Yu dɔn ɛva yɛri bɔt asɛtilkɔlin , ɔ (ACh)? Sɔntɛm yu dɔktɔ dɔn tɛl yu bɔt am, ɔ yu dɔn rid bɔt am sɔnsay. Na smɔl bɔt rili impɔtant kemikal na wi bɔdi. I tan lɛk smɔl postman we de kɛr mɛsej dɛn insay wi bɔdi. So, tide wi go tɔk bɔt asɛtilkolin insay wan simpul we we yu go ɔndastand.
Wetin rili na Asetilkɔlin?
Fɔ tɔk am simpul wan, asɛtilkolin na nyurotransmitta . Tink bɔt am, yu bren nid fɔ sɛn smɔl smɔl ilɛktrik mɛsej fɔ muv yu an, tink, mɛmba sɔntin, ɔl dɛn tin ya. Acetylcholine na kemikal mɛsenja we de ɛp fɔ kɛr dɛn mɛsej dɛn de tru di nerve cells .
dis dεn kכl am bak " εksitatory " nyurotransmitta . Yu no wetin na dat? i de "wek" wan nεv sεl, dat na, i de mek i stimulate, εn mek i "sεnd" mεsej fast fast. I tan lɛk se yu nak pɔsin we de slip in domɔt ɛn se, "Na ya, tek dis lɛta."
Di nem asetilkolin kɔmɔt frɔm tu tin dɛn we de mek am. Wan pan dɛn na wan grup we gɛt asɛtil . dis kכmכt frכm wan kכmpawnd we dεn kכl asetil kכεnzym A, we dεn mek frכm di shuga glukכs. Di ɔda wan na wan tin we dɛn kɔl kɔlin . Kɔlin de na di eg yolk, soya, liva, vɛjitebul, ɛn ligɛm. Dɛn kin mek kɔlin bak na wi liva.
asetilkolin de involv insay plεnti imכtant wok dεm na wi bכdi, spεshal mכsul dεm we wi want fכ muv.Dis kin rili ɛp wi fɔ du tin dɛn we wi de tink bɔt, lɛk fɔ muv wi an ɛn fut dɛn ɛn fɔ waka. I de mek di nɛv sɛl dɛn we de na wi mɔsul dɛn wok, ɛn dis kin mek dɛn kɔntrakt. nכto dat nכmכ, bכt i rili imכtant bak fכ di nεv sεl dεm na wi bren, εn fכ prכsεs dεm lεk mεmכri, tink, εn lan.
Aw asɛtilkolin (ACh) de wok?
di asetilkolin de stכr na di εnd dεm na di nεv sεl dεm, te dεn nid fכ sεnd mεsej. We “sayn” kam fɔ sɛn mɛsej, dis asetilkolin we dɛn dɔn kip de kɔmɔt. We dɛn dɔn fri am, i kin travul go na wan smɔl gap bitwin tu nɛv sɛl dɛn. Dɛn kɔl dis gap di sinaptik kleft .
afta dεn kכros di sinaptik cleft, tu t כp rεsεpכta dεm de we asetilkolin kin biεn to. Dɛn na:
- Nikotin risepta dɛn
- Muscarinic risεptor dεm
afta i tay pan dεn rεsεpכta dεm ya, di kεmikכl mεsej de travul go na di nεks nεv sεl. afta dεn sεnd di mεsej, di asetilkolin we de rεst na di sinaptik kleft nכ de jכs go west. כda εnzym we dεn kכ l asetilkolinεstεrayz de kam wit am εn i de brok dis asetilkolin dכn insay in kכnstityushכn pat dεm, kolεn εn asetεt. Dɔn dɛn kin tek dɛn pat dɛn ya we dɔn brok bak, yuz dɛn bak, ɛn yuz dɛn fɔ kɛr ɔda mɛsej we gɛt kemikal. Wan sistɛm we rili efyushɔn!
Wetin kin apin to asetilkolin (ACh)?
