He mea paʻakikī ke hoʻopuka i nā huaʻōlelo i kou manaʻo ke ʻike ʻoe he maʻi kanesa kou. Akā, ke kamaʻilio ke kauka e pili ana i ka lāʻau lapaʻau a lohe ʻoe i nā huaʻōlelo e like me 'chemotherapy', he mea maʻamau ke manaʻo ʻoi aku ka makaʻu, ka hoihoi, a me ka huikau. ʻO kekahi o nā lāʻau chemo i hoʻohana pinepine ʻia no ka mālama ʻana i ka maʻi kanesa ʻo 'Taxane.' I kēia lā, e kamaʻilio mākou e pili ana i kēia me ka maʻalahi loa, ma ke ʻano hiki iā ʻoe ke hoʻomaopopo, me he mea lā e kamaʻilio ana ʻoe me kahi hoaaloha pili.
He aha maoli ʻo Taxane?
I ka ʻōlelo maʻalahi, ʻo nā taxanes kahi papa o nā lāʻau chemotherapy e pepehi i nā hunaola kanesa a hoʻōki i ka ulu ʻana o nā puʻupuʻu. Pili ka Chemotherapy i ka hoʻohui ʻana i kēia mau lāʻau i ko mākou kahe koko, kahi e hele ai ma ke kino e ʻimi a luku i nā hunaola kanesa.
ʻO ka mea e hoʻokaʻawale ai i kēia mau lāʻau taxane, ʻo ia ka mea i loaʻa maoli mai nā lāʻau. Ua unuhi mua ʻia lākou mai ka ʻili o ka lāʻau 'Yew' . ʻO ka ʻoiaʻiʻo, ʻo nā taxanes kekahi o nā ʻano lāʻau chemo ʻelua i loaʻa mai nā mea kanu. ʻO kekahi ʻano he hui o nā lāʻau i kapa ʻia ʻo 'Vinca alkaloids', i loaʻa mai ka mea kanu 'Mella'.
I kēia mau lā, ke aʻo nei nā kānaka ʻepekema i ke ʻano kemika o nā taxanes i loaʻa mai kēia mau mea kanu a ke hana nei hoʻi e hana iā lākou ma ke ʻano synthetic i loko o nā keʻena hoʻokolohua.
Pehea e pepehi ai kēia lāʻau i nā hunaola kanesa?
I mea e hoʻomaopopo ai i kēia, pono mua kākou e hoʻomaopopo pehea e laha ai nā hunaola kanesa. Hoʻolaha ka maʻi kanesa ma ka māhele ʻana i hoʻokahi hunaola kanesa i ʻelua, kahi e māhele ai i ʻehā, a laila hoʻonui koke. I ka lāʻau lapaʻau, ʻo ke kaʻina hana e māhele ai kahi hunaola i ʻelua ua kapa ʻia ʻo mitosis .
ʻO ka hana a nā lāʻau taxane, ʻo ia ke keakea i ke kaʻina hana o ka mahele ʻana o nā cell.
E noʻonoʻo i ka wā e māhele ai kahi cell, pono e māhele pono ʻia ka mea genetic i loko o kēlā cell i ʻelua a hoʻouna ʻia i nā cell hou ʻelua. Aia nā ʻano i loko o ke kelepona e kōkua ana i kēia hana, e like me nā kaula liʻiliʻi. Ua kapa ʻia kēia mau mea he microtubules . ʻO kēia nā mea e huki ai i nā ʻāpana e pono ai no nā cell hou ʻelua.
Ke lawe ʻia ka lāʻau taxane i loko o ke kino, hoʻolilo ia i kēia mau kaula i kapa ʻia ʻo microtubules i mea ʻoʻoleʻa pono ʻole . A laila ʻaʻole hiki iā lākou ke pelu a wehe pono paha. No laila, ʻo ke kaʻina hana o ka māhele ʻana i ke kelepona i ʻelua e pau i ka hapalua. Ke hiki ʻole ke hana ʻia kēia mahele ʻana, make ke kelepona makua ma hope o kekahi manawa.
Hoʻomake nā lāʻau lapaʻau Taxane i ke kanesa ma ka luku ʻana i ka hiki o nā hunaola kanesa ke māhele a ulu.
He aha nā ʻano maʻi kanesa e hoʻohana ʻia ai nā lāʻau taxane?
He papa lāʻau koʻikoʻi loa nā taxanes i hoʻohana ʻia e mālama i nā ʻano maʻi kanesa like ʻole. Hoʻohana ʻia kekahi o kēia mau mea ma ke ʻano he lāʻau lapaʻau mua no kekahi mau maʻi kanesa, aʻo kekahi e hoʻohana ʻia no nā maʻi kanesa metastatic.
| Nā ʻano maʻi kanesa i mālama ʻia me Taxane | |
|---|---|
| Ka maʻi kanesa i hoʻohana nui ʻia | |
| Ka maʻi ʻōpū | Ka maʻi ʻaʻai umauma |
| ʻO nā ʻano maʻi ʻē aʻe i mālama ʻia | |
| Ka maʻi ʻōpū | Ka maʻi ʻaʻai o ka ʻōpū |
| Ka maʻi ʻōpū | Nā maʻi ʻaʻai poʻo a me ka ʻāʻī |
| Ka maʻi ʻaʻai prostate | Ka maʻi ʻaʻai māmā (Ka maʻi ʻaʻai māmā ʻaʻole liʻiliʻi) |
| Ka maʻi ʻōpū | ʻO ka maʻi ʻōpū |
I kekahi mau hihia, hāʻawi ʻia nā taxanes me ka hui pū ʻana me nā lāʻau chemotherapy ʻē aʻe. Na kāu kauka e hoʻoholo i ka lāʻau lapaʻau kūpono loa no kou kūlana.
