He puʻupuʻu kou ma kou kelepa pituitary? (Pituitary Adenoma) E aʻo kākou e pili ana i ia mea!

Loaʻa paha iā ʻoe kekahi mau ʻeha poʻo me ke kumu ʻole? A i ʻole ke manaʻo nei ʻoe ua nāwaliwali iki kou ʻike maka, a ʻaʻole hiki iā ʻoe ke ʻike pono i nā mea e hele mai ana mai nā ʻaoʻao? A i ʻole, loaʻa iā ʻoe kekahi ʻeha i hoʻokumu ʻia e kekahi mau loli i nā hormones o kou kino? Malia paha ke kumu ma hope o kēia mau mea he puʻupuʻu liʻiliʻi e ulu ana i loko o kou gland pituitary. I kēia lā, e kamaʻilio kikoʻī mākou e pili ana i kēia maʻi i kapa ʻia ʻo 'Pituitary Adenoma' . Mai hopohopo, ʻaʻole kēia he maʻi kanesa.

He aha ka adenoma pituitary?

I ka ʻōlelo maʻalahi, ʻo ka adenoma pituitary he puʻupuʻu ʻaʻole kanesa (benign) e ulu ana i loko o kou kelepa pituitary. ʻAʻole ia e laha i nā ʻāpana ʻē aʻe o ke kino e like me ke kanesa. ʻO ia ka mea nui loa. Eia naʻe, i ka ulu ʻana o kēia adenoma, hiki iā ia ke kaomi i nā mea e like me nā aʻalolo a me nā kīʻaha koko a puni. ʻO ia ka manawa e hoʻomaka ai nā hōʻailona e ʻike ʻia.

No laila, he aha kēia kelepa pituitary?

E noʻonoʻo, ma hope o ko kākou ihu, i pili i ke kumu o ka lolo, ʻo ia hoʻi ka "Hypothalamus", aia kahi ʻōpū liʻiliʻi e like me ka nui o ka pī. ʻO ia ka mea i kapa ʻia ʻo ka pituitary gland. ʻOiai he liʻiliʻi ia, hana ia i kahi hana koʻikoʻi loa i loko o ko kākou kino. ʻElua ʻāpana nui o kēia ʻōpū:

• Lobe mua
• Lobe Hope

Hoʻopuka a hoʻokuʻu kēia mau ʻāpana ʻelua i nā ʻano hormones like ʻole i loko o ke koko. Ua like nā hormones me nā ʻelele kemika e kāohi a hoʻonohonoho i nā hana like ʻole i loko o ko mākou kino. Hele lākou ma ke koko a hāʻawi i nā leka e pono ai i ko mākou mau ʻōpū, nā ʻiʻo, a me nā ʻiʻo ʻē aʻe. Eia kekahi o nā hormones koʻikoʻi i hana ʻia e ka pituitary gland:

• ʻO ka hormone Adrenocorticotropic (ACTH a i ʻole Corticotropin)
• ʻO ka hormone antidiuretic (ADH a i ʻole Vasopressin)
• ʻO ka hormone hoʻouluulu follicle (` FSH` )
• ʻO ka hormone ulu (`GH`)
• ʻO ka hormone Luteinizing (`LH`)
• ʻOkitokina ( ʻOkitokina )
• ʻO Prolactin
• ʻO ka hormone hoʻoulu thyroid (`TSH`)

ʻAʻole wale kēia, ke "hōʻailona" nei hoʻi ka pituitary gland i nā kelepa endocrine ʻē aʻe i loko o ko mākou kino e hana i nā hormones. No laila hiki iā ʻoe ke hoʻomaopopo inā he pilikia me kēia pituitary gland, e like me ka adenoma, hiki ke hoʻopilikia ʻia ka hana o hoʻokahi hormone a i ʻole kekahi mau hormones.

Pehea e ʻike ʻia ai kēia mau ʻano adenomas?

Hoʻokaʻawale nā ​​kauka i nā adenomas pituitary i ʻelua mau ʻano nui: 1. Ma muli o ka hana ʻana o lākou i nā hormones a i ʻole:

• Adenoma hana/huna:Eia kekahi, hana kēia ʻano adenomas i hoʻokahi a ʻoi aku paha mau hormones pituitary. No laila, hiki ke ʻike ʻia nā hōʻailona a me nā kūlana like ʻole ma muli o ka hormone i hana nui ʻia.
• ʻAdenomas Hana ʻole/Hūnā ʻole: ʻAʻole hana kēia mau adenomas i nā hormones. Eia nō naʻe, inā ulu nui lākou, hiki iā lākou ke hana i nā hōʻailona ma ke kaomi ʻana i nā wahi lolo a i ʻole nā ​​​​aʻalolo kokoke . ʻO kēia ke ʻano o ka adenoma a nā kauka e hālāwai pinepine ai.

