Puas muaj leej twg hauv koj tsev neeg muaj tus kab mob ntshav qab zib hom 1? Los yog puas muaj ib tug kws kho mob hais rau koj tias koj muaj feem yuav mob? Yog tias muaj, hnub no peb tab tom tham txog ib yam tshuaj tshiab uas tuaj yeem ncua qhov pib ntawm cov tsos mob ntshav qab zib mus rau ntau xyoo. Qhov no yog ib yam dab tsi uas tau coj kev cia siab loj rau ntau tus neeg. Cia peb saib seb cov tshuaj no yog dab tsi thiab nws ua haujlwm li cas.
Kab mob ntshav qab zib hom 1 thiab lub luag haujlwm ntawm Tzield cov tshuaj
Ua ntej, cia peb nkag siab yooj yim txog hom mob ntshav qab zib hom 1. Qhov tseeb, nws yog ib yam kab mob autoimmune . Hais yooj yim xwb, lub cev tiv thaiv kab mob, uas zoo li 'tub rog' uas tiv thaiv peb lub cev ntawm kab mob, pib ua yuam kev tawm tsam peb cov hlwb zoo. Hauv hom mob ntshav qab zib hom 1, qhov 'kev tawm tsam' no tshwm sim rau cov hlwb beta hauv peb lub txiav.
Xav txog cov beta cell no zoo li cov chaw tsim khoom me me uas tsim cov tshuaj hormones hu ua insulin, uas yog qhov tseem ceeb rau peb lub cev. Insulin pab cov cell hloov cov suab thaj (glucose) hauv cov khoom noj uas peb noj mus ua lub zog. Yog li, thaum lub cev tiv thaiv kab mob rhuav tshem cov beta cell no, kev tsim cov insulin maj mam txo qis.
Qhov kev puas tsuaj no yuav tsis tshwm sim ib zaug xwb. Nws yuav tshwm sim ua peb theem.
- Theem 1: Lub cev tiv thaiv kab mob pib tawm tsam cov beta cell, tab sis lawv tseem tsim cov insulin txaus.
- Theem 2: Beta cell puas tsuaj ntau ntxiv, cov ntshav qab zib pib txawv me ntsis, tab sis tseem tsis muaj tsos mob sab nraud.
- Theem 3: Feem ntau ntawm cov beta cell raug rhuav tshem, thiab lub cev tsis muaj peev xwm tsim cov insulin txaus. Cov ntshav qab zib nce siab heev. Qhov no yog thaum cov tsos mob ntawm tus kab mob ntshav qab zib, xws li nqhis dej ntau dhau thiab tso zis ntau zaus, tshwm sim.
Nov yog qhov uas tshuaj hu ua Tzield (teplizumab-mzwv) los pab. Tzield yog ib yam tshuaj siv los kho mob. Nws tuaj yeem ua rau lub cev tiv thaiv kab mob qeeb qeeb rau cov beta cell ntawm cov neeg uas muaj mob ntshav qab zib hom 1 theem 2. Qhov no txhais tau tias nws tuaj yeem ncua qhov kev loj hlob ntawm tus kab mob mus rau theem 3, thaum cov tsos mob tshwm sim thiab yuav tsum tau txhaj tshuaj insulin txhua hnub.
Cov tshuaj no yog muab los ntawm cov leeg ntshav (intravenous infusion, los yog IV) . Cov kev kho mob no yog muab ib zaug ib hnub rau 14 hnub sib law liag.
Qhov kev kho mob Tzield no puas haum rau kuv?
Kab mob ntshav qab zib hom 1 tuaj yeem cuam tshuam rau txhua tus neeg txhua lub hnub nyoog thiab txhua txoj kev ua neej. Kev kho mob Tzield tej zaum yuav yog rau koj yog tias koj ua tau raws li cov qauv no:
- Yog koj muaj mob ntshav qab zib hom 1 theem 2 .
- Rau kojYog tias koj tsis muaj mob ntshav qab zib hom 2 .
- Yog koj muaj hnub nyoog 8 xyoo lossis laus dua .
Yuav kom paub tseeb tias koj puas muaj ntshav qab zib hom 1 nyob rau theem ob, koj tus kws kho mob yuav ua qee qhov kev kuaj ntshav tshwj xeeb. Qhov tseem ceeb tshaj plaws ntawm cov no yog kev kuaj xyuas cov autoantibodies tiv thaiv beta cells thiab kev kuaj ntshav qab zib hauv qhov ncauj . Lawv kuj tseem yuav kuaj xyuas koj cov ntshav cell thiab cov enzymes siab kom pom tias cov tshuaj no puas muaj kev nyab xeeb rau koj.
Txawm hais tias nws yog ib qho kev pheej hmoo kom muaj ib tug neeg hauv koj tsev neeg muaj tus kab mob ntshav qab zib hom 1, nco ntsoov tias feem ntau ntawm cov neeg uas muaj tus kab mob no tsis muaj keeb kwm tsev neeg.
Cov teebmeem ntawm cov tshuaj Tzield tau raug kawm li cas?
Muaj kev tshawb fawb tshwj xeeb hu ua TN-10 los tshawb nrhiav cov txiaj ntsig thiab kev pheej hmoo ntawm cov tshuaj no. Lo lus nug tseem ceeb uas nws nug yog, "Puas yog Tzield tuaj yeem nres lossis ncua qhov kev nce qib ntawm tus kab mob ntshav qab zib hom 1 mus rau theem 3 rau cov neeg uas muaj kev pheej hmoo siab?"
Cov neeg koom nrog tau muab faib ua ob pawg. Ib pawg tau muab tshuaj Tzield. Lwm pawg tau muab tshuaj placebo . Uas yog, cov kua saline uas zoo li cov tshuaj tab sis tsis muaj tshuaj. Cov neeg mob thiab cov kws kho mob tsis paub tias leej twg tau txais dab tsi.
Koj tuaj yeem pom yooj yim txog qhov tsim nyog thiab qhov tsis tsim nyog rau kev koom nrog txoj kev tshawb fawb los ntawm lub rooj hauv qab no.
| Cov Qauv Kev Koom Tes | Cov Qauv Tsis Pub Lwm Tus Paub |
|---|---|
| Muaj hnub nyoog ntawm 8 txog 45 xyoos. | Muaj mob ntshav qab zib theem 3. |
| Muaj ib tug neeg hauv tsev neeg uas muaj tus kab mob ntshav qab zib hom 1. | Cov qe ntshav lossis cov enzyme hauv siab tsis zoo li qub. |
| Qhov muaj tsawg kawg yog ob hom autoantibodies tshwj xeeb. | Muaj keeb kwm ntawm kev kis kab mob xws li HIV, kab mob siab B lossis C. |
| Cov txiaj ntsig tsis zoo los ntawm kev sim ua kom qab zib tsis kam. | Ua niam cev xeeb tub lossis pub niam mis. |
Cov txiaj ntsig ntawm txoj kev tshawb fawb no yog dab tsi?
Tom qab 14 hnub ntawm kev kho mob, cov neeg no tau raug saib xyuas li ntawm 5 xyoos. Cov txiaj ntsig yeej txhawb siab heev.
Qhov txiaj ntsig tseem ceeb yog tias cov neeg uas noj tshuaj Tzield tau nce mus rau theem 3 ntshav qab zib los ntawm qhov nruab nrab li ob xyoos tom qab dua li cov neeg uas tsis noj tshuaj (placebo).
Hais yooj yim xwb, nws siv sijhawm li 4 xyoos rau cov neeg noj Tzield kom muaj cov tsos mob, thaum cov neeg noj placebo tau muaj cov tsos mob li 2 xyoos. Tshwj xeeb tshaj yog nyob rau hauv thawj xyoo ntawm kev kho mob, tsuas yog muaj tsawg tus neeg noj Tzield tau muaj kev mob hnyav zuj zus. Thaum kawg ntawm kev tshawb fawb, 57% ntawm cov neeg noj Tzield tseem noj qab nyob zoo thiab tsis muaj cov tsos mob ntshav qab zib. Tab sis tsuas yog 28% ntawm cov neeg noj placebo tau muaj.
Cov kev mob tshwm sim ntawm Tzield yog dab tsi?
Ib yam li lwm yam tshuaj, Tzield muaj peev xwm muaj cov kev mob tshwm sim. Tab sis tsis txhob txhawj, feem ntau ntawm cov no tuaj yeem tswj tau.
Cov kev mob tshwm sim feem ntau:
- Mob pob khaus ntawm daim tawv nqaij: Qhov no feem ntau yog ib qho cim qhia txog kev ua xua. Feem ntau, nws tsis loj heev thiab yuav ploj mus ntawm nws tus kheej. Khaws daim tawv nqaij kom noo thiab tsis txhob khawb. Tej yam xws li ntxuav nrog dej txias lossis da dej hauv oatmeal tuaj yeem pab tau. Tham nrog koj tus kws kho mob txog qhov no. Nws yuav sau tshuaj yog tias tsim nyog. Txawm li cas los xij , yog tias mob pob khaus nrog rau tus nplaig lossis caj pas o, lossis yog tias koj ua pa nyuaj, mus rau chav kho mob ceev (ETU) ntawm tsev kho mob tam sim ntawd.
- Cov qe ntshav dawb qis (Lymphopenia): Koj cov qe ntshav dawb yuav txo qis ib ntus thaum ob peb hnub thawj zaug ntawm kev kho mob. Qhov no yuav tsis cuam tshuam rau koj, tab sis nws yuav ua rau koj muaj feem yuav kis tau kab mob ntau dua. Qhov no yuav rov qab mus rau qhov qub hauv ob peb lub lis piam. Koj tus kws kho mob yuav saib xyuas koj tsis tu ncua rau qhov no.
- Mob taub hau: Tej zaum yuav mob taub hau me ntsis xwb. Feem ntau nws yuav ploj mus nws tus kheej. Yog tias mob taub hau tseem muaj lossis hnyav zuj zus, qhia rau koj tus kws kho mob paub.
Cov kev mob tshwm sim loj uas yuav tsum tau ceev faj txog:
- Cytokine Release Syndrome:Vim tias cov tshuaj uas cuam tshuam rau lub cev tiv thaiv kab mob, xws li Tzield, qee zaum tuaj yeem ua rau muaj ntau cov tshuaj tiv thaiv kab mob hu ua cytokines kom raug tso tawm rau hauv cov ntshav ib zaug. Qhov no tuaj yeem tshwm sim thaum ntxov ntawm kev kho mob. Cov tsos mob xws li kub taub hau, xeev siab, mob lub cev, thiab qaug zog heev yuav tshwm sim. Koj tus kws kho mob yuav muab lwm yam tshuaj rau koj (piv txwv li paracetamol) ua ntej kev kho mob kom txo cov no. Yog tias koj muaj ib qho ntawm cov tsos mob no, qhia rau koj tus kws kho mob tam sim ntawd.
- Cov qe ntshav dawb tsawg zuj zus: Yog tias qhov mob no hnyav zuj zus, nws tuaj yeem ua rau muaj kev kis kab mob loj heev. Yog tias koj muaj cov tsos mob ntawm kev kis kab mob xws li kub taub hau, mob khaub thuas, hnoos, thiab qaug zog heev , qhia rau koj tus kws kho mob tam sim ntawd.
Cov no tsis yog txhua yam kev mob tshwm sim ntawm Tzield. Yog tias koj muaj cov tsos mob uas ua rau koj ntxhov siab, nco ntsoov mus ntsib koj tus kws kho mob kom tau txais kev qhia kho mob.
Koj paub li cas tias cov tshuaj ua haujlwm?
Lub hom phiaj ntawm Tzield yog kom ncua qhov pib ntawm cov tsos mob. Yog li ntawd, koj yuav tsis pom qhov txawv ntau tom qab noj tshuaj. Qhov no yog kev kho mob ib zaug xwb 14 hnub. Tom qab ntawd, koj tus kws kho mob yuav kuaj xyuas koj tus kab mob ntshav qab zib tsis tu ncua kom pom tias nws zoo li cas. Tsis txhob tsum noj tshuaj lossis hloov lub sijhawm yam tsis tau koj tus kws kho mob qhia.
Puas muaj teeb meem dab tsi nrog lwm cov tshuaj?
Ua ntej koj pib kho Tzield, nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob txog lwm yam tshuaj uas koj noj (xws li cov vitamins, cov tshuaj ntxiv, Ayurvedic lossis tshuaj ntsuab).
Tshwj xeeb, koj yuav tsum ceev faj txog kev txhaj tshuaj tiv thaiv kab mob thaum noj Tzield. Qee cov tshuaj tiv thaiv kab mob yuav tsis zoo, thiab qee cov yuav tsis muaj kev nyab xeeb. Yog li ntawd , ua ntej txhaj tshuaj tiv thaiv kab mob, qhia rau koj tus kws kho mob tias koj tab tom noj Tzield.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Tzield (Teplizumab) yog ib yam tshuaj tshiab uas tuaj yeem ncua qhov pib ntawm cov tsos mob thiab qhov xav tau insulin ntau xyoo rau cov neeg uas muaj ntshav qab zib hom 1 theem 2.
- Qhov no ua haujlwm los ntawm kev qeeb qeeb ntawm qhov ceev uas lub cev tiv thaiv kab mob rhuav tshem cov hlwb beta tsim cov insulin hauv lub txiav.
- Koj tus kws kho mob yuav txiav txim siab seb qhov kev kho mob no puas yog rau koj tom qab kuaj ntshav tshwj xeeb.
- Tej zaum yuav muaj tej yam tsis zoo xws li ua pob khaus ntawm daim tawv nqaij thiab mob taub hau thiab koj yeej tswj tau. Txawm li cas los xij, yog tias muaj tej yam mob hnyav xws li ua pa nyuaj lossis kub taub hau, nrhiav kev pab kho mob tam sim ntawd.
- Nco ntsoov nrog koj tus kws kho mob tham txog lwm yam tshuaj thiab tshuaj tiv thaiv kab mob uas koj tab tom noj.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus