Loaʻa iā ʻoe ka maʻi diabetes Type 2? Ua kuhikuhi paha kāu kauka iā ʻoe i kahi pila i kapa ʻia ʻo Jardiance. Makemake paha ʻoe e ʻike hou aʻe e pili ana i kēia lāʻau lapaʻau. He aha ke ʻano o ia lāʻau lapaʻau, he aha ka mea e hana ai i kou kino, a me nā hana palekana āu e lawe ai. No laila i kēia lā, e kamaʻilio pōkole kākou e pili ana iā Jardiance, pehea e hana ai, kona mau pono, a me nā mea āu e makaʻala ai.
He aha ʻo Jardiance? Pehea e hana ai i loko o ke kino?
He lāʻau lapaʻau ʻo Jardiance i hoʻohana ʻia no ka mālama ʻana i nā pākeke a me nā keiki me ka maʻi diabetes type 2. Hana ia ma ke kāohi ʻana i nā pae kō koko. Kōkua pū ia i ka hōʻemi ʻana i ka pilikia o ka hōʻeha puʻuwai a me ka hahau ʻana i nā pākeke me ka maʻi diabetes. Eia naʻe, ʻaʻole i ʻae ʻia no ka maʻi diabetes type 1. Hoʻohana ʻia kekahi manawa i nā poʻe ʻaʻohe maʻi diabetes akā loaʻa ka hāʻule ʻana o ka puʻuwai a i ʻole ka maʻi puʻupaʻa.
ʻAe, e nānā kākou pehea e hana ai kēia. I ka ʻōlelo maʻalahi, ʻo ka mea maʻamau a ko kākou mau puʻupaʻa e hana ai, ʻo ia ke kānana i ke kō (glucose) i loko o ke koko a hoʻihoʻi hou iā ia i loko o ke kino. ʻAʻole lākou e hoʻokuʻu iā ia i waho i loko o ka mimi.
Aia kekahi protein kūikawā e kōkua ana i nā puʻupaʻa me kēia hana, i kapa ʻia ʻo SGLT2 (Sodium-glucose cotransporter-2) .
Hoʻopale ka pila Jardiance i ka hana o ka protein SGLT2 no kekahi manawa. ʻAe kēia i ke kō keu i hiki ʻole i ke kino ke omo hou e hele ma o ka mimi. Hoʻohaʻahaʻa kēia i nā pae kō koko. Hiki i kēia kaʻina hana ke kōkua iā ʻoe e hōʻemi i kekahi kaumaha a kaohi i kou koko .
I ka nui hea i hōʻoia ʻia ai nā pono o kēia lāʻau lapaʻau?
Ua hana ʻia nā haʻawina lapaʻau nui he nui e ʻike ai i ka palekana a me ka pono o Jardiance. Ua nānā nui kēia mau haʻawina i ka pono o ka lāʻau lapaʻau i ka hoʻemi ʻana i ka HbA1c (kahi hoʻāʻo e hōʻike ana i ka awelika o ke kō koko i nā mahina 3 i hala).
Ua komo pū nā haʻawina i nā pākeke me ka maʻi diabetes type 2, nā keiki 10-17 makahiki, nā poʻe me ka maʻi puʻupaʻa, a me nā poʻe me ka maʻi puʻuwai. Ua hoʻohālikelike ʻia nā hopena o ka lāʻau me nā lāʻau lapaʻau maʻi diabetes ʻē aʻe (e.g., insulin, metformin, glimepiride).
ʻAe, e nānā kākou i nā hopena o kēia mau haʻawina i loaʻa. E hoʻomanaʻo, he mau hopena maʻamau kēia. Hiki ke ʻokoʻa kāu mau hopena ma muli o kou kino.