2. Ma ka nui:

• Microadenomas: He mau ʻōpū kēia i liʻiliʻi ma mua o 10 millimeters (ʻo ia hoʻi, 1 kenimika).
• Macroadenomas: He mau puʻupuʻu kēia i ʻoi aku ma mua o 10 milimita. ʻOi aku ka nui o nā Macroadenomas ma mua o nā microadenomas. ʻOi aku ka nui o ko lākou hiki ke hoʻoulu i nā pae haʻahaʻa o hoʻokahi a ʻoi aku paha nā hormones pituitary (kahi kūlana i kapa ʻia ʻo hypopituitarism).

Ua manaʻo ʻia kēia he puʻupuʻu lolo?

ʻO ke kelepa pituitary kahi ʻano i pili i ka ʻōnaehana endocrine, a ʻaʻole ia he ʻāpana o ka lolo. Hoʻopili ʻia ia i ke kumu o ka lolo. Eia nō naʻe, manaʻo nā kauka he ʻano puʻupuʻu lolo nā adenomas pituitary. ʻO 10% wale nō o nā puʻupuʻu lolo mua nā adenomas pituitary.

ʻO wai ka mea e loaʻa pinepine ai kēia? Pehea ka maʻamau?

Hiki ke ulu nā adenomas pituitary i kēlā me kēia makahiki. Eia nō naʻe, ʻoi aku ka maʻamau o lākou i nā poʻe i ko lākou mau makahiki 30 a me 40. ʻOi aku ka nui o ka ulu ʻana o nā wahine ma mua o nā kāne. He mea maʻamau loa lākou a he 10% a 15% o nā puʻupuʻu āpau e ulu ana i loko o ke poʻo. Wahi a nā helu helu, ma kahi o 77 o 100,000 poʻe i loaʻa i ke ʻano. Eia nō naʻe, manaʻoʻiʻo nā kānaka noiʻi he nui aku ka poʻe, malia paha he 20%, e ulu i hoʻokahi i kekahi manawa o ko lākou ola. I nā manawa he nui, ʻoiai ka poʻe me nā microadenomas ('microadenomas'), ʻaʻohe o lākou mau hōʻailona, ​​​​no laila ʻaʻole lākou i ʻike ʻia.

He aha nā hōʻailona o ka adenoma pituitary?

Hiki ke ʻokoʻa loa nā hōʻailona o ka adenoma pituitary mai kēlā kanaka a kēia kanaka. Aia nui ia i kekahi mau kumu:

• Inā paha e ulu ana ka adenoma i ka nui a hōʻino i ka pituitary gland ponoʻī, a inā paha e hoʻoulu ia i kahi "hopena nui" ma nā hale a puni.
• He adenoma huna hormone ('hana') paha ia? Inā pēlā, e hilinaʻi nā hōʻailona i ke ʻano o ka hormone āna e hana ai.

Nā hōʻailona o ka 'Mass Effect' i hoʻokumu ʻia e nā 'Macroadenomas' (nā ʻōpū nui)

ʻO nā adenomas nui ('Macroadenomas') ke kumu o nā hōʻailona ma muli o ke kaomi ma luna o nā ʻiʻo a puni.

E noʻonoʻo wale, inā ʻoe e kau i kahi mea nui i loko o kahi lumi liʻiliʻi, me he mea lā ʻaʻohe wahi kūpono no nā mea ʻē aʻe a ua piha.

• Nā pilikia ʻike maka:

Ma kahi o 40% a 60% o ka poʻe me kahi adenoma pituitary nuiʻO ka nalowale ʻana o ka ʻike (ʻike pōwehiwehi, ʻike pālua). Hana ʻia kēia no ka mea ke kaomi nei ka adenoma i ka optic chiasm, ka mea e hoʻopili ai i nā maka a me ka lolo. Hiki i kēia ke kumu o ka nalowale ʻana o ka ʻike peripheral, ʻoiai ma ka ʻaoʻao. Ua like ia me ka lio e nalowale ana kona ʻike ma nā ʻaoʻao ʻelua.

• Nā ʻeha poʻo :

He nui ka poʻe me nā adenomas pituitary e hoʻopiʻi nei i nā ʻeha poʻo pinepine. Hiki paha kēia ma muli o ke kaomi ʻana o ka puʻupuʻu i nā ʻiʻo a puni. Eia nō naʻe, ʻoiai ʻo ka maʻamau o ke poʻo poʻo ke kumu o nā mea he nui, hiki ke hana ʻia e nā mea ʻē aʻe.

• Ka hemahema o ka hormonal:

Hiki i nā adenomas nui (`Macroadenomas`) ke hōʻino i ka ʻiʻo o ka pituitary gland a hōʻemi i ka hana ʻana o hoʻokahi a ʻoi aku paha mau hormones pituitary. Ua kapa ʻia kēia ʻano he `Hypopituitarism`. ʻOkoʻa nō hoʻi nā hōʻailona e kū mai ana ke hoʻemi ʻia kēlā me kēia hormone.

• Ke emi ka nui o nā hormones LH a me FSH ('Hypogonadism'): E emi ana ka nui o ka ' Oestrogen' i nā wahine a me ka ' Testosterone' i nā kāne. Hiki i kēia ke hana i nā hōʻailona e like me ka hou nui ʻana, ka maloʻo o ka ʻōpū i nā wahine, ka ' Erectile Dysfunction' i nā kāne, ka emi ʻana o ka ulu ʻana o ka lauoho maka a me ke kino, nā loli o ke ʻano i nā kāne ʻelua, ka emi ʻana o ka makemake moekolohe, a me ka luhi nui.
• Ke emi ka pae o ka hormone TSH (`Hypothyroidism`): E emi ana ka nui o nā hormones i hana ʻia e ka thyroid gland. Hiki i kēia ke hana i nā hōʻailona e like me ka luhi, ka paʻa ʻana o ka ʻōpū, ka lohi o ka puʻuwai, ka ʻili maloʻo, ka pehu ʻana o nā lālā, a me nā reflexes i hoʻopilikia ʻia.
• Ke haʻahaʻa ka hormone ACTH (`Adrenal Insufficiency`): E emi ana ka hana ʻana o ke kino i ka hormone `Cortisol`. Hiki i kēia ke hana i nā hōʻailona e like me ke koko haʻahaʻa, ka nausea, ka luaʻi ʻana, ka ʻeha o ka ʻōpū, a me ka nalowale o ka makemake.
• GH (Growth Hormone Deficiency): ʻOkoʻa nā hōʻailona ma muli o ka makahiki. Hiki i nā pākeke ke ʻike i ka luhi a me ka nalowale ʻana o ka nui o nā ʻiʻo.

Nā hōʻailona o nā adenomas hana

Ma waho aʻe o ka hūnā ʻana i hoʻokahi a ʻoi aku paha nā hormones, hiki i kahi adenoma hana ke hana i nā hōʻailona like ʻole a me nā kūlana e pili ana i kēlā me kēia hormone.

• ʻO nā Prolactinomas (ʻike ʻia hoʻi ʻo Lactotroph Adenomas):

Hoʻopuka kēia mau adenomas i ka nui o ka hormone prolactin . Ua kapa ʻia kēia ʻano he hyperprolactinemia. He 4 wale nō o 10 mau puʻupuʻu pituitary o kēia ʻano. ʻO kēia ke ʻano maʻamau o ka adenoma pituitary.Ke piʻi aʻe ka nui o ka prolactin, hiki ke hoʻopilikia ʻia ka hana maʻamau o ka ʻōnaehana hānau keiki i nā wahine a me nā kāne.

• ʻO ka hānau ʻole kahi kūlana e pilikia ai nā kāne a me nā wahine i ka hāpai ʻana i nā keiki.
• He kahe waiū mai nā umauma ʻoiai ʻaʻole hāpai ('Galactorrhea').

• Nā Adenoma Somatotroph:

Hoʻopuka kēia mau adenomas i ka nui o ka hormone ulu ('Growth Hormone' a i ʻole 'Somatotropin') . Ma kahi o 2 o 10 mau puʻupuʻu pituitary o kēia ʻano. ʻOkoʻa nā hōʻailona i hoʻokumu ʻia e kēia me ka makahiki.