Acetylcholine gɛt bɔku bɛnifit fɔ wi bɔdi. Lɛ wi tek wan luk pan di men wan dɛn.
| Risɛptɔ tayp | Men wok dɛn we dɛn kin du |
|---|---|
| Muscarinic risεptor dεm |
|
| Nikotinik rεsεpכta dεm (Nicotinic) . |
|
di tu kayn risepta dεm de involv insay wi mεmכri . Dat min se dɛn impɔtant fɔ mɛmba fɔ lɔng tɛm, fɔ mɛmba fɔ shɔt tɛm, fɔ mek mɛmori, fɔ mek dɛn kɔnsolidɛt, ɛn fɔ mek dɛn gɛt bak. Insay di bren, asetilkolin de involv pan ɔda tin dɛn. I de mek wi gɛt motiveshɔn, intres/atɛnshɔn, lan, ɛn REM slip (di stej we wi de slip we wi de drim).
Wetin na di kכndishכn dεm we de apin we di asetilkolin (ACh) lεvεl dεm dכn dכn?
If yu nɔ gɛt bɛtɛ asɛtilkolin, ɔ yu nɔ gɛt am, dat kin mek yu gɛt bɔku sik dɛn. Di tin dɛn we impɔtant pas ɔl na:
- Alzaima sik : Pipul wae gɛt Alzaima sik nɔr kin gɛt bɛtɛ asɛtilkolin na dɛn bren. Dis kin mek i nɔ ebul fɔ mɛmba tin na wan big sayn.
- Lambert-Eaton myasthenic syndrome : Dis sik de kam bikɔs di asɛtilkolin we de kɔmɔt na di nεv sεl dεm de dכn.
- Myasthenia gravis : Dis na ɔtoimyun sik we de mek di skel mɔsul dɛn wik kwik kwik wan afta dɛn dɔn yuz am bɔku tɛm.
Impɔtant:If yu gɛt ɛni wan pan dɛn sayn ya, go to dɔktɔ wantɛm wantɛm. Nɔ fɔ no yusɛf.
Wetin na di drɔgs dɛm we de tɔch asɛtilkolin (ACh)?
di cholinesterase inhibitors na wan klas fכ dכg dεm we de wok bay we dεn de inaktiv di εnzym we de brok dכn asetylcholine εn inkrεs di aktiviti fכ di asetylcholine rεsεpכta dεm. Dɛn kin yuse dɛn fɔ trit Alzaima sik ɛn myasthenia gravis. Donepezil (Aricept®), Rivastigmine (Exelon®), ɛn Galantamine (Razadyne®) na sɔm pan dɛn mɛrɛsin ya.
Us it dεm gεt kolεn, we de εp fכ mek asetilkolin (ACh)?
Choline, we na wan nyutrient we kin chenj to asetilkolin, de insay bɔku it dɛn. Fɔ ɛgzampul:
- Bif liva
- Eg (especially di yolks) .
- Bif top raun
- Roast soya bin, tin kidni bins
- Roast chicken breast we dɛn dɔn rost
- Kod fish `(Kɔd)`
- Kinoa we dɛn dɔn kuk
- Shiitake mushroom we dɛn kuk, brɔkoli we dɛn dɔn bɔyl ɛn Brussels sprouts
- Milk (1%) `(Milk (1%))`, vanila yogɔt we nɔ gɛt fat `(vanila yogɔt we nɔ gɛt fat)`
Tray fɔ ad dɛn it ya to yu it. Fɔ it fayn fayn tin dɛn rili impɔtant fɔ mek yu gɛt wɛlbɔdi.
Mɛsej we dɛn kin kɛr go na os
So, naw yu go dɔn ɔndastand se asɛtilkolin (ACh) na nyurotransmitta we rili impɔtant fɔ wi bren wok, mɛmori, ɛn bɔdi wok lɛk we di mɔsul dɛn kɔntrakt. If in lɛvɛl go dɔŋ, i kin gɛt prɔblɛm wit di mɛmori ɛn sik dɛn we gɛt fɔ du wit di mɔsul dɛn. Di tin we impɔtant pas ɔl na dat, if yu gɛt ɛni wɛlbɔdi prɔblɛm, tɔk to dɔktɔ bɔt am. Nɔ go fɔ tritmɛnt pan asɔmpshɔn. Stay wit wɛlbɔdi!
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