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He aha ke ʻano lāʻau lapaʻau ʻo Orserdu?
I ka ʻōlelo maʻalahi, ʻo Orserdu kahi lāʻau lapaʻau hormonal i kuhikuhi ʻia . I kēia manawa ke noʻonoʻo nei paha ʻoe, "He aha ia?" I ka lāʻau chemotherapy a mākou e lohe pinepine ai, aneane hiki ke hoʻopilikia ʻia nā ʻāpana āpau e māhele wikiwiki ana. ʻO ke ʻano kēia, ʻaʻole wale nā pūnaewele kanesa, akā ʻo nā ʻāpana olakino hoʻi i loko o ko mākou kino e hōʻino ʻia. Akā i ka lāʻau lapaʻau i kuhikuhi ʻia, hana ʻia kekahi mea ʻokoʻa. He akamai loa kēia mau lāʻau lapaʻau, e ʻike ana i kahi mea, e like me kahi protein a i ʻole gene kikoʻī, e kōkua ana i nā ʻāpana kanesa e ulu, a kuhikuhi iā ia. Ua ʻae kūikawā ʻia ʻo Orserdu no:- ʻO ka mea hoʻokipa Estrogen -maikaʻi (ER-maikaʻi ) a me
- ʻO ka mea loaʻa ulu ulu epidermal kanaka 2-maikaʻi ʻole ( HER2-maikaʻi ʻole ),
- No ke kanesa o ka umauma i pālahalaha i nā ʻāpana ʻē aʻe o ke kino (holomua a metastatic paha).
Pehea e hana ai kēia lāʻau lapaʻau ma ke kino?
I mea e hoʻomaopopo ai i kēia, e nānā mua kākou i ke kanesa ER-positive. Ua like kēia ʻano cell kanesa me kahi mea kanu liʻiliʻi. Pono kēlā mea kanu i kahi hormone i kapa ʻia ʻo 'estrogen' e like me ka wai e ulu ai. No laila, ʻo ka hapa nui o nā lāʻau lapaʻau hormone e pale aku i kēia estrogen mai ka hele ʻana i ke cell kanesa. Akā i kekahi manawa, ke lawe ʻoe i kēia lāʻau lapaʻau no kekahi manawa, loli kahi gene i kapa ʻia ʻo ESR1 i loko o nā cell kanesa . Ma muli o kēia loli, ʻaʻole hiki i nā lāʻau hormone i hāʻawi mua ʻia ke kāohi i ke kanesa. Hoʻomaka hou ke kanesa e ulu.E noʻonoʻo he mea loaʻa kūikawā kahi hunaola kanesa i hiki ke hopu ʻia e ka hormone estrogen. Hana ʻo Orserdu ma ke kuhikuhi ʻana i nā hunaola kanesa i kū mua i nā lāʻau lapaʻau ma muli o kēlā hoʻololi ʻana o ka genetic.ʻO ka manaʻo, ʻo ia ke hiki i kēlā puka i loko o ka lua, e hiki i laila ma mua o ka estrogen, a pani i kēlā puka. A laila, ʻaʻohe manawa kūpono o ka hormone estrogen e ulu ai ke kinoea kanesa.
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Check Availability →Pehea e ʻike ai inā kūpono ʻo Orserdu iaʻu?
He nīnau koʻikoʻi loa kēia. ʻAʻole ʻo Orserdu kahi lāʻau lapaʻau i hāʻawi ʻia i nā poʻe maʻi maʻi umauma āpau. ʻO kāu kauka maʻi kanesa ka mea kūpono loa e hana i kēia hoʻoholo. Ma ke ʻano laulā, ua noʻonoʻo ʻia kēia lāʻau lapaʻau no nā poʻe maʻi e hoʻokō ana i nā kūlana aʻe: Nā kūlana e noʻonoʻo ʻia ai ʻoe no ka mālama ʻana iā Orserdu
Na kāu kauka e hoʻoholo hope loa inā kūpono kēia lāʻau lapaʻau iā ʻoe ma hope o ka hana ʻana i nā hoʻokolohua genetic e pono ai a me ka nānā ʻana i kāu mau moʻolelo lapaʻau piha.| Ke kūlana o ka mea maʻi | Pono ʻoe he wahine postmenopausal a he kāne makua paha. |
| ʻAno maʻi kanesa | Pono ke kanesa he ER-positive a he HER2-negative. |
| Ka laha ʻana o ke kanesa | Pono ke kanesa e holomua a i ʻole ua pālahalaha aku i nā ʻāpana ʻē aʻe o ke kino (metastatic). |
| Nā hoʻokolohua genetic | Pono e hōʻoia nā hoʻokolohua kikoʻī he hoʻololi gene ESR1 kou maʻi ʻaʻai. |
| Lapaʻau mua | Pono ʻoe i loaʻa ma ka liʻiliʻi hoʻokahi ʻano lāʻau lapaʻau hormone ma mua a pono e hoʻi mai ke kanesa i ka wā a ma hope paha o kēlā lāʻau lapaʻau. |
Nā hopena ʻaoʻao o Orserdu a pehea e hana ai me lākou?
E like me nā lāʻau lapaʻau āpau, hiki iā Orserdu ke hana i kekahi mau hopena ʻaoʻao. Eia nō naʻe, ʻo ka hapa nui o kēia mau mea he akahai a hiki ke mālama ʻia. ʻO ka mea nui loa, ʻo ia ke haʻi koke aku i kāu kauka e pili ana i nā hōʻailona hou āu e ʻike ai.| Nā hopena ʻaoʻao maʻamau | Nā Manaʻo no ka Hoʻokele ʻana |
|---|---|
| ʻEha ʻiʻo a me nā hono, ʻeha poʻo | E kamaʻilio me kāu kauka e pili ana i ka loaʻa ʻana o kahi lāʻau hoʻopau ʻeha kūpono no kēia. |
| Ka luaʻi ʻana, ka ʻeha o ka ʻōpū, ka maʻi pākī, a i ʻole ka paʻa ʻana o ka ʻōpū | - E ʻai i nā meaʻai liʻiliʻi i nā manawa he nui i ka lā. - E hōʻalo i nā meaʻai ʻaila a me nā mea momona. - E hoʻohui i nā mea kanu a me nā huaʻai hou aku. |
| ʻAʻohe ʻono | - E ʻai i nā meaʻai liʻiliʻi i ka lā a pau ke pōloli ʻoe. - E hoʻāʻo i nā meaʻai momona a i ʻole nā meaʻai wai. |
| Nā ʻūhū wela | - E ʻaʻahu i nā lole māmā a palupalu. - E hōʻemi i ke kaumaha. Hiki i nā hoʻomaʻamaʻa hanu hohonu ke kōkua. |
| Luhi | E hoʻomaha i ka nui e like me ka hiki. ʻO ka hoʻolālā ʻana i nā hana o kāu lā e hiki ke kōkua iā ʻoe e mālama i ka ikehu. |
Pehea e launa pū ai ʻo Orserdu me nā lāʻau lapaʻau a me nā meaʻai ʻē aʻe?
He mea nui loa kēia. Ma mua o kou hoʻomaka ʻana e lawe iā Orserdu, pono ʻoe e haʻi i kāu kauka oncology e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei (me nā lāʻau lapaʻau no nā kūlana ʻē aʻe, nā huaora, a me nā huahana lāʻau) . ʻO kēia no ka mea hiki i kekahi mau lāʻau lapaʻau a me nā meaʻai ke hoʻopilikia i ke ʻano o ka hana a Orserdu i loko o ke kino.- Nā mea hoʻopaʻa CYP3A: Hiki i kēia papa o nā lāʻau lapaʻau a meaʻai paha ke hoʻopaneʻe i ka hoʻopau ʻana o Orserdu mai ke kino. Hiki i kēia ke hoʻonui i ka pae o ka lāʻau lapaʻau i loko o ke kino,Hiki ke hoʻonui ʻia nā hopena ʻaoʻao . Nā laʻana: Kekahi mau antibiotics, antifungals, a me nā huaʻai e like me ka grapefruit a me ka pomelos.
- Nā mea hoʻoulu CYP3A: ʻO kēia papa o nā lāʻau lapaʻau ke kumu e wehe koke ʻia ai ʻo Orserdu mai ke kino. Hiki paha i kēia ke hōʻemi i ka pono o ka lāʻau lapaʻau. Nā laʻana: Kekahi mau lāʻau lapaʻau no ka maʻi epilepsy, kekahi mau antibiotics.
Leka Lawe-Home
- ʻO Orserdu (elacestrant) kahi lāʻau lapaʻau hormone hou i hoʻolālā ʻia no ka mālama ʻana i ka maʻi ʻaʻai umauma holomua, ER-positive, HER2-negative.
- ʻOi aku ka paipai ʻia o kēia lāʻau lapaʻau no nā poʻe maʻi i loaʻa kahi mutation gene ESR1 a ʻaʻole i pane i nā lāʻau lapaʻau hormonal ʻē aʻe.
- Ua hōʻike ʻia e ka noiʻi e hoʻolōʻihi kēia lāʻau i ke ola me ka ʻole o ka holomua (ka manawa e hiki ai ke kāohi i ke kanesa me ka ʻole e ʻoi aku ka ʻino).
- Hiki ke loaʻa nā hopena ʻaoʻao e like me ka nausea, ka ʻeha hui, a me ka luhi, akā hiki ke mālama ʻia. E hōʻike i nā hopena ʻaoʻao i kāu kauka.
- He mea nui loa e hoʻomaopopo i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, nā huaora, a me nā mea hoʻopihapiha āu e lawe nei.
- E hoʻoholo kāu kauka maʻi kanesa inā kūpono kēia lāʻau lapaʻau iā ʻoe ma hope o nā hoʻokolohua.
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