• Nā Mākua: Loaʻa kahi maʻi kakaikahi akā koʻikoʻi i kapa ʻia ʻo 'Acromegaly'. I loko o kēia, ulu ʻē nā iwi a me nā ʻiʻo o ke kino. I ka hala ʻana o ka manawa, lilo nā lima, nā wāwae, a me ke poʻo i mea nui aʻe, a loli ke ʻano o ka maka. Hoʻopilikia pū ia i ka kaohi ʻana i ke kō koko, a hiki ke hoʻonui ʻia ka ʻiʻo puʻuwai.
• Nā keiki a me nā ʻōpio: Hana ʻia kahi kūlana i kapa ʻia ʻo gigantism. Ulu lākou i ke kiʻekiʻe ma muli o ka nui o ka hormone ulu.

• Nā Adenoma Corticotroph:

Hoʻopuka kēia mau adenomas i ka nui o ka ACTH (adrenocorticotropic hormone) . Ma kahi o 1 i loko o 10 mau puʻupuʻu pituitary o kēia ʻano. Hoʻoulu ka hormone ACTH i nā kelepa adrenal e hana i nā hormones steroid hou aʻe e like me cortisol. ʻO kēia ke kumu o ka Cushing's Syndrome (cortisol keu).

• Ke koko kiʻekiʻe.
• Ka nāwaliwali o nā ʻiʻo.
• ʻEha maʻalahi.
• ʻIke ʻia nā kaha poni ākea (ʻoi aku ma mua o 1 kenimika) (ʻO nā māka Stretch`) ma ka ʻōpū.
• ʻO ka osteoporosis.
• Nā haki hoʻopaʻa.
• ʻO ka maʻi diabetes mellitus ʻano 2.

• Nā Adenoma Thyrotroph:

Hoʻopuka kēia mau adenomas i ka nui o ka TSH (hormone hoʻoulu thyroid) . He mea kākaʻikahi loa kēia. Hoʻoulu ka TSH i ka ʻōpū thyroid e hana i nā hormones thyroid hou aku. ʻO kēia ke kumu o ka 'Hyperthyroidism' (ke kūlana thyroid overactive), ka mea e wikiwiki ai ka metabolism o ke kino.

• Hoʻonui ʻia ka helu o ka puʻuwai.
• Ka pohō kaumaha me ke kumu ʻole.
• Nā noho palupalu pinepine.
• Ke hou nei.
• Nā haʻalulu lima.
• Hopohopo.

He mea nui: Nui nā kumu ʻē aʻe o ka hyperthyroidism. He kumu kakaikahi loa ka pituitary adenoma.

• Nā Adenoma Gonadotroph:

Hoʻopuka kēia mau adenomas i nā nui nui o nā gonadotropins (ʻo ia hoʻi, nā hormones LH a me FSH). He mea kākaʻikahi loa nō hoʻi kēia.

• Hiki i kēia ke hoʻoulu i nā wahine e loaʻa i nā pōʻaiapuni menstrual kūpono ʻole a me nā kūlana e like me Ovarian Hyperstimulation Syndrome (OHSS).
• Hiki i nā kāne ke ʻike i nā hōʻailona e like me ka hoʻonui ʻia ʻana o nā testicles, ka hohonu o ka leo, ka nalowale o ka lauoho (ma hope o nā pepeiao), a me ka ulu wikiwiki ʻana o ka lauoho maka.
• Hiki i nā keiki ke ʻike i ka wā ʻelemakule mua.

He aha nā kumu o ka adenoma pituitary?

ʻAʻole maopopo loa i nā kānaka ʻepekema ke kumu o kēia mau adenomas. Eia nō naʻe, ua manaʻo ʻia ua pili kekahi mau adenomas i nā loli maʻamau (`mutations`) i loko o nā genes (`DNA`) i loko o kā mākou mau cell. ʻO kēia mau loli genetic ke kumu o ka ulu wikiwiki ʻana o nā cell i loko o ka pituitary gland a hana i kahi puʻupuʻu. I kekahi manawa hiki ke hoʻoilina ʻia kēia mau loli genetic mai nā mākua a i nā keiki (hereditary), a i ʻole hiki iā lākou ke ulu maʻamau ʻole. Eia kekahi, hiki ke hoʻopili ʻia nā pituitary adenomas i kekahi mau kūlana genetic kakaikahi . ʻO kekahi mau laʻana:

• ʻO ka Neoplasia Endocrine Nui ʻano 1 (MEN1)
• ʻO ka Neoplasia Endocrine Nui ʻano 4 (MEN4)
• ʻO ka hale paʻakikī ʻo Carney
• ʻO ka maʻi X-LAG
• ʻO ka adenoma pituitary familial e pili ana i ka dehydrogenase Succinate
• ʻO ke ʻano neurofibromatosis 1
• ʻO ka maʻi Von Hippel-Lindau

ʻO ke kanaka me kēia maʻi hoʻoilina, ua ʻoi aku ka nui o ka pilikia o ka loaʻa ʻana o kahi adenoma pituitary. Eia nō naʻe, he mea nui e hoʻomanaʻo e hiki i nā kānaka me ka ʻole o kēlā ʻano maʻi hoʻoilina ke loaʻa i kēia mau adenomas.

Pehea e ʻike ai nā kauka i kēia maʻi?

ʻOkoʻa ke kaʻina hana o ka ʻike ʻana i kahi adenoma pituitary ma muli o ke ʻano o ka adenoma āu e loaʻa ai a inā paha ke kumu o nā hōʻailona. I ka hapanui o nā hihia, ʻike mua ʻia kahi kanaka me ka adenoma huna hormone (ʻO Cushing's Syndrome, ʻO Acromegaly) me kahi hormonal imbalance (e.g. ʻO Cushing's Syndrome, ʻO Acromegaly) ma muli o nā hōʻailona. A laila wale nō e ʻike ʻia ai ka adenoma ke noiʻi ʻia ke kumu. ʻO kēia no ka mea he nui nā kūlana i hoʻokumu ʻia e nā hormones keu hiki ke loaʻa nā kumu ʻē aʻe ma waho aʻe o nā adenomas pituitary. Hiki ke ʻōlelo like e pili ana i ka hemahema o ka hormone pituitary (ʻO Hypopituitarism). I kekahi manawa, ʻike ʻia kahi adenoma pituitary ma ke ʻano he ʻIke Kūpono ʻole i ka wā o ka nānā ʻana i ke poʻo (ʻO Imaging Test) no kekahi kūlana ʻē aʻe. ʻO ka hapa nui o nā adenomas i loaʻa e like me kēia he liʻiliʻi ka nui a ʻaʻole hana.

He aha nā hoʻokolohua i hana ʻia no kēia?

Inā kānalua kāu kauka he adenoma pituitary kou, e nānā pono ʻo ia i kāu mau hōʻailona, ​​​​mōʻaukala olakino, a hana i kahi hoʻokolokolo kino. Eia kekahi, hiki iā lākou ke paipai i hoʻokahi a ʻoi aku paha o kēia mau hoʻokolohua:

• Nā hoʻāʻo koko: Ma muli o kāu mau hōʻailona, ​​​​hiki ke kauoha ʻia nā hoʻāʻo koko e nānā i nā pae o nā hormones pituitary like ʻole.
• Nā Hoʻāʻo Kiʻi: ʻO kahi scan MRI (Magnetic Resonance Imaging) o ke poʻo a i ʻoleHiki i kahi scan `CT (Computed Tomography)` ke hana i nā kiʻi maopopo o nā ʻano i loko o ke poʻo. Hiki i kēia mau hoʻokolohua ke hōʻoia inā aia kahi adenoma pituitary a pehea kona nui. ʻO ka hoʻokolohua `MRI` ka hoʻokolohua kūpono loa a koʻikoʻi hoʻi no kēia.
• Hoʻokolohua Maka: Inā loaʻa iā ʻoe kekahi pilikia ʻike maka, hiki i kāu kauka ke kauoha i kahi hoʻokolohua ʻike maka. He mea nui kēia hoʻokolohua no ka mea hiki i nā adenomas pituitary nui ke hoʻoulu i nā pilikia ʻike maka ma ke kaomi ʻana i ke aʻalolo optic, ka mea e hoʻopili ai i nā maka i ka lolo.

Pehea e mālama ʻia ai ka adenoma pituitary?

ʻEkolu mau ala nui e mālama ai i nā adenomas pituitary: ke ʻoki kino, ka lāʻau lapaʻau, a me ka radiation therapy. I kekahi manawa hiki ke hoʻohana pū ʻia kekahi a ʻoi aku paha o kēia mau ʻano. No ka mea he ʻokoʻa nā adenoma a me ke kūlana o kēlā me kēia kanaka, hiki iā ʻoe a me kāu hui lapaʻau ke hana pū e hoʻoholo i ka hoʻolālā lapaʻau kūpono loa iā ʻoe.

ʻO ke ʻoki kino e wehe i ka adenoma

Inā loaʻa iā ʻoe kahi adenoma e hoʻoulu ai i nā hormonal imbalances a i ʻole e hoʻopilikia i kou ʻike, e ʻōlelo paha kāu kauka i ke ʻoki ʻana e wehe i ka adenoma āpau a i ʻole kekahi hapa. Ma muli o ka nui o ka adenoma a me ke koʻikoʻi o kāu mau hōʻailona, ​​​​pono paha ma mua o hoʻokahi ʻoki ʻana. Hana pinepine nā kauka i kēia kaʻina hana me ka hoʻohana ʻana i kahi ʻano hana i kapa ʻia ʻo 'Transsphenoidal Surgery' . Pili kēia i ka hele ʻana ma o ka ihu a ma o ka sphenoid sinus (kahi hakahaka ma hope o ke ana ihu, ma lalo o ka lolo) e hiki ai i ka pituitary gland a wehe i ka adenoma. Ma kahi o 95% o nā puʻupuʻu pituitary e wehe ʻia ma kēia ʻano. He hana palekana ia. Eia nō naʻe, inā nui loa ka adenoma e wehe ʻia ma o ka ihu a i ʻole aia ma kahi paʻakikī, pono paha ke kauka e hana i kahi ʻoki transcranial. He hana kakaikahi kēia no nā adenomas pituitary.

Lapaʻau me ka lāʻau lapaʻau

Hiki ke kāohi ʻia a hoʻēmi ʻia kekahi mau ʻano adenomas pituitary, ʻoiai nā prolactinomas , me ka lāʻau lapaʻau. ʻO ka poʻe me nā prolactinomas (ʻo ia ke ʻano maʻamau) e mālama mua ʻia me kahi agonist dopamine, e like me Cabergoline (Dostinex®) a i ʻole Bromocriptine (Cycloset®), no kekahi mau mahina.

ʻO ka nūhou maikaʻi, ma kahi o 80% o nā hihia, hoʻemi kēia mau lāʻau i ka prolactinoma a hoʻihoʻi i nā pae hormone prolactin i ka maʻamau.

Inā ʻaʻole holo pono nā lāʻau lapaʻau a inā he ʻano ʻē aʻe o ka adenoma, hiki i kāu kauka ke ʻōlelo i ke ʻoki ʻana.

Hoʻōla Pāhawewe

Hoʻohana ka radiation therapy i nā kukuna X-ikehu kiʻekiʻe e luku i nā hunaola adenoma, e hoʻēmi ana i ka puʻupuʻu a i ʻole e hoʻōki iā ia mai ka ulu ʻana. Stereotactic Radiosurgery no nā Pituitary Adenomas(e.g. `Gamma Knife`®) Hoʻohana ʻia kahi ʻano lapaʻau radiation kūikawā a pololei loa. Ma kēia, ua kuhikuhi ʻia kekahi mau kukuna o ka radiation i ka adenoma mai nā ʻaoʻao like ʻole, e hōʻemi ana i ka hōʻino ʻana i nā ʻiʻo olakino a puni. Hoʻohana ʻia kēia ʻano hana no nā wahi i koe ma hope o ke ʻoki ʻana a i ʻole i nā hihia kahi hiki ʻole ai ke ʻoki ʻana.

He aha nā hopena ʻaoʻao o ka lāʻau lapaʻau?

E like me nā lāʻau lapaʻau a pau, hiki i ka mālama ʻana no ka adenoma pituitary ke loaʻa kekahi mau hopena ʻaoʻao.

• Ma hope o ke ʻoki kino a/a i ʻole ka radiation therapy, ma kahi o 60% o ka poʻe me nā adenomas pituitary e loaʻa paha ka `Hypopituitarism` (ka emi ʻana o ka hana ʻana o hoʻokahi a ʻoi aku paha mau hormones pituitary). ʻOiai he maʻi kēia no ke ola holoʻokoʻa, hiki i nā lāʻau lapaʻau hoʻololi hormone ke kōkua i nā kānaka e ola i ke ola maʻamau.
• Nā pilikia e hiki mai ana mai ke ʻoki ʻana:
• Ke kahe ʻana o ke koko.
• Ka wai Cerebrospinal (CSF) e kahe ana (ka wai e puka mai ana mai loko mai o ka ihu).
• ʻO ka meningitis (kahi maʻi o nā membrane e uhi ana i ka lolo).
• ʻO ka maʻi diabetes insipidus (ka mimi nui a me ka makewai nui ma muli o ka nele o ka hormone antidiuretic).
• ʻO nā hopena ʻaoʻao maʻamau o nā lāʻau dopamine agonist no ka prolactinoma e komo pū ana: ka ʻeha poʻo, ka nausea, ka luaʻi ʻana, ka dizziness, a i kekahi manawa he ʻano compulsive.
• Nā hopena ʻaoʻao hiki ke loaʻa mai ka radiation therapy:
• ʻO ka hemahema o ka hormone pituitary (hiki ke hana i ka hala ʻana o ka manawa).
• Ka Hoʻopilikia ʻana i ka Hānau Keiki.
• Ka nalowale ʻana o ka ʻike a me ka hōʻino ʻana i nā ʻiʻo o ka lolo (kākaʻikahi loa).
• Hiki ke ulu aʻe kekahi puʻupuʻu ma kahi like i nā makahiki ma hope o ka mālama ʻana (kākaʻikahi loa).

Hiki ke pale ʻia ke kūkulu ʻia ʻana o kēia mau adenomas?

ʻO ka mea pōʻino, ʻaʻohe mea hiki iā ʻoe ke hana e pale aku i nā adenomas pituitary. ʻO ka hapa nui o ka manawa, hiki mai lākou me ka manaʻo ʻole. Eia nō naʻe, pili paha lākou me kekahi o nā kūlana genetic kakaikahi i ʻōlelo ʻia ma mua. Inā he ʻano genetic kekahi lālā o ka ʻohana pili (kaikuaʻana, kaikuahine, a makua paha), hiki iā ʻoe ke kamaʻilio me kāu kauka e pili ana i ke aʻo ʻana a me ka hoʻāʻo ʻana i ka genetic e ʻike inā loaʻa iā ʻoe ke ʻano. Inā loaʻa iā ʻoe, hiki i kāu kauka ke nānā pono iā ʻoe a ʻike a mālama i nā adenomas e ulu koke ana.

He aha ka wānana o kēia kūlana?

ʻO ka nānā ʻana no kahi adenoma pituitary, ʻo ia hoʻi, kou hoʻōla ʻana a me ke olakino i ka wā e hiki mai ana, e pili ana i ka nui a me ke ʻano o ka adenoma, a me ka lāʻau āu e loaʻa ai .

ʻO ka nūhou maikaʻi, i ka hapanui o nā hihia, ke wehe loa ʻia a kāohi ʻia paha ka adenoma me ka lāʻau lapaʻau, hiki i nā mea maʻi ke ola hou i ke ola piha a olakino.

I kekahi mau hihia, hiki i ka lāʻau lapaʻau ke hōʻemi i ka hana ʻana o nā hormones e ka pituitary gland. Inā hana ʻia kēia, pono paha ʻoe e lawe i nā lāʻau hoʻololi hormone no ke koena o kou ola e pani i nā hormones i hoʻemi ʻia. Hiki i nā Adenomas ke hoʻi hou i kekahi manawa. ʻO ke ʻano kēia e pono paha e mālama hou ʻia ma hope o kekahi manawa. Hōʻike nā helu helu ma kahi o 18% o ka poʻe me nā adenomas hana ʻole a ma kahi o 25% o ka poʻe me ka prolactinoma e pono hou i ka lāʻau lapaʻau i ka wā e hiki mai ana. No laila, he mea nui loa ia e mālama mau i ka launa pū ʻana me kāu kauka a loaʻa nā nānā mau.

Hiki ke ola me kahi adenoma pituitary?

ʻAe, hiki iā ʻoe. Inā liʻiliʻi ka pituitary adenoma a ʻaʻole ia e hōʻike i kekahi mau hōʻailona, ​​​​hiki iā ʻoe ke noho me ia ma ke ʻano maʻamau. ʻO kaʻoiaʻiʻo, ʻike wale ka poʻe he nui he adenoma ko lākou ke loaʻa iā lākou kahi scan poʻo no kekahi kumu ʻē aʻe. Eia nō naʻe, inā hoʻomau ka ulu ʻana o ka adenoma a hoʻomaka paha e hōʻike i nā hōʻailona, ​​​​pono ʻoe e mālama ʻia. Inā loaʻa iā ʻoe kahi adenoma pituitary nui a/a i ʻole hana (hormone-producing), pono ʻoe e mālama ʻia. ʻO kēia no ka mea hiki i kekahi mau adenomas pituitary ke loaʻa ka hopena koʻikoʻi i kou olakino a me ke ʻano o ke ola.

He aha nā pilikia e hiki mai ana inā ʻaʻole mālama ʻia?

Inā ʻaʻole mālama ʻia, hiki i kekahi mau adenomas pituitary - ʻoiai nā adenomas nui (`Macroadenomas`) a me nā adenomas hana (`Secreting`) - ke hana i nā pilikia olakino koʻikoʻi . Pili nui kēia mau pilikia olakino i ke ʻano o ka hormone i hūnā ʻia e ka adenoma (ua kūkākūkā mākou i kēia ma mua ma ka ʻāpana 'Symptoms`). ʻO kahi pilikia kakaikahi loa akā weliweli loa o nā adenomas pituitary i mālama ʻole ʻia ʻo 'Pituitary Apoplexy`. He 'Medical Emergency' kēia. Hana ʻia kēia i ka wā e kahe ana ke koko i loko a i waho paha o ka pituitary gland. ʻO ka 'Pituitary Apoplexy' ka mea pinepine i hoʻokumu ʻia e ke kahe ʻana i loko o kahi adenoma pituitary. Hoʻonui koke ka puʻupuʻu, e hōʻino ana i ka pituitary gland. ʻO ka nui o ka adenoma, ʻoi aku ka nui o ka pilikia o ka hoʻomohala ʻana i ka 'Pituitary Apoplexy'. ʻIke pinepine ʻia nā hōʻailona o 'Pituitary Apoplexy' me ka wikiwiki loa a hiki ke hoʻoweliweli i ke ola . ʻO nā hōʻailona nui:

• He ʻeha poʻo nui loa (e like me ke ʻeha poʻo ʻino loa aʻu i loaʻa ai i koʻu ola).
• ʻIke pālua a i ʻole ka hiki ʻole ke hāpai i kahi lihilihi ma muli o ka hana pono ʻole o nā ʻiʻo maka.
• Ka nalowale ʻana o ka ʻike ʻaoʻao a i ʻole ka nalowale piha ʻana o ka ʻike ma kekahi a i ʻole nā ​​maka ʻelua.
• ʻO ka lawa ʻole o ka adrenal acute ke kumu o ke koko haʻahaʻa, ka nausea, a me ka luaʻi.
• Nā loli o ke ʻano o ke kanaka (e.g., huikau) ma muli o ka hāiki koke ʻana o ke aʻa lolo mua i loko o ka lolo.

He maʻi laha ʻole ka pituitary apoplexy, akā he mea koʻikoʻi loa ia. Inā ʻike ʻoe i kekahi a ʻoi aku paha o kēia mau hōʻailona, ​​e kāhea koke aku i nā lawelawe lapaʻau ulia pōpilikia (e like me 911) a i ʻole e lawe kekahi iā ʻoe i ka lumi ulia pōpilikia kokoke loa i ka haukapila.

Āhea ʻoe e ʻike ai i ke kauka?

• Inā loaʻa iā ʻoe kekahi mau pilikia ʻike (ʻike pōwehiwehi, ʻike pālua, emi ʻana o ka ʻike peripheral) a/a i ʻole ke poʻo ʻeha mau a hoʻi hou paha (ʻoi aku hoʻi ma ka lae), e ʻike i ke kauka a haʻi iā lākou e pili ana i ia mea.
• Inā ua ʻike mua ʻia ʻoe me kahi adenoma pituitary, pono ʻoe e ʻike pinepine i kāu kauka e nānā i ke kūlana o ka adenoma a e hōʻoia i ka hana pono ʻana o ka lāʻau.

ʻO ka mea hope loa, e hoʻomanaʻo i kēia mau mea:

He mea maʻamau loa ka makaʻu a me ka hopohopo ke ʻike ʻoe he puʻupuʻu kou. Eia nō naʻe, ʻo ka nūhou maikaʻi e pili ana i nā adenomas pituitary, ʻo ka hapa nui (ma luna o 99%) ʻaʻole ia he maʻi kanesa (benign) a i ka hapa nui o nā hihia, hiki i ka lāʻau lapaʻau ke alakaʻi i nā hopena maikaʻi loa. E hoʻomanaʻo, ʻo kāu kauka kou hoa hana i ka hoʻokō ʻana i kou olakino maikaʻi loa. No laila, mai kānalua e hoʻomaopopo i kāu kauka e pili ana i kekahi mau hōʻailona, ​​​​​​ʻoluʻolu ʻole, a i ʻole nā ​​​​​​nīnau āu e loaʻa ai e pili ana i kāu lāʻau lapaʻau. Me ka ʻike kūpono a me ka lāʻau lapaʻau kūpono, hiki iā ʻoe ke hoʻokele pono i kēia kūlana.