Txawm noj tshuaj los koj cov ntshav siab puas tsis qis? Cia peb kawm txog hyperaldosteronism.

Puas muaj tej lub sij hawm koj xav tias, 'Vim li cas kuv cov ntshav siab thiaj tsis qis txawm tias noj tshuaj los xij?'? Ib txhia neeg kuj muaj teeb meem zoo li no. Muaj tej lub sij hawm uas nyuaj rau tswj lawv cov ntshav siab, txawm tias tom qab noj tshuaj lawm los xij. Thaum lub sij hawm zoo li no, peb yuav tsum xav txog seb puas muaj ib qho ua rau muaj qhov teeb meem no. Hnub no, peb yuav tham txog ib qho mob uas qee zaum nyuaj rau kuaj mob, tab sis tuaj yeem kho tau yog tias kho kom zoo. Qhov ntawd yog hyperaldosteronism .

Hyperaldosteronism yog dab tsi?

Hais yooj yim xwb, hyperaldosteronism yog thaum koj cov qog adrenal tsim ntau dhau ntawm cov tshuaj hormones hu ua aldosterone . Xav txog nws li no, aldosterone zoo li ib tug kws ua haujlwm me me uas tswj peb cov ntshav siab. Nws pab tswj peb cov ntshav siab kom nyob rau theem zoo los ntawm kev tswj cov qib ntawm potassium thiab sodium hauv peb lub cev.

Tam sim no tej zaum koj yuav xav paub tias, 'Cov qog adrenal no yog dab tsi?' Cov no yog ib feem ntawm peb lub endocrine system . Lawv zoo li cov chaw tsim khoom me me uas tsim ntau yam tshuaj hormones uas peb lub cev xav tau los ua haujlwm txhua hnub. Peb muaj ob lub qog adrenal no, uas nyob rau saum peb lub raum, zoo li lub hau.

Cov hom hyperaldosteronism yog dab tsi?

Muaj ob hom hyperaldosteronism tseem ceeb.

1. Mob Aldosteronism Tseem Ceeb: Qhov no qee zaum hu ua Conn's syndrome . Qhov tshwm sim ntawm no yog tias muaj qee yam tsis raug nrog koj cov qog adrenal lawv tus kheej, ua rau lawv tsim cov aldosterone ntau dhau. Xav txog nws zoo li muaj teeb meem hauv lub Hoobkas thiab lawv tsim cov khoom ntau dhau.

2. Mob Aldosteronism Thib Ob: Qhov no tsis yog teeb meem nrog cov qog adrenal. Nws yog teeb meem nyob rau lwm qhov hauv koj lub cev uas ua rau cov qog adrenal raug txhawb nqa thiab pib tsim ntau aldosterone. Qhov no txhais tau tias lub Hoobkas ua haujlwm dhau sijhawm vim muaj kev cuam tshuam sab nraud.

Txawm li cas los xij, qhov kawg yog koj cov aldosterone hauv cov ntshav nce ntxiv, ua rau ntshav siab (ntshav siab) thiab koj cov potassium hauv cov ntshav txo qis. Qhov kev txo qis ntawm potassium no hu ua hypokalemia .

Leej twg raug tus mob no ntau tshaj? Nws tshwm sim ntau npaum li cas?

Hyperaldosteronism feem ntau pom muaj nyob rau hauv cov neeg hnub nyoog ntawm 30 thiab 50 xyoo.Tsis tas li ntawd xwb, tus mob no feem ntau tshwm sim ntawm cov poj niam ntau dua li cov txiv neej.

Nws nyuaj rau cov kws tshawb fawb hais tias qhov no tshwm sim ntau npaum li cas, vim tias qee zaum nws raug kuaj mob tsis raug. Tab sis qee qhov kev tshawb fawb qhia tias ntawm 5% thiab 10% ntawm cov neeg uas muaj ntshav siab yuav muaj hyperaldosteronism thawj zaug. Cov kws tshaj lij kwv yees tias ntau txog li 25% ntawm cov neeg uas muaj ntshav siab tiv taus tshuaj yuav muaj tus mob no. Yog li, nws tsis yog qhov tsis tshua muaj, puas yog?

Cov tsos mob ntawm Hyperaldosteronism yog dab tsi?

Cov tsos mob ntawm hyperaldosteronism yuav txawv ntawm ib tus neeg mus rau ib tus neeg, nyob ntawm seb qhov mob hnyav npaum li cas. Ib txhia neeg yuav tsis muaj tsos mob dab tsi li , tshwj xeeb tshaj yog tias qhov mob tsis hnyav heev.

Txawm li cas los xij, qhov tseem ceeb thiab feem ntau cov tsos mob ntawm tus mob no yog ntshav siab (hypertension) , tshwj xeeb tshaj yog ntshav siab uas tsis tuaj yeem tswj tau yooj yim txawm tias muaj tshuaj los xij.

Tsis tas li ntawd xwb, yog tias koj muaj lwm cov tsos mob, feem ntau lawv yog los ntawm ntshav siab nruab nrab mus rau hnyav thiab/lossis cov potassium qis hauv cov ntshav (hypokalemia).

Cov tsos mob uas yuav tshwm sim vim muaj ntshav siab (hypertension):

• Mob taub hau
• kiv taub hau
• Kev hloov pauv ntawm qhov muag pom kev
• Ua pa nyuaj

Cov tsos mob uas yuav tshwm sim vim yog cov ntshav potassium qis (hypokalemia):

• Cov leeg tsis muaj zog - Qee zaum mob hnyav, tej zaum yuav muaj mob zoo li tuag tes tuag taw ib ntus.
• Cov leeg nqaij ntswj los yog ntswj (cov leeg nqaij ntswj)
• Tingling thiab loog
• Kev qaug zog
• Nqhis dej heev (qhov no hu ua polydipsia)
• Tso zis ntau zaus

Tam sim no koj nkag siab lawm, vim tias qee cov tsos mob no feem ntau tshwm sim rau lwm yam kab mob, qee zaum nws yuav lig dhau los paub qhov no.

Dab tsi ua rau qhov no?

Cov ua rau muaj hyperaldosteronism sib txawv nyob ntawm seb nws yog thawj zaug lossis thib ob. Cia peb saib seb yuav ua li cas.

Cov ua rau muaj tus kab mob Hyperaldosteronism thawj zaug

Zoo li kuv tau hais ua ntej lawm, Primary Hyperaldosteronism yog ib qho teeb meem nrog koj cov qog adrenal lawv tus kheej, ua rau lawv tsim cov aldosterone ntau dhau.

Qhov ua rau muaj qhov no feem ntau yog cov qog tsis yog mob qog noj ntshav hu ua adrenal adenomas uas tsim nyob rau hauv cov qog adrenal . Cov no yog cov qog me me, tsis muaj teeb meem dab tsi, tab sis lawv tuaj yeem ua rau muaj kev tso tawm ntau dhau ntawm cov tshuaj hormones aldosterone.

Tsis tas li ntawd xwb, muaj ntau lwm yam ua rau muaj qhov teeb meem no :

• Unilateral adrenal hyperplasia - Qhov no txhais tau tias tsuas muaj ib lub adrenal gland ntawm ib sab xwb thiaj li o, loj zuj zus, thiab tsim ntau cov tshuaj hormones.
• Cov qog nqaij hlav adrenal uas tsim cov aldosterone - Cov no yog cov qog nqaij hlav. Txawm li cas los xij, lawv tsis tshua muaj.
• Tsev neeg hyperaldosteronism hom 1 - Qhov no yog ib qho mob uas tau txais los ntawm niam txiv mus rau cov menyuam.

Ua rau muaj mob hyperaldosteronism theem ob

Qhov ua rau muaj hyperaldosteronism theem ob yog vim cov ntshav uas mus txog koj lub raum tsawg zuj zus .

Yuav kom nkag siab tias qhov no tshwm sim li cas, koj yuav tsum paub tias cov tshuaj hormones aldosterone yog ib feem ntawm cov tshuaj hormones uas tswj peb cov ntshav siab. Xav txog nws zoo li kev sib xyaw ua ke.

Lub cev no hu ua lub renin-angiotensin-aldosterone system . Nws ua haujlwm li no:

1. Thaum koj lub cev hnov ​​​​​​tias cov ntshav siab qis lossis cov ntsev sodium qis hauv koj cov ntshav, koj lub raum tso tawm ib qho enzyme hu ua renin .

2. Cov renin no mus thiab hloov cov tshuaj hu ua angiotensinogen (ua ntej rau angiotensin) uas koj lub siab tsim tawm mus ua angiotensin I. (Angiotensin yog ib yam tshuaj hormones uas ua rau peb cov hlab ntsha nqaim.)

3. Tom ntej no, qhov angiotensin I no dhau los ua angiotensin II .

4. Thaum kawg, nws yog qhov angiotensin II no uas ua rau cov hlab ntsha nqaim ntxiv thiab ua rau cov qog adrenal tso tawm cov tshuaj hormone aldosterone .

Tam sim no xav txog, yog tias muaj qee qhov laj thawj uas cov ntshav mus rau lub raum txo qis, lub raum xav tias, 'Auj, kuv cov ntshav siab tau poob qis.' Tom qab ntawd lawv ua yuam kev qhib lub renin-angiotensin-aldosterone system no. Qhov tshwm sim yog tias qib ntawm aldosterone hauv lub cev nce ntxiv, txawm tias nws tsis tsim nyog tiag tiag.

Cov ua rau kom cov ntshav ntws mus rau lub raum tsawg dua thiab ua rau muaj hyperaldosteronism theem obNov yog ob peb yam:

• Kab mob ntawm cov hlab ntsha hauv lub raum - zoo li cov yeeb nkab dej txhaws.
• Kev mob ntshav siab hauv lub raum
• Cov mob uas cov kua dej sib sau ua ke hauv lub cev (edema) , piv txwv li:
• Lub plawv tsis ua haujlwm
• Kab mob siab cirrhosis
• Nephrotic syndrome yog ib qho kab mob raum.

Koj kuaj qhov no li cas?

Feem ntau tus kws kho mob kuaj mob hyperaldosteronism los ntawm kev kuaj ntshav . Txawm li cas los xij, ntau tus neeg yeej tsis tau kuaj pom tias muaj tus mob no vim muaj ntau lwm yam ua rau thiab ntau yam ua rau muaj ntshav siab.

Qee cov cim qhia tias koj muaj hyperaldosteronism suav nrog:

• Ntshav siab uas tiv taus tshuaj.
• Nov yog cov txiaj ntsig los ntawm koj daim ntawv qhia txog kev kuaj ntshav electrolyte :
• Ntshav sodium ntau me ntsis (hypernatremia) .
• Cov magnesium qis me ntsis (hypomagnesemia) .
• Tsis tas li ntawd, cov poov tshuaj tsawg (hypokalemia) .

Yog tias koj tus kws kho mob xav tias koj muaj hyperaldosteronism raws li cov cim thiab cov tsos mob no, nws yuav xaj ob qhov kev kuaj ntshav tshwj xeeb: Plasma Renin Concentration (PRC) lossis Plasma Renin Activity (PRA) .

• Yog koj muaj Primary Hyperaldosteronism , koj cov PRC thiab PRA yuav qis dua li qub.
• Yog tias koj muaj hyperaldosteronism theem ob , cov qib no yuav siab dua li qub.

Ntxiv rau, koj kuj tseem yuav tsum tau kuaj xyuas aldosterone suppression . Qhov kev kuaj no suav nrog kev muab sodium (ntsev) rau koj los ntawm qhov ncauj lossis los ntawm kev txhaj tshuaj saline (IV) rau ib lub sijhawm. Tom qab ntawd, koj cov zis yuav raug sau rau lub sijhawm 24 teev thiab qhov ntau ntawm aldosterone hauv cov zis ntawd yuav raug ntsuas hauv chav kuaj mob.

Yog tias cov kev kuaj no lees paub tias koj muaj hyperaldosteronism, koj tus kws kho mob yuav xaj kom kuaj ntxiv kom nrhiav tau qhov ua rau. Piv txwv li, CT scan (computed tomography scan) kom pom tias qhov mob qog tsis yog mob qog noj ntshav ua rau muaj hyperaldosteronism.Tej zaum yuav muaj lus nug kom koj ua qhov kev kuaj duab .

Cov kev kho mob rau qhov no yog dab tsi?

Kev kho mob rau hyperaldosteronism nyob ntawm seb ua rau muaj li cas, tab sis lub hom phiaj tseem ceeb yog tswj koj cov ntshav siab .

• Rau qhov mob hyperaldosteronism thawj zaug, uas yog ib qho mob uas tshwm sim los ntawm qog adrenal gland, cov kws kho mob feem ntau pom zoo kom phais tshem tawm cov qog . Txawm li cas los xij, qee zaum, cov qog no tuaj yeem kho tau nrog tshuaj xwb. Txawm tias tom qab phais lawm los xij, koj tseem yuav muaj ntshav siab, yog li koj yuav tsum noj tshuaj kom tswj tau nws.

• Kev kho mob hyperaldosteronism theem ob yog kho los ntawm kev tswj koj cov ntshav siab nrog cov tshuaj, thaum tseem kho qhov ua rau muaj teeb meem (piv txwv li, kab mob plawv) .

Muaj ntau hom tshuaj uas tuaj yeem pab kho hyperaldosteronism:

• Spironolactone (Spironolactone - Aldactone®)
• Eplerenone (Eplerenone - Inspra®)
• Amiloride (Amiloride - Midamor®)

Ib qho uas yuav tsum nco ntsoov yog tias kev siv cov tshuaj aldosterone-blocking mus sij hawm ntev, xws li Spironolactone , tuaj yeem ua rau muaj qee qhov kev phiv rau cov txiv neej. Piv txwv li, erectile dysfunction thiab gynecomastia tuaj yeem tshwm sim. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tham nrog koj tus kws kho mob txog cov tshuaj twg zoo tshaj plaws rau koj, koj yuav tsum noj nws ntev npaum li cas, thiab cov kev phiv yog dab tsi.

Qhov no puas tiv thaiv tau?

Qhov tseeb, feem ntau, tsis muaj dab tsi koj ua tau los tiv thaiv qhov mob hyperaldosteronism no. Vim tias nws yog los ntawm kev hloov pauv hauv peb lub cev cov txheej txheem sab hauv. Txawm li cas los xij, koj tuaj yeem tswj koj txoj kev noj qab haus huv tag nrho los ntawm kev ua raws li kev ua neej noj qab haus huv, noj zaub mov kom zoo, thiab tawm dag zog.

Qhov kev kwv yees rau tus mob no yog dab tsi?

Qhov kev kwv yees ntawm hyperaldosteronism nyob ntawm seb ua rau muaj li cas.

• Yog tias kuaj pom tias muaj mob hyperaldosteronism thawj zaug thiab kho kom zoo, feem ntau yuav muaj txiaj ntsig zoo . Yog tias tshem tawm ib qho qog, feem ntau qhov mob yuav tswj tau.
• Kev mob hyperaldosteronism theem obYav tom ntej ntawm tus kab mob nyob ntawm seb tus mob tseem ceeb (piv txwv li, kab mob plawv, kab mob siab) tuaj yeem tswj tau zoo npaum li cas.

Cov teeb meem tseem ceeb uas tshwm sim los ntawm hyperaldosteronism yog cov teeb meem ntawm lub plawv thiab cov hlab ntsha uas tshwm sim los ntawm ntshav siab. Cov no suav nrog:

• Atrial fibrillation - lub plawv dhia tsis sib xws.
• Sab laug ventricular hypertrophy - tuab ntawm cov phab ntsa ntawm sab laug chamber ntawm lub plawv.
• Mob plawv nres
• Mob stroke

Yog vim li ntawd nws thiaj li tseem ceeb heev uas yuav tsum kuaj mob no sai sai thiab tau txais kev kho mob kom zoo.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog tias koj tau kuaj pom tias muaj hyperaldosteronism, koj yuav tsum mus ntsib koj tus kws kho mob tsis tu ncua kom paub tseeb tias cov tshuaj uas koj tau muab rau koj ua haujlwm zoo . Nws tseem ceeb heev uas yuav tsum ua raws li koj tus kws kho mob cov lus qhia.

Yog koj muaj cov tsos mob tshiab, lossis pom muaj kev hloov pauv ntawm cov tsos mob uas twb muaj lawm , qhia rau koj tus kws kho mob tam sim ntawd.

Qhov tseem ceeb tshaj plaws yog, yog tias koj muaj ntshav siab uas tsis kam siv tshuaj, nrog koj tus kws kho mob tham txog koj qhov kev txhawj xeeb, xws li, "Kuv puas tuaj yeem muaj hyperaldosteronism?" Nws tuaj yeem soj ntsuam koj tus mob thiab pom zoo rau txhua qhov kev kuaj mob tsim nyog.

Nco ntsoov tias, muaj ntau yam ua rau ntshav siab. Hyperaldosteronism tsuas yog ib qho ntawm lawv xwb. Qhov xov xwm zoo yog tias qhov no yog ib qho mob uas kho tau.

Cov Lus Qhia Txog Kev Coj Mus Tsev

Zoo, yog li kuv vam tias koj tam sim no nkag siab zoo dua txog qhov peb tau tham txog, Hyperaldosteronism. Nov yog qee yam uas yuav tsum nco ntsoov:

• Hyperaldosteronism yog qhov ua rau muaj ntau dhau ntawm cov tshuaj hormones aldosterone los ntawm cov qog adrenal.
• Qhov no tuaj yeem ua rau muaj ntshav siab (ntshav siab) thiab cov ntshav potassium qis (hypokalemia) .
• Muaj ob hom tseem ceeb: Primary ( teeb meem nrog cov qog adrenal lawv tus kheej) thiab Secondary (kev txhawb nqa ntawm cov qog adrenal vim muaj teeb meem nyob rau lwm qhov).
• Yog koj muaj ntshav siab uas tsis tau noj tshuaj tswj , koj yuav tsum ua tib zoo xav txog qhov no.
• Qhov no kuaj pom los ntawm kev kuaj ntshav .
• Kev kho mob suav nrog kev tswj cov ntshav siab thiab kho qhov ua rau muaj qhov teeb meem .
• Yog tias kuaj pom thiab kho thaum ntxov, yuav ua tau cov txiaj ntsig zoo .

Yog koj muaj lus nug ntxiv txog qhov no, thov nug koj tus kws kho mob. Nyob kom noj qab nyob zoo!

Hyperaldosteronism , Hyperaldosterinism, Aldosterone, Ntshav siab, ntshav siab, Potassium, Cov qog adrenal, Conn's syndrome