| Nā hopena no nā pākeke (Nā pākeke me ka maʻi diabetes Type 2) | ||
|---|---|---|
| Ka nui o ka lāʻau | Ua hoʻemi ʻia ke kō koko hoʻokē ʻai (mg/dL) | Ua emi ka HbA1c |
| Jardiance 10 mg (me ka ʻole o nā lāʻau lapaʻau ʻē aʻe) | Ma kahi o 19 mg/dL | Ma kahi o 0.7% |
| Jardiance 25 mg (me ka ʻole o nā lāʻau lapaʻau ʻē aʻe) | Ma kahi o 25 mg/dL | Ma kahi o 0.8% |
| Jardiance (me nā lāʻau lapaʻau ʻē aʻe) | Ma kahi o 10 - 22 mg/dL | Ma waena o 0.2% - 2.1% |
| Nā Hopena i nā Mākua me ka Maʻi Puʻuwai | |
|---|---|
| Lapaʻau | Ka pakeneka o nā make mai ka hōʻeha puʻuwai, ka hahau ʻana, a i ʻole ka maʻi cardiovascular |
| Jardiance 10 mg a i ʻole 25 mg | 10.5% |
| ʻO ka placebo | 12.1% |
Nā hopena no nā keiki a me nā maʻi puʻupaʻa
Ua hōʻike ʻia ʻo Jardiance e hōʻemi nui i nā pae HbA1c a me nā pae kō koko hoʻokē ʻai i nā keiki 10-17 mau makahiki. Ua kōkua pū ia i ka hōʻemi ʻana i nā pae HbA1c i nā pākeke me ka maʻi diabetes a me nā maʻi puʻupaʻa.
Hiki i nā lāʻau lapaʻau ʻē aʻe ke launa pū me Jardiance?
ʻAe, he mea nui loa ka mālama ʻana i kēia.
- Haʻahaʻa ke kō koko: Inā ʻoe e lawe i nā lāʻau lapaʻau ʻē aʻe no ka maʻi diabetes, ʻoiai ka insulin a i ʻole sulfonylureas (e like me ka glimepiride), hiki iā ʻoe ke loaʻa i ke kō koko haʻahaʻa (hypoglycemia) ke hoʻomaka ʻoe iā Jardiance. No laila, hiki i kāu kauka ke hōʻemi i ka nui o kāu mau lāʻau lapaʻau ʻē aʻe.
- Ka maloʻo ʻana o ka wai: Inā ʻoe e lawe ana i nā diuretics, ʻo ka lawe ʻana iā lākou me Jardiance e hiki ke hoʻomaloʻo i ka wai. No laila, he mea nui e inu i ka nui o nā wai.
- Lithium: Inā ʻoe e lawe ana i ka lithium no kahi maʻi noʻonoʻo, hiki ke loli kona hopena ke hoʻomaka ʻoe iā Jardiance. E kamaʻilio me kāu kauka e pili ana i kēia a loaʻa nā hoʻāʻo koko inā pono.
Pehea e pale aku ai i nā hopena ʻino?
He mea nui loa kēia ʻāpana. ʻOiai he lāʻau lapaʻau pono loa ʻo Jardiance, aia kekahi mau hopena ʻaoʻao koʻikoʻi e pono ai mākou e makaʻala.
1. Ketoacidosis Diabetic (DKA):
- He kūlana weliweli iki kēia. Ke hiki ʻole i ke kino ke hoʻohana i ke kō, hoʻohana ia i kahi ala ʻē aʻe e loaʻa ai ka ikehu. Hoʻokumu kēia i nā kemika i kapa ʻia he ketones . Ke hōʻiliʻili kēia mau mea i loko o ke koko, hiki iā lākou ke lilo i mea weliweli loa.
- Nā hōʻailona: nausea, luaʻi, ʻeha o ka ʻōpū, luhi nui, paʻakikī i ka hanu ʻana.
- > Inā ʻike ʻoe i kēia mau hōʻailona, e hoʻōki koke i ka lawe ʻana iā Jardiance a e ʻike i ke kauka a i ʻole e hele i kahi lumi pilikia o ka haukapila (ETU). He pilikia kēia.
2. Nā maʻi:
- Hoʻonui kēia lāʻau lapaʻau i ka nui o ke kō i loko o ka mimi, kahi e hoʻonui ai i ka pilikia o nā maʻi bacteria a me ka hū. Hiki ke loaʻa nā maʻi i loko o ke ala mimi, ka ʻōpū mimi, a me nā wahi genital.
- ʻO ka Gangrene o Fournier: He maʻi laha ʻole loa, akā he maʻi weliweli loa ia e hiki ke hana a puni ka ʻāpana genital. E ʻimi koke i ke kōkua lapaʻau inā loaʻa iā ʻoe ka ʻeha, ka ʻulaʻula, a i ʻole ka pehu ʻana ma ia wahi me ke kuni a me ka nāwaliwali.
3. Nā pilikia o ka wāwae a me nā wāwae:
- Ua hōʻike kekahi mau noiʻi i ka piʻi iki ʻana o nā amputations, ʻoi aku hoʻi i nā poʻe me ka maʻi peripheral artery.
- No laila e nānā pono i kou mau wāwae i kēlā me kēia lā.Inā loaʻa iā ʻoe kekahi mau ʻeha, nā ʻōpū, nā māwae, a i ʻole nā hōʻailona o ka maʻi, e haʻi koke aku i kāu kauka.
4. Nā hopena ma nā puʻupaʻa:
- Hiki i ka maloʻo ʻana o ka wai ke hoʻopilikia i ka hana o nā puʻupaʻa. No laila, he mea nui e inu i ka wai he nui. Hiki i kāu kauka ke kauoha i kahi hoʻāʻo koko e nānā i ka hana o kāu puʻupaʻa.
5. Nā hopena maʻi ʻaleka:
- Inā loaʻa iā ʻoe nā hopena alerika koʻikoʻi e like me ka pehu ʻana o nā lehelehe, ka maka, a i ʻole ke alelo, ka paʻakikī o ka hanu ʻana, a i ʻole nā ʻulaʻula o ka ʻili, e hoʻōki koke i ka lawe ʻana i ka lāʻau lapaʻau a e ʻimi i ke kōkua lapaʻau.
Pehea e hoʻohana pono ai i ka lāʻau lapaʻau?
He pila ʻo Jardiance āu e lawe ai i hoʻokahi manawa i ka lā. E lawe i ka nui (10mg a i ʻole 25mg) i kuhikuhi ʻia e kāu kauka.
- ʻOi aku ka maikaʻi o ka lawe ʻana i ke kakahiaka: Manaʻo ka hapa nui o nā kauka e lawe i ke kakahiaka. ʻO ke kumu, hoʻonui ia i ka pinepine o ka mimi ʻana, i hiki ai ke hana i ke ao me ka ʻole o ka hoʻopilikia ʻana i ka hiamoe i ka pō.
- Pehea ʻoe e ʻike ai inā e hana ana ka lāʻau lapaʻau?: Hiki iā ʻoe ke ʻike ma ka emi ʻana o kou pae kō koko a me HbA1c. Akā, ma kahi o 3 mau mahina e loli ai kou HbA1c. Inā ʻoe e hana i kahi hoʻāʻo mimi i kou wā e lawe ana iā Jardiance, e hōʻike ana he kō i loko o kou mimi. He mea maʻamau kēia, mai hopohopo no ia mea. ʻO ia hoʻi, ke hana nei ka lāʻau lapaʻau.
Leka Lawe-Home
- ʻO Jardiance kahi lāʻau lapaʻau no ka maʻi diabetes type 2 e hoʻohaʻahaʻa i ke kō koko ma o ka hoʻokuʻu ʻana i ke kō i loko o ka mimi.
- E lawe wale i ka nui i kuhikuhi ʻia e kāu kauka, i ka manawa i kuhikuhi ʻia (ʻoi aku ka maikaʻi i ke kakahiaka).
- E inu i ka wai nui i ka lā a pau e pale aku ai i ka maloʻo ʻana.
- E makaʻala i nā hōʻailona o ke kō koko haʻahaʻa (hypoglycemia) a me nā hōʻailona weliweli o ka diabetic ketoacidosis (DKA) (luaʻi, ʻeha ʻōpū, paʻakikī ka hanu ʻana). E ʻimi koke i ke kōkua lapaʻau inā loaʻa iā ʻoe nā hōʻailona o DKA.
- E nānā i kou mau wāwae i kēlā me kēia lā no nā ʻeha, nā ʻeha, a i ʻole nā hōʻailona o ka maʻi.
- E kamaʻilio me kāu kauka e pili ana i nā hopena ʻaoʻao a i ʻole nā pilikia āu e ʻike ai. Mai hoʻōki i ka lawe ʻana i kāu lāʻau lapaʻau a hoʻololi paha i ka nui me ka ʻole o ke aʻo ʻana a ke kauka.
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