ua hōʻike ka lāʻau lapaʻau ʻo `Pembrolizumab` i nā hopena hoʻohiki i nā hoʻokolohua lapaʻau, ʻoiai hoʻi he lāʻau lapaʻau no ke ʻano ʻoi aku ka ikaika o ka maʻi umauma ʻo `Triple-Negative`.

Ka ʻike hou ʻana i ke ʻano o ka laha ʻana o ka maʻi kanesa

Me kēia mau lāʻau lapaʻau hou, ke ʻike nei nā kānaka ʻepekema i nā mea hou e pili ana i ke ʻano o ka laha ʻana o ke kanesa ma ke kino holoʻokoʻa (metastasis). He mea nui loa kēia ʻike no nā lāʻau lapaʻau e hiki mai ana.

E noʻonoʻo, ua manaʻo mākou ua laha ka maʻi kanesa e like me ke koa mai kahi pūʻali koa e haʻalele ana a hoʻonohonoho i kahi hoʻomoana ma kahi hou. ʻO ia hoʻi, hele kahi hunaola kanesa hoʻokahi ma ke kahe koko a hele i kekahi ʻano ʻē aʻe, e like me ke akepaʻa a i ʻole nā ​​māmā.

He mea nui loa kēia ʻike ʻana no ka mea, ke ʻike pono kākou i ke ʻano o ka hana ʻana o ke kanesa, e maʻalahi i nā kānaka ʻepekema ke hoʻomohala i nā lāʻau lapaʻau i ʻoi aku ka kikoʻī e hiki ke hoʻōki i kēlā mau hui. ʻO ia hoʻi, ʻoi aku ka maikaʻi o ka hoʻōki ʻana i kahi hui mai ka neʻe ʻana ma mua o ka hoʻōki ʻana i hoʻokahi cell.

Pehea ʻoe e kōkua ai ma kēia huakaʻi?

Me kēia mau ʻike hou, loaʻa paha iā ʻoe nā manawa kūpono e hāʻawi i kēia hakakā ma kekahi ʻano.

ʻO ka mea nui loa, ʻo ia ke kamaʻilio me kāu kauka . E nīnau, "Aia kekahi mau lāʻau lapaʻau hou a i ʻole nā ​​hoʻokolohua lapaʻau ma ko mākou ʻāina i kūpono paha iaʻu?" ʻO nā hoʻokolohua lapaʻau he mau haʻawina i nānā pono ʻia e hoʻāʻo ana i ka pono a me ka palekana o nā lāʻau lapaʻau hou ma mua o ka hāʻawi ʻia ʻana i ka lehulehu.

E hiki i kāu kauka ke wehewehe i nā pono, nā pilikia, a me nā mea i manaʻo ʻia o ke komo ʻana i ia ʻano hoʻokolohua. He mea nui e kūkākūkā me kāu kauka ma mua o ka hoʻoholo ʻana.

Eia kekahi, e nānā i nā hui kākoʻo no nā maʻi kanesa. Hiki iā lākou ke hāʻawi iā ʻoe i ke kākoʻo naʻau a me ka ʻike hou. E hoʻomanaʻo, ʻaʻole ʻoe hoʻokahi i kēia huakaʻi.