Pehea e hāʻawi ʻia ai kēia lāʻau lapaʻau? A he aha nā hopena ʻaoʻao?
Pehea e hāʻawi ʻia ai ka lāʻau lapaʻau
Hāʻawi ʻia nā taxanes ma o ka intravenous (IV) . Hāʻawi ʻia lākou ma o kahi cannula (catheter), e like me ka saline solution. Hiki i kēia lāʻau ke hala i hoʻokahi hola a i ʻole kekahi mau hola. Pono paha ʻoe e loaʻa i kēia lāʻau i hoʻokahi manawa i ka pule, a i ʻole hoʻokahi manawa i kēlā me kēia mau pule. Na kāu kauka e hoʻoholo i ka papa hana lapaʻau e pili ana i kou kūlana.
Nā hopena ʻaoʻao i ʻike pinepine ʻia
ʻOiai ke kuhikuhi nei nā lāʻau chemotherapy i nā hunaola kanesa e māhele wikiwiki ana, hiki iā lākou ke hoʻopilikia i nā hunaola olakino e māhele wikiwiki ana i loko o ko mākou kino. No ka laʻana, nā mea e like me ko mākou mau hunaola follicle lauoho, nā hunaola ʻili, a me nā hunaola koko. ʻO ia ke kumu e loaʻa ai nā hopena ʻaoʻao.
| Hopena ʻaoʻao | He wehewehe maʻalahi |
|---|---|
| ʻO ka neutropenia | ʻO ka emi ʻana o ka helu o nā neutrophils, kahi ʻano o ke koko keʻokeʻo e hakakā nei i ka maʻi i loko o ke kino, kahi e hoʻonui ai i ka pilikia o ka hoʻomohala ʻana i nā maʻi. |
| ʻO ka neuropathy peripheral | Ka hōʻino ʻana o ke aʻalolo i nā lima a me nā wāwae. Hiki i kēia ke hana i ka mae ʻana, ka ʻeha, a i ʻole ka nāwaliwali i nā lima a me nā wāwae . |
| Pohō lauoho | He hopena maʻamau kēia, akā e ulu hou ka lauoho ma hope o ka pau ʻana o ka mālama ʻana. |
| Ka luaʻi a me ka nausea | He mea maʻamau ia i nā lā lapaʻau. Hāʻawi ʻia ka lāʻau lapaʻau e kāohi i kēia. |
| ʻEha ʻiʻo a me nā hono | Aia paha ka ʻeha ma ke kino a me ka ʻoʻoleʻa ma nā hono. |
| Nā loli o ke koko | Hiki ke piʻi a emi paha ke koko. |
| Nā hunaola koko i hoʻemi ʻia | ʻO ka emi ʻana o nā hunaola koko ʻulaʻula hiki ke alakaʻi i ka anemia a ʻo ka emi ʻana o nā platelets (thrombocytopenia) hiki ke alakaʻi i ka pilikia o ke kahe ʻana o ke koko. |
ʻAʻole loaʻa kēia mau hopena ʻaoʻao i nā kānaka a pau. Eia kekahi, hiki ke hoʻomalu ʻia ka nui o lākou. He mea nui loa ia e hoʻomaopopo i kāu kauka a i ʻole nā limahana kahu maʻi e pili ana i kekahi ʻano ʻoluʻolu ʻole āu e manaʻo ai.
Aia kekahi mau pilikia i kēia lāʻau lapaʻau?
He lāʻau lapaʻau kūpono loa nā taxanes i hoʻolōʻihi i ke ola o nā maʻi kanesa. Eia nō naʻe, e like me nā lāʻau lapaʻau āpau, aia kekahi mau pilikia.
I kekahi manawa, hiki i nā hopena ʻaoʻao i ʻōlelo ʻia ma luna ke koʻikoʻi. I ia mau hihia, hiki i kāu kauka ke hoʻoholo e hoʻololi i kāu papa hana lapaʻau a hoʻōki paha iā ia no kekahi manawa.
ʻO kekahi mea nui ʻē aʻe, ʻo ia ka hala ʻana o ka manawa, hiki i nā hunaola kanesa ke hoʻomaka e 'maʻa' i kēia lāʻau. ʻO ia hoʻi, hoʻomohala lākou i ka chemoresistance . A laila e emi paha ka hopena o ka lāʻau. Akā inā hana ʻia kēlā, e huli kāu kauka i nā koho e like me ka hoʻāʻo ʻana i kahi hui lāʻau ʻokoʻa a i ʻole ke kuhikuhi ʻana i kahi ʻano lapaʻau ʻokoʻa.
Leka Lawe-Home
- He papa ikaika loa ʻo Taxane o nā lāʻau chemotherapy i loaʻa mai nā mea kanu e kāohi ana i ka māhele ʻana o nā hunaola kanesa.
- Hoʻōla maikaʻi kēia i nā ʻano maʻi kanesa he nui, me ka umauma, ka ovarian, a me ka māmā.
- Hiki ke loaʻa nā hopena ʻaoʻao e like me ka hāʻule ʻana o ka lauoho, ka mae ʻana o ka ʻōpū, a me nā ʻeha kino, akā hiki ke mālama ʻia ka hapa nui o lākou.
- He mea nui loa e haʻi aku i kāu kauka a kahu maʻi paha e pili ana i kekahi ʻeha iki āu e ʻike ai i ka wā o ka mālama ʻana.
- He huakaʻi ka mālama ʻana i ka maʻi kanesa. E hoʻomanaʻo mau ʻaʻole ʻoe hoʻokahi ma kēia huakaʻi a he hui lapaʻau akamai kāu e kōkua iā ʻoe.
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