Koj tus kws kho mob puas tau qhia koj tias koj muaj ib yam mob uas tsis tshua muaj hu ua Systemic Mastocytosis ? Tej zaum koj yuav ntshai thiab txhawj me ntsis thaum koj hnov tias. Nws yog ib qho ib txwm muaj. Tab sis tsis txhob txhawj. Tam sim no muaj cov kev kho mob zoo thiab zoo rau cov mob zoo li no. Hnub no peb yuav tham txog cov tshuaj Ayvakit (avapritinib) uas koj tau txais. Cia peb nkag siab txhua yam txog tus kab mob no thiab cov tshuaj yooj yim thiab meej.
Systemic Mastocytosis (SM) yog dab tsi tiag?
Hais yooj yim xwb, Systemic Mastocytosis yog ib qho mob tsis tshua muaj uas ib hom cell hu ua 'mast cells' hauv peb lub cev loj hlob ntau dhau. Cov mast cell no yog ib feem ntawm peb lub cev tiv thaiv kab mob. Zoo li peb lub teb chaws tiv thaiv kab mob. Thaum muaj ib yam dab tsi txawv teb chaws nkag mus rau hauv lub cev, cov cell no yuav ua haujlwm thiab tso cov tshuaj lom neeg xws li 'histamine'.
Xav txog tias thaum tus yoov tshaj cum tom koj, thaj chaw ntawd yuav khaus thiab liab, puas yog? Qhov ntawd yog qhov tshwm sim vim yog cov tshuaj histamine no. Tab sis rau ib tus neeg uas muaj Systemic Mastocytosis, cov mast cell no sib sau ua ke hauv lub cev tsis tswj hwm. Lawv sib sau ua ke hauv daim tawv nqaij, pob txha, lossis cov kabmob sab hauv xws li lub siab thiab lub zais zis. Vim li no, lub cev tuaj yeem muaj cov tsos mob ua xua, xws li khaus, liab ntawm daim tawv nqaij, mob plab, thiab kiv taub hau, tsis muaj laj thawj pom tseeb.
Lo lus "systemic" txhais tau hais tias nws tuaj yeem cuam tshuam rau tag nrho lub cev, tsis yog ib qho xwb. Muaj ntau hom kab mob no sib txawv, txij li hom mob me me, loj qeeb (tsis muaj zog) mus rau hom mob qog noj ntshav uas loj hlob sai.
Kuv yuav paub li cas tias Ayvakit yog qhov zoo rau kuv?
Koj tus kws kho mob yuav ua ntau yam kev kuaj mob kom paub tseeb tias koj muaj hom mob Systemic Mastocytosis twg. Cov txiaj ntsig ntawm cov kev kuaj mob ntawd thiab koj cov tsos mob yuav txiav txim siab seb Ayvakit puas yog rau koj. Tam sim no Ayvakit tau pom zoo los kho ntau hom mob Systemic Mastocytosis rau cov neeg laus.
| Hom kab mob | Ib qho lus piav qhia yooj yim |
|---|---|
| Mastocytosis Txheej Txheem Siab (AdvSM) - hom mob hnyav, kis tau sai | |
| Kev Txhawj Xeeb Txog Mastocytosis | Kev sib sau ua ke ntawm cov hlwb mast ntau dhau ua rau muaj kev ua haujlwm tsis zoo ntawm cov kabmob xws li lub siab, txoj hnyuv zom zaub mov, thiab pob txha. |
| SM nrog rau kev mob ntshav (hematological neoplasm) | Thaum cov mast cell loj hlob tuaj, lwm yam kab mob ntsig txog ntshav (piv txwv li myelodysplastic syndromes) yuav tshwm sim. |
| Kab mob leukemia mast cell | Qhov no yog ib qho mob qog noj ntshav uas tsis tshua muaj, loj hlob sai uas cov hlwb mast sib sau ua ke ntau heev (ntau dua 20%) hauv cov nqaij. |
| Indolent Systemic Mastocytosis (ISM) - ib hom mob me me, loj hlob qeeb | |
| Kev kuaj mob Mastocytosis uas tsis muaj zog (ISM) | Qhov no tsis yog mob qog noj ntshav. Cov hlwb mast loj hlob qeeb qeeb. Txawm hais tias lawv tuaj yeem ua rau muaj cov tsos mob tsis zoo, tab sis feem ntau cov hlwb tsis ua haujlwm. |
Tseem Ceeb: Nws tuaj yeem ua rau muaj kev phom sij yog tias koj cov ntshav platelet qis dhau. Cov platelets yog ib hom cell uas pab tiv thaiv kom tsis txhob los ntshav. Koj tus kws kho mob yuav kuaj xyuas koj cov ntshav platelet tsis tu ncua ua ntej koj pib noj cov tshuaj no thiab thaum koj noj nws. Qhov no yog los txo qhov kev pheej hmoo ntawm cov kev mob tshwm sim loj, xws li los ntshav hauv lub hlwb.
Cov tshuaj Ayvakit no ua haujlwm li cas rau lub cev?
Ayvakit yog ib yam tshuaj uas koom nrog ib pawg tshuaj hu ua 'kinase inhibitors'. Kinases yog ib hom enzyme protein uas pab xa cov cim qhia ntawm cov cell hauv peb lub cev. Cov cim qhia no tseem ceeb heev rau tej yam xws li kev loj hlob ntawm cell thiab kev faib.
Muaj coob tus neeg uas muaj tus kab mob Systemic Mastocytosis muaj kev hloov pauv hauv cov protein hu ua KIT uas pom muaj nyob rau hauv cov hlwb mast . Qhov kev hloov pauv no ua rau cov protein KIT ua haujlwm ntau dhau, ua rau cov hlwb mast loj hlob tsis tuaj yeem tswj tau.
Cov tshuaj Ayvakit tsom mus rau qhov KIT protein uas hloov pauv lawm thiab ua rau nws tsis ua haujlwm.Zoo li ua kom lub pej thuam uas muab lub teeb liab tsis raug ntsiag to. Qhov no tiv thaiv kev tsim cov hlwb mast ntau dhau, txo cov tsos mob, thiab tswj kev puas tsuaj rau cov kabmob.
Kuv yuav tsum siv cov tshuaj Ayvakit li cas?
Ayvakit yog ib lub tshuaj ntsiav. Qhov tseem ceeb tshaj plaws thaum noj nws yog noj nws thaum lub plab khoob . Qhov ntawd txhais tau tias, koj yuav tsum noj nws tsawg kawg yog ib teev ua ntej noj mov, lossis ob teev tom qab noj mov. Thaum ntawd yog lub sijhawm uas cov tshuaj nqus tau zoo tshaj plaws los ntawm lub cev.
Cov koob tshuaj uas feem ntau tau muab yog raws li nram no:
- Rau mob Mastitis Txheej Txheem Siab (Advanced Systemic Mastitis TOS ) (AdvSM): 200mg ib zaug ib hnub.
- Rau kev kho mob Indolent Systemic Mastocytosis (ISM): 25mg ib zaug ib hnub.
Qhov no feem ntau yog kev kho mob mus sij hawm ntev. Koj tus kws kho mob yuav qhia koj kom noj tshuaj kom txog thaum koj tau txais txiaj ntsig zoo los ntawm nws thiab tsis muaj kev phiv loj heev. Yog tias koj muaj kev phiv, koj tus kws kho mob yuav txiav txim siab txo koj cov tshuaj, tsum nws ib ntus, lossis tsum nws tag nrho.
Ua raws li koj tus kws kho mob cov lus qhia kom meej. Tsis txhob tsum noj koj cov tshuaj lossis hloov qhov ntau npaum li cas yam tsis tau nrog koj tus kws kho mob tham. Nrhiav kev pab kho mob tam sim ntawd yog tias koj muaj tej yam tshwm sim uas zoo li hnyav heev.
Cov kev tshawb fawb hais li cas txog kev vam meej ntawm Ayvakit?
Muaj cov ntaub ntawv hais txog peb qhov kev sim tshuaj uas tau ua los tshawb nrhiav qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj Ayvakit.
Rau AdvSM (hnyav): Hauv ob txoj kev tshawb fawb, EXPLORER thiab PATHFINDER, 57% ntawm cov neeg uas tau noj Ayvakit, lossis ntau dua ib nrab, tau txo cov tsos mob thiab rov qab ua haujlwm ntawm cov kab mob uas cuam tshuam. Ib nrab ntawm cov neeg uas pom cov txiaj ntsig tau tswj hwm qhov kev txhim kho ntawd rau 38 lub hlis, lossis ntau dua 3 xyoos.
Rau ISM (hom me me): Hauv kev tshawb fawb PIONEER, cov neeg uas noj Ayvakit muaj cov tsos mob tsawg dua (xws li khaus, mob plab, thiab qaug zog) dua li cov neeg uas noj placebo. Qhov no txhais tau tias cov tshuaj no tau muab kev pab ntau rau kev txhim kho lub neej zoo.
Cov kev tshawb fawb no qhia tau tias Ayvakit yog ib txoj kev kho mob zoo heev rau Systemic Mastocytosis. Txawm li cas los xij, nco ntsoov tias nws tsis kho tau tus kab mob tag nrho, thiab cov txiaj ntsig yuav tsis zoo ib yam rau txhua tus.
Puas muaj teeb meem nrog lwm cov tshuaj? (Kev Sib Cuam Tshuam Tshuaj)
Yog, Ayvakit tuaj yeem cuam tshuam nrog qee cov tshuaj. Tshwj xeeb tshaj yog cov uas cuam tshuam rau cov enzyme CYP3A hauv peb lub siab. Qee cov tshuaj tuaj yeem ua rau kom muaj Ayvakit ntau ntxiv hauv lub cev thiab ua rau muaj kev phiv ntau ntxiv, thaum lwm cov tshuaj tuaj yeem ua rau kom muaj Ayvakit tsawg dua thiab txo nws cov txiaj ntsig.
Yog li ntawd, nco ntsoov qhia rau koj tus kws kho mob txog txhua yam tshuaj uas koj noj (tshuaj rau lwm yam kab mob, cov vitamins, cov tshuaj ib txwm muaj, cov tshuaj ntxiv). Tom qab ntawd nws tuaj yeem kuaj xyuas seb puas muaj teeb meem thiab, yog tias tsim nyog, hloov koj cov tshuaj lossis hloov qhov ntau npaum li cas ntawm Ayvakit.
Tsis tas li ntawd xwb, yog tias koj noj cov tshuaj ua kom cov ntshav nyias, xws li warfarin (Coumadin, Jantoven) , koj qhov kev pheej hmoo ntawm kev los ntshav rau hauv lub hlwb los ntawm Ayvakit yuav nce me ntsis. Yog li ntawd, koj tus kws kho mob yuav saib xyuas koj kom zoo dua yog tias koj noj cov tshuaj no.
Yuav ua li cas thiaj tau txais tshuaj Ayvakit?
Ayvakit yog tshuaj uas yuav tsum tau kev tso cai los ntawm kws kho mob xwb, feem ntau yog kws kho mob ntshav lossis kws kho mob qog nqaij hlav sau ntawv rau koj.
Cov tshuaj no tsis yog cov tshuaj uas koj tuaj yeem yuav tau ntawm cov tsev muag tshuaj ib txwm muaj . Nws muaj nyob rau ntawm 'tsev muag tshuaj tshwj xeeb'. Thaum koj tus kws kho mob tau xa daim ntawv yuav tshuaj mus rau lub tsev muag tshuaj tshwj xeeb ntawd, lawv tuaj yeem xa cov tshuaj mus rau koj lub tsev lossis mus rau koj tus kws kho mob lub chaw ua haujlwm.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Systemic Mastocytosis (SM) yog ib qho mob tsis tshua muaj uas tshwm sim los ntawm kev sib sau ua ke ntawm cov mast cell ntau dhau hauv lub cev.
- Ayvakit yog ib yam tshuaj kho mob niaj hnub uas muaj txiaj ntsig zoo heev uas tsom mus rau qhov ua rau muaj tus kab mob no thiab kho nws.
- Cov tshuaj no yuav tsum tau noj thaum lub plab khoob (ib teev ua ntej lossis ob teev tom qab noj mov).
- Nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob txog txhua yam tshuaj, cov vitamins, thiab cov tshuaj ntxiv uas koj noj.
- Koj yuav tsum tsis txhob tsum noj tshuaj lossis hloov qhov ntau npaum li cas yam tsis tau kev qhia los ntawm kws kho mob.
- Tham nrog koj tus kws kho mob tam sim ntawd txog txhua yam kev tsis xis nyob lossis cov kev mob tshwm sim. Tsis txhob ntshai, paub cov ntaub ntawv raug, thiab nrog kev kho mob kom zoo, koj tuaj yeem ua neej noj qab nyob zoo